A Political Companion to Walker Percy

In 1962, Walker Percy (1916–1990) made a dramatic entrance onto the American literary scene when he won the National Book Award for fiction with his first novel, The Moviegoer. A physician, philosopher, and devout Catholic, Percy dedicated his life to understanding the mixed and somewhat contradictory foundations of American life as a situation faced by the wandering and won-dering human soul. His controversial works combined existential questioning, scientific investigation, the insight of the southern stoic, and authentic religious faith to produce a singular view of humanity’s place in the cosmos that ranks among the best American political thinking. An authoritative guide to the political thought of this celebrated yet complex American author, A Political Companion to Walker Percy includes seminal essays by Ralph C. Wood, Richard Reinsch II, and James V. Schall, S.J., as well as new analyses of Percy’s view of Thomistic realism and his reaction to the American pursuit of happiness. Editors Peter Augustine Lawler and Brian A. Smith have assembled scholars of diverse perspectives who provide a necessary lens for interpreting Percy’s works. This comprehensive introduction to Percy’s “American Thomism” is an indispensable resource for students of American literature, culture, and politics. Peter Augustine Lawler is Dana Professor of Government at Berry College. He is the author of numerous books, including Modern and American Dignity: Who We Are as Persons, and What That Means for Our Future. Brian A. Smith is assistant professor of political science at Montclair State University. Walker Percy is an important writer who is not easily pigeonholed, and he offers an interesting and unique perspective on being human and living in America in his fiction and essays. -- Steven D. Ealy -- Senior Fellow at Liberty Fund, Inc. A splendid set of essays inspired by the audacious thought that American public discourse can be enriched by reflection on the novels of Walker Percy, chronicler of the hopes and fears, the disorders and longings of one of the strangest creatures ever to find itself lost in the cosmos, the ordinary American citizen. If the essays do not quite make the case that Percy contains the key to reforming the political order, they succeed in demonstrating that Percy is an indispensable aid in showing us how to endure political disorder with wisdom and wit. -- Thomas Hibbs -- Baylor University Peter Lawler and Brian Smith have assembled a first-rate collection of essays that wonderfully illumine Walker Percy’s art as well as the political and philosophical thought that informs it. In these pages, one confronts an intrepid critic of the illusions of modernity, from the abstractions of the Cartesian mind to the rampant scientism that today threatens the integrity of the soul. But one also witnesses on every page Percy’s humanity, his confidence in the ability of language to give us access to truth, and his refusal to succumb to anything resembling nihilism and despair. The volume is particularly impressive in drawing out the multiple ways that Percy’s thought can help save American liberty from self-destruction. -- Daniel J. Mahoney -- Augustine Chair in Distinguished Scholarship, Assumption Collegehttps://uknowledge.uky.edu/upk_english_language_and_literature_north_america/1074/thumbnail.jp

Cognitive Health among Older Adults: Evidence from Rural Sub-Saharan Africa

Cognitive health is an important dimension of well-being in older ages, but few studies have investigated cognitive health in sub-Saharan Africa’s (SSA) growing population of mature adults (= persons age 45+). We use data from the Malawi Longitudinal Study of Families and Health (MLSFH) to document the age and gender patterns of cognitive health, the contextual and life-course correlates of poor cognitive health, and the understudied linkages between cognitive and physical/mental well-being. Surprisingly, the age-pattern of decline in cognitive health for both men and women is similar to that observed in the U.S. We also find that women have substantially worse cognitive health than men, and experience a steeper decline of cognitive ability with age. Strong social ties and exposure to socially complex environments are associated with higher cognitive health, as is higher socioeconomic status. Poor cognitive health is associated with adverse social and economic well-being outcomes such as less nutrition intake, lower income, and reduced work efforts even in this subsistence agriculture context. Lower levels of cognitive health are also strongly associated with increased levels of depression and anxiety, and are associated with worse physical health measured through both self-reports and physical performance

Interaction, Emotion, and Collective Identities

[Excerpt] This chapter poses the question: How do emotional aspects of social interaction affect the emergence and salience of collective identities? I assume that social interaction inherently involves an implicit or explicit joint task—namely to accomplish some result that can only be produced with others. The most fundamental “task” of social interaction can be construed as the coordination and alignment of behavior, such that actors successfully conclude the interact ion episode. Essential to this task is a working consensus about definitions of self and other in the social situation, i.e., consensual self-other identities. A central component of my argument is that social interaction has emotional effects that vary with the success of actors at accomplishing this fundamental task. This paper theorizes the conditions under which emotional effects of social interaction promote collective identities that bridge or transcend self-other role identities

Signaling in Secret: Pay-for-Performance and the Incentive and Sorting Effects of Pay Secrecy

Key Findings: Pay secrecy adversely impacts individual task performance because it weakens the perception that an increase in performance will be accompanied by increase in pay; Pay secrecy is associated with a decrease in employee performance and retention in pay-for-performance systems, which measure performance using relative (i.e., peer-ranked) criteria rather than an absolute scale (see Figure 2 on page 5); High performing employees tend to be most sensitive to negative pay-for- performance perceptions; There are many signals embedded within HR policies and practices, which can influence employees’ perception of workplace uncertainty/inequity and impact their performance and turnover intentions; and When pay transparency is impractical, organizations may benefit from introducing partial pay openness to mitigate these effects on employee performance and retention

Australian spiny mountain crayfish and their temnocephalan ectosymbionts: an ancient association on the edge of coextinction?

