MONITORING OF SYSTEMIC HEMODYNAMICS INDICATORS DURING THE WORKING DAY ON THE EXAMPLE OF WOMEN OF CHILDBEARING AGE

It has been established that the state of the cardiovascular system in humans undergoes age-related changes, leading to an increase in the frequency of blood pressure disorders. Moreover, in the age category of 18-19 years, the proportion of cases with high blood pressure was 71.4%, and in other age categories from 28.5 to 71.4%. The upper pressure was in the range of 90 to 130 mmHg, and the lower pressure was from 60 to 80 mmHg. For the prevention of disorders, a set of five specially selected exercises aimed at improving cardiac rhythm and blood supply to the brain is recommended. The classes were aimed at the work of the muscles of the neck-shoulder girdle, back, legs, arms. The greatest effect after a course of exercises is achieved in reducing the waist circumference and increasing the vital volume of the lungs. In comparison with the initial measurements, the proportion of occurrence of blood pressure disorders decreased in group I – by 42.9%, in group II – by 23.8%. In group III as a whole, there was a decrease in blood pressure closer to the normal level, however, the number of violations did not decrease, and was in the range of 28.5-57.1%

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium.

BACKGROUND: The relevance of blood lipid concentrations to long-term incidence of cardiovascular disease and the relevance of lipid-lowering therapy for cardiovascular disease outcomes is unclear. We investigated the cardiovascular disease risk associated with the full spectrum of bloodstream non-HDL cholesterol concentrations. We also created an easy-to-use tool to estimate the long-term probabilities for a cardiovascular disease event associated with non-HDL cholesterol and modelled its risk reduction by lipid-lowering treatment. METHODS: In this risk-evaluation and risk-modelling study, we used Multinational Cardiovascular Risk Consortium data from 19 countries across Europe, Australia, and North America. Individuals without prevalent cardiovascular disease at baseline and with robust available data on cardiovascular disease outcomes were included. The primary composite endpoint of atherosclerotic cardiovascular disease was defined as the occurrence of the coronary heart disease event or ischaemic stroke. Sex-specific multivariable analyses were computed using non-HDL cholesterol categories according to the European guideline thresholds, adjusted for age, sex, cohort, and classical modifiable cardiovascular risk factors. In a derivation and validation design, we created a tool to estimate the probabilities of a cardiovascular disease event by the age of 75 years, dependent on age, sex, and risk factors, and the associated modelled risk reduction, assuming a 50% reduction of non-HDL cholesterol. FINDINGS: Of the 524 444 individuals in the 44 cohorts in the Consortium database, we identified 398 846 individuals belonging to 38 cohorts (184 055 [48·7%] women; median age 51·0 years [IQR 40·7-59·7]). 199 415 individuals were included in the derivation cohort (91 786 [48·4%] women) and 199 431 (92 269 [49·1%] women) in the validation cohort. During a maximum follow-up of 43·6 years (median 13·5 years, IQR 7·0-20·1), 54 542 cardiovascular endpoints occurred. Incidence curve analyses showed progressively higher 30-year cardiovascular disease event-rates for increasing non-HDL cholesterol categories (from 7·7% for non-HDL cholesterol <2·6 mmol/L to 33·7% for ≥5·7 mmol/L in women and from 12·8% to 43·6% in men; p<0·0001). Multivariable adjusted Cox models with non-HDL cholesterol lower than 2·6 mmol/L as reference showed an increase in the association between non-HDL cholesterol concentration and cardiovascular disease for both sexes (from hazard ratio 1·1, 95% CI 1·0-1·3 for non-HDL cholesterol 2·6 to <3·7 mmol/L to 1·9, 1·6-2·2 for ≥5·7 mmol/L in women and from 1·1, 1·0-1·3 to 2·3, 2·0-2·5 in men). The derived tool allowed the estimation of cardiovascular disease event probabilities specific for non-HDL cholesterol with high comparability between the derivation and validation cohorts as reflected by smooth calibration curves analyses and a root mean square error lower than 1% for the estimated probabilities of cardiovascular disease. A 50% reduction of non-HDL cholesterol concentrations was associated with reduced risk of a cardiovascular disease event by the age of 75 years, and this risk reduction was greater the earlier cholesterol concentrations were reduced. INTERPRETATION: Non-HDL cholesterol concentrations in blood are strongly associated with long-term risk of atherosclerotic cardiovascular disease. We provide a simple tool for individual long-term risk assessment and the potential benefit of early lipid-lowering intervention. These data could be useful for physician-patient communication about primary prevention strategies. FUNDING: EU Framework Programme, UK Medical Research Council, and German Centre for Cardiovascular Research

Alternative power resources in the motor vehicles supply

© Published under licence by IOP Publishing Ltd. The rapid development of engineering, technology and mass motorization during the transition to the fourth industrial revolution is accompanied by negative processes in ecosystems and leads to a change in the economic paradigm-to the circular economy. Reducing resource consumption while decreasing the growth of waste production and consumption will reduce the negative load on the environment. The search for global solutions to ensure comfortable living conditions on the planet is determined by minimizing the adverse environmental impact of solid industrial and household waste (MSW). The article presents a new technology of energy- A nd resource saving in automobile transport using MSW as an alternative fuel and exhaust gas cleaning filters for internal combustion engines, that will allow to reduce pollution by the slowly decomposing polyethylene of the world ocean, which is now becoming a global scale catastrophe

