KoKoo (Kontent Kooration) Evolving a Content Curation System To a comprehensive Editorial backend platform

The aim of this paper is to show how a prototypal system, designed as a general purpose stand-alone content curation tool could be evolved by following some alpha user's feedbacks to an comprehensive multi-service platform. The widespread diffusion of mobile devices, such as smartphones and tablets as long as the availability of mobile wideband services are increasing day by day the number of players in the ICT Market. In such a scenario, following the user needs becomes a critical issue, since it is likely for the users. to find products and services quite similar to the one you are offering, better fulfilling their needs. KOKOO (KOntent + KOO(Ù)ration) is a comprehensive platform made by Telecom Italia R&D division. It is a solution for solving the growing content provider needs to find new and most interesting news to offer to other users on different media, aggregating them in a personal journal with a similar look and feel. Chapter 2 will show the old system (presented also at Nem Summit 2012 showcase), chapter 3 will present user feedbacks and chapter 4 will show the new system and all of its aggregated services, stressing how this was designed by following user feedback

HE4 in the differential diagnosis of ovarian masses

Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries. According to the current guidelines, measurement of CA125 tumor marker remains the gold standard in the management of ovarian cancer. Recently, HE4 has been proposed as emerging biomarker in the differential diagnosis of adnexal masses and in the early diagnosis of ovarian cancer. Discrimination of benign and malignant ovarian tumors is very important for correct patient referral to institutions specializing in care and management of ovarian cancer. Tumor markers CA125 and HE4 are currently incorporated into the Risk of Ovarian Malignancy Algorithm” (ROMA) with menopausal status for discerning malignant from benign pelvic masses. The availability of a good biomarker such as HE4, closely associated with the differential and early diagnosis of ovarian cancer, could reduce medical costs related to more expensive diagnostic procedures. Finally, it is important to note that HE4 identifies platinum non-responders thus enabling a switch to second line chemotherapy and improved survival

Audio-vestibular symptoms in systemic autoimmune diseases

Immune-mediated inner ear disease can be primary, when the autoimmune response is against the inner ear, or secondary. The latter is characterized by the involvement of the ear in the presence of systemic autoimmune conditions. Sensorineural hearing loss is the most common audiovestibular symptom associated with systemic autoimmune diseases, although conductive hearing impairment may also be present. Hearing loss may present in a sudden, slowly, rapidly progressive or fluctuating form, and is mostly bilateral and asymmetric. Hearing loss shows a good response to corticosteroid therapy that may lead to near-complete hearing restoration. Vestibular symptoms, tinnitus, and aural fullness can be found in patients with systemic autoimmune diseases; they often mimic primary inner ear disorders such as Menière’s disease and mainly affect both ears simultaneously. Awareness of inner ear involvement in systemic autoimmune diseases is essential for the good response shown to appropriate treatment. However, it is often misdiagnosed due to variable clinical presentation, limited knowledge, sparse evidence, and lack of specific diagnostic tests. The aim of this review is to analyse available evidence, often only reported in the form of case reports due to the rarity of some of these conditions, of the different clinical presentations of audiological and vestibular symptoms in systemic autoimmune diseases

Vestibular schwannoma and ipsilateral endolymphatic hydrops: an unusual association

Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual nding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with uctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging. Clinical audio-vestibular and radiological examination con rmed the presence of coexisting vestibular schwannoma and endolymphatic hydrops. Hydrops was treated pharmacologically; vestibular schwannoma was monitored over time with a wait and scan protocol through conventional MRI. The association of vestibular schwannoma and endolymphatic hydrops is rare, but represents a possible nding in clinical practice. It is therefore recommended investigating the presence of inner ear disorders in patients with vestibular schwannoma and, similarly, to exclude the presence of this condition in patients with symptoms typical of inner ear disorders

Somatic tinnitus

Modulation of tinnitus characteristics such as pitch and loudness has been extensively described following movements of the head, neck and limbs, vertical or horizontal eye gaze, pressure on myofascial trigger points, cutaneous stimulation of the hands, electrical stimulation of the median nerve, and transcranial direct current stimulation. Modulation of tinnitus follows complex interactions between auditory and somatosensory afferents and can be favored by underlying somatic disorders. When tinnitus appears to be preceded or strictly linked to a somatic disorder, and therefore related to problems of the musculoskeletal system rather than of the ear, it is defined somatic tinnitus. A correct diagnosis and treatment of somatic disorders underlying tinnitus play a central role for a correct management of somatic tinnitus. However, the identification of somatic tinnitus may be complex in some cases. In this paper, after a general review of the current evidences for somatic tinnitus available in the literature, we present and discuss some cases of patients in which somatic modulation of tinnitus played a role - although different from case to case - in their tinnitus, describing the diagnostic and therapeutic approaches followed in each individual case and the results obtained, also highlighting unexpected findings and pitfalls that may be encountered when approaching somatic tinnitus patients

Evaluation of lymphocyte levels in a random sample of 218 elderly individuals from São Paulo city