Australian spiny mountain crayfish (Euastacus, Parastacidae) and their ecotosymbiotic temnocephalan flatworms (Temnocephalida, Platyhelminthes) may have co-occurred and interacted through deep time, during a period of major environmental change. Therefore, reconstructing the history of their association is of evolutionary, ecological, and conservation significance. Here, time-calibrated Bayesian phylogenies of Euastacus species and their temnocephalans (Temnohaswellia and Temnosewellia) indicate near-synchronous diversifications from the Cretaceous. Statistically significant cophylogeny correlations between associated clades suggest linked evolutionary histories. However, there is a stronger signal of codivergence and greater host specificity in Temnosewellia, which co-occurs with Euastacus across its range. Phylogeography and analyses of evolutionary distinctiveness (ED) suggest that regional differences in the impact of climate warming and drying had major effects both on crayfish and associated temnocephalans. In particular, Euastacus and Temnosewellia show strong latitudinal gradients in ED and, conversely, in geographical range size, with the most distinctive, northern lineages facing the greatest risk of extinction. Therefore, environmental change has, in some cases, strengthened ecological and evolutionary associations, leaving host-specific temnocephalans vulnerable to coextinction with endangered hosts. Consequently, the extinction of all Euastacus species currently endangered (75%) predicts coextinction of approximately 60% of the studied temnocephalans, with greatest loss of the most evolutionarily distinctive lineages

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management

The Near-Earth Object Surveyor Mission

The Near-Earth Object (NEO) Surveyor mission is a NASA observatory designed to discover and characterize near-Earth asteroids and comets. The mission's primary objective is to find the majority of objects large enough to cause severe regional impact damage ($>$140 m in effective spherical diameter) within its five-year baseline survey. Operating at the Sun-Earth L1 Lagrange point, the mission will survey to within 45 degrees of the Sun in an effort to find the objects in the most Earth-like orbits. The survey cadence is optimized to provide observational arcs long enough to reliably distinguish near-Earth objects from more distant small bodies that cannot pose an impact hazard. Over the course of its survey, NEO Surveyor will discover $\sim$200,000 - 300,000 new NEOs down to sizes as small as $\sim$10 m and thousands of comets, significantly improving our understanding of the probability of an Earth impact over the next century.Comment: accepted to PS

Chemical Compositions of Red Giant Stars in Old Large Magellanic Cloud Globular Clusters

We have observed ten red giant stars in four old Large Magellanic Cloud globular clusters with the high-resolution spectrograph MIKE on the Magellan Landon Clay 6.5-m telescope. The stars in our sample have up to 20 elemental abundance determinations for the alpha-, iron-peak, and neutron-capture element groups. We have also derived abundances for the light odd-Z elements Na and Al. We find NGC 2005 and NGC 2019 to be more metal-rich than previous estimates from the Ca II triplet, and we derive [Fe/H] values closer to those obtained from the slope of the red giant branch. However, we confirm previous determinations for Hodge 11 and NGC 1898 to within 0.2 dex. The LMC cluster [Mg/Fe] and [Si/Fe] ratios are comparable to the values observed in old Galactic globular cluster stars, as are the abundances [Y/Fe], [Ba/Fe], and [Eu/Fe]. The LMC clusters do not share the low-Y behavior observed in some dwarf spheroidal galaxies. [Ca/Fe], [Ti/Fe], and [V/Fe] in the LMC, however, are significantly lower than what is seen in the Galactic globular cluster system. Neither does the behavior of [Cu/Fe] as a function of [Fe/H] in our LMC clusters match the trend seen in the Galaxy, staying instead at a constant value of ~0.8. Because not all [alpha/Fe] ratios are suppressed, these abundance ratios cannot be attributed solely to the injection of Type Ia SNe material, and instead reflect the differences in star formation history of the LMC vs. the Milky Way. We conclude that many of the abundances in the LMC globular clusters we observed are distinct from those observed in the Milky Way, and these differences are intrinsic to the stars in those systems.Comment: To be published in ApJ, 21 pages, 12 figures. Tables 2 (equivalent widths) and 3 (hyperfine splitting information) included separatel

Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome

BACKGROUND: The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeutics. We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV. METHODS AND FINDINGS: In order to characterize clinically relevant parameters of SARS-CoV infection in NHPs, we infected cynomolgus macaques with SARS-CoV in three groups: Group I was infected in the nares and bronchus, group II in the nares and conjunctiva, and group III intravenously. Nonhuman primates in groups I and II developed mild to moderate symptomatic illness. All NHPs demonstrated evidence of viral replication and developed neutralizing antibodies. Chest radiographs from several animals in groups I and II revealed unifocal or multifocal pneumonia that peaked between days 8 and 10 postinfection. Clinical laboratory tests were not significantly changed. Overall, inoculation by a mucosal route produced more prominent disease than did intravenous inoculation. Half of the group I animals were infected with a recombinant infectious clone SARS-CoV derived from the SARS-CoV Urbani strain. This infectious clone produced disease indistinguishable from wild-type Urbani strain. CONCLUSIONS: SARS-CoV infection of cynomolgus macaques did not reproduce the severe illness seen in the majority of adult human cases of SARS; however, our results suggest similarities to the milder syndrome of SARS-CoV infection characteristically seen in young children