Preschool teachers' well-being. Impact of relationships between happiness, emotional intelligence, affect, burnout, and engagement for their initial and permanent training

From a Positive Psychology model applied to Education, the objective is to analyze emotional and motivational competencies of 82 preschool teachers, using the TMMS-24, PANAS, UWES, SHS and MBI and to establish recommendations for teacher training and student’s well-being. High levels of happiness, commitment, emotional intelligence and positive affect were found. Results ratify relationships between emotional intelligence, positive affect, engagement and personal accomplishment observed by studies in that population. Strong correlations (p> .01) were found between clarity, repair and positive affect, repair and vigor, and between vigor, dedication, absorption, and personal accomplishment. The 40.6% of the variance in teacher well-being was explained by emotional intelligence and affective competencies, with positive affect and repair competence the most important to predict happiness level. These results allow us to identify the competencies that should be included in pre-service university plans and in permanent training centers.Desde un modelo de Psicología positiva aplicado a la Educación, el objetivo es analizar las competencias emocionales y motivacionales de 82 docentes de Infantil, utilizando las pruebas TMMS- 24, PANAS, UWES, SHS y MBI y establecer recomendaciones para la formación docente y el bienestar del alumnado. Se encontraron altos niveles de felicidad, compromiso laboral, inteligencia emocional y afecto positivo. Los resultados también ratifican, en esta población, las relaciones encontradas por otros estudios entre inteligencia emocional, afecto positivo, implicación en el trabajo y compromiso personal. Se encontraron altas correlaciones (p> ,01) entre claridad y reparación y afecto positivo, y entre reparación y energía, y entre energía, dedicación, absorción y compromiso personal. El 40,6% de la varianza del bienestar docente (felicidad) se explicó por las puntuaciones en inteligencia emocional y afecto, siendo la capacidad afectiva positiva y la de reparación emocional las que mejor predijeron el nivel en felicidad. Estos resultados permiten identificar las competencias que deberían incluirse en los planes universitarios y en los centros de formación permanente

Local avifauna : a tool for conservation, ecotourism and environmental education

1 recurso en línea (páginas 17-34).Photographic records of animal species in their environment have been widely used by researchers for species identification and ecological studies. In this study, we used photography as a tool to record and identify birds of the municipality of Páez, Boyacá, located in the Llanos foothills, with a landscape dominated by cloud forests, pastures and crops. We photographed and identified 133 bird species in roads and footpaths of the municipality; we found that the families Tyrannidae and Thraupidae, and the genus Tangara had the highest species diversity. All species reported here are in the Least Concern category of the International Union for Conservation of Nature, and 11 are migratory. The bird diversity of the municipality has a great potential for sustainable use. We report local common names for 63.16% of the registered species, and the sighting of 73.68% of these birds, identified with help from the community. In consequence, we propose further scientific research to assess the ecosystem services provided by birds and the use of the diversity and attractiveness of the avifauna to establish ecotouristic programs that promote the development of local communities.El registro fotográfico de especies animales en su ambiente ha sido ampliamente utilizado por los investigadores para su identificación y estudio. Con el propósito de explorar la avifauna del municipio de Páez (Boyacá, Colombia), localizado en el piedemonte llanero, con un paisaje dominado por áreas de bosque de niebla, pasturas y cultivos, se utilizó la fotografía como herramienta para registrarla e identificarla. Así, se fotografiaron e identificaron 133 especies de aves en caminos y carreteras del municipio, encontrando que las familias Tyrannidae y Thraupidae, así como el género Tangara, presentan la mayor diversidad. Todas las especies aquí reportadas se encuentran en la categoría de amenaza de Preocupación Menor de la Unión Internacional para la Conservación de la Naturaleza, y 11 de estas especies son migratorias. Se identificaron, con ayuda de la comunidad, los nombres comunes locales para el 63.16% de las especies registradas, y se reporta el avistamiento del 73.68% de ellas. En consecuencia, proponemos adelantar investigaciónes científicas para evaluar los servicios ecosistémicos proporcionados por las aves, y el uso de la diversidad y el atractivo de la avifauna para establecer programas ecoturísticos que promuevan el desarrollo de las comunidades locales.Bibliografía y webgrafía: páginas 30-34