Treatment of gastroparesis with botulinum toxin in patient after allogenic bone marrow transplantation

The case report of botulinum toxin treatment of gastroparesis in a patient following allogenic bone marrow transplantation is described. The causes of gastroparesis and methods of prevention and treatment are discussed. It was noted that pyloric injection of botulinum toxin can improve symptoms and gastric emptying

Molecular genetic prognostic factors for metastatic regional lymph node involvement in breast cancer patients

Objective. To identify molecular genetic prognostic factors for metastatic regional lymph node involvement in breast cancer (BC) on the basis of the gene-expression profiling analysis of primary tumors. Subjects and methods. The investigation enrolled 200 patients with morphologically verified unicentric invasive BC (T1-4N0-3M0,) who had been treated at the Ulyanovsk Regional Clinical Oncology Dispensary in 2012 to 2015. A tumor tissue molecular genetic study was performed using reverse transcription-polymerase chain reaction (RT-PCR) assay; a diagnostic panel consisted of 28 functional genes. Results. In the metastatic regional lymph node involvement group, the primary breast tumor was characterized by enhanced proliferative activity in terms of the expression of the Ki-67 gene (p = 0.028) and by the higher mRNA levels of the NAT (p = 0.039) and CD68 (p &lt;0.001) genes with a reduction in PTEN expression (p &lt;0.001) and with decreased ESR1 gene expression (p = 0.043). A discriminant analysis showed that the accuracy in predicting the presence or absence of metastatic regional lymph node involvement on the basis of a primary tumor molecular genetic study using a 7-gene expression panel was 91.9 and 78.8%, respectively. Conclusion. The primary breast tumor tissue molecular genetic study involving a set of 7 genes (PTEN, CD68, CCNB1, MGB1, MYC, BCL2, and ESR1) can become an additional diagnostic tool for assessing the presence of metastatic lymph node involvement when planning the volume of axillary lymph node dissection in BC patients. © 2020, Bionika Media Ltd.. All rights reserved

Divergence of supreme values of Russian world and western civilization social and philosophical analysis

The relevance of the study is determined by growing tensions in the relations between the Russian Federation and the countries of the Western world, as well as the aggravating Russophobia and anti-Russian propaganda. One of the reasons for this is the divergence of the supreme values of these cultural and civilizational paradigms. Social and philosophical conception of the phenomenon of supreme values and differences in their meaning are important, because in the modern world, they are among the most crucial elements of the formation of national consciousness and civic identity, and, as a spiritual and social construct, can be understood using some philosophical methods with a glance to new realities of life. The article provides a social and philosophical analysis of various approaches to the understanding of the phenomenon of supreme values, their particular features in the framework of the Russian World and Western civilization historically and in the modern science. It is established that the divergences in the value orientations of the two modern global civilizations trace their origins to the contradictions of the Orthodoxy and Protestantism. It is found that in recent decades, the universal supreme values of the Western world have been undergoing a significant transformation due to the influence of postmodern ideas, while in the Russian world the traditional values continue to prevail. © 2019, Ecozone, OAIMDD. All rights reserved

The dermatoglyphics peculiarities for patients with gastroesophageal reflux disease and for patients with chronic gastritis

Usage of dermatoglyphic analysis as a method of prenosological diagnostics gastroesophageal reflux disease and chronic gastritis allows to add a clinical presentation of the disease, to specify the diagnosis, and also to detect genetic predisposition

The dermatoglyphics peculiarities for children with chronic gastritis disease

The study object is dermatoglyphics peculiarities for children with chronic gastritis. The possibility of using dermatoglyphic analysis for the prenosological diagnosis of this disease is under discussion. Boys with chronic gastritis noted the following special characteristics of dermatoglyphic pattern: true loop patterns in third (43,5%) and fourth (47,8%) areas of interfinger spaces, the end of the main line a in the third field (56,5%), the helix pattern on the fourth finger (54,3%) of the left hand, the true patterns in the loop of third (21,7%) and fourth (58,7%) areas of interfinger spaces, the end the main palmar line a in the palmar field 5‘ (47,8 %) of the right hand.Объектом исследования являются особенности дерматоглифики у детей при хроническом гастрите. Показана возможность использования дерматоглифического анализа для донозологической диагностики данной патологии. У мальчиков с хроническим гастритом отмечены следующие характерные особенности дерматоглифического рисунка: истинные петлевые узоры в области третьего (43,5%) и четвертого (47,8%) межпальцевых промежутков, окончание главной линии а в 3 поле (56,5%), завитковый узор на четвертом пальце (54,3%) левой руки, истинные петлевые узоры в области третьего (21,7%) и четвертого (58,7%) межпальцевых промежутков, окончание главной ладонной линии а в ладонном поле 5’ (47,8%) правой руки