<i>Rehabilitation doxa</i> and practitioner judgment. An analysis of symbolic violence on health care provision in the Scottish prison system

This paper presents an analysis of the symbolic conditions which govern health care provision in the Scottish prison system. The paper considers the wider context of Scottish prisons, where health care provision follows a similar structure both in juvenile and adult prisons. Our intention is to provoke a debate about the doxa (Bourdieu, 1977), which underlies decision making in respect of health care in prison, in a political environment where pragmatism, allied to the ‘pathologisation’ of social policies, health and criminal justice has been a hegemonic force.<br/

Susceptibility of Pseudomonas aeruginosa Biofilm to Alpha-Helical Peptides: D-enantiomer of LL-37

Pseudomonas aeruginosa is a highly versatile opportunistic pathogen and its ability to produce biofilms is a direct impediment to the healing of wounds and recovery from infection. Interest in anti-microbial peptides (AMPs) has grown due to their potential therapeutic applications and their possible use against antibiotic resistant bacteria. LL-37 is the only cathelicidin expressed by humans. In this study, we tested LL-37 and the effect of a protease-resistant LL-37 peptide mimetic, the peptide enantiomer D-LL-37, for anti-microbial and anti-biofilm activity against P. aeruginosa. Both forms of the peptide were equally effective as AMPs with similar killing kinetics. Circular dichroism spectra were obtained to demonstrate the chirality of D- and L-LL-37, and the trypsin resistance of D-LL-37 was confirmed. The helical cathelicidin from the cobra Naja atra (NA-CATH), and synthetic peptide variations (ATRA-1, ATRA-2, NA-CATH:ATRA1-ATRA1) were also tested. Although the cobra cathelicidin and related peptides had strong anti-microbial activity, those tested did not inhibit Pseudomonas biofilm formation, neither did control peptides. Both D- and L-LL-37 inhibited the attachment of Pseudomonas to a 96-well plate and decreased the amount of pre-formed (established) biofilm. D-LL-37 is able to promote Pseudomonas motility and decrease biofilm formation by altering the rate of twitching as well as by downregulating the expression of the biofilm-related genes, rhlA and rhlB, similar to L-LL-37. Both L- and D-LL-37 protected Galleria mellonella in vivo against Pseudomonas infection, while NA-CATH:ATRA1-ATRA1 peptide did not. This study demonstrates the ability and equivalence of D-LL-37 compared to L-LL-37 to promote bacterial twitching motility and inhibit biofilm formation, and protect against in vivo infection, and suggests that this peptide could be a critical advancement in the development of new treatments for P. aeruginosa infection

Development of a Socketed Foundation for the Midwest Weak Post V1

A socketed foundation was designed and evaluated for use with the Midwest Weak Post (MWP), Version 1. Dynamic component testing was conducted on five different design configurations with varying embedment depths, steel reinforcement, and soil conditions. The low strength of the MWPs limited the force transferred into the foundations and prevented damage in the form of concrete cracking or fracture. Additionally, the lateral movements of the socketed foundations were all within the 1-in. (25-mm) limit established to ensure reuse of the foundations without resetting. The selected design consisted of a 12-in. (305-mm) diameter concrete shaft reinforced with four vertical bars and transverse hoop steel spaced at 6½ in. (165 mm) on center. A 4-in. x 3-in. x ¼-in. (102-mm x 76-mm x 6-mm) steel tube socket was placed in the middle of the shaft. Finally, guidelines were given for the length, or embedment depth, of the foundation based on surrounding soil conditions and risk of frost heave

Evidence of construct similarity in executive functions and fluid reasoning abilities

Executive Functions and Fluid Reasoning are both considered to be core aspects of intelligence and mediated by frontal lobe functioning. However, both constructs considerably overlap, and the distinction between the two constructs is unclear. For this study, three measures of Executive Functions and three measures of Fluid Reasoning were administered to a group of participants. Significant correlations were found establishing an empirical association between these two constructs. Factor analysis and confirmatory factor analysis also provide evidence for construct similarity. Future research in defining these constructs for measurement purposes and using tests of these constructs in clinical practice is discussed