998 research outputs found
The Partisan Politics of New Social Risks in Advanced Postindustrial Democracies: Social Protection for Labor Market Outsiders
Advanced postindustrialization generates numerous challenges for the European social model. Central among these challenges is declining income, unstable employment, and inadequate training of semi- and unskilled workers. In this chapter, I assess the partisan basis of support for social policies that address the needs of these marginalized workers. I specifically consider the impacts of postindustrial cleavages among core constituencies of social democratic parties on the capacity of these parties to pursue inclusive social policies. I argue – and find support for in empirical analyses – that encompassing labor organization is the most important factor in strengthening the ability of left parties to build successful coalitions in support of outsider-friendly policies. I go beyond existing work on the topic by considering the full array of postindustrial cleavages facing left parties, by more fully elaborating why encompassing labor organization is crucial, and by considering a more complete set of measures of outsider policies than extant work. I compare my arguments and findings to important new work that stresses coalition building and partisan politics but minimizes the role of class organization
Some Findings Concerning Requirements in Agile Methodologies
gile methods have appeared as an attractive alternative to conventional methodologies. These methods try to reduce the time to market and, indirectly, the cost of the product through flexible development and deep customer involvement. The processes related to requirements have been extensively studied in literature, in most cases in the frame of conventional methods. However, conclusions of conventional methodologies could not be necessarily valid for Agile; in some issues, conventional and Agile processes are radically different. As recent surveys report, inadequate project requirements is one of the most conflictive issues in agile approaches and better understanding about this is needed. This paper describes some findings concerning requirements activities in a project developed under an agile methodology. The project intended to evolve an existing product and, therefore, some background information was available. The major difficulties encountered were related to non-functional needs and management of requirements dependencies
Metamorphic testing as a test case selection strategy
Abstract not available
Functional Integration of Grafted Neural Stem Cell-Derived Dopaminergic Neurons Monitored by Optogenetics in an In Vitro Parkinson Model
Intrastriatal grafts of stem cell-derived dopamine (DA) neurons induce behavioral recovery in animal models of Parkinson's disease (PD), but how they functionally integrate in host neural circuitries is poorly understood. Here, Wnt5a-overexpressing neural stem cells derived from embryonic ventral mesencephalon of tyrosine hydroxylase-GFP transgenic mice were expanded as neurospheres and transplanted into organotypic cultures of wild type mouse striatum. Differentiated GFP-labeled DA neurons in the grafts exhibited mature neuronal properties, including spontaneous firing of action potentials, presence of post-synaptic currents, and functional expression of DA D2 autoreceptors. These properties resembled those recorded from identical cells in acute slices of intrastriatal grafts in the 6-hydroxy-DA-induced mouse PD model and from DA neurons in intact substantia nigra. Optogenetic activation or inhibition of grafted cells and host neurons using channelrhodopsin-2 (ChR2) and halorhodopsin (NpHR), respectively, revealed complex, bi-directional synaptic interactions between grafted cells and host neurons and extensive synaptic connectivity within the graft. Our data demonstrate for the first time using optogenetics that ectopically grafted stem cell-derived DA neurons become functionally integrated in the DA-denervated striatum. Further optogenetic dissection of the synaptic wiring between grafted and host neurons will be crucial to clarify the cellular and synaptic mechanisms underlying behavioral recovery as well as adverse effects following stem cell-based DA cell replacement strategies in PD
Clonal human fetal ventral mesencephalic dopaminergic neuron precursors for cell therapy research
A major challenge for further development of drug screening procedures, cell replacement therapies and developmental studies is the identification of expandable human stem cells able to generate the cell types needed. We have previously reported the generation of an immortalized polyclonal neural stem cell (NSC) line derived from the human fetal ventral mesencephalon (hVM1). This line has been biochemically, genetically, immunocytochemically and electrophysiologically characterized to document its usefulness as a model system for the generation of A9 dopaminergic neurons (DAn). Long-term in vivo transplantation studies in parkinsonian rats showed that the grafts do not mature evenly. We reasoned that diverse clones in the hVM1 line might have different abilities to differentiate. In the present study, we have analyzed 9 hVM1 clones selected on the basis of their TH generation potential and, based on the number of v-myc copies, v-myc down-regulation after in vitro differentiation, in vivo cell cycle exit, TH+ neuron generation and expression of a neuronal mature marker (hNSE), we selected two clones for further in vivo PD cell replacement studies. The conclusion is that homogeneity and clonality of characterized NSCs allow transplantation of cells with controlled properties, which should help in the design of long-term in vivo experimentsThis work was supported by grants from the Spanish Ministry of Economy and Competitiveness (formerly Science and Innovation; PLE2009-0101,
