The clinical relevance of oliguria in the critically ill patient : Analysis of a large observational database

Funding Information: Marc Leone reports receiving consulting fees from Amomed and Aguettant; lecture fees from MSD, Pfizer, Octapharma, 3 M, Aspen, Orion; travel support from LFB; and grant support from PHRC IR and his institution. JLV is the Editor-in-Chief of Critical Care. The other authors declare that they have no relevant financial interests. Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Urine output is widely used as one of the criteria for the diagnosis and staging of acute renal failure, but few studies have specifically assessed the role of oliguria as a marker of acute renal failure or outcomes in general intensive care unit (ICU) patients. Using a large multinational database, we therefore evaluated the occurrence of oliguria (defined as a urine output 16 years) patients in the ICON audit who had a urine output measurement on the day of admission were included. To investigate the association between oliguria and mortality, we used a multilevel analysis. Results: Of the 8292 patients included, 2050 (24.7%) were oliguric during the first 24 h of admission. Patients with oliguria on admission who had at least one additional 24-h urine output recorded during their ICU stay (n = 1349) were divided into three groups: transient - oliguria resolved within 48 h after the admission day (n = 390 [28.9%]), prolonged - oliguria resolved > 48 h after the admission day (n = 141 [10.5%]), and permanent - oliguria persisting for the whole ICU stay or again present at the end of the ICU stay (n = 818 [60.6%]). ICU and hospital mortality rates were higher in patients with oliguria than in those without, except for patients with transient oliguria who had significantly lower mortality rates than non-oliguric patients. In multilevel analysis, the need for RRT was associated with a significantly higher risk of death (OR = 1.51 [95% CI 1.19-1.91], p = 0.001), but the presence of oliguria on admission was not (OR = 1.14 [95% CI 0.97-1.34], p = 0.103). Conclusions: Oliguria is common in ICU patients and may have a relatively benign nature if only transient. The duration of oliguria and need for RRT are associated with worse outcome.publishersversionPeer reviewe

Rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART): Study protocol for a randomized controlled trial

Background: Acute respiratory distress syndrome (ARDS) is associated with high in-hospital mortality. Alveolar recruitment followed by ventilation at optimal titrated PEEP may reduce ventilator-induced lung injury and improve oxygenation in patients with ARDS, but the effects on mortality and other clinical outcomes remain unknown. This article reports the rationale, study design, and analysis plan of the Alveolar Recruitment for ARDS Trial (ART). Methods/Design: ART is a pragmatic, multicenter, randomized (concealed), controlled trial, which aims to determine if maximum stepwise alveolar recruitment associated with PEEP titration is able to increase 28-day survival in patients with ARDS compared to conventional treatment (ARDSNet strategy). We will enroll adult patients with ARDS of less than 72 h duration. The intervention group will receive an alveolar recruitment maneuver, with stepwise increases of PEEP achieving 45 cmH(2)O and peak pressure of 60 cmH2O, followed by ventilation with optimal PEEP titrated according to the static compliance of the respiratory system. In the control group, mechanical ventilation will follow a conventional protocol (ARDSNet). In both groups, we will use controlled volume mode with low tidal volumes (4 to 6 mL/kg of predicted body weight) and targeting plateau pressure <= 30 cmH2O. The primary outcome is 28-day survival, and the secondary outcomes are: length of ICU stay; length of hospital stay; pneumothorax requiring chest tube during first 7 days; barotrauma during first 7 days; mechanical ventilation-free days from days 1 to 28; ICU, in-hospital, and 6-month survival. ART is an event-guided trial planned to last until 520 events (deaths within 28 days) are observed. These events allow detection of a hazard ratio of 0.75, with 90% power and two-tailed type I error of 5%. All analysis will follow the intention-to-treat principle. Discussion: If the ART strategy with maximum recruitment and PEEP titration improves 28-day survival, this will represent a notable advance to the care of ARDS patients. Conversely, if the ART strategy is similar or inferior to the current evidence-based strategy (ARDSNet), this should also change current practice as many institutions routinely employ recruitment maneuvers and set PEEP levels according to some titration method.Hospital do Coracao (HCor) as part of the Program 'Hospitais de Excelencia a Servico do SUS (PROADI-SUS)'Brazilian Ministry of Healt

O processo de humanização do ambiente hospitalar centrado no trabalhador El proceso de humanización del ambiente hospitalario centrado en el trabajador The humanization process of the hospital environment centered around the worker

A humanização do ambiente hospitalar não se concretiza se estiver centrada unicamente em fatores motivacionais externos ou somente no usuário. Um programa de humanização necessita ser assumido como um processo de construção participativa que requer respeito e valorização do ser humano que cuida. Pautado em valores e princípios humanos e éticos e em idéias de Freire, este trabalho tem por objetivo explicitar como se desencadeou um processo de humanização, numa instituição hospitalar, centrado, inicialmente, no trabalhador, mediante a problematização coletiva da realidade concreta e a construção de relações dialógicas, horizontais e reflexivas. A proposta possibilitou maior compreensão do significado de humanização, com o resgate de iniciativas anteriores de humanização já adotadas, a adoção de um Banco de Idéias como um espaço para a emersão de subjetividades, a organização de ambientes coletivos acolhedores e uma maior aproximação entre a direção e trabalhadores.<br>La humanización del ambiente hospitalario no se concretiza si estuviera centrada únicamente en factores de motivación externas o solamente en el usuario. Un programa de humanización necesita ser asumido como un proceso de construcción participativa que requiere respeto y valorización del ser humano que cuida. Basados en valores y principios humanos y éticos y en ideas de Freire, este trabajo tuvo por objetivo explicitar cómo se desencadenó el proceso de humanización, en una institución hospitalaria, centrado, inicialmente, en el trabajador, mediante la problematización colectiva de la realidad concreta y la construcción de relaciones dialógicas, horizontales y reflexivas. La propuesta posibilitó mayor comprensión del significado de humanización, con el rescate de iniciativas anteriores de humanización ya adoptada, la adopción de un Banco de Ideas como un espacio para la emergencia de subjetividades, la organización de ambientes colectivos acogedores y una mayor aproximación entre la dirección y los trabajadores.<br>The humanization of the hospital environment cannot be achieved if the focus is directed only to external motivational factors or just to the user. A humanization program needs to be assumed as a participative construction process that demands respect and valuing of the human being that provides care. Based on human and ethics values and principles and on Freire's ideas, this study aims to describe how a humanization process was unchained in a hospital, initially centering on the worker, through the collective discussion of concrete problems and the construction of horizontal, reflective dialogical relations. The proposal made possible a better comprehension of the meaning of humanization, with the rescue of previous initiatives of humanization, the elaboration of a databank in which there is room for subjectivity, the creation of warm collective areas and a closer relationship between directors and workers