White box radial basis function classifiers with component selection for clinical prediction models

Objective: To propose a new flexible and sparse classifier that results in interpretable decision support systems. Methods: Support vector machines (SVMs) for classification are very powerful methods to obtain classifiers for complex problems. Although the performance of these methods is consistently high and non-linearities and interactions between variables can be handled efficiently when using non-linear kernels such as the radial basis function (RBF) kernel, their use in domains where interpretability is an issue is hampered by their lack of transparency. Many feature selection algorithms have been developed to allow for some interpretation but the impact of the different input variables on the prediction still remains unclear. Alternative models using additive kernels are restricted to main effects, reducing their usefulness in many applications. This paper proposes a new approach to expand the RBF kernel into interpretable and visualizable components, including main and two-way interaction effects. In order to obtain a sparse model representation, an iterative l-regularized parametric model using the interpretable components as inputs is proposed. Results: Results on toy problems illustrate the ability of the method to select the correct contributions and an improved performance over standard RBF classifiers in the presence of irrelevant input variables. For a 10-dimensional x-or problem, an SVM using the standard RBF kernel obtains an area under the receiver operating characteristic curve (AUC) of 0.947, whereas the proposed method achieves an AUC of 0.997. The latter additionally identifies the relevant components. In a second 10-dimensional artificial problem, the underlying class probability follows a logistic regression model. An SVM with the RBF kernel results in an AUC of 0.975, as apposed to 0.994 for the presented method. The proposed method is applied to two benchmark datasets: the Pima Indian diabetes and the Wisconsin Breast Cancer dataset. The AUC is in both cases comparable to those of the standard method (0.826 versus 0.826 and 0.990 versus 0.996) and those reported in the literature. The selected components are consistent with different approaches reported in other work. However, this method is able to visualize the effect of each of the components, allowing for interpretation of the learned logic by experts in the application domain. Conclusions: This work proposes a new method to obtain flexible and sparse risk prediction models. The proposed method performs as well as a support vector machine using the standard RBF kernel, but has the additional advantage that the resulting model can be interpreted by experts in the application domain. © 2013 Elsevier B.V

Reconstruction of delayed scleral flap melting with bovine pericardium after trabeculectomy with mitomycin C.

Aim: To present a challenging case of hypotony after trabeculectomy and its treatment. Case description: A 22-year-old woman with juvenile glaucoma underwent a conventional trabeculectomy with mitomycin C on the right eye (OD). In the immediate postoperative period, we observed a hyperfiltration bleb with hypotony refractory to conservative measures leading to hypotony maculopathy. A surgical revision with scleral flap resuture and conjunctival graft was performed with a satisfactory result and resolution of hypotony maculopathy. After two years, the patient complained of low visual acuity (VA) of the OD. During examination, we observed a fine and avascular bleb with Seidel and visualization of the underlying uveal tissue, an intraocular pressure (IOP) of 5 mmHg, and chorioretinal folds. A new revision of the trabeculectomy was performed. During the procedure, it was not possible to identify the scleral flap, so the fistula was closed with a patch of collagenous membrane derived from bovine pericardium (Tutopatch® graft). A good clinical evolution occurred. After 2 months, IOP was 15 mmHg without Seidel or changes in the fundus and VA was 20/20. After 8 months of follow-up, the IOP remains stable without further complaints. Conclusion: This case illustrates the difficulties faced in the management of a common complication of trabeculectomy and highlights some of the options available for its treatment. There are few reports of scleral melting after trabeculectomy. However, trauma and scleral necrosis associated with mitomycin are listed as the main causes. The use of a scleral patch derived from bovine pericardium allows effective suturing and closure of the aqueous leak.info:eu-repo/semantics/publishedVersio

Pharmacological characterisation of arthritis induced by Bothrops jararaca venom in rabbits: a positive cross talk between bradykinin, nitric oxide and prostaglandin E2.

BACKGROUND: Our previous results showed that nitric oxide (NO) and bradykinin (BK) mediate the arthritis induced by Bothrops jararaca venom (BjV) in rabbits. In this study, we investigated the contribution of each receptor of BK as well as the inter-relationship between NO and eicosanoids in BjV-induced arthritis. METHODS: The arthritis was induced in rabbits with 16 microg of BjV injected intra-articularly. Prostaglandin E2 (PGE2), thromboxane B2 (TxB2), leukotriene B4 (LTB4) (radioimmunoassay) and nitrite/nitrate concentrations (NO2/NO3) (Griess reaction) were evaluated in the synovial fluid 4 h later. The animals were prior treated with NO synthase inhibitor (L-NAME; 20 mg/kg/day for 14 days), the B2 antagonist of BK (HOE-140) and the B1 antagonist of BK (des-Arg9[Leu8]-bradykinin), both at a dose of 0.3mg/kg, 30 min prior to the venom injection. RESULTS: Data show that L-NAME and HOE-140 treatment were equally able to reduce PGE2 and NO2/NO3 levels without interfering with TxB2 and LTB4 production. On the contrary, the B1 antagonist of BK inhibited TxB2 and LTB4 production, and did not alter PGE2 and NO metabolites levels in the inflamed joint. DISCUSSIONS: The results presented clarify the contribution of the kinin system, mainly through the B2 receptor, to the local inflammatory response induced by BjV, as well as its positive interaction with PGE2 and NO production

Experimental investigation of a quantum heat engine powered by generalized measurements