SAF2010-17167), Comunidad Autónoma Madrid (S2011-BMD-2336), Instituto Salud Carlos III (RETICS TerCel, RD06/0010/0009) and European Union (Excell, NMP4-SL-2008-214706). This work was also supported by an institutional grant from Foundation Ramón Areces to the Center of Molecular Biology Severo Ocho
Determination of the Bending Rigidity of Graphene via Electrostatic Actuation of Buckled Membranes
The small mass and atomic-scale thickness of graphene membranes make them
highly suitable for nanoelectromechanical devices such as e.g. mass sensors,
high frequency resonators or memory elements. Although only atomically thick,
many of the mechanical properties of graphene membranes can be described by
classical continuum mechanics. An important parameter for predicting the
performance and linearity of graphene nanoelectromechanical devices as well as
for describing ripple formation and other properties such as electron
scattering mechanisms, is the bending rigidity, {\kappa}. In spite of the
importance of this parameter it has so far only been estimated indirectly for
monolayer graphene from the phonon spectrum of graphite, estimated from AFM
measurements or predicted from ab initio calculations or bond-order potential
models. Here, we employ a new approach to the experimental determination of
{\kappa} by exploiting the snap-through instability in pre-buckled graphene
membranes. We demonstrate the reproducible fabrication of convex buckled
graphene membranes by controlling the thermal stress during the fabrication
procedure and show the abrupt switching from convex to concave geometry that
occurs when electrostatic pressure is applied via an underlying gate electrode.
The bending rigidity of bilayer graphene membranes under ambient conditions was
determined to be eV. Monolayers have significantly lower
{\kappa} than bilayers
Scaling Limits for Internal Aggregation Models with Multiple Sources
We study the scaling limits of three different aggregation models on Z^d:
internal DLA, in which particles perform random walks until reaching an
unoccupied site; the rotor-router model, in which particles perform
deterministic analogues of random walks; and the divisible sandpile, in which
each site distributes its excess mass equally among its neighbors. As the
lattice spacing tends to zero, all three models are found to have the same
scaling limit, which we describe as the solution to a certain PDE free boundary
problem in R^d. In particular, internal DLA has a deterministic scaling limit.
We find that the scaling limits are quadrature domains, which have arisen
independently in many fields such as potential theory and fluid dynamics. Our
results apply both to the case of multiple point sources and to the
Diaconis-Fulton smash sum of domains.Comment: 74 pages, 4 figures, to appear in J. d'Analyse Math. Main changes in
v2: added "least action principle" (Lemma 3.2); small corrections in section
4, and corrected the proof of Lemma 5.3 (Lemma 5.4 in the new version);
expanded section 6.
Mutation, selection, and ancestry in branching models: a variational approach
We consider the evolution of populations under the joint action of mutation
and differential reproduction, or selection. The population is modelled as a
finite-type Markov branching process in continuous time, and the associated
genealogical tree is viewed both in the forward and the backward direction of
time. The stationary type distribution of the reversed process, the so-called
ancestral distribution, turns out as a key for the study of mutation-selection
balance. This balance can be expressed in the form of a variational principle
that quantifies the respective roles of reproduction and mutation for any
possible type distribution. It shows that the mean growth rate of the
population results from a competition for a maximal long-term growth rate, as
given by the difference between the current mean reproduction rate, and an
asymptotic decay rate related to the mutation process; this tradeoff is won by
the ancestral distribution.
Our main application is the quasispecies model of sequence evolution with
mutation coupled to reproduction but independent across sites, and a fitness
function that is invariant under permutation of sites. Here, the variational
principle is worked out in detail and yields a simple, explicit result.Comment: 45 pages,8 figure
Information flows at inter-team boundaries in agile information systems development
Agile software development methods are being used on larger projects thus the study of inter-team communication are becoming an important topic of interest for researchers. This research addresses inter-team communication by exploring the tools and three different boundaries, inter-team, team and customers, and geographically separated teams. In this research, we gathered data from semi-structured face-to-face interviews which were analyzed following the grounded theory approach. Our study reveals consensus from different teams on the importance of virtual Kanban boards. Also, some teams members tend to adapt to other teams’ preferred communication tool. We observed challenges around interdependent user stories among the different teams and highlighted the problems that rise at the different boundaries.
Keywords: agile information system development • inter-team communication • agile team boundary • communication • agile methods • cooperating agile team
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