Ongoing monkeypox virus outbreak, Portugal, 29 April to 23 May 2022

Up to 27 May 2022, Portugal has detected 96 confirmed cases of monkeypox. We describe 27 confirmed cases (median age: 33 years (range: 22–51); all males), with an earliest symptom onset date of 29 April. Almost all cases (n = 25) live in the Lisbon and Tagus Valley health region. Most cases were neither part of identified transmission chains, nor linked to travel or had contact with symptomatic persons or with animals, suggesting the possible previously undetected spread of monkeypox.info:eu-repo/semantics/publishedVersio

FALCON: A phase III randomised trial of fulvestrant 500 mg vs. anastrozole for hormone receptor-positive advanced breast cancer

Background: This Phase III, randomised, double-blind, multicentre trial (FALCON; NCT01602380) compared the selective estrogen receptor (ER) degrader (SERD) fulvestrant with anastrozole in patients with ER- and/or progesterone receptor-positive locally advanced or metastatic breast cancer who had not received prior hormonal therapy. Methods: Patients were randomised 1:1 to fulvestrant (500 mg IM on Days 0, 14, 28, then each 28 days) or anastrozole (1 mg daily). The primary endpoint was progression-free survival (PFS), assessed via RECIST 1.1, surgery/radiotherapy for disease worsening, or death. Secondary endpoints were: overall survival (OS); objective response rate (ORR, complete response [CR] or partial response [PR]); duration of response (DoR); expected DoR (EDoR); clinical benefit rate (CBR; CR, PR, or stable disease ≥24 weeks); duration of clinical benefit (DoCB); expected DoCB (EDoCB); health-related quality of life (HRQoL); and safety

Magnetocaloric effect of Co62Nb6Zr2B 30 amorphous alloys obtained by mechanical alloying or rapid quenching

Amorphous samples of nominal composition Co62Nb 6Zr2B30 have been prepared using mechanical alloying (MA) and rapid quenching (RQ) techniques. Differences appear in Curie temperature and the phases developed after crystallization. Refrigerant capacity is enhanced 20% in the MA-sample with respect to that of RQ-sample. Neglecting the demagnetizing factor of powder samples significantly affects the exponent n characterizing the field dependence of the maximum magnetic entropy change. © 2014 AIP Publishing LLC.Peer Reviewe

Exequibilidade do estudo funcional respiratório em idade pré-escolar na prática clínica

Resumo: Introdução: A avaliação da função respiratória em idade pré-escolar reveste-se de particularidades metodológicas, tendo ganho recentemente um interesse crescente. A sua exequibilidade na prática clínica, em grandes grupos de doentes, continua, no entanto, por investigar. Objetivo: Avaliar a exequibilidade do estudo funcional respiratório em idade pré-escolar e o grau de sucesso de acordo com a idade. Métodos: Análise retrospetiva de provas funcionais respiratórias realizadas em crianças com 2 a 6 anos no laboratório de exploração funcional respiratória do Hospital CUF Descobertas entre Setembro de 2006 e Agosto de 2011. Foi efetuada pletismografia corporal sem oclusão para avaliação da resistência específica das vias aéreas (sRaw) e espirometria animada, com equipamento Jaeger4.65 (VIASYS Healthcare) antes e após 400 ug de salbutamol inalado em câmara expansora. Foram cumpridos os critérios internacionais (ATS/ERS) para aceitabilidade e reprodutibilidade. Resultados: De 1 239 provas funcionais respiratórias realizadas, 1 092 (88%) tinham uma espirometria com critérios de aceitabilidade e reprodutibilidade (crianças com idade média de 4,3 ± 0,91 anos; 60,7% do sexo masculino), e 979 (79%) sucesso na determinação de sRaw. Foi possível reportar FEV1 em 801 (65%) provas (crianças com idade média 4,5 ± 0,89 anos). Em 23 (2%) das provas apenas foi possível reportar FEV0,5 (crianças com idade média de 3,5 ± 0,67 anos) e em 268 (22%) apenas FEV0,75 (crianças com idade média de 4,0 ± 0,89 anos). Conclusão: A espirometria e a avaliação de resistências em idade pré-escolar são exequíveis na prática clínica diária, com um aumento do sucesso em crianças mais velhas. O registo de manobras com duração de 0,5 ou 0,75 s permite a avaliação funcional respiratória de um maior número de crianças. Abstract: Introduction: The assessment of respiratory function in preschool children, which has recently been attracting considerable interest, has several methodological particularities. Whether this is feasible in clinical practice with large groups of patients still needs to be investigated. Aim: To assess the feasibility of pulmonary function testing in preschool children in clinical practice, and report the degree of success achieved according to age. Methods: Retrospective analysis of lung function tests performed in children from 2 to 6 years old at the respiratory function laboratory of CUF Descobertas Hospital between September 2006 and August 2011. Whole-body pletismography without occlusion for specific airway resistance (sRaw) assessment and animated spirometry were performed using the equipment Jaeger 4.65 (Viasys Healthcare), before and after 400 μg of inhaled salbutamol via a spacer device. The research fulfilled international criteria (ATS/ERS) for acceptability and reproducibility. Results: Of 1,239 lung function tests performed, 1,092 (88%) had acceptable and reproducible criteria for spirometry (children with a mean age of 4.3 ± 0.91 years; 60.7% male), and 979 (79%) for sRaw measurement. We were able to report FEV1 in 801 (65%) tests (children with a mean age of 4.5 ± 0.89 years). In 23 (2%) tests it was only possible to report FEV0.5 (children with a mean age of 3.5 ± 0.67 years) and in 268 (22%) only FEV0.75 (children with a mean age of 4.0 ± 0.89 years). Conclusion: Spirometry and sRaw assessment in preschool children can be used in clinical practice, with an increasing success rate as children get older. Reporting maneuvers of 0.5 or 0.75 seconds facilitates spirometric evaluation in a larger number of children. Palavras-chave: Espirometria, Exequibilidade, Pré-escolar, Provas de função respiratória, Resistência específica das vias aéras, Keywords: Spirometry, Feasibility, Preschool, Respiratory function tests, Specific airway resistanc

Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology

Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching. It is classified as allergic rhinitis, infectious rhinitis and nonallergic, noninfectious rhinitis. Similar symptoms may occur with other conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal corticosteroids are both appropriate for first-line AR treatment although the latter are more effective. Once-daily forms of corticosteroids are preferred given their improved safety profile. Potentially useful add-on therapies for AR include oral leukotriene receptor antagonists, short bursts of a nasal decongestant, saline douches and nasal anticholinergics. Allergen-specific immunotherapy is helpful in IgE-mediated AR and may prevent the progression of allergic disease. There are still a number of areas that need to be clarified in the management of rhinitis in children and adolescents

Paediatric rhinitis: Position paper of the European Academy of Allergy and Clinical Immunology

Rhinitis is a common problem in childhood and adolescence and impacts negatively on physical, social and psychological well-being. This position paper, prepared by the European Academy of Allergy and Clinical Immunology Taskforce on Rhinitis in Children, aims to provide evidence-based recommendations for the diagnosis and therapy of paediatric rhinitis. Rhinitis is characterized by at least two nasal symptoms: rhinorrhoea, blockage, sneezing or itching. It is classified as allergic rhinitis, infectious rhinitis and nonallergic, noninfectious rhinitis. Similar symptoms may occur with other conditions such as adenoidal hypertrophy, septal deviation and nasal polyps. Examination by anterior rhinoscopy and allergy tests may help to substantiate a diagnosis of allergic rhinitis. Avoidance of relevant allergens may be helpful for allergic rhinitis (AR). Oral and intranasal antihistamines and nasal corticosteroids are both appropriate for first-line AR treatment although the latter are more effective. Once-daily forms of corticosteroids are preferred given their improved safety profile. Potentially useful add-on therapies for AR include oral leukotriene receptor antagonists, short bursts of a nasal decongestant, saline douches and nasal anticholinergics. Allergen-specific immunotherapy is helpful in IgE-mediated AR and may prevent the progression of allergic disease. There are still a number of areas that need to be clarified in the management of rhinitis in children and adolescents. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

Geological evidence of pre-historical and historical tsunamis in a tidal channel of Southwestern Spain

The sedimentological, palaeontological and radiometric analyses of two cores collected in the Domingo Rubio tidal channel (Huelva estuary, SW Spain) permit us to recognize the main features of several tsunamigenic layers with different ages. Two tsunamigenic facies were differentiated with a foraminiferal record, largely dependent on the palaeogeography of the estuary. These bioclastic beds were deposited during a prehistorical tsunami (3.6-3.0 cal ka BP) and a historical tsunami (1531 CE), the latter is the first geological record of this high-energy event in Spain. © 2013 by Nova Science Publishers, Inc. All rights reserved

Occurrence of fungi and mycotoxins in corn silage, Jalisco State, Mexico

The sedimentological, palaeontological and radiometric analyses of two cores collected in the Domingo Rubio tidal channel (Huelva estuary, SW Spain) permit us to recognize the main features of several tsunamigenic layers with different ages. Two tsunamigenic facies were differentiated with a foraminiferal record, largely dependent on the palaeogeography of the estuary. These bioclastic beds were deposited during a prehistorical tsunami (3.6-3.0 cal ka BP) and a historical tsunami (1531 CE), the latter is the first geological record of this high-energy event in Spain. " 2013 by Nova Science Publishers, Inc. All rights reserved.",,,,,,,,,"http://hdl.handle.net/20.500.12104/41750","http://www.scopus.com/inward/record.url?eid=2-s2.0-84895383459&partnerID=40&md5=d27d0756c6f71af00438c9309eb17ed8",,,,,,,,"Holocene: Perspectives, Environmental Dynamics and Impact Events",,"10