Aspects of the confinement mechanism in Coulomb-gauge QCD

Phenomenological consequences of the infrared singular, instantaneous part of the gluon propagator in Coulomb gauge are investigated. The corresponding quark Dyson-Schwinger equation is solved, neglecting retardation and transverse gluons and regulating the resulting infrared singularities. While the quark propagator vanishes as the infrared regulator goes to zero, the frequency integral over the quark propagator stays finite and well-defined. Solutions of the homogeneous Bethe-Salpeter equation for the pseudoscalar and vector mesons as well as for scalar and axial-vector diquarks are obtained. In the limit of a vanishing infrared regulator the diquark masses diverge, while meson properties and diquark radii remain finite and well-defined. These features are interpreted with respect to the resulting aspects of confinement for colored quark-quark correlations.Comment: 4 pages, 6 figure

A profile-driven dynamic risk assessment framework for connected and autonomous vehicles

The Internet of Things has already demonstrated clear benefits when applied in many areas. In connected and autonomous vehicles (CAV), IoT data can help the autonomous systems make better decisions for safer and more secure transportation. For example, different IoT data sources can extend CAV's risk awareness, while the incoming data can update these risks in real-time for faster reactions that may mitigate possible damages. However, the current state of the art CAV research has not addressed this matter well enough. This paper proposes a profile-driven approach to manage IoT data in the context of CAV systems through a dynamic risk management framework. Unlike the current inflexible risk assessment strategies, the framework encourages more flexible investigation of risks through different risk profiles, each representing risk knowledge through a set of risk input considerations, assessment methods and optimal reaction strategies. As the risks change frequently with time and location, there will be no single profile that can cover all the risks that CAVs face on the road. The uses of different risk profiles, therefore can help interested parties to better understand the risks and adapt to various situations appropriately. Our framework includes the effective management of IoT data sources to enable the run-time risk assessment. We also describe a case study of using the proposed framework to manage the risks for the POD being developed in the Innovate UK-funded CAPRI project

Shock statistics in higher-dimensional Burgers turbulence

We conjecture the exact shock statistics in the inviscid decaying Burgers equation in D>1 dimensions, with a special class of correlated initial velocities, which reduce to Brownian for D=1. The prediction is based on a field-theory argument, and receives support from our numerical calculations. We find that, along any given direction, shocks sizes and locations are uncorrelated.Comment: 4 pages, 8 figure

Incorporation of stochastic chemistry on dust grains in the PDR code using moment equations

Unlike gas-phase reactions, chemical reactions taking place on interstellar dust grain surfaces cannot always be modeled by rate equations. Due to the small grain sizes and low flux,these reactions may exhibit large fluctuations and thus require stochastic methods such as the moment equations. We evaluate the formation rates of H2, HD and D2 molecules on dust grain surfaces and their abundances in the gas phase under interstellar conditions. We incorporate the moment equations into the Meudon PDR code and compare the results with those obtained from the rate equations. We find that within the experimental constraints on the energy barriers for diffusion and desorption and for the density of adsorption sites on the grain surface, H2, HD and D2 molecules can be formed efficiently on dust grains. Under a broad range of conditions, the moment equation results coincide with those obtained from the rate equations. However, in a range of relatively high grain temperatures, there are significant deviations. In this range, the rate equations fail while the moment equations provide accurate results. The incorporation of the moment equations into the PDR code can be extended to other reactions taking place on grain surfaces

Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience

Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01-2.0 cc). Median prescribed dose was 17.5 Gy to the 50% isodose line (range: 14-22 Gy). Median survival after GK SRS treatment to brainstem lesion was 17.2 months (range: 2.8-45.6 months). The experience at Indiana University confirms the safety and efficacy of range of GK SRS prescription doses (14-22 Gy) to brainstem metastases

Remediation of mud pumping on a ballasted railway track

Maintenance of ballasted railway tracks is a major cost for railway infrastructure owners. In many developed countries, much of the railway infrastructure is mature and was built for service requirements long since superseded. The increased demands on historic infrastructure can lead to the development or exacerbation of localised trackbed problems that require disproportionate levels of maintenance. Identifying these and applying cost effective remediation has the potential to reduce maintenance spend in the long term. However, it is not always clear what the most cost effective remediation will be. One type of localised maintenance issue is the development of wet beds or wet spots, which can occur where saturated clayey subgrade soils are overloaded and result in the development of mud pumping as trains pass. This leads to the migration of fines into the ballast bed and a deterioration in local track performance. Over time the track overlying the wet bed settles disproportionately more, sleepers become progressively more voided, and train ride quality deteriorates. Maintenance of the wet bed may involve locally digging out and replacing the ballast; however, unless the underlying cause is addressed the problem is likely to recur, requiring repeated localised maintenance interventions. This is costly, reactive and ultimately an ineffective approach to managing the problem. This paper presents a study of a wet bed in the UK, both prior to and after a full track renewal. Transient track deflections during train passage were monitored using sleeper mounted geophones and high speed filming techniques. Loaded track geometry data were obtained from a track recording vehicle. It is shown that local maintenance interventions were generally ineffective, but that a renewal of the top 200 mm of the trackbed including placement of a geotextile filter and geogrid appears to have been successful in remediating the problem, at least in the short term

