Evolución geodinámica de la fosa del Empordà y las Sierras Transversales

The Emporda basin, together with the half graben system of the Sierras Transversales, form a segment of the European Rift, which is defined here by the NW-SE-trending fault system of northeastern Catalonia.The study area, which partially includes the Sierras Transversales and the southem margin of the Emporda basin, is internally structured by normal faults with listric geometry. Those with measured dip slips of about 1,000 meters are here called main faults; those located in the hanging walls of the main ones are called minor faults, and their dip slips are, at least, lesser in one order of magnitude. The hanging walls of the main faults hold half graben basins, with a sedimentary infill mainly neogene in age in the Emporda, and of quaternay age in the Sierras Transversales. Both areas are geologically bounded by the Camós-Celra fault. This rift segment is also characterized by the occurence of numerous volcanic emission centres. The timing of activity and burial of each fault, constrained by the ages of the associated sediments and vulcanism, suggest a piggy-back sequence of propagation from Miocene to recent times. The geological cross-section constructed from surface data, allowed us the elaboration of a geometric model in clepth for the whole fault system, usiug the inclined shear method. The calculated extension from this method gives us a value of B=1.27. On the other han4 the very high calculated magma ascent rates strongiy constrain the structure in the footwall (crust); subsequently, high angle discontinuities favouring a very fast magmatic ascent have to be definied. These discontinuities would form two imbricate systems (extensional duplexes), with a roof detachment coinciding with the floor detachment of the shallow fault system and a floor detachment located in the MOHO discontinuity. A similar crustal structuration is observed in the neighbouring segment of the Gulf of Lions

Zealots Attack and the Revenge of the Commons: Quality vs Quantity in the Best-of-n

© 2020, Springer Nature Switzerland AG. In this paper we study the effect of inflexible individuals with fixed opinions, or zealots, on the dynamics of the best-of-n collective decision making problem, using both the voter model and the majority rule decision mechanisms. We consider two options with different qualities, where the lower quality option is associated to a higher number of zealots. The aim is to study the trade-off between option quality and zealot quantity for two different scenarios: one in which all agents can modulate dissemination of their current opinion proportionally to the option quality, and one in which this capability is only possessed by the zealots. In both scenarios, our goal is to determine in which conditions consensus is more biased towards the high or low quality option, and to determine the indifference curve separating these two regimes. Using both numerical simulations and ordinary differential equation models, we find that: i) if all agents can modulate the dissemination time based on the option quality, then consensus can be driven to the high quality option when the number of zealots for the other option is not too high; ii) if only zealots can modulate the dissemination time based on the option quality, whil e all normal agents cannot distinguish the two options and cannot differentially disseminate, then consensus no longer depends on the quality and is driven to the low quality option by the zealots

Hepatitis B infection, viral load and resistance in HIV-infected patients in Mozambique and Zambia

BACKGROUND: Few data on the virological determinants of hepatitis B virus (HBV) infection are available from southern Africa. METHODS: We enrolled consecutive HIV-infected adult patients initiating antiretroviral therapy (ART) at two urban clinics in Zambia and four rural clinics in Northern Mozambique between May 2013 and August 2014. HBsAg screening was performed using the Determine ® rapid test. Quantitative real-time PCR and HBV sequencing were performed in HBsAg-positive patients. Risk factors for HBV infection were evaluated using Chi-square and Mann-Whitney tests and associations between baseline characteristics and high level HBV replication explored in multivariable logistic regression. RESULTS: Seventy-eight of 1,032 participants in Mozambique (7.6%, 95% confidence interval [CI]: 6.1-9.3) and 90 of 797 in Zambia (11.3%, 95% CI: 9.3-13.4) were HBsAg-positive. HBsAg-positive individuals were less likely to be female compared to HBsAg-negative ones (52.3% vs. 66.1%, p20,000 UI/mL). HBsAg-positive individuals had higher levels of ALT and AST compared to HBsAg-negative ones (both p<0.001). In multivariable analyses, male sex (adjusted odds ratio: 2.59, 95% CI: 1.22-5.53) and CD4 cell count below 200/μl (2.58, 1.20-5.54) were associated with high HBV DNA. HBV genotypes A1 (58.8%) and E (38.2%) were most prevalent. Four patients had probable resistance to lamivudine and/or entecavir. CONCLUSION: One half of HBsAg-positive patients demonstrated high HBV viremia, supporting the early initiation of tenofovir-containing ART in HIV/HBV-coinfected adults

Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks

The impact of the DART spacecraft into Dimorphos, moon of the asteroid Didymos, changed Dimorphos' orbit substantially, largely from the ejection of material. We present results from twelve Earth-based facilities involved in a world-wide campaign to monitor the brightness and morphology of the ejecta in the first 35 days after impact. After an initial brightening of ~1.4 magnitudes, we find consistent dimming rates of 0.11-0.12 magnitudes/day in the first week, and 0.08-0.09 magnitudes/day over the entire study period. The system returned to its pre-impact brightness 24.3-25.3 days after impact through the primary ejecta tail remained. The dimming paused briefly eight days after impact, near in time to the appearance of the second tail. This was likely due to a secondary release of material after re-impact of a boulder released in the initial impact, through movement of the primary ejecta through the aperture likely played a role.Comment: 16 pages, 5 Figures, accepted in the Astrophysical Journal Letters (ApJL) on October 16, 202

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Ejecta Evolution Following a Planned Impact into an Asteroid: The First Five Weeks

The impact of the Double Asteroid Redirection Test spacecraft into Dimorphos, moon of the asteroid Didymos, changed Dimorphos’s orbit substantially, largely from the ejection of material. We present results from 12 Earth-based facilities involved in a world-wide campaign to monitor the brightness and morphology of the ejecta in the first 35 days after impact. After an initial brightening of ∼1.4 mag, we find consistent dimming rates of 0.11–0.12 mag day−1 in the first week, and 0.08–0.09 mag day−1 over the entire study period. The system returned to its pre-impact brightness 24.3–25.3 days after impact though the primary ejecta tail remained. The dimming paused briefly eight days after impact, near in time to the appearance of the second tail. This was likely due to a secondary release of material after re-impact of a boulder released in the initial impact, though movement of the primary ejecta through the aperture likely played a role