Spectral decomposition of the stellar kinematics in the polar disk galaxy NGC 4650A

Context. The prototype of Polar Ring Galaxies NGC 4650A contains two main structural components, a central spheroid, which is the host galaxy, and an extended polar disk. Both photometric and kinematic studies revealed that these two components co-exist on two different planes within the central regions of the galaxy. Aims. The aim of this work is to study the spectroscopic and kinematic properties of the host galaxy and the polar disk in the central regions of NGC 4650A by disentangling their contributions to the observed galaxy spectrum. Methods. We applied the spectral decomposition technique introduced in previous works to long-slit spectroscopic observations in the CaII triplet region. We focused the analysis along the PA = 152 that corresponds to the photometric minor axis of the host galaxy, where the superimposition of the two components is more relevant and the spectral decomposition is necessary. We aim to disentangle the stars that move in the equatorial plane of the host galaxy from those that move in the meridan plane, which is along the polar disk. Results. We successfully disentangled the spectra of the two structural components of NGC 4650A and measured their line-of-sight velocity and velocity dispersion profiles, and the stellar content along PA = 152. The host galaxy shows significant rotation along its photometric minor axis, indicating that the gravitational potential is not axisymmetric. The polar disk shows a kinematic decoupling: the inner regions counter-rotating with respect the outer-regions and the host spheroid. This suggests a complex formation history for the polar disk, characterised by mass accretion with decoupled angular momenta.Comment: Accepted for publication in Astronomy and Astrophysics. 7 pages, 5 figure

Photometric structure of the peculiar galaxy ESO 235-G58

We present the near-infrared and optical properties of the peculiar galaxy ESO 235-G58, which resembles a late-type ringed barred spiral seen close to face-on. However, the apparent bar of ESO 235-G58 is in reality an edge-on disk galaxy of relatively low luminosity. We have analyzed the light and color distributions of ESO 235-G58 in the NIR and optical bands and compared them with the typical properties observed for other morphological galaxy types, including polar ring galaxies. Similar properties are observed for ESO 235-G58, polar ring galaxies, and spiral galaxies, which leads us to conclude that this peculiar system is a polar-ring-related galaxy, characterized by a low inclined ring/disk structure, as pointed out by Buta & Crocker in an earlier study, rather than a barred galaxy.Comment: 16 pages, 15 figures, accepted for publication in Astronomy & Astrophysic

The NIR structure of the barred galaxy NGC253 from VISTA

[abridged] We used J and Ks band images acquired with the VISTA telescope as part of the science verification to quantify the structures in the stellar disk of the barred Sc galaxy NGC253. Moving outward from the galaxy center, we find a nuclear ring within the bright 1 kpc diameter nucleus, then a bar, a ring with 2.9 kpc radius. From the Ks image we obtain a new measure of the deprojected length of the bar of 2.5 kpc. The bar's strength, as derived from the curvature of the dust lanes in the J-Ks image, is typical of weak bars. From the deprojected length of the bar, we establish the corotation radius (R_CR=3 kpc) and bar pattern speed (Omega_b = 61.3 km /s kpc), which provides the connection between the high-frequency structures in the disk and the orbital resonances induced by the bar. The nuclear ring is located at the inner Lindblad resonance. The second ring does not have a resonant origin, but it could be a merger remnant or a transient structure formed during an intermediate stage of the bar formation. The inferred bar pattern speed places the outer Lindblad resonance within the optical disk at 4.9 kpc, in the same radial range as the peak in the HI surface density. The disk of NGC253 has a down-bending profile with a break at R~9.3 kpc, which corresponds to about 3 times the scale length of the inner disk. We discuss the evidence for a threshold in star formation efficiency as a possible explanation of the steep gradient in the surface brightness profile at large radii. The NIR photometry unveils the dynamical response of the NGC253 stellar disk to its central bar. The formation of the bar may be related to the merger event that determined the truncation of stars and gas at large radii and the perturbation of the disk's outer edge.Comment: Accepted for publication in Astronomy & Astrphysics. High resolution pdf file is available at the following link: https://www.dropbox.com/s/4o4cofs1lyjrtpv/NGC253.pd