Local avifauna : a tool for conservation, ecotourism and environmental education

1 recurso en línea (páginas 17-34).Photographic records of animal species in their environment have been widely used by researchers for species identification and ecological studies. In this study, we used photography as a tool to record and identify birds of the municipality of Páez, Boyacá, located in the Llanos foothills, with a landscape dominated by cloud forests, pastures and crops. We photographed and identified 133 bird species in roads and footpaths of the municipality; we found that the families Tyrannidae and Thraupidae, and the genus Tangara had the highest species diversity. All species reported here are in the Least Concern category of the International Union for Conservation of Nature, and 11 are migratory. The bird diversity of the municipality has a great potential for sustainable use. We report local common names for 63.16% of the registered species, and the sighting of 73.68% of these birds, identified with help from the community. In consequence, we propose further scientific research to assess the ecosystem services provided by birds and the use of the diversity and attractiveness of the avifauna to establish ecotouristic programs that promote the development of local communities.El registro fotográfico de especies animales en su ambiente ha sido ampliamente utilizado por los investigadores para su identificación y estudio. Con el propósito de explorar la avifauna del municipio de Páez (Boyacá, Colombia), localizado en el piedemonte llanero, con un paisaje dominado por áreas de bosque de niebla, pasturas y cultivos, se utilizó la fotografía como herramienta para registrarla e identificarla. Así, se fotografiaron e identificaron 133 especies de aves en caminos y carreteras del municipio, encontrando que las familias Tyrannidae y Thraupidae, así como el género Tangara, presentan la mayor diversidad. Todas las especies aquí reportadas se encuentran en la categoría de amenaza de Preocupación Menor de la Unión Internacional para la Conservación de la Naturaleza, y 11 de estas especies son migratorias. Se identificaron, con ayuda de la comunidad, los nombres comunes locales para el 63.16% de las especies registradas, y se reporta el avistamiento del 73.68% de ellas. En consecuencia, proponemos adelantar investigaciónes científicas para evaluar los servicios ecosistémicos proporcionados por las aves, y el uso de la diversidad y el atractivo de la avifauna para establecer programas ecoturísticos que promuevan el desarrollo de las comunidades locales.Bibliografía y webgrafía: páginas 30-34

Drug Repurposing for Cancers With Limited Survival: Protocol for a Retrospective Cohort Study

Only 5% of the molecules tested in oncology phase 1 trials reach the market after an average of 7.5 years of waiting and at a cost of tens of millions of dollars. To reduce the cost and shorten the time of discovery of new treatments, drug repurposing (research with molecules already approved for another indication) and the use of secondary data (not collected for the purpose of research) have been proposed. Due to advances in informatics in clinical care, secondary data can, in some cases, be of equal quality to primary data generated through prospective studies.Objective: The objective of this study is to identify drugs currently marketed for other indications that may have an effect on the prognosis of patients with cancer.Methods: We plan to monitor a cohort of patients with high-lethality cancers treated in the public health system of Catalonia between 2006 and 2012, retrospectively, for survival for 5 years after diagnosis or until death. A control cohort, comprising people without cancer, will also be retrospectively monitored for 5 years. The following study variables will be extracted from different population databases: type of cancer (patients with cancer cohort), date and cause of death, pharmacological treatment, sex, age, and place of residence. During the first stage of statistical analysis of the patients with cancer cohort, the drugs consumed by the long-term survivors (alive at 5 years) will be compared with those consumed by nonsurvivors. In the second stage, the survival associated with the consumption of each relevant drug will be analyzed. For the analyses, groups will be matched for potentially confounding variables, and multivariate analyses will be performed to adjust for residual confounding variables if necessary. The control cohort will be used to verify whether the associations found are exclusive to patients with cancer or whether they also occur in patients without cancer.Results: We anticipate discovering multiple significant associations between commonly used drugs and the survival outcomes of patients with cancer. We expect to publish the initial results in the first half of 2024.Conclusions: This retrospective study may identify several commonly used drugs as candidates for repurposing in the treatment of various cancers. All analyses are considered exploratory; therefore, the results will have to be confirmed in subsequent clinical trials. However, the results of this study may accelerate drug discovery in oncology

High Levels of Proinflammatory Cytokines, but Not Markers of Tissue Injury, in Unaffected Intestinal Areas from Patients with IBD

Intestinal alterations in IBD are triggered and maintained by an overexpression of proinflammatory cytokines. Additionally, increased immune activation has been found in the adjacent intestinal areas without displaying any apparent histological alterations, however, the regulatory environment is not well established. Biopsy specimens from patients with ulcerative colitis (UC) and Crohn's disease (CD), from both affected and unaffected areas, and also from a group of colonic biopsies from healthy controls, were included in our study. Cytokines and markers of mucosal damage were analyzed by real-time PCR, and some of the results confirmed by western-blot and ELISA. Levels of IFNγ, TNFα, IL-6, IL-15, IL-18, and IL-23 were increased (above healthy controls) in both affected and unaffected areas from IBD. IL-1β, IL-6, IL-12, and IL-27 were higher in affected areas compared to unaffected ones in UC but not CD. In general, a correlation was observed between mRNA levels of these cytokines and both iNOS and Granzyme B. SOCS-2 and SOCS-3 were also increased in the affected areas. In conclusion, the unaffected areas from IBD show increased levels of a restricted set of cytokines that may exert immune activating roles in these areas without being able to trigger tissue damage

