Relationship between cardiac diffusion tensor imaging parameters and anthropometrics in healthy volunteers

Background: In vivo cardiac diffusion tensor imaging (cDTI) is uniquely capable of interrogating laminar myocardial dynamics non-invasively. A comprehensive dataset of quantative parameters and comparison with subject anthropometrics is required. Methods: cDTI was performed at 3T with a diffusion weighted STEAM sequence. Data was acquired from the mid left ventricle in 43 subjects during the systolic and diastolic pauses. Global and regional values were determined for fractional anisotropy (FA), mean diffusivity (MD), helix angle gradient (HAg, degrees/%depth) and the secondary eigenvector angulation (E2A). Regression analysis was performed between global values and subject anthropometrics. Results: All cDTI parameters displayed regional heterogeneity. The RR interval had a significant, but clinically small effect on systolic values for FA, HAg and E2A. Male sex and increasing left ventricular end diastolic volume were associated with increased systolic HAg. Diastolic HAg and systolic E2A were both directly related to left ventricular mass and body surface area. There was an inverse relationship between E2A mobility and both age and ejection fraction. Conclusions: Future interpretations of quantitative cDTI data should take into account anthropometric variations observed with patient age, body surface area and left ventricular measurements. Further work determining the impact of technical factors such as strain and SNR is required

Balmer Emission Line Profiles and the Complex Properties of Broad Line Regions in Active Galactic Nuclei

In this work we analyze a sample of AGN spectra, selected from the 6th Data Release of the Sloan Digital Sky Survey, exploiting a generalized technique of line profile analysis, designed to take into account the whole profiles of their broad emission lines. We find that the line profile broadening functions result from a complex structure, but we may be able to infer some constraints about the role of the geometrical factor, thus improving our ability to estimate AGN properties and their relation with the host galaxy. Our results suggest that flattening and inclination within the structure of the Broad Line Region (BLR) must be taken into account. We detect low inclinations of the BLR motion plane with respect to our line of sight, typically i < 20 degrees, with a geometrical effect which generally decreases as the line profile becomes broader.Comment: 13 pages, 11 figures, updated reference list. ApJ accepte

Real-time full field laser Doppler imaging

We present a full field laser Doppler imaging instrument, which enables real-time in vivo assessment of blood flow in dermal tissue and skin. This instrument monitors the blood perfusion in an area of about 50 cm2 with 480 × 480 pixels per frame at a rate of 12–14 frames per second. Smaller frames can be monitored at much higher frame rates. We recorded the microcirculation in healthy skin before, during and after arterial occlusion. In initial clinical case studies, we imaged the microcirculation in burned skin and monitored the recovery of blood flow in a skin flap during reconstructive surgery indicating the high potential of LDI for clinical applications. Small animal imaging in mouse ears clearly revealed the network of blood vessels and the corresponding blood perfusion

On the non-evolution of the dependence of black hole masses on bolometric luminosities for QSOs

There are extremely luminous quasi stellar objects (QSOs) at high redshift which are absent at low redshift. The lower luminosities at low redshifts can be understood as the external manifestation of either a lower Eddington ratio or a lower mass. To distinguish between both effects, we determine the possible dependence of masses and Eddington ratios of QSOs with a fixed luminosity as a function of redshifts; this avoids the Malmquist bias or any other selection effect. For the masses and Eddington ratios derived for a sample of QSOs in the Sloan Digital Sky Survey, we model their evolution by a double linear fit separating the dependence on redshifts and luminosities. The validity of the fits and possible systematic effects were tested by the use of different estimators of masses or bolometric luminosities, and possible intergalactic extinction effects. The results do not show any significant evolution of black hole masses or Eddington ratios for equal luminosity QSOs. The black hole mass only depends on the bolometric luminosity without significant dependence on the redshift as M_{BH}(10^9 M_sun) = 3.4[L_{bol}(10^{47} erg/s})]^{0.65} on average for z<5. This must not be confused with the possible evolution in the formation of black holes in QSOs. The variations of environment might influence the formation of the black holes but not its subsequent accretion. It also leaves a question to be solved: Why are there not QSOs with very high mass at low redshift? A brief discussion of the possible reasons for this is tentatively pointed out.Comment: Accepted to be published in RA

