Duality in Off-Shell Electromagnetism

In this paper, we examine the Dirac monopole in the framework of Off-Shell Electromagnetism, the five dimensional U(1) gauge theory associated with Stueckelberg-Schrodinger relativistic quantum theory. After reviewing the Dirac model in four dimensions, we show that the structure of the five dimensional theory prevents a natural generalization of the Dirac monopole, since the theory is not symmetric under duality transformations. It is shown that the duality symmetry can be restored by generalizing the electromagnetic field strength to an element of a Clifford algebra. Nevertheless, the generalized framework does not permit us to recover the phenomenological (or conventional) absence of magnetic monopoles.Comment: 18 page

The Role of Damage-Associated Molecular Patterns in Human Diseases : Part I - Promoting inflammation and immunity

There is increasing interest by physicians in the impact of the innate immune system on human diseases. In particular, the role of the molecules that initiate and amplify innate immune pathways, namely damage associated molecular patterns (DAMPs), is of interest as these molecules are involved in the pathogenesis of many human disorders. The first part of this review identifies five classes of cell stress/tissue injury-induced DAMPs that are sensed by various recognition receptor-bearing cells of the innate immune system, thereby mounting inflammation, promoting apoptosis and shaping adaptive immune responses. The DAMPs activate and orchestrate several innate immune machineries, including inflammasomes and the unfolded protein response that synergistically operates to induce inflammatory, metabolic and adaptive immune pathologies. Two examples of autoimmune diseases are discussed as they represent a typical paradigm of the intimate interplay between innate and adaptive immune responses

Cosmic microwave background anomalies viewed via Gumbel Statistics

We describe and discuss the application of Gumbel statistics, which model extreme events, to WMAP 5-year measurements of the cosmic microwave background. We find that temperature extrema of the CMB are well modelled by the Gumbel formalism and describe tests for Gaussianity that the approach can provide. Comparison to simulations reveals Gumbel statistics to have only weak discriminatory power for the conventional statistic: $f_{NL}<1000$, though it may probe other regimes of non-Gaussianity. Tests based on hemispheric cuts reveal interesting alignment with other reported CMB anomalies. The approach has the advantage of model independence and may find further utility with smaller scale data.Comment: 5 pages, 8 figures, accepted for publication in MNRAS. This version: added reference

Characterization of light production and transport in tellurium dioxide crystals

Simultaneous measurement of phonon and light signatures is an effective way to reduce the backgrounds and increase the sensitivity of CUPID, a next-generation bolometric neutrinoless double-beta decay (0νββ) experiment. Light emission in tellurium dioxide (TeO2) crystals, one of the candidate materials for CUPID, is dominated by faint Cherenkov radiation, and the high refractive index of TeO2 complicates light collection. Positive identification of 0νββ events therefore requires high-sensitivity light detectors and careful optimization of light transport. A detailed microphysical understanding of the optical properties of TeO2 crystals is essential for such optimization. We present a set of quantitative measurements of light production and transport in a cubic TeO2 crystal, verified with a complete optical model and calibrated against a UVT acrylic standard. We measure the optical surface properties of the crystal, and set stringent limits on the amount of room-temperature scintillation in TeO2 for β and α particles of 5.3 and 8 photons/MeV, respectively, at 90% confidence. The techniques described here can be used to optimize and verify the particle identification capabilities of CUPID

Cherenkov and Scintillation Light Separation in Organic Liquid Scintillators

The CHErenkov / Scintillation Separation experiment (CHESS) has been used to demonstrate the separation of Cherenkov and scintillation light in both linear alkylbenzene (LAB) and LAB with 2g/L of PPO as a fluor (LAB/PPO). This is the first such demonstration for the more challenging LAB/PPO cocktail and improves on previous results for LAB. A time resolution of 338 +/- 12 ps FWHM results in an efficiency for identifying Cherenkov photons in LAB/PPO of 70 +/- 3% and 63 +/- 8% for time- and charge-based separation, respectively, with scintillation contamination of 36 +/- 5% and 38 +/- 4%. LAB/PPO data is consistent with a rise time of 0.75 +/- 0.25 ns

Genus Topology of the Cosmic Microwave Background from the WMAP 3-Year Data

We have independently measured the genus topology of the temperature fluctuations in the cosmic microwave background seen in the Wilkinson Microwave Anisotropy Probe (WMAP) 3-year data. A genus analysis of the WMAP data indicates consistency with Gaussian random-phase initial conditions, as predicted by standard inflation. We set 95% confidence limits on non-linearities of -101 < f_{nl} < 107. We also find that the observed low l (l <= 8) modes show a slight anti-correlation with the Galactic foreground, but not exceeding 95% confidence, and that the topology defined by these modes is consistent with that of a Gaussian random-phase distribution (within 95% confidence).Comment: MNRAS LaTeX style (mn2e.cls), EPS and JPEG figure

Methodology for urban rail and construction technology research and development planning

A series of transit system visits, organized by the American Public Transit Association (APTA), was conducted in which the system operators identified the most pressing development needs. These varied by property and were reformulated into a series of potential projects. To assist in the evaluation, a data base useful for estimating the present capital and operating costs of various transit system elements was generated from published data. An evaluation model was developed which considered the rate of deployment of the research and development project, potential benefits, development time and cost. An outline of an evaluation methodology that considered benefits other than capital and operating cost savings was also presented. During the course of the study, five candidate projects were selected for detailed investigation; (1) air comfort systems; (2) solid state auxiliary power conditioners; (3) door systems; (4) escalators; and (5) fare collection systems. Application of the evaluation model to these five examples showed the usefulness of modeling deployment rates and indicated a need to increase the scope of the model to quantitatively consider reliability impacts