Asymptotic analysis of flow near a glacier terminus

The non-linearly viscous ice flow in the vicinity of a glacier terminus, an observation region, depends crucially on the upstream flow as well as on the local surface and bed conditions. The former requires a likely complex solution of the balance laws and boundary conditions for the complete glacier. However, if the profile and downstream surface tangential velocity in the observation region are measured at an observation time t = 0, and a two-dimensional flow approximation is satisfactory, the complete stress and velocity fields satisfying local reduced model equations in the observation region at time t = 0 can be determined by asymptotic expansions in upstream distance from the (moving) terminus. Thus the full strain-rate and stress tensors are determined without prescribing the basal conditions. The terminus velocity is determined in terms of the net accumulation or melt flux and surface velocity at the terminus, with bounds for advance or retreat. The analysis and illustration are presented for a plane flow approximation

A constitutive law for the viscous and tertiary creep responses of ice to applied stress

Given the initial (secondary creep) viscous response of ice to applied stress, the subsequent tertiary creep is described by an orthotropic fabric evolution relation motivated by crystal rotation arguments. That is, the ice is described as a non-simple anisotropic fluid with dependence on the evolving deformation. Extension and modification of previous formulations are proposed, in which a general orthotropic flow law for stress includes terms which are quadratic functions of the strain-rate tensor, compared to previously analysed relations in which only linear in the strain-rate tensor terms were considered. Ice response functions in the extended law are constructed in such a way that the validity equalities and inequalities between the instantaneous directional viscosities at each stage of the tertiary creep are satisfied, and correlations with families of idealised uni-axial and simple shear tertiary creep curves for different applied stresses are possible. It is shown for a range of free parameters in the proposed orthotropic model how accurately the assumed uni-axial and shear creep curves can be approximated by the constructed response functions

Reconceptualizing CSR in the media industry as relational accountability

In this paper, we reconceptualize CSR in the media industries by combining empirical data with theoretical perspectives emerging from the communication studies and business ethics literature. We develop a new conception of what corporate responsibility in media organizations may mean in real terms by bringing Bardoel and d’Haenens’ (European Journal of Communication 19 165–194 2004) discussion of the different dimensions of media accountability into conversation with the empirical results from three international focus group studies, conducted in France, the USA and South Africa. To enable a critical perspective on our findings, we perform a philosophical analysis of its implications for professional, public, market, and political accountability in the media, drawing on the insights of Paul Virilio. We come to the conclusion that though some serious challenges to media accountability exist, the battle for responsible media industries is not lost. In fact, the speed characterizing the contemporary media environment may hold some promise for fostering the kind of relational accountability that could underpin a new understanding of CSR in the media

Cortical atrophy predicts visual performance in long-term central retinal disease; GCL, pRNFL and cortical thickness are key biomarkers

Purpose: The aim of this study was to assess both retinal and cortical structure in a cohort of patients with long-term acquired central retinal disease in order to identify potential disease biomarkers and to explore the relationship between the anterior and posterior visual pathways. Methods: Fourteen participants diagnosed with long-term central retinal disease underwent structural assessments of the retina using spectral-domain optical coherence tomography, including macular ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness. Structural magnetic resonance imaging was used to measure visual cortex, including cortical volume of the entire occipital lobe and cortical thickness of the occipital pole and calcarine sulcus, representing the central and peripheral retina, respectively. Results: Mean thickness was significantly reduced in both the macular GCL and the inferior temporal pRNFL across patients. Cortical thickness was significantly reduced in both the occipital pole and calcarine sulcus, representing the central and peripheral retina, respectively. Disease duration significantly correlated with GCL thickness with a large effect size, whereas a medium effect size suggests the possibility that cortical thickness in the occipital pole may correlate with visual acuity. Conclusions: Long-term central retinal disease is associated with significant structural changes to both the retina and the brain. Exploratory analysis suggests that monitoring GCL thickness may be a sensitive biomarker of disease progression and reductions in visual cortical thickness may be associated with reduced visual acuity. Although this study is limited by its heterogeneous population, larger cohort studies would be needed to better establish some of the relationships detected between disease dependent structural properties of the anterior and posterior visual pathway given the effect sizes reported in our exploratory analysis

