445 research outputs found
Perturbative behaviour of a vortex in a trapped Bose-Einstein condensate
We derive a set of equations that describe the shape and behaviour of a
single perturbed vortex line in a Bose-Einstein condensate. Through the use of
a matched asymptotic expansion and a unique coordinate transform a relation for
a vortex's velocity, anywhere along the line, is found in terms of the
trapping, rotation, and distortion of the line at that location. This relation
is then used to find a set of differential equations that give the line's
specific shape and motion. This work corrects a previous similar derivation by
Anatoly A. Svidzinsky and Alexander L. Fetter [Phys. Rev. A \textbf{62}, 063617
(2000)], and enables a comparison with recent numerical results.Comment: 12 pages with 3 figure
Combinatorial 3-manifolds with transitive cyclic symmetry
In this article we give combinatorial criteria to decide whether a transitive
cyclic combinatorial d-manifold can be generalized to an infinite family of
such complexes, together with an explicit construction in the case that such a
family exists. In addition, we substantially extend the classification of
combinatorial 3-manifolds with transitive cyclic symmetry up to 22 vertices.
Finally, a combination of these results is used to describe new infinite
families of transitive cyclic combinatorial manifolds and in particular a
family of neighborly combinatorial lens spaces of infinitely many distinct
topological types.Comment: 24 pages, 5 figures. Journal-ref: Discrete and Computational
Geometry, 51(2):394-426, 201
Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease
INTRODUCTION: Several blood‐based biomarkers are associated with neuronal injury, but their utility in interventional clinical trials is unclear. This study retrospectively evaluated the utility of plasma neurofilament light (NfL) and total tau (t‐tau) in an 18‐month trial in mild Alzheimer's disease (AD). METHODS: Correlation and conditional independence analyses and Gaussian graphical models were used to investigate cross‐sectional and longitudinal relations between NfL, t‐tau, and clinical scales. RESULTS: NfL had a stronger association than t‐tau with clinical scales; t‐tau did not hold additional information to that given by NfL (P > 0.05 at all time points). NfL held independent information about shorter‐term (3‐ to 6‐month) progression beyond patient age and clinical scores. However, no meaningful gain in power was found when adjusting a longitudinal analysis of cognitive scores for baseline NfL. DISCUSSION: Plasma NfL is superior to t‐tau in mild AD. The ability of NfL to detect changes before clinical manifestations makes it a promising biomarker of drug response in trials of disease‐modifying drugs
Interatomic Coulombic Decay following Photoionization of the Helium Dimer: Observation of Vibrational Structure
Using synchrotron radiation we simultaneously ionize and excite one helium
atom of a helium dimer (He_2) in a shakeup process. The populated states of the
dimer ion (i.e. He^[*+](n = 2; 3)-He) are found to deexcite via interatomic
coulombic decay. This leads to the emission of a second electron from the
neutral site and a subsequent coulomb explosion. In this letter we present a
measurement of the momenta of fragments that are created during this reaction.
The electron energy distribution and the kinetic energy release of the two He^+
ions show pronounced oscillations which we attribute to the structure of the
vibrational wave function of the dimer ion.Comment: 8 pages, 5 figure
Sialic acids on B cells are crucial for their survival and provide protection against apoptosis.
Sialic acids (Sias) on the B cell membrane are involved in cell migration, in the control of the complement system and, as sialic acid-binding immunoglobulin-like lectin (Siglec) ligands, in the regulation of cellular signaling. We studied the role of sialoglycans on B cells in a mouse model with B cell-specific deletion of cytidine monophosphate sialic acid synthase (CMAS), the enzyme essential for the synthesis of sialoglycans. Surprisingly, these mice showed a severe B cell deficiency in secondary lymphoid organs. Additional depletion of the complement factor C3 rescued the phenotype only marginally, demonstrating a complement-independent mechanism. The B cell survival receptor BAFF receptor was not up-regulated, and levels of activated caspase 3 and processed caspase 8 were high in B cells of Cmas-deficient mice, indicating ongoing apoptosis. Overexpressed Bcl-2 could not rescue this phenotype, pointing to extrinsic apoptosis. These results show that sialoglycans on the B cell surface are crucial for B cell survival by counteracting several death-inducing pathways
Single photon double ionization of the helium dimer
We show that a single photon can ionize the two helium atoms of the helium
dimer in a distance up to 10 {\deg}A. The energy sharing among the electrons,
the angular distributions of the ions and electrons as well as comparison with
electron impact data for helium atoms suggest a knock-off type double
ionization process. The Coulomb explosion imaging of He_2 provides a direct
view of the nuclear wave function of this by far most extended and most diffuse
of all naturally existing molecules.Comment: 10 pages, 5 figure
Feature Lines for Illustrating Medical Surface Models: Mathematical Background and Survey
This paper provides a tutorial and survey for a specific kind of illustrative
visualization technique: feature lines. We examine different feature line
methods. For this, we provide the differential geometry behind these concepts
and adapt this mathematical field to the discrete differential geometry. All
discrete differential geometry terms are explained for triangulated surface
meshes. These utilities serve as basis for the feature line methods. We provide
the reader with all knowledge to re-implement every feature line method.
Furthermore, we summarize the methods and suggest a guideline for which kind of
surface which feature line algorithm is best suited. Our work is motivated by,
but not restricted to, medical and biological surface models.Comment: 33 page
Critical Behaviour of Non-Equilibrium Phase Transitions to Magnetically Ordered States
We describe non-equilibrium phase transitions in arrays of dynamical systems
with cubic nonlinearity driven by multiplicative Gaussian white noise.
Depending on the sign of the spatial coupling we observe transitions to
ferromagnetic or antiferromagnetic ordered states. We discuss the phase
diagram, the order of the transitions, and the critical behaviour. For global
coupling we show analytically that the critical exponent of the magnetization
exhibits a transition from the value 1/2 to a non-universal behaviour depending
on the ratio of noise strength to the magnitude of the spatial coupling.Comment: 4 pages, 5 figure
Nitrate stable isotopes and major ions in snow and ice samples from four Svalbard sites
Increasing reactive nitrogen (N-r) deposition in the Arctic may adversely impact N-limited ecosystems. To investigate atmospheric transport of N-r to Svalbard, Norwegian Arctic, snow and firn samples were collected from glaciers and analysed to define spatial and temporal variations (1 10 years) in major ion concentrations and the stable isotope composition (delta N-15 and delta O-18) of nitrate (NO3-) across the archipelago. The delta N-15(NO3-) and delta O-18(NO3-) averaged -4 parts per thousand and 67 parts per thousand in seasonal snow (2010-11) and -9 parts per thousand and 74 parts per thousand in firn accumulated over the decade 2001-2011. East-west zonal gradients were observed across the archipelago for some major ions (non-sea salt sulphate and magnesium) and also for delta N-15(NO3-) and delta O-18(NO3-) in snow, which suggests a different origin for air masses arriving in different sectors of Svalbard. We propose that snowfall associated with long-distance air mass transport over the Arctic Ocean inherits relatively low delta N-15(NO3-) due to in-transport N isotope fractionation. In contrast, faster air mass transport from the north-west Atlantic or northern Europe results in snowfall with higher delta N-15(NO3-) because in-transport fractionation of N is then time-limited
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