Heterogeneity of fractional anisotropy and mean diffusivity measurements by in vivo diffusion tensor imaging in normal human hearts

Background: Cardiac diffusion tensor imaging (cDTI) by cardiovascular magnetic resonance has the potential to assess microstructural changes through measures of fractional anisotropy (FA) and mean diffusivity (MD). However, normal variation in regional and transmural FA and MD is not well described. Methods: Twenty normal subjects were scanned using an optimised cDTI sequence at 3T in systole. FA and MD were quantified in 3 transmural layers and 4 regional myocardial walls. Results: FA was higher in the mesocardium (0.46 ±0.04) than the endocardium (0.40 ±0.04, p≤0.001) and epicardium (0.39 ±0.04, p≤0.001). On regional analysis, the FA in the septum was greater than the lateral wall (0.44 ±0.03 vs 0.40 ±0.05 p = 0.04). There was a transmural gradient in MD increasing towards the endocardium (epicardium 0.87 ±0.07 vs endocardium 0.91 ±0.08×10-3 mm2/s, p = 0.04). With the lateral wall (0.87 ± 0.08×10-3 mm2/s) as the reference, the MD was higher in the anterior wall (0.92 ±0.08×10-3 mm2/s, p = 0.016) and septum (0.92 ±0.07×10-3 mm2/s, p = 0.028). Transmurally the signal to noise ratio (SNR) was greatest in the mesocardium (14.5 ±2.5 vs endocardium 13.1 ±2.2, p<0.001; vs epicardium 12.0 ± 2.4, p<0.001) and regionally in the septum (16.0 ±3.4 vs lateral wall 11.5 ± 1.5, p<0.001). Transmural analysis suggested a relative reduction in the rate of change in helical angle (HA) within the mesocardium. Conclusions: In vivo FA and MD measurements in normal human heart are heterogeneous, varying significantly transmurally and regionally. Contributors to this heterogeneity are many, complex and interactive, but include SNR, variations in cardiac microstructure, partial volume effects and strain. These data indicate that the potential clinical use of FA and MD would require measurement standardisation by myocardial region and layer, unless pathological changes substantially exceed the normal variation identified

Microclimate monitoring in the Carcer Tullianum: temporal and spatial correlation and gradients evidenced by multivariate analysis; first campaign

Too often microclimate studies in the field of cultural heritage are published without any or scarce information on sampling design, sensors (type, number, position) and instrument validation. Lacking of this fundamental information does not allow an open discussion in the scientific community. This work aims to be an invitation for a different approach

On the cosmic evolution of the scaling relations between black holes and their host galaxies: Broad Line AGN in the zCOSMOS survey

(Abriged) We report on the measurement of the rest frame K-band luminosity and total stellar mass of the hosts of 89 broad line Active Galactic Nuclei detected in the zCOSMOS survey in the redshift range 1<z<2.2. The unprecedented multiwavelength coverage of the survey field allows us to disentangle the emission of the host galaxy from that of the nuclear black hole in their Spectral Energy Distributions. We derive an estimate of black hole masses through the analysis of the broad Mg II emission lines observed in the medium-resolution spectra taken with VIMOS/VLT as part of the zCOSMOS project. We found that, as compared to the local value, the average black hole to host galaxy mass ratio appears to evolve positively with redshift, with a best fit evolution of the form (1+z)^{0.68 \pm0.12 +0.6 -0.3}, where the large asymmetric systematic errors stem from the uncertainties in the choice of IMF, in the calibration of the virial relation used to estimate BH masses and in the mean QSO SED adopted. A thorough analysis of observational biases induced by intrinsic scatter in the scaling relations reinforces the conclusion that an evolution of the MBH-M* relation must ensue for actively growing black holes at early times: either its overall normalization, or its intrinsic scatter (or both) appear to increase with redshift. This can be interpreted as signature of either a more rapid growth of supermassive black holes at high redshift, a change of structural properties of AGN hosts at earlier times, or a significant mismatch between the typical growth times of nuclear black holes and host galaxies.Comment: 47 pages, 8 figures. Accepted for publication in Ap