Generalized measurements may allow the control of its invasiveness on the quantum system interpolating from a very weak to strong projective action. Such a measurement can fuel a quantum heat engine or extract work depending on the system-meter interaction. Here, we performed a proof-of-concept experiment using Nuclear Magnetic Resonance techniques to investigate a spin quantum heat engine driven by non-selective generalized (weak) measurements without feedback control. Our prototype of a quantum thermal device operates with a measurement protocol and a single heat bath. The protocol is composed of two non-selective measurement channels with variable measurement strengths, one dedicated to fueling the device (analogous to a hot heat source) and the other committed to work extraction. The experimental results highlight that this kind of quantum thermal device can reach unit efficiency with maximum extracted power by fine-tuning of the measurement strengths.Comment: 8 pages, 6 figure

Presynaptic Proteins As Markers Of The Neurotoxic Activity Of Bmjetx-i And Bmjetx-ii Toxins From Bothrops Marajoensis (marajo Lancehead) Snake Venom

Neuromuscular preparations exposed to B. marajoensis venom show increases in the frequency of miniature end-plate potentials and twitch tension facilitation followed by presynaptic neuromuscular paralysis, without evidences of muscle damage. Considering that presynaptic toxins interfere into the machinery involved in neurotransmitter release (synaptophysin, synaptobrevin, and SNAP25 proteins), the main objective of this communication is to analyze, by immunofluorescence and western blotting, the expression of the synaptic proteins, synaptophysin, synaptobrevin, and SNAP25 and by myography, light, and transmission electron microscopy the pathology of motor nerve terminals and skeletal muscle fibres of chick biventer cervicis preparations (CBC) exposed in vitro to BmjeTX-I and BmjeTX-II toxins from B. marajoensis venom. CBC incubated with toxins showed irreversible twitch tension blockade and unaffected KCl- and ACh-evoked contractures, and the positive colabelling of acetylcholine receptors confirmed that their action was primarily at the motor nerve terminal. Hypercontraction and loose myofilaments and synaptic vesicle depletion and motor nerve damage indicated that the toxins displayed both myotoxic and neurotoxic effect. The blockade resulted from interference on synaptophysin, synaptobrevin, and SNAP25 proteins leading to the conclusion that BmjeTX-I and BmjeTX-II affected neurotransmitter release machinery by preventing the docking of synaptic vesicles to the axolemma of the nerve terminal

Modelagem a vazio do sistema teste de distribuição de 34 nós IEEE pelo software Simulink em ambiente MatLab™

This work proposes a Simulink/MATLAB model for the IEEE 34 radial distribution test feeder with no load condition. It is useful to test and compare computer programs for analysis of radial distribution feeders. The results show that, although unstable, the voltage levels for both, the three phase and single phase line sections, are within the expected values, considering the lines resistance and reactance, and also no regulation and no load conditions. The model created in this work is intended for systems studies.Este trabalho propõe um modelo em simulink/MatLab para o sistema teste de distribuição de 34 nós IEEE operando a vazio. É usado para testar e comparar os programas computacionais existentes para análise de alimentadores de distribuição radial. Os resultados mostram que, apesar de instáveis, os níveis de tensão para ambos, as secções trifásicas e monofásicas, estão dentro dos valores esperados, considerando a resistência e reatância das linhas, e também a regulação não e não condições de carga. O modelo criado neste trabalho destina-se a estudos de sistemas

Development of antennal sensilla of Tetragonisca angustula Latreille, 1811 (Hymenoptera: Meliponini) during pupation

The antennal sensilla are sensory organs formed by a group of neurons and accessory cells, which allow perception of environmental cues, which play a role as mechanoreceptors and chemoreceptors. This study describes the post-embryonic development of the antennal sensilla of the stingless Tetragonisca angustula (Hymenoptera: Meliponini) workers. The development of the antennal sensilla begins in the transition stage of the pre-pupae to white-eyed pupae. The sensilla are completely developed at the black-eyed pupae stage, but they are covered by the old cuticle. The sensilla are exposed to the environment only in newly emerged workers of T. angustula, but it is possible that environmental stimuli can be recognized due to the pores in the old cuticle.As sensilas antenais são órgãos sensoriais formados por um conjunto de neurônios que captam estímulos ambientais e células acessórias, desempenhando as funções de mecanorreceptores e quimiorrecepterores. Este trabalho descreve o desenvolvimento pós-embrionário das sensilas antenais de operárias das abelhas sem ferrão Tetragonisca angustula (Hymenoptera: Meliponini). O desenvolvimento das sensilas tem início na transição de pré-pupa para pupa de olho branco e estão completamente desenvolvidas no estágio de pupa de olho preto, mas ainda estão cobertas pela cutícula velha. As sensilas estão completamente expostas em operárias recém-emergidas de T. angustula, mas é possível que estímulos ambientais sejam percebidos em estágios anteriores devido aos poros presentes na cutícula velha

Specific heat and magnetic measurements in Nd0.5Sr0.5MnO3, Nd0.5Ca0.5MnO3 and Ho0.5Ca0.5MnO3 samples

We studied the magnetization as a function of temperature and magnetic field in the compounds Nd0.5Sr0.5MnO3, Nd0.5Ca0.5MnO3 and Ho0.5Ca0.5MnO3. It allowed us to identify the ferromagnetic, antiferromagnetic and charge ordering phases in each case. The intrinsic magnetic moments of Nd3+ and Ho3+ ions experienced a short range order at low temperatures. We also did specific heat measurements with applied magnetic fields between 0 and 9 T and temperatures between 2 and 300 K in all three samples. Close to the charge ordering and ferromagnetic transition temperatures the specific heat curves showed peaks superposed to the characteristic response of the lattice oscillations. Below 10 K the specific heat measurements evidenced a Schottky-like anomaly for all samples. However, we could not successfully fit the curves to either a two level nor a distribution of two-level Schottky anomaly. Our results indicated that the peak temperature of the Schottky anomaly was higher in the compounds with narrower conduction band.Comment: submitted to PR