20 research outputs found
Study of structural capacity and serviceability affecting the obstruction of residential door
Risk assessment of the lead intake by consumption of red deer and wild boar meat in Southern Spain
Salud, globalizaciĂłn e interculturalidad: una mirada antropolĂłgica a la situaciĂłn de los pueblos indĂgenas de SudamĂ©rica
Global urban environmental change drives adaptation in white clover.
Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale
Global urban environmental change drives adaptation in white clover
Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale
Incidental durotomies during lumbar discectomies DurotomĂas incidentales en discectomĂas lumbares
Objective: To assess the evolution of patients submitted to operative treatment for lumbar discal herniation in which occurred accidental lesion of the dura mater during the procedure ("accidental durotomy"). Methods: retrospective study. It were analyzed the charts of patients operated on between June 2005 and November 2007. It was selected the patients that presented accidental lesions of the dura mater membrane and these were studied concerning the means of repairing of the lesion and their clinical evolution. Results: During theperiodofthe study it was realized 449 diskectomies for lumbar discal herniations from which 391 as a primary surgery, 48 as a first recurrence and ten as a second recurrence. In 11 (2.4%) patients it was found an accidental durotomy. The average age of the patients was 38.4 years. All the patients were submitted to elective surgical procedure, eight for primary discal herniation, one as a first recurrence and two as a second recurrence, meaning a total of 2
Toward a Critical Pedagogy of Race: Ethnic Studies and Literacies of Power in High School Classrooms
Clonal Dissemination, Emergence of Mutator Lineages and Antibiotic Resistance Evolution in Pseudomonas aeruginosa Cystic Fibrosis Chronic Lung Infection
Mapa epidemiológico transversal de las ataxias y paraparesias espåsticas hereditarias en España
Resume: IntroducciĂłn: Las ataxias (AT) y paraparesias espĂĄsticas hereditarias (PEH) son sĂndromes neurodegenerativos raros. Nos proponemos conocer la prevalencia de las AT y PEH en España en 2019. Pacientes y mĂ©todos: Estudio transversal, multicĂ©ntrico, descriptivo y retrospectivo de los pacientes con AT y PEH, desde marzo de 2018 a diciembre de 2019 en toda España. Resultados: Se obtuvo informaciĂłn de 1933 pacientes procedentes de 11 Comunidades AutĂłnomas, de 47 neurĂłlogos o genetistas. Edad media: 53,64 años ± 20,51 desviaciĂłn estĂĄndar (DE); 938 varones (48,5%), 995 mujeres (51,5%). En 920 pacientes (47,6%) no se conoce el defecto genĂ©tico. Por patologĂas, 1.371 pacientes (70,9%) diagnosticados de AT, 562 diagnosticados de PEH (29,1%). La prevalencia estimada de AT es 5,48/100.000 habitantes, y la de PEH es 2,24 casos/100.000 habitantes. La AT dominante mĂĄs frecuente es la SCA3. La AT recesiva mĂĄs frecuente es la ataxia de Friedreich (FRDA). La PEH dominante mĂĄs frecuente es la SPG4, y la PEH recesiva mĂĄs frecuente es la SPG7. Conclusiones: La prevalencia estimada de AT y PEH en nuestra serie es de 7,73 casos/100.000 habitantes. Estas frecuencias son similares a las del resto del mundo. En el 47,6% no se ha conseguido un diagnĂłstico genĂ©tico. A pesar de las limitaciones, este estudio puede contribuir a estimar los recursos, visibilizar estas enfermedades, detectar las mutaciones mĂĄs frecuentes para hacer los screenings por comunidades, y favorecer los ensayos clĂnicos. Abstract: Introduction: Ataxia and hereditary spastic paraplegia are rare neurodegenerative syndromes. We aimed to determine the prevalence of these disorders in Spain in 2019. Patients and methods: We conducted a cross-sectional, multicentre, retrospective, descriptive study of patients with ataxia and hereditary spastic paraplegia in Spain between March 2018 and December 2019. Results: We gathered data from a total of 1933 patients from 11 autonomous communities, provided by 47 neurologists or geneticists. Mean (SD) age in our sample was 53.64 (20.51) years; 938 patients were men (48.5%) and 995 were women (51.5%). The genetic defect was unidentified in 920 patients (47.6%). A total of 1371 patients (70.9%) had ataxia and 562 (29.1%) had hereditary spastic paraplegia. Prevalence rates for ataxia and hereditary spastic paraplegia were estimated at 5.48 and 2.24 cases per 100 000 population, respectively. The most frequent type of dominant ataxia in our sample was SCA3, and the most frequent recessive ataxia was Friedreich ataxia. The most frequent type of dominant hereditary spastic paraplegia in our sample was SPG4, and the most frequent recessive type was SPG7. Conclusions: In our sample, the estimated prevalence of ataxia and hereditary spastic paraplegia was 7.73 cases per 100 000 population. This rate is similar to those reported for other countries. Genetic diagnosis was not available in 47.6% of cases. Despite these limitations, our study provides useful data for estimating the necessary healthcare resources for these patients, raising awareness of these diseases, determining the most frequent causal mutations for local screening programmes, and promoting the development of clinical trials