Chiropractic and self-care for back-related leg pain: design of a randomized clinical trial

<p>Abstract</p> <p>Background</p> <p>Back-related leg pain (BRLP) is a common variation of low back pain (LBP), with lifetime prevalence estimates as high as 40%. Often disabling, BRLP accounts for greater work loss, recurrences, and higher costs than uncomplicated LBP and more often leads to surgery with a lifetime incidence of 10% for those with severe BRLP, compared to 1-2% for those with LBP.</p> <p>In the US, half of those with back-related conditions seek CAM treatments, the most common of which is chiropractic care. While there is preliminary evidence suggesting chiropractic spinal manipulative therapy is beneficial for patients with BRLP, there is insufficient evidence currently available to assess the effectiveness of this care.</p> <p>Methods/Design</p> <p>This study is a two-site, prospective, parallel group, observer-blinded randomized clinical trial (RCT). A total of 192 study patients will be recruited from the Twin Cities, MN (n = 122) and Quad Cities area in Iowa and Illinois (n = 70) to the research clinics at WHCCS and PCCR, respectively.</p> <p>It compares two interventions: chiropractic spinal manipulative therapy (SMT) plus home exercise program (HEP) to HEP alone (minimal intervention comparison) for patients with subacute or chronic back-related leg pain.</p> <p>Discussion</p> <p>Back-related leg pain (BRLP) is a costly and often disabling variation of the ubiquitous back pain conditions. As health care costs continue to climb, the search for effective treatments with few side-effects is critical. While SMT is the most commonly sought CAM treatment for LBP sufferers, there is only a small, albeit promising, body of research to support its use for patients with BRLP.</p> <p>This study seeks to fill a critical gap in the LBP literature by performing the first full scale RCT assessing chiropractic SMT for patients with sub-acute or chronic BRLP using important <b>patient-oriented </b>and <b>objective biomechanical </b>outcome measures.</p> <p>Trial Registration</p> <p>ClinicalTrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT00494065">NCT00494065</a></p

Atherosclerosis in young Brazilians suffering violent deaths: a pathological study

<p>Abstract</p> <p>Background</p> <p>Atherosclerosis is the leading cause of coronary heart disease and ischemic stroke, which can cause sudden death in adulthood. In general, the clinical manifestations of cardiovascular diseases are caused by atherosclerosis, which is a process that starts during middle age. More recent studies indicate that the atherosclerotic process begins during childhood.</p> <p>Methods</p> <p>To evaluate the extent of atherosclerotic disease in young Brazilians, we conducted a study of the pathological alterations in the major arteries of victims of violent death. Samples of the right carotid artery, left coronary artery, and thoracic aorta of young victims of violent death were analyzed and graded in accordance with the histological atherosclerotic lesion types proposed by the American Heart Association. Samples were collected from 100 individuals who had died from external causes, aged from 12 to 33 years.</p> <p>Results</p> <p>The majority of cases (83%) were male, and 66% of deaths were homicides caused by firearms. The median age was 20.0 years and mean body mass index was 20.9 kg/m². Of the right carotid artery specimens, 3% were normal, 55% had type I, 40% had type II, 1% had type III, and 1% had type IV atherosclerotic lesions. Of the left coronary artery specimens, 5% were normal, 48% had type I, 41% had type II, 3% had type III, and 3% had type IV lesions. Of the thoracic aorta specimens, none were normal, 13% had type I, 64% had type II, 22% had type III, and 1% had type IV lesions. Overall, 97.34% of arteries examined had some degree of atherosclerosis. The most common histological type was type II (foam cells). No thoracic aorta specimens were normal, and the coronary artery specimens had the most atherosclerosis.</p> <p>Conclusions</p> <p>Our results show a high prevalence of atherosclerotic lesions among young people in Brazil. Intervention should be undertaken to decrease the rate of sudden cardiac death in the adult population.</p