BACKGROUND: Age-associated changes in the immune system cause decreased protection after vaccination and increased rates of infections and tumor development. METHODS: Lymphocyte percentages were compared by gender and age to establish differences between subtypes. Three mL blood samples were obtained from 218 randomly selected individuals (60-101 years old) who live in São Paulo city. Blood was lysed with Tris phosphate buffer and stained for 30 minutes with monoclonal antibodies (CD3PerCP, CD4FITC, CD8Pe, CD19Pe) for analysis by flow cytometry. Statistical analysis was by ANOVA. RESULTS: The percentage of CD4+ T cells (p-value = 0.005) and the CD4/CD8 ratio (p-value = 0.010) were lower in men, whereas the percentage of CD8+ T cells was lower (p-value = 0.002) in women; the percentage of B cells (CD19+ ) was similar between groups. Individuals grouped by gender and age range and compared showed a drop in CD4+ cells in 75 to 79-year-old men (female: 46.1% ± 8.1% and male: 38.8% ± 10.5%; p-value = 0.023). Also, the 80 to 84-year-old group of men had a higher percentage of CD8+ (female: 20.8% ± 8.2%, and male: 27.2% ± 8.2%; p-value = 0.032). Low percentages of B cells were detected in men in the 75 to 79-year-old (p-value = 0.003), 85 to 89-year-old (p-value = 0.020) and older than 90 year old (p-value = 0.002) age ranges. CONCLUSION: Elderly men present with more changes in lymphocyte subsets compared to elderly women. These findings could demonstrate impairment in the immune response since the lower CD4+ in men would provide less help to B cells (also lower in men) in terms of antibody production. In addition, the increase in CD8+ cells in this group could represent chronic inflammation observed during the aging process.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo (UNIFESP) Immunology DepartmentUniversidade de São Paulo Faculdade de Medicina de Ribeirão PretoUniversidade de São Paulo Escola de Saúde PúblicaUniversidade Federal de São Paulo (UNIFESP) Biosciences DepartmentUNIFESP, Immunology DepartmentUNIFESP, Biosciences DepartmentSciEL

The Luminosity Function of the NoSOCS Galaxy Cluster Sample

We present the analysis of the luminosity function of a large sample of galaxy clusters from the Northern Sky Optical Cluster Survey, using latest data from the Sloan Digital Sky Survey. Our global luminosity function (down to M_r<= -16) does not show the presence of an upturn at faint magnitudes, while we do observe a strong dependence of its shape on both richness and cluster-centric radius, with a brightening of M^* and an increase of the dwarf to giant ratio with richness, indicating that more massive systems are more efficient in creating/retaining a population of dwarf satellites. This is observed both within physical (0.5 R_200) and fixed (0.5 Mpc) apertures, suggesting that the trend is either due to a global effect, operating at all scales, or to a local one but operating on even smaller scales. We further observe a decrease of the relative number of dwarf galaxies towards the cluster center; this is most probably due to tidal collisions or collisional disruption of the dwarfs since merging processes are inhibited by the high velocity dispersions in cluster cores and, furthermore, we do not observe a strong dependence of the bright end on the environment. We find indication that the dwarf to giant ratio decreases with increasing redshift, within 0.07<z<0.2. We also measure a trend for stronger suppression of faint galaxies (below M^*+2) with increasing redshift in poor systems, with respect to more massive ones, indicating that the evolutionary stage of less massive galaxies depends more critically on the environment. Finally we point out that the luminosity function is far from universal; hence the uncertainties introduced by the different methods used to build a composite function may partially explain the variety of faint-end slopes reported in the literature as well as, in some cases, the presence of a faint-end upturn.Comment: 16 pages, 12 figures. Accepted for publication in MNRA

The Importance of Human Mental Workload in Web Design

The focus of this study is the introduction of the construct of Human Mental Workload (HMW) in Web design, aimed at supporting current interaction design practices. An experiment has been conducted using the original Wikipedia and Google web-interfaces, and using two slightly different versions. Three subjective psychological mental workload assessment techniques (NASA-TLX, Workload Profile and SWAT) with a well-established assessments usability tool (SUS) have been adopted. T-tests have been performed to study the statistical significance of the original and modified web-pages, in terms of workload required by typical tasks and perceived usability. Preliminary results show that, in one ideal case, increments of usability correspond to decrements of generated workload, confirming the negative impact of the structural changes on the interface. In another case, changes are significant in terms of usability but not in terms of generated workloads, thus raising research questions and underlying the importance of Human Mental Workload in Interaction Design

Targeting CXCR4 reverts the suppressive activity of T-regulatory cells in renal cancer

With the intent to identify biomarkers in renal cell carcinoma (RCC) the functional status of T-regulatory cells (Tregs) was investigated in primary RCC. Tregs were isolated from tumoral-(TT), peritumoral tissue-(PT) and peripheral blood-(PB) of 42 primary RCC patients and function evaluated through effector T cells (Teff) proliferation, cytokines release and demethylation of Treg Specific Region (TSDR). The highest value of Tregs was detected in TT with the uppermost amount of effector-Tregs-(CD4+CD25hiFOXP3hiCD45RA-). PB-RCC Tregs efficiently suppress Teff proliferation compared to healthy donor (HD)-Tregs and, at the intrapatient evaluation, TT-derived Tregs were the most suppressive. Higher demethylation TSDR was detected in TT- and PB-RCC Tregs vs HD-Tregs (P <0,001). CXCR4 is highly expressed on Tregs, thus we wished to modulate Tregs function through CXCR4 inhibition. CXCR4 antagonism, elicited by a new peptidic antagonist, Peptide-R29, efficiently reversed Tregs suppression of Teff proliferation. Thus Tregs functional evaluation precisely reflects Tregs status and may be a reliable biomarker of tumoral immune response. In addition, treatment with CXCR4 antagonist, impairing Tregs function, could improve the anticancer immune response, in combination with conventional therapy and/or immunotherapy such as checkpoints inhibitors