Deuterium fractionation in the Horsehead edge

Deuterium fractionation is known to enhance the [DCO+]/[HCO+] abundance ratio over the D/H elemental ratio of about 1e-5 in the cold and dense gas typically found in pre-stellar cores. We report the first detection and mapping of very bright DCO+ J=3-2 and J=2-1 lines (3 and 4 K respectively) towards the Horsehead photodissociation region (PDR) observed with the IRAM-30m telescope. The DCO+ emission peaks close to the illuminated warm edge of the nebula (< 50" or about 0.1 pc away). Detailed nonlocal, non-LTE excitation and radiative transfer analyses have been used to determine the prevailing physical conditions and to estimate the DCO+ and H13CO+ abundances from their line intensities. A large [DCO+]/[HCO+] abundance ratio (>= 0.02) is inferred at the DCO+ emission peak, a condensation shielded from the illuminating far-UV radiation field where the gas must be cold (10-20 K) and dense (>= 2x10^5 cm-3). DCO+ is not detected in the warmer photodissociation front, implying a lower [DCO+]/[HCO+] ratio (< 1e-3). According to our gas phase chemical predictions, such a high deuterium fractionation of HCO+ can only be explained if the gas temperature is below 20 K, in good agreement with DCO+ excitation calculations.Comment: 4 pages, 3 PostScript figures. Accepted for publication in Astronomy & Astrophysics in the letter section. Uses aa LaTeX macro

Optimisation of recombinant production of active human cardiac SERCA2a ATPase

Methods for recombinant production of eukaryotic membrane proteins, yielding sufficient quantity and quality of protein for structural biology, remain a challenge. We describe here, expression and purification optimisation of the human SERCA2a cardiac isoform of Ca2+ translocating ATPase, using Saccharomyces cerevisiae as the heterologous expression system of choice. Two different expression vectors were utilised, allowing expression of C-terminal fusion proteins with a biotinylation domain or a GFP- His8 tag. Solubilised membrane fractions containing the protein of interest were purified onto Streptavidin-Sepharose, Ni-NTA or Talon resin, depending on the fusion tag present. Biotinylated protein was detected using specific antibody directed against SERCA2 and, advantageously, GFP-His8 fusion protein was easily traced during the purification steps using in-gel fluorescence. Importantly, talon resin affinity purification proved more specific than Ni-NTA resin for the GFP-His8 tagged protein, providing better separation of oligomers present, during size exclusion chromatography. The optimised method for expression and purification of human cardiac SERCA2a reported herein, yields purified protein (> 90%) that displays a calcium-dependent thapsigargin-sensitive activity and is suitable for further biophysical, structural and physiological studies. This work provides support for the use of Saccharomyces cerevisiae as a suitable expression system for recombinant production of multi-domain eukaryotic membrane proteins

The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding

The early life gut microbiota plays a crucial role in regulating and maintaining the intestinal barrier, with disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epithelial cells. Here we sought to determine pathological cell shedding outcomes throughout the postnatal developmental period, and which host and microbial factors mediate these responses. Surprisingly, neonatal mice (Day 14 and 21) were highly refractory to induction of cell shedding after intraperitoneal administration of liposaccharide (LPS), with Day 29 mice showing strong pathological responses, more similar to those observed in adult mice. These differential responses were not linked to defects in the cellular mechanisms and pathways known to regulate cell shedding responses. When we profiled microbiota and metabolites, we observed significant alterations. Neonatal mice had high relative abundances of Streptococcus, Escherichia, and Enterococcus and increased primary bile acids. In contrast, older mice were dominated by Candidatus Arthromitus, Alistipes, and Lachnoclostridium, and had increased concentrations of SCFAs and methyamines. Antibiotic treatment of neonates restored LPS-induced small intestinal cell shedding, whereas adult fecal microbiota transplant alone had no effect. Our findings further support the importance of the early life window for microbiota-epithelial interactions in the presence of inflammatory stimuli and highlights areas for further investigation