Mapping the inner regions of the polar disk galaxy NGC4650A with MUSE

[abridged] The polar disk galaxy NGC4650A was observed during the commissioning of the MUSE at the ESO VLT to obtain the first 2D map of the velocity and velocity dispersion for both stars and gas. The new MUSE data allow the analysis of the structure and kinematics towards the central regions of NGC4650A, where the two components co-exist. These regions were unexplored by the previous long-slit literature data available for this galaxy. The extended view of NGC~4650A given by the MUSE data is a galaxy made of two perpendicular disks that remain distinct and drive the kinematics right into the very centre of this object. In order to match this observed structure for NGC4650A, we constructed a multicomponent mass model made by the combined projection of two disks. By comparing the observations with the 2D kinematics derived from the model, we found that the modelled mass distribution in these two disks can, on average, account for the complex kinematics revealed by the MUSE data, also in the central regions of the galaxy where the two components coexist. This result is a strong constraint on the dynamics and formation history of this galaxy; it further supports the idea that polar disk galaxies like NGC~4650A were formed through the accretion of material that has different angular momentum.Comment: 14 pages, 10 figures; accepted for publication in Astronomy & Astrophysic

Epigenome chaos: Stochastic and deterministic dna methylation events drive cancer evolution

Cancer evolution is associated with genomic instability and epigenetic alterations, which contribute to the inter and intra tumor heterogeneity, making genetic markers not accurate to monitor tumor evolution. Epigenetic changes, aberrant DNA methylation and modifications of chromatin proteins, determine the “epigenome chaos”, which means that the changes of epigenetic traits are randomly generated, but strongly selected by deterministic events. Disordered changes of DNA methylation profiles are the hallmarks of all cancer types, but it is not clear if aberrant methylation is the cause or the consequence of cancer evolution. Critical points to address are the profound epigenetic intra-and inter-tumor heterogeneity and the nature of the heterogeneity of the methylation patterns in each single cell in the tumor population. To analyze the methylation heterogeneity of tumors, new technological and informatic tools have been developed. This review discusses the state of the art of DNA methylation analysis and new approaches to reduce or solve the complexity of methylated alleles in DNA or cell populations

Ganglion cell complex analysis in glaucoma patients: what can it tell us?

Glaucoma is a group of optic neuropathies characterized by a progressive degeneration of retina ganglion cells (RGCs) and their axons that precedes functional changes detected on the visual field. The macular ganglion cell complex (GCC), available in commercial Fourier-domain optical coherence tomography, allows the quantification of the innermost retinal layers that are potentially involved in the glaucomatous damage, including the retinal nerve fiber (RNFL), ganglion cell and inner plexiform layers. The average GCC thickness and its related parameters represent a reliable biomarker in detecting preperimetric glaucomatous damage. The most accurate GCC parameters are represented by average and inferior GCC thicknesses, and they can be associated with progressive visual field loss. Although the diagnostic accuracy increases with more severe glaucomatous damage and higher signal strength values, it is not affected by increasing axial length, resulting in a more accurate discrimination of glaucomatous damage in myopic eyes with respect to the traditional RNFL thickness. The analysis of the structure-function relationship revealed a good agreement between the loss in retinal sensitivity and GCC thickness. The use of a 10-2° visual field grid, adjusted for the anatomical RGCs displacement, describes more accurately the relationship between RGCs thickness and visual field sensitivity loss

Dramatically different levels of cacna1a gene expression between pre-weaning wild type and leaner mice

Loss of function mutations of the CACNA1A gene, coding for the α1A subunit of P/Q type voltage-gated calcium channel (Ca(V)2.1), are responsible for Episodic Ataxia type 2 (EA2), an autosomal dominant disorder. A dominant negative effect of the EA2 mutated protein, rather than a haploinsufficiency mechanism, has been hypothesised both for protein-truncating and missense mutations. We analysed the cacna1a mRNA expression in leaner mice carrying a cacna1a mutation leading to a premature stop codon. The results showed a very low mutant mRNA expression compared to the wild type allele. Although the mutant mRNA slightly increases with age, its low level is likely due to degradation by nonsense mediated decay, a quality control mechanism that selectively degrades mRNA harbouring premature stop codons. These data have implications for EA2 in humans, suggesting a haploinsufficiency mechanism at least for some of the CACNA1A mutations leading to a premature stop codon

