The 2+1 Kepler Problem and Its Quantization

We study a system of two pointlike particles coupled to three dimensional Einstein gravity. The reduced phase space can be considered as a deformed version of the phase space of two special-relativistic point particles in the centre of mass frame. When the system is quantized, we find some possibly general effects of quantum gravity, such as a minimal distances and a foaminess of the spacetime at the order of the Planck length. We also obtain a quantization of geometry, which restricts the possible asymptotic geometries of the universe.Comment: 59 pages, LaTeX2e, 9 eps figure

Hamiltonian solutions of the 3-body problem in (2+1)-gravity

We present a full study of the 3-body problem in gravity in flat (2+1)-dimensional space-time, and in the nonrelativistic limit of small velocities. We provide an explicit form of the ADM Hamiltonian in a regular coordinate system and we set up all the ingredients for canonical quantization. We emphasize the role of a U(2) symmetry under which the Hamiltonian is invariant and which should generalize to a U(N-1) symmetry for N bodies. This symmetry seems to stem from a braid group structure in the operations of looping of particles around each other, and guarantees the single-valuedness of the Hamiltonian. Its role for the construction of single-valued energy eigenfunctions is also discussed.Comment: 25 pages, no figure. v2: some calculation details removed to make the paper more concise (see v1 for the longer version), minor correction in a formula in the section on quantization, references added; results and conclusions unchange

Mechanical Instabilities of Biological Tubes

We study theoretically the shapes of biological tubes affected by various pathologies. When epithelial cells grow at an uncontrolled rate, the negative tension produced by their division provokes a buckling instability. Several shapes are investigated : varicose, enlarged, sinusoidal or sausage-like, all of which are found in pathologies of tracheal, renal tubes or arteries. The final shape depends crucially on the mechanical parameters of the tissues : Young modulus, wall-to-lumen ratio, homeostatic pressure. We argue that since tissues must be in quasistatic mechanical equilibrium, abnormal shapes convey information as to what causes the pathology. We calculate a phase diagram of tubular instabilities which could be a helpful guide for investigating the underlying genetic regulation

Hamiltonian structure and quantization of 2+1 dimensional gravity coupled to particles

It is shown that the reduced particle dynamics of 2+1 dimensional gravity in the maximally slicing gauge has hamiltonian form. This is proved directly for the two body problem and for the three body problem by using the Garnier equations for isomonodromic transformations. For a number of particles greater than three the existence of the hamiltonian is shown to be a consequence of a conjecture by Polyakov which connects the auxiliary parameters of the fuchsian differential equation which solves the SU(1,1) Riemann-Hilbert problem, to the Liouville action of the conformal factor which describes the space-metric. We give the exact diffeomorphism which transforms the expression of the spinning cone geometry in the Deser, Jackiw, 't Hooft gauge to the maximally slicing gauge. It is explicitly shown that the boundary term in the action, written in hamiltonian form gives the hamiltonian for the reduced particle dynamics. The quantum mechanical translation of the two particle hamiltonian gives rise to the logarithm of the Laplace-Beltrami operator on a cone whose angular deficit is given by the total energy of the system irrespective of the masses of the particles thus proving at the quantum level a conjecture by 't Hooft on the two particle dynamics. The quantum mechanical Green's function for the two body problem is given.Comment: 34 pages LaTe

Discrete structures in gravity

Discrete approaches to gravity, both classical and quantum, are reviewed briefly, with emphasis on the method using piecewise-linear spaces. Models of 3-dimensional quantum gravity involving 6j-symbols are then described, and progress in generalising these models to four dimensions is discussed, as is the relationship of these models in both three and four dimensions to topological theories. Finally, the repercussions of the generalisations are explored for the original formulation of discrete gravity using edge-length variables.Comment: 30 pages, 4 figure

How valid are assessments of conception probability in ovulatory cycle research? Evaluations, recommendations, and theoretical implications

Over the past two decades, a large literature examining psychological changes across women's ovulatory cycles has accumulated, emphasizing comparisons between fertile and non-fertile phases of the cycle. While some studies have verified ovulation using luteinizing hormone (LH) tests, counting methods – assessments of conception probability based on counting forward from actual or retrospectively recalled onset of last menses, or backward from actual or anticipated onset of next menses – are more common. The validity of these methods remains largely unexplored. Based on published data on the distributions of the lengths of follicular and luteal phases, we created a sample of 58,000+ simulated cycles. We used the sample to assess the validity of counting methods. Aside from methods that count backward from a confirmed onset of next menses, validities are modest, generally ranging from about .40–.55. We offer power estimates and make recommendations for future work. We also discuss implications for interpreting past research

Estimation of cold plasma outflow during geomagnetic storms

Low-energy ions of ionospheric origin constitute a significant contributor to the magnetospheric plasma population. Measuring cold ions is difficult though. Observations have to be done at sufficiently high altitudes and typically in regions of space where spacecraft attain a positive charge due to solar illumination. Cold ions are therefore shielded from the satellite particle detectors. Furthermore, spacecraft can only cover key regions of ion outflow during segments of their orbit, so additional complications arise if continuous longtime observations, such as during a geomagnetic storm, are needed. In this paper we suggest a new approach, based on a combination of synoptic observations and a novel technique to estimate the flux and total outflow during the various phases of geomagnetic storms. Our results indicate large variations in both outflow rates and transport throughout the storm. Prior to the storm main phase, outflow rates are moderate, and the cold ions are mainly emanating from moderately sized polar cap regions. Throughout the main phase of the storm, outflow rates increase and the polar cap source regions expand. Furthermore, faster transport, resulting from enhanced convection, leads to a much larger supply of cold ions to the near-Earth region during geomagnetic storms. ©2015. The Authors

Infinite factorization of multiple non-parametric views

Combined analysis of multiple data sources has increasing application interest, in particular for distinguishing shared and source-specific aspects. We extend this rationale of classical canonical correlation analysis into a flexible, generative and non-parametric clustering setting, by introducing a novel non-parametric hierarchical mixture model. The lower level of the model describes each source with a flexible non-parametric mixture, and the top level combines these to describe commonalities of the sources. The lower-level clusters arise from hierarchical Dirichlet Processes, inducing an infinite-dimensional contingency table between the views. The commonalities between the sources are modeled by an infinite block model of the contingency table, interpretable as non-negative factorization of infinite matrices, or as a prior for infinite contingency tables. With Gaussian mixture components plugged in for continuous measurements, the model is applied to two views of genes, mRNA expression and abundance of the produced proteins, to expose groups of genes that are co-regulated in either or both of the views. Cluster analysis of co-expression is a standard simple way of screening for co-regulation, and the two-view analysis extends the approach to distinguishing between pre- and post-translational regulation