652 research outputs found
The innovative "Bio-Oil Spread" prevents metabolic disorders and mediates preconditioning-like cardioprotection in rats
The Impact of the Physical Environment on Intrapartum Maternity Care: Identification of Eight Crucial Building Spaces.
OBJECTIVES, PURPOSE, OR AIM: This article investigates whether the physical environment in which childbirth occurs impacts the intrapartum intervention rates and how this might happen. The study explores the spatial physical characteristics that can support the design of spaces to promote the health and well-being of women, their supporters, and maternity care professionals. BACKGROUND: Medical interventions during childbirth have consequences for the health of women and babies in the immediate and long term. The increase in interventions is multifactorial and may be influenced by the model of care adopted, the relationships between caregivers and the organizational culture, which is made up of many factors, including the built environment. In the field of birth architecture research, there is a gap in the description of the physical characteristics of birth environments that impact users' health. METHOD: A scoping review on the topic was performed to understand the direct and indirect impacts of the physical environment on birth intervention rates. RESULTS AND DISCUSSION: The findings are organized into three tables reporting the influence that the physical characteristics of a space might have on people's behaviors, experiences, practices and birth health outcomes. Eight building spaces that require further investigation and research were highlighted: unit layout configuration, midwives' hub/desk, social room, birth philosophy vectors, configuration of the birth room, size and shape of the birth room, filter, and sensory elements. CONCLUSIONS: The findings show the importance of considering the physical environment in maternity care and that further interdisciplinary studies focused on architectural design are needed to enrich the knowledge and evidence on this topic and to develop accurate recommendations for designers
Cytotoxic lymphocytes in B-cell chronic lymphocytic leukemia
The occurrence of cytotoxic lymphocyte subpopulations (i.e., CD 16+, CD57+ and cytotoxic CD 8+) was studied in the peripheral blood of 18 B-cell chronic lymphocytic leukemia (B-CLL) patients. The absolute numbers of CD 57+, CD 16+ and cytotoxic CD 8+ lymphocytes were increased in the peripheral blood of untreated patients as compared with healthy donors, suggesting a causal relation with the accumulation of malignant B-cells. For 5 B-CLL patients and 5 hematological normal donors, the lymphocyte subpopulations in peripheral blood, lymph nodes and bone marrow were determined. A significant immune response was observed in the lymph nodes of the patients, as reflected by the CD 3+ lymphocytes, which were 1.7–27 times larger in the patients lymph nodes than in their peripheral blood and bone marrow. In contrast, with peripheral blood this was mainly caused by an increase in CD 4+ lymphocytes. The CD 57 lymphocytes in the lymph nodes of the patients had abnormal orthogonal light-scattering signals and an abnormal density of CD 57+ receptors in comparison with their peripheral blood CD 57+ lymphocytes or the CD57+ lymphocytes in the peripheral blood, bone marrow and tonsils of the hematological normal donors. This study shows that although a significant increase of cytotoxic lymphocytes in the peripheral blood of B-CLL patients is observed, the actual distributions of the non-malignant lymphocytes can be quite different at the actual tumor sites, i.e., bone marrow and lymph node
Procedure for short-lived particle detection in the OPERA experiment and its application to charm decays
The OPERA experiment, designed to perform the first observation of oscillations in appearance mode through the detection of
the leptons produced in charged current interactions, has
collected data from 2008 to 2012. In the present paper, the procedure developed
to detect particle decays, occurring over distances of the order of 1 mm
from the neutrino interaction point, is described in detail. The results of its
application to the search for charmed hadrons are then presented as a
validation of the methods for appearance detection
Integration of decision support systems to improve decision support performance
Decision support system (DSS) is a well-established research and development area. Traditional isolated, stand-alone DSS has been recently facing new challenges. In order to improve the performance of DSS to meet the challenges, research has been actively carried out to develop integrated decision support systems (IDSS). This paper reviews the current research efforts with regard to the development of IDSS. The focus of the paper is on the integration aspect for IDSS through multiple perspectives, and the technologies that support this integration. More than 100 papers and software systems are discussed. Current research efforts and the development status of IDSS are explained, compared and classified. In addition, future trends and challenges in integration are outlined. The paper concludes that by addressing integration, better support will be provided to decision makers, with the expectation of both better decisions and improved decision making processes
Determination of the muon charge sign with the dipolar spectrometers of the OPERA experiment
The OPERA long-baseline neutrino-oscillation experiment has observed the
direct appearance of in the CNGS beam. Two large muon
magnetic spectrometers are used to identify muons produced in the
leptonic decay and in interactions by measuring their charge and
momentum. Besides the kinematic analysis of the decays, background
resulting from the decay of charmed particles produced in
interactions is reduced by efficiently identifying the muon track. A new method
for the charge sign determination has been applied, via a weighted angular
matching of the straight track-segments reconstructed in the different parts of
the dipole magnets. Results obtained for Monte Carlo and real data are
presented. Comparison with a method where no matching is used shows a
significant reduction of up to 40\% of the fraction of wrongly determined
charges.Comment: 10 pages. Improvements in the tex
Limits on muon-neutrino to tau-neutrino oscillations induced by a sterile neutrino state obtained by OPERA at the CNGS beam
The OPERA experiment, exposed to the CERN to Gran Sasso beam,
collected data from 2008 to 2012. Four oscillated Charged Current
interaction candidates have been detected in appearance mode, which are
consistent with oscillations at the atmospheric within the "standard" three-neutrino framework. In this paper, the OPERA
appearance results are used to derive limits on the mixing
parameters of a massive sterile neutrino.Comment: 11 pages, 4 figures; reference to Planck result updated in the
Introduction. Submitted to JHE
A facility to Search for Hidden Particles (SHiP) at the CERN SPS
A new general purpose fixed target facility is proposed at the CERN SPS
accelerator which is aimed at exploring the domain of hidden particles and make
measurements with tau neutrinos. Hidden particles are predicted by a large
number of models beyond the Standard Model. The high intensity of the SPS
400~GeV beam allows probing a wide variety of models containing light
long-lived exotic particles with masses below (10)~GeV/c,
including very weakly interacting low-energy SUSY states. The experimental
programme of the proposed facility is capable of being extended in the future,
e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa
Observation of nu_tau appearance in the CNGS beam with the OPERA experiment
The OPERA experiment is searching for nu_mu -> nu_tau oscillations in
appearance mode i.e. via the direct detection of tau leptons in nu_tau charged
current interactions. The evidence of nu_mu -> nu_tau appearance has been
previously reported with three nu_tau candidate events using a sub-sample of
data from the 2008-2012 runs. We report here a fourth nu_tau candidate event,
with the tau decaying into a hadron, found after adding the 2012 run events
without any muon in the final state to the data sample. Given the number of
analysed events and the low background, nu_mu -> nu_tau oscillations are
established with a significance of 4.2sigma.Comment: Submitted to Progress of Theoretical and Experimental Physics (PTEP
Evidence for appearance in the CNGS neutrino beam with the OPERA experiment
The OPERA experiment is designed to search for oscillations in appearance mode i.e. through the direct observation
of the lepton in charged current interactions. The
experiment has taken data for five years, since 2008, with the CERN Neutrino to
Gran Sasso beam. Previously, two candidates with a decaying
into hadrons were observed in a sub-sample of data of the 2008-2011 runs. Here
we report the observation of a third candidate in the
decay channel coming from the analysis of a sub-sample of the
2012 run. Taking into account the estimated background, the absence of
oscillations is excluded at the 3.4
level.Comment: 9 pages, 5 figures, 1 table
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