A beam-beam monitoring detector for the MPD experiment at NICA

The Multi-Purpose Detector (MPD) is to be installed at the Nuclotron Ion Collider fAcility (NICA) of the Joint Institute for Nuclear Research (JINR). Its main goal is to study the phase diagram of the strongly interacting matter produced in heavy-ion collisions. These studies, while providing insight into the physics of heavy-ion collisions, are relevant for improving our understanding of the evolution of the early Universe and the formation of neutron stars. In order to extend the MPD trigger capabilities, we propose to include a high granularity beam-beam monitoring detector (BE-BE) to provide a level-0 trigger signal with an expected time resolution of 30 ps. This new detector will improve the determination of the reaction plane by the MPD experiment, a key measurement for flow studies that provides physics insight into the early stages of the reaction. In this work, we use simulated Au+Au collisions at NICA energies to show the potential of such a detector to determine the event plane resolution, providing further redundancy to the detectors originally considered for this purpose namely, the Fast Forward Detector (FFD) and the Hadron Calorimeter (HCAL). We also show our results for the time resolution studies of two prototype cells carried out at the T10 beam line at the CERN PS complex.Comment: 16 pages, 12 figures. Updated to published version with added comments and correction

Application of a dynamic event tree methodolgy to steam generator tube rupture sequences

The Integrated Safety Assessment (ISA) methodology, developed by the Spanish Nuclear Safety Council (CSN), has been applied to a thermo-hydraulical analysis of a Westinghouse 3-loop PWR plant by means of the dynamic event trees (DET) for Steam Generator Tube Rupture (SGTR) sequences. The ISA methodology allows obtaining the SGTR Dynamic Event Tree taking into account the operator actuation times. Simulations are performed with SCAIS (Simulation Code system for Integrated Safety Assessment), which includes a dynamic coupling with MAAP thermal hydraulic code. The results show the capability of the ISA methodology and SCAIS platform to obtain the DET of complex sequences

The p.(Cys150Tyr) variant in CSRP3 is associated with late-onset hypertrophic cardiomyopathy in heterozygous individuals

INTRODUCTION AND OBJECTIVES: Up to 50% of patients with hypertrophic cardiomyopathy (HCM) show no disease-causing variants in genetic studies. Mutations in CSRP3 have been associated with HCM, but evidence supporting pathogenicity is inconclusive. In this study, we describe an HCM cohort with a missense variant in CSRP3 (p.Cys150Tyr) with supporting evidence for pathogenicity and a description of the associated phenotype. METHODS: CSRP3 was sequenced in 6456 index cases with a diagnosis of HCM and in 5012 probands with other cardiomyopathies. In addition, 3372 index cases with hereditary cardiovascular disorders other than cardiomyopathies (mainly channelopathies and aortopathies) were used as controls. RESULTS: The p.(Cys150Tyr) variant was identified in 11 unrelated individuals of the 6456 HCM probands, and it was not identified in patients with other cardiomyopathies (p < 0.0001) or in our control population (p < 0.0001). Ten of the index cases were heterozygous and one was homozygous. Homozygous had a more severe phenotype. Family screening identified 17 other carriers. Wild-type individuals showed no signs of disease. The mean age at diagnosis of affected individuals was 55 ± 13 years, and the mean left ventricular wall thickness was 18 ± 3 mm. The variant showed highly age-dependent penetrance. After a mean follow-up of 11 (±8) years, no adverse events were reported in any of the HCM patients. CONCLUSIONS: The p.(Cys150Tyr) variant in CSRP3 causes late-onset and low risk form of hypertrophic cardiomyopathy in heterozygous carriers

Consensus of experts from the Spanish pharmacogenetics and pharmacogenomics society and the Spanish society of medical oncology for the genotyping of DPYD in cancer patients who are candidates for treatment with fluoropyrimidines

5-Fluorouracil (5-FU) and oral fluoropyrimidines, such as capecitabine, are widely used in the treatment of cancer, especially gastrointestinal tumors and breast cancer, but their administration can produce serious and even lethal toxicity. This toxicity is often related to the partial or complete deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme, which causes a reduction in clearance and a longer half-life of 5-FU. It is advisable to determine if a DPD deficiency exists before administering these drugs by genotyping DPYD gene polymorphisms. The objective of this consensus of experts, in which representatives from the Spanish Pharmacogenetics and Pharmacogenomics Society and the Spanish Society of Medical Oncology participated, is to establish clear recommendations for the implementation of genotype and/or phenotype testing for DPD deficiency in patients who are candidates to receive fluoropyrimidines. The genotyping of DPYD previous to treatment classifies individuals as normal, intermediate, or poor metabolizers. Normal metabolizers do not require changes in the initial dose, intermediate metabolizers should start treatment with fluoropyrimidines at doses reduced to 50%, and poor metabolizers are contraindicated for fluoropyrimidinesThis project has been financed with SEOM and SEFF resource