295 research outputs found
Second large-scale Monte Carlo study for the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) represents the next generation of ground
based instruments for Very High Energy gamma-ray astronomy. It is expected to
improve on the sensitivity of current instruments by an order of magnitude and
provide energy coverage from 20 GeV to more than 200 TeV. In order to achieve
these ambitious goals Monte Carlo (MC) simulations play a crucial role, guiding
the design of CTA. Here, results of the second large-scale MC production are
reported, providing a realistic estimation of feasible array candidates for
both Northern and Sourthern Hemisphere sites performance, placing CTA
capabilities into the context of the current generation of High Energy
-ray detectors.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
Monte Carlo Performance Studies of Candidate Sites for the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) is the next-generation gamma-ray
observatory with sensitivity in the energy range from 20 GeV to beyond 300 TeV.
CTA is proposed to consist of two arrays of 40-100 imaging atmospheric
Cherenkov telescopes, with one site located in each of the Northern and
Southern Hemispheres. The evaluation process for the candidate sites for CTA is
supported by detailed Monte Carlo simulations, which take different attributes
like site altitude and geomagnetic field configuration into account. In this
contribution we present the comparison of the sensitivity and performance of
the different CTA site candidates for the measurement of very-high energy gamma
rays.Comment: In Proceedings of the 34th International Cosmic Ray Conference
(ICRC2015), The Hague, The Netherlands. All CTA contributions at
arXiv:1508.0589
The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes
In the present study, we tested the hypothesis that chronic treatment with the direct rennin inhibitor aliskiren improves the remodelling of resistance arteries in dTGR (double-transgenic rats). dTGR (5 weeks) were treated with aliskiren (3 mg/kg of body mass per day) or ramipril (1 mg/kg of body mass per day) for 14 days and compared with age-matched vehicle-treated dTGR. BP (blood pressure) was similarly reduced in both aliskiren-treated and ramipril-treated rats compared with control dTGR (167± 1 and 169± 2 mmHg compared with 197± 4 mmHg respectively; P<0.05). The M/L (media-to-lumen) ratio assessed on pressurized preparations was equally reduced in aliskiren-treated and ramipril-treated rats compared with controls (6.3± 0.5 and 6.4±0.2% compared with 9.8± 0.4% respectively; P<0.05). Endothelium-dependent and -independent relaxations were similar among the groups. L-NAME (NG-nitro-L-arginine methyl ester) significantly reduced acetylcholine-induced dilation in drug-treated dTGR. This effect was significantly more prominent in aliskiren-treated rats. eNOS (endothelial NO synthase) expression showed a 2-fold increase only in aliskiren-treated dTGR as compared with controls (P<0.01) and ramipril-treated dTGR (P<0.05). Plasma nitrite, as an index of NO production, was significantly increased in dTGR treated with either aliskiren or ramipril compared with controls. Only aliskiren induced a 2-fold increase in plasma nitrite, which was significantly greater than that induced by ramipril (P<0.05). gp91phox expression and ROS (reactive oxygen species) production in aorta were significantly and similarly reduced by both drugs. In conclusion, equieffective hypotensive doses of aliskiren or ramipril reduced the M/L ratio of mesenteric arteries and improved oxidative stress in dTGR. However, only aliskiren increased further NO production in the vasculature. Hence, in dTGR, direct renin inhibition induces favourable effects similar to that induced by ACE (angiotensin-converting enzyme) inhibition in improving vascular remodelling through different mechanisms. © The Authors Journal compilation. 2013 Biochemical Society
Monte Carlo Performance Studies for the Site Selection of the Cherenkov Telescope Array
The Cherenkov Telescope Array (CTA) represents the next generation of
ground-based instruments for very-high-energy (VHE) gamma-ray astronomy, aimed
at improving on the sensitivity of current-generation experiments by an order
of magnitude and providing coverage over four decades of energy. The current
CTA design consists of two arrays of tens of imaging atmospheric Cherenkov
telescopes, comprising Small, Medium and Large-Sized Telescopes, with one array
located in each of the Northern and Southern Hemispheres. To study the effect
of the site choice on the overall \gls{cta} performance and support the site
evaluation process, detailed Monte Carlo simulations have been performed. These
results show the impact of different site-related attributes such as altitude,
night-sky background and local geomagnetic field on CTA performance for the
observation of VHE gamma rays.Comment: 34 pages, 11 figures, Accepted for publication in AP
A Protein-Interaction Array Inside a Living Cell
Protein-interaction arrays were generated in living cells by the interaction of bait-presenting artificial receptor constructs (bait-PARCs) with micrometer-scaled antibody surface patterns (see figure). This method was applied to simultaneously monitor the interaction kinetics of a prey protein with two distinct bait proteins in individual living cells