On flow of a heat conducting fluid through a porous medium

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72083/1/j.1365-246X.1986.tb04557.x.pd

Following the status of visual cortex over time in patients with macular degeneration reveals atrophy of visually deprived brain regions

Purpose: Previous research has shown atrophy of visual cortex can occur in retinotopic representations of retinal lesions resulting from eye disease. However, the time course of atrophy cannot be established from these cross-sectional studies, which included patients with long-standing disease of varying severity. Our aim therefore was to measure visual cortical structure over time in participants after onset of unilateral visual loss resulting from age-related macular degeneration (AMD). Methods: Inclusion criteria were onset of acute unilateral neovascular AMD with bilateral dry-AMD based on clinical examination. Therefore, substantial loss of unilateral visual input to cortex was relatively well-defined in time. Changes in cortical anatomy were assessed in the occipital lobe as a whole, and in cortical representations of the lesion and intact retina, the lesion and intact projection zones, respectively. Whole brain, T1-weighted MRI was taken at diagnosis (before anti-angiogenic treatment to stabilise the retina), during the 3-4-month initial treatment period, with a long-term follow-up ~5 (range 3.8 – 6.1 years) years later. Results: Significant cortical atrophy was detected at long-term follow-up only, with a reduction in mean cortical volume across the whole occipital lobe. Importantly, this reduction was explained by cortical thinning of the lesion projection zone, which suggests additional changes to those associated with normal ageing. Over the period of study, anti-angiogenic treatment stabilised visual acuity and central retinal thickness, suggesting that the atrophy detected was most likely governed by long-term decreased visual input. Conclusions: Our results indicate that consequences of eye disease on visual cortex are atrophic and retinotopic. Our work also raises the potential to follow the status of visual cortex in individuals over time to inform on how best to treat patients, particularly with restorative techniques

Assessing the structure of the posterior visual pathway in bilateral macular degeneration

Abstract Macular degeneration (MD) embodies a collection of disorders causing a progressive loss of central vision. Cross-sectional MRI studies have revealed structural changes in the grey and white matter in the posterior visual pathway in MD but there remains a need to understand how such changes progress over time. To that end we assessed the posterior pathway, characterising the visual cortex and optic radiations over a ~ 2-year period in MD patients and controls. We performed cross-sectional and longitudinal analysis of the former. Reduced cortical thickness and white matter integrity were observed in patients compared to controls, replicating previous findings. While faster, neither the rate of thinning in visual cortex nor the reduction in white matter integrity during the ~ 2-year period reached significance. We also measured cortical myelin density; cross-sectional data showed this was higher in patients than controls, likely as a result of greater thinning of non-myelinated tissue in patients. However, we also found evidence of a greater rate of loss of myelin density in the occipital pole in the patient group indicating that the posterior visual pathway is at risk in established MD. Taken together, our results revealed a broad decline in grey and white matter in the posterior visual pathway in bilateral MD; cortical thickness and fractional anisotropy show hints of an accelerated rate of loss also, with larger effects emerging in the occipital pole

Simulating regoliths in microgravity

Despite their very low surface gravities, the surfaces of asteroids and comets are covered by granular materials – regolith – that can range from a fine dust to a gravel-like structure of varying depths. Understanding the dynamics of granular materials is, therefore, vital for the interpretation of the surface geology of these small bodies and is also critical for the design and/or operations of any device planned to interact with their surfaces. We present the first measurements of transient weakening of granular material after shear reversal in microgravity as well as a summary of experimental results recently published in other journals, which may have important implications for small-body surfaces. Our results suggest that the force contact network within a granular material may be weaker in microgravity, although the influence of any change in the contact network is felt by the granular material over much larger distances. This could mean that small-body surfaces are even more unstable than previously imagined. However, our results also indicate that the consequences of, e.g., a meteorite impact or a spacecraft landing, may be very different depending on the impact angle and location, and depending on the prior history of the small-body surface