102 research outputs found
Radial distribution of a single-pass amplified radiation in the active elements of CuBr lasers
The paper presents the results of study of single-pass amplified radiation distribution of copper bromide vapor laser active elements used in high-speed laser monitors. The possibility of modifying the profile of a single-pass amplified light beam by changing the copper bromide vapor concentration is demonstrated. This means of influence on the radiation profile seems to be easiest due to implementation by varying only one parameter of operation. Gaussian, ring-shaped or flat profiles can be achieved depending on the temperature of the containers with copper bromide. The diameter of the beam becomes narrower when increasing the concentration of copper bromide vapor. This feature is characteristic of the discharge tubes as small (diameter 2.5, length 5 cm) and large (diameter 5 cm, length 90 cm) active volume
Advances on ELIC Design Studies
An electron-ion collider of a center-of-mass energy up to 90 GeV at luminosity up to 1035 cm-2s-1 with both beams highly polarized is essential for exploring the new QCD frontier of strong color fields in nuclear and precisely imaging the sea-quarks and gluons in the nucleon. A conceptual design of a ring-ring collider based on CEBAF (ELIC) with energies up to 9 GeV for electrons/positrons and up to 225 GeV for protons and 100 GeV/u for ions has been proposed to fulfill the science desire and to serve as the next step for CEBAF after the planned 12 GeV energy upgrade of the fixed target program. Here, we summarize recent design progress for the ELIC complex with four interaction points (IP); including interaction region optics with chromatic aberration compensation scheme and complete lattices for the Figure-8 collider rings. Further optimization of crab crossing angles at the IPs, simulations of beam-beam interactions and electron polarization in the Figure-8 ring and its matching at the IPs are also discussed
Science Requirements and Conceptual Design for a Polarized Medium Energy Electron-Ion Collider at Jefferson Lab
This report presents a brief summary of the science opportunities and program
of a polarized medium energy electron-ion collider at Jefferson Lab and a
comprehensive description of the conceptual design of such a collider based on
the CEBAF electron accelerator facility.Comment: 160 pages, ~93 figures This work was supported by the U.S. Department
of Energy, Office of Nuclear Physics, under Contract No. DE-AC05-06OR23177,
DE-AC02-06CH11357, DE-AC05-060R23177, and DESC0005823. The U.S. Government
retains a non-exclusive, paid-up, irrevocable, world-wide license to publish
or reproduce this manuscript for U.S. Government purpose
The global catalogue of microorganisms 10K type strain sequencing project: closing the genomic gaps for the validly published prokaryotic and fungi species
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Advances on ELIC Design Studies
A conceptual design of a ring-ring electron-ion collider based on CEBAF with a center-of-mass energy up to 90 GeV at luminosity up to 1035 cm-2s-1 has been proposed at JLab to fulfil science requirements. Here, we summarize design progress including collider ring and interaction region optics with chromatic aberration compensation. Electron polarization in the Figure-8 ring, stacking of ion beams in an accumulator-cooler ring, beam-beam simulations and a faster kicker for the circulator electron cooler ring are also discussed
The global catalogue of microorganisms 10K type strain sequencing project: closing the genomic gaps for the validly published prokaryotic and fungi species
Genomic information is essential for taxonomic, phylogenetic and functional studies to comprehensively decipher the characteristics of microorganisms, to explore microbiomes through metagenomics, and to answer fundamental questions of nature and human life. However, large gaps remain in the available genomic sequencing information published for bacterial and archaeal species, and the gaps are even larger for fungal type strains. The Global Catalogue of Microorganisms (GCM) leads an internationally coordinated effort to sequence type strains and close gaps in the genomic maps of microbes. Hence, the GCM aims to promote research by deep-mining genomic data.This work was supported by the Strategic Priority Research Program
of the Chinese Academy of Sciences (grant XDA19050301),
the Bureau of International Cooperation of the Chinese
Academy of Sciences (grants 153211KYSB20160029 and
153211KYSB20150010), the National Key Research Program
of China (grants 2017YFC1201202, 2016YFC1201303, and
2016YFC0901702), the 13th Five-year Informatization Plan of
the Chinese Academy of Sciences (grant XXH13506), and the
National Science Foundation for Young Scientists of China
(grant 31701157).info:eu-repo/semantics/publishedVersio
European Strategy for Particle Physics -- Accelerator R&D Roadmap
The 2020 update of the European Strategy for Particle Physics emphasised the
importance of an intensified and well-coordinated programme of accelerator R&D,
supporting the design and delivery of future particle accelerators in a timely,
affordable and sustainable way. This report sets out a roadmap for European
accelerator R&D for the next five to ten years, covering five topical areas
identified in the Strategy update. The R&D objectives include: improvement of
the performance and cost-performance of magnet and radio-frequency acceleration
systems; investigations of the potential of laser / plasma acceleration and
energy-recovery linac techniques; and development of new concepts for muon
beams and muon colliders. The goal of the roadmap is to document the collective
view of the field on the next steps for the R&D programme, and to provide the
evidence base to support subsequent decisions on prioritisation, resourcing and
implementation.Comment: 270 pages, 58 figures. Editor: N. Mounet. LDG chair: D. Newbold.
Panel chairs: P. V\'edrine (HFM), S. Bousson (RF), R. Assmann (plasma), D.
Schulte (muon), M. Klein (ERL). Panel editors: B. Baudouy (HFM), L. Bottura
(HFM), S. Bousson (RF), G. Burt (RF), R. Assmann (plasma), E. Gschwendtner
(plasma), R. Ischebeck (plasma), C. Rogers (muon), D. Schulte (muon), M.
Klein (ERL
Effect of carbon nanotubes addition on the mechanical and thermal properties of epoxy matrices
A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction
Background: Carbohydrates play a major role in cell signaling in many biological processes. We have developed a set of glycomimetic drugs that mimic the structure of carbohydrates and represent a novel source of therapeutics for endothelial dysfunction, a key initiating factor in cardiovascular complications. Purpose: Our objective was to determine the protective effects of small molecule glycomimetics against free fatty acidinduced endothelial dysfunction, focusing on nitric oxide (NO) and oxidative stress pathways. Methods: Four glycomimetics were synthesized by the stepwise transformation of 2,5dihydroxybenzoic acid to a range of 2,5substituted benzoic acid derivatives, incorporating the key sulfate groups to mimic the interactions of heparan sulfate. Endothelial function was assessed using acetylcholineinduced, endotheliumdependent relaxation in mouse thoracic aortic rings using wire myography. Human umbilical vein endothelial cell (HUVEC) behavior was evaluated in the presence or absence of the free fatty acid, palmitate, with or without glycomimetics (1µM). DAF2 and H2DCFDA assays were used to determine nitric oxide (NO) and reactive oxygen species (ROS) production, respectively. Lipid peroxidation colorimetric and antioxidant enzyme activity assays were also carried out. RTPCR and western blotting were utilized to measure Akt, eNOS, Nrf2, NQO1 and HO1 expression. Results: Ex vivo endotheliumdependent relaxation was significantly improved by the glycomimetics under palmitateinduced oxidative stress. In vitro studies showed that the glycomimetics protected HUVECs against the palmitateinduced oxidative stress and enhanced NO production. We demonstrate that the protective effects of preincubation with glycomimetics occurred via upregulation of Akt/eNOS signaling, activation of the Nrf2/ARE pathway, and suppression of ROSinduced lipid peroxidation. Conclusion: We have developed a novel set of small molecule glycomimetics that protect against free fatty acidinduced endothelial dysfunction and thus, represent a new category of therapeutic drugs to target endothelial damage, the first line of defense against cardiovascular disease
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