Impact of bioactive substances on the gastrointestinal tract and performance of weaned piglets: a review

The EU ban on in-feed antibiotics has stimulated research on weaning diets as a way of reducing post-weaning gut disorders and growth check in pigs. Many bioactive components have been investigated but only few have shown to be effective. Amongst these, organic acids (OA) have been shown to exert a bactericidal action mediated by non-dissociated OA, by lowering gastric pH, increasing gut and pancreas enzyme secretion and improving gut wall morphology. It has been postulated that they may also enhance non-specific immune responses and improve disease resistance. In contrast, relatively little attention has been paid to the impact of OA on the stomach but recent data show they can differently affect gastric histology, acid secretion and gastric emptying. Butyrate and precursors of butyric acid have received special attention and although promising results have been obtained, their effects are dependent upon the dose, treatment duration, initial age of piglets, gastrointestinal site and other factors. The amino acids (AA) like glutamine, tryptophan and arginine are supportive in improving digestion, absorption and retention of nutrients by affecting tissue anabolism, stress and (or) immunity. Glutamine, cysteine and threonine are important for maintaining mucin and permeability of intestinal barrier function. Spray-dried plasma (SDP) positively affects gut morphology, inflammation and reduces acquired specific immune responses via specific and a-specific influences of immunoglobulins and other bioactive components. Effects are more pronounced in early-weaned piglets and under poorer health conditions. Little interaction between plasma protein and antibiotics has been found, suggesting distinct modes of action and additive effects. Bovine colostrum may act more or less similarly to SDP The composition of essential oils is highly variable, depending on environmental and climatic conditions and distillation methods. These oils differ widely in their antimicrobial activity in vitro and some components of weaning diets may decrease their activity Results in young pigs are highly variable depending upon the product and doses used. These studies suggest that relatively high concentrations of essential oils are needed for beneficial effects to be observed and it has been assumed that these plant extracts mimic most of the effects of antibiotics active on gut physiology, microbiology and immunology. Often, bioactive substances protective to the gut also stimulate feed intake and growth performance. New insights on the effects of selected OA and AA, protein sources (especially SDP bovine colostrum) and plant extracts with anti-bacterial activities on the gut are reported in this review

Barrier function and cell protection of the intestinal epithelium. Applications to the pig during weaning

This review focuses on recent progress on the understanding of intestinal barrier function and epithelial cell protection by heat shock proteins (HSP). Barrier function regulation and its importance for the swine species are presented. Major progress in the understanding of gut barrier function and epithelial cell protection and their regulation has been made recently. Tight junctions and HSP appear to have a major role. These defence systems are highly dynamic, integrated and finely regulated at the epithelial monolayer. The first level of regulation is a direct cross-talk between the gut microbiota and the host. The second level involves the nervous system, mucosal mast cells and various mediators acting on the epithelium. Gut barrier function and its regulation can be altered by stress and disturbances of the microbiota. Additional studies need to be conducted in swine for developing appropriate strategies for preventing post-weaning gut disordersCette revue fait le point sur les récents progrès dans la compréhension de la fonction de barrière intestinale et de la cytoprotection épithéliale par les protéines du choc thermique (HSP). La régulation de la fonction de barrière et son importance pour l’espèce porcine sont présentées. Des progrès importants dans la compréhension de la fonction de barrière et de la cytoprotection ont été réalisés récemment. Les jonctions serrées et les HSP jouent un rôle majeur. Ces systèmes de protection sont hautement dynamiques, intégrés et finement régulés au niveau de l’épithélium intestinal. Le premier niveau de régulation est exercé par le microbiote. Le second niveau implique le système nerveux, le mastocyte et divers médiateurs agissant sur l’épithélium. La barrière est influencée par le stress ou par des perturbations du microbiote. Des études complémentaires méritent d’être conduites chez le porc pour définir des stratégies alimentaires et d’élevage destinées à limiter les perturbations digestives du sevrag

Analisis Brand Equity Pada Produk Sepatu Sport Di Online Shop

This study aims to to analyze brand awareness ,brand association, perception of the qualities ( perceived quality and their brand loyalty) of their products shoes sport in online shop. The population of the study are all customers shoes sport in online shop on students FEB Muhammadiyah University Surakarta. The research sample this is 100 customers shoes sport in online shop on students FEB Muhammadiyah University Surakarta. The research sample this is 100 customers shoes sport in online shop on students FEB Muhammadiyah University Surakarta. Analysis of data was undertaken with an analysis brand equity consisting of the trial differensial, semantic scale cochran, test Importance-Performance Analysis ( IPA) brand switching his patterns and the matrix. Based on the research done be seen that a brand that to be top of mind through to the customer is nike brand, sport shoes that was followed by the adidas brand, reebok and brands other. sport shoesBased on measurements on brand perceived quality got that third, sport that is nike branded shoes adidas, and reebok not substantially.These feelings are reflected in an average rate of approaching the same for all attributes the lab test.But the attribute of being the highest value in the eyes of customers for the third out to reposition the brand is on an attribute availability.In the form of associations asosociation brand products shoes sport is their prices affordable save to use high in quality, as well as ease of getting this product in a shop online. The results of brand loyalty of all three branded shoes sport can be determined with manifest to all customers loyal with the buy benar-benar kebiasaaan because that can be identified with a pattern of a pembeliannya. beruntunan together Keywords: awareness , association, perceptions and loyalt

Maternal antibiotic treatment affects offspring gastric sensing for umami taste and ghrelin regulation in the pig

Background: Scarce is knowledge on the process regulating the development of acid secretion, orexigenic signaling, and chemosensing in the stomach of young pigs. Changes of early microbial encounters by suckling pigs can interact with the gut maturation, by the induction of different molecular signaling. Our goal was to assess if the age of offspring and the maternal environment, influenced by sow antibiotic treatment peripartum, could affect gastric morphology and the expression of genes involved in the control of hydrochloric secretion, feed intake, taste, and inflammation in offspring stomach. Methods: 84 pigs from sows fed a diet with amoxicillin (on –d10 to +d21 from farrowing, ANT) or without (CON) were sacrificed at d14, d21, d28 (weaning) or d42. Samples of oxyntic (OXY), pyloric (PY) and cardiac mucosae close to OXY were collected and parietal and enteroendocrine cells (EECs) were counted. Relative gene expression of a set of 11 key genes (ATP4A, SSTR2, GAST, GHRL, MBOAT4, PCSK1, GNAT1, TAS1R1, TAS1R3, IL8 and TNF) was assessed by qRT-PCR. In addition, 40 offspring obtained from the same ANT and CON sows were offered a normal or a fat-enriched diet for 4 weeks between 140 and 169 d of age, and then OXY and PY were sampled. Results: The number of parietal and EECs increased with age (P < 0.001). ATP4A increased with age (within suckling, P = 0.043, post-weaning vs. suckling, P < 0.001), SSTR2 increased only after weaning (P < 0.001). In OXY, GHRL increased during suckling (P = 0.012), and post-weaning as a trend (P = 0.088). MBOAT4 tended to increase during suckling (P = 0.062). TAS1R1 increased from suckling to post-weaning period (P =0.001) and was lower in ANT offspring (P = 0.013). GNAT1 in PY was higher in ANT offspring (P = 0.041). Antibiotic treatment of sows peripartum increased expression of GHRL and MBOAT4 in OXY of growing-finishing offspring aged 5 months. Conclusions: Data show that sensing for umami taste and ghrelin regulation can be affected by maternal environment, but the development of acid secretion, orexigenic signaling and taste perception in the stomach are mostly developmentally controlled