Cherenkov Telescope Array Data Management
Very High Energy gamma-ray astronomy with the Cherenkov Telescope Array (CTA)
is evolving towards the model of a public observatory. Handling, processing and
archiving the large amount of data generated by the CTA instruments and
delivering scientific products are some of the challenges in designing the CTA
Data Management. The participation of scientists from within CTA Consortium and
from the greater worldwide scientific community necessitates a sophisticated
scientific analysis system capable of providing unified and efficient user
access to data, software and computing resources. Data Management is designed
to respond to three main issues: (i) the treatment and flow of data from remote
telescopes; (ii) "big-data" archiving and processing; (iii) and open data
access. In this communication the overall technical design of the CTA Data
Management, current major developments and prototypes are presented.Comment: 8 pages, 2 figures, In Proceedings of the 34th International Cosmic
Ray Conference (ICRC2015), The Hague, The Netherlands. All CTA contributions
at arXiv:1508.0589
Search for spontaneous muon emission from lead nuclei
We describe a possible search for muonic radioactivity from lead nuclei using
the base elements ("bricks" composed by lead and nuclear emulsion sheets) of
the long-baseline OPERA neutrino experiment. We present the results of a Monte
Carlo simulation concerning the expected event topologies and estimates of the
background events. Using few bricks, we could reach a good sensitivity level.Comment: 12 pages, 4 figure
Electron/pion separation with an Emulsion Cloud Chamber by using a Neural Network
We have studied the performance of a new algorithm for electron/pion
separation in an Emulsion Cloud Chamber (ECC) made of lead and nuclear emulsion
films. The software for separation consists of two parts: a shower
reconstruction algorithm and a Neural Network that assigns to each
reconstructed shower the probability to be an electron or a pion. The
performance has been studied for the ECC of the OPERA experiment [1].
The separation algorithm has been optimized by using a detailed Monte
Carlo simulation of the ECC and tested on real data taken at CERN (pion beams)
and at DESY (electron beams). The algorithm allows to achieve a 90% electron
identification efficiency with a pion misidentification smaller than 1% for
energies higher than 2 GeV
Expected performance of the ASTRI-SST-2M telescope prototype
ASTRI (Astrofisica con Specchi a Tecnologia Replicante Italiana) is an
Italian flagship project pursued by INAF (Istituto Nazionale di Astrofisica)
strictly linked to the development of the Cherenkov Telescope Array, CTA.
Primary goal of the ASTRI program is the design and production of an end-to-end
prototype of a Small Size Telescope for the CTA sub-array devoted to the
highest gamma-ray energy region. The prototype, named ASTRI SST-2M, will be
tested on field in Italy during 2014. This telescope will be the first
Cherenkov telescope adopting the double reflection layout in a
Schwarzschild-Couder configuration with a tessellated primary mirror and a
monolithic secondary mirror. The collected light will be focused on a compact
and light-weight camera based on silicon photo-multipliers covering a 9.6 deg
full field of view. Detailed Monte Carlo simulations have been performed to
estimate the performance of the planned telescope. The results regarding its
energy threshold, sensitivity and angular resolution are shown and discussed.Comment: In Proceedings of the 33rd International Cosmic Ray Conference
(ICRC2013), Rio de Janeiro (Brazil). All CTA contributions at arXiv:1307.223
Emulsion sheet doublets as interface trackers for the OPERA experiment
New methods for efficient and unambiguous interconnection between electronic
counters and target units based on nuclear photographic emulsion films have
been developed. The application to the OPERA experiment, that aims at detecting
oscillations between mu neutrino and tau neutrino in the CNGS neutrino beam, is
reported in this paper. In order to reduce background due to latent tracks
collected before installation in the detector, on-site large-scale treatments
of the emulsions ("refreshing") have been applied. Changeable Sheet (CSd)
packages, each made of a doublet of emulsion films, have been designed,
assembled and coupled to the OPERA target units ("ECC bricks"). A device has
been built to print X-ray spots for accurate interconnection both within the
CSd and between the CSd and the related ECC brick. Sample emulsion films have
been extensively scanned with state-of-the-art automated optical microscopes.
Efficient track-matching and powerful background rejection have been achieved
in tests with electronically tagged penetrating muons. Further improvement of
in-doublet film alignment was obtained by matching the pattern of low-energy
electron tracks. The commissioning of the overall OPERA alignment procedure is
in progress.Comment: 19 pages, 19 figure
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