Cryptic speciation in gentoo penguins is driven by geographic isolation and regional marine conditions: Unforeseen vulnerabilities to global change

The conservation of biodiversity is hampered by data deficiencies, with many new species and subspecies awaiting description or reclassification. Population genomics and ecological niche modelling offer complementary new tools for un-covering functional units of phylogenetic diversity. We hypothesize that phyloge-netically delineated lineages of gentoo penguins (Pygoscelis papua) distributed across Antarctica and sub-Antarctic Islands are subject to spatially explicit ecological con-ditions that have limited gene flow, facilitating genetic differentiation, and thereby speciation processes

Yeast Mitochondrial Interactosome Model: Metabolon Membrane Proteins Complex Involved in the Channeling of ADP/ATP

The existence of a mitochondrial interactosome (MI) has been currently well established in mammalian cells but the exact composition of this super-complex is not precisely known, and its organization seems to be different from that in yeast. One major difference is the absence of mitochondrial creatine kinase (MtCK) in yeast, unlike that described in the organization model of MI, especially in cardiac, skeletal muscle and brain cells. The aim of this review is to provide a detailed description of different partner proteins involved in the synergistic ADP/ATP transport across the mitochondrial membranes in the yeast Saccharomyces cerevisiae and to propose a new mitochondrial interactosome model. The ADP/ATP (Aacp) and inorganic phosphate (PiC) carriers as well as the VDAC (or mitochondrial porin) catalyze the import and export of ADP, ATP and Pi across the mitochondrial membranes. Aacp and PiC, which appear to be associated with the ATP synthase, consist of two nanomotors (F0, F1) under specific conditions and form ATP synthasome. Identification and characterization of such a complex were described for the first time by Pedersen and co-workers in 2003

mTOR: from growth signal integration to cancer, diabetes and ageing

In all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense energy, nutrients and stress and, in metazoans, growth factors. Mammalian TOR complex 1 (mTORC1) and mTORC2 exert their actions by regulating other important kinases, such as S6 kinase (S6K) and Akt. In the past few years, a significant advance in our understanding of the regulation and functions of mTOR has revealed the crucial involvement of this signalling pathway in the onset and progression of diabetes, cancer and ageing.National Institutes of Health (U.S.)Howard Hughes Medical InstituteWhitehead Institute for Biomedical ResearchJane Coffin Childs Memorial Fund for Medical Research (Postdoctoral Fellowship)Human Frontier Science Program (Strasbourg, France

Implicit interest indicators

Recommender systems provide personalized suggestions about items that users will find interesting. Typically, recommender systems require a user interface that can "intelligently" determine the interest of a user and use this information to make suggestions. The common solution, "explicit ratings", where users tell the system what they think about a piece of information, is well-understood and fairly precise. However, having to stop to enter explicit ratings can alter normal patterns of browsing and reading. A more "intelligent " method is to use implicit ratings, where a rating is obtained by a method other than obtaining it directly from the user. These implicit interest indicators have obvious advantages, including removing the cost of the user rating, and that every user interaction with the system can contribute to an implicit rating. Current recommender systems mostly do not use implicit ratings, nor is the ability of implicit ratings to predict actual user interest well-understood. This research studies the correlation between various implicit ratings and the explicit rating for a single Web page. A Web browser was developed to record the user's actions (implicit ratings) and the explicit rating of a page. Actions included mouse clicks, mouse movement, scrolling and elapsed time. This browser was used by over 80 people that browsed more than 2500 Web pages. Using the data collected by the browser, the individual implicit ratings and some combinations of implicit ratings were analyzed and compared with the explicit rating. We found that the time spent on a page, the amount of scrolling on a page and the combination of time and scrolling had a strong correlation with explicit interest, while individual scrolling methods and mouse-clicks were ineffective in predicting explicit interest.

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