VEGAS: a VST Early-type GAlaxy Survey. IV. NGC 1533, IC 2038 and IC 2039: an interacting triplet in the Dorado group

This paper focuses on NGC 1533 and the pair IC 2038 and IC 2039 in Dorado a nearby, clumpy, still un-virialized group. We obtained their surface photometry from deep OmegaCAM@ESO-VST images in g and r bands. For NGC 1533, we map the surface brightness down to $\mu_g \simeq 30.11$ mag/arcsec$^{2}$ and $\mu_r \simeq 28.87$ mag/arcsec$^{2}$ and out to about $4R_e$. At such faint levels the structure of NGC 1533 appear amazingly disturbed with clear structural asymmetry between inner and outer isophotes in the North-East direction. We detect new spiral arm-like tails in the outskirts, which might likely be the signature of a past interaction/merging event. Similarly, IC 2038 and IC 2039 show tails and distortions indicative of their ongoing interaction. Taking advantages of deep images, we are able to detect the optical counterpart to the HI gas. The analysis of the new deep data suggests that NGC 1533 had a complex history made of several interactions with low-mass satellites that generated the star-forming spiral-like structure in the inner regions and are shaping the stellar envelope. In addition, the VST observations show that also the two less luminous galaxies, IC 2038 and IC 2039, are probably interacting each-other and, in the past, IC 2038 could have also interacted with NGC 1533, which stripped away gas and stars from its outskirts. The new picture emerging from this study is of an interacting triplet, where the brightest galaxy NGC 1533 has ongoing mass assembly in the outskirts.Comment: Accepted for publication in The Astronomical Journal. High-resolution version of paper is available at the following link: https://www.dropbox.com/preview/VEGAS_IV.pdf?role=persona

Whatever the cost: Grain trade and the Genoese dominating minority in Sicily and Tabarka (16th-18th centuries)

This is the final version. Available from Routledge via the DOI in this record.This work analyses the activities of Genoese merchant communities in the grain trade in western Mediterranean markets. Our goal is to shed light on their ability to integrate into foreign lands, taking advantage of their privileged position within the Spanish Crown. Our analysis is focussed on two case studies, strictly connected from a theoretical point of view: Sicily and Tabarka. Both Genoese minorities living on these two islands used the port of Genoa as their commercial hub. Regarding Sicily, this study has mostly drawn information from a yet unexploited source: general average procedures drawn up in Genoa. General average (GA) was (and still is nowadays) a legal instrument used in maritime trade to share between all parties involved the expenses which can befall ships and cargoes from the time of their loading aboard until their unloading (due to accidents, jettison, etc.). These documents have been collected in an online database soon to be published as part of the ERC-funded AveTransRisk project. They offer valuable insights on shipmasters and merchants, cargo values, ports of destination, wheat prices, etc. All the sources are available on the online database resulting from the AveTransRisk project, of which we are members (http://humanities-research.exeter.ac.uk/avetransrisk). For the trade in North African wheat, we have mostly used documents related to the Genoese ‘colony’ of Tabarka, administered by the Lomellini family. These sources are kept in the Genoese archives as well as in the Archives Nationales of Paris.H2020 European Research Council (ERC

Methylation of the suppressor gene p16INK4a: Mechanism and consequences

Tumor suppressor genes in the CDKN2A/B locus (p15INK4b, p16INK4a, and p14ARF) function as biological barriers to transformation and are the most frequently silenced or deleted genes in human cancers. This gene silencing frequently occurs due to DNA methylation of the promoter regions, although the underlying mechanism is currently unknown. We present evidence that methylation of p16INK4a promoter is associated with DNA damage caused by interference between transcription and replication processes. Inhibition of replication or transcription significantly reduces the DNA damage and CpGs methylation of the p16INK4a promoter. We conclude that de novo methylation of the promoter regions is dependent on local DNA damage. DNA methylation reduces the expression of p16INK4a and ultimately removes this barrier to oncogene-induced senescence