283 research outputs found
Circuitos biosaludables y cumplimiento de las recomendaciones sobre actividad fĂsica para mayores
PrĂ©server la singularitĂ© de la relation face aux recommandations. Le cas de lâannonce du diagnostic de la mucoviscidose
Relationship between age, category and experience with the soccer referee's self-efficacy
This study has been funded by the project PPJIA2020.04, of the Precompetitive Research Projects program for Young Researchers of the Own Plan 2020, of the University of Granada. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Soccer referees (SRs) encounter stressful situations during competitions and sometimes
even outside them, which may affect their decision making. Therefore, it is important
that they possess or acquire optimal levels of self-efficacy, since it is related to less
stress during competition, also guaranteeing sports performance and prevent sports
abandonment. The objectives of this study were to characterize the profile, in terms of
self-efficacy, of SRs depending on their category, age, and experience and to determine
the relationship of these factors on SR self-efficacy. Two-hundred fifty-six Spanish
referees participated in this study and Referee Self-Efficacy Scale was administered and
completed. The results indicated that the SRs older than 25 years, of national category,
and with experience greater than or equal to 8 years, have higher levels of self-efficacy
than those with the least (p<:01). Likewise, moderate positive correlations were also
observed between global self-efficacy and the category, age, and experience of the SRs.
In conclusion, age, category and experience factors relate the self-efficacy of the SR,
which can explain up to 17% of the variance, affecting decision-making and other
decisive behaviors in the competition. These findings are of interest to delegations
and referee committees seeking to implement psychological intervention programs to
prevent burnout and abandonment of sports practice due to the consequences of low
self-efficacy.University of Granada PPJIA2020.0
Neonatal Screening of Cystic Fibrosis in France: a socio-material configuration of biomedical diagnostics and therapeutics
Advanced Technology Composite Fuselage-Structural Performance
Boeing is studying the technologies associated with the application of composite materials to commercial transport fuselage structure under the NASA-sponsored contracts for Advanced Technology Composite Aircraft Structures (ATCAS) and Materials Development Omnibus Contract (MDOC). This report addresses the program activities related to structural performance of the selected concepts, including both the design development and subsequent detailed evaluation. Design criteria were developed to ensure compliance with regulatory requirements and typical company objectives. Accurate analysis methods were selected and/or developed where practical, and conservative approaches were used where significant approximations were necessary. Design sizing activities supported subsequent development by providing representative design configurations for structural evaluation and by identifying the critical performance issues. Significant program efforts were directed towards assessing structural performance predictive capability. The structural database collected to perform this assessment was intimately linked to the manufacturing scale-up activities to ensure inclusion of manufacturing-induced performance traits. Mechanical tests were conducted to support the development and critical evaluation of analysis methods addressing internal loads, stability, ultimate strength, attachment and splice strength, and damage tolerance. Unresolved aspects of these performance issues were identified as part of the assessments, providing direction for future development
NLRC5 promotes transcription of BTN3A1-3 genes and VÎł9VÎŽ2 T cell-mediated killing
BTN3A molecules-BTN3A1 in particular-emerged as important mediators of VÎł9VÎŽ2 T cell activation by phosphoantigens. These metabolites can originate from infections, e.g. with Mycobacterium tuberculosis, or by alterations in cellular metabolism. Despite the growing interest in the BTN3A genes and their high expression in immune cells and various cancers, little is known about their transcriptional regulation. Here we show that these genes are induced by NLRC5, a regulator of MHC class I gene transcription, through an atypical regulatory motif found in their promoters. Accordingly, a robust correlation between NLRC5 and BTN3A gene expression was found in healthy, in M. tuberculosis-infected donors' blood cells, and in primary tumors. Moreover, forcing NLRC5 expression promoted VÎł9VÎŽ2 T-cell-mediated killing of tumor cells in a BTN3A-dependent manner. Altogether, these findings indicate that NLRC5 regulates the expression of BTN3A genes and hence open opportunities to modulate antimicrobial and anticancer immunity
Anesthesia triggers drug delivery to experimental glioma in mice by hijacking caveolar transport
Abstract Background: Pharmaceutical intervention in the CNS is hampered by the shielding function of the blood-brain barrier (BBB). To induce clinical anesthesia, general anesthetics such as isoflurane readily penetrate the BBB. Here, we investigated whether isoflurane can be utilized for therapeutic drug delivery. Methods: Barrier function in primary endothelial cells was evaluated by transepithelial/transendothelial electrical resistance, and nanoscale STED and SRRF microscopy. In mice, BBB permeability was quantified by extravasation of several fluorescent tracers. Mouse models including the GL261 glioma model were evaluated by MRI, immunohistochemistry, electron microscopy, western blot, and expression analysis. Results: Isoflurane enhances BBB permeability in a time- and concentration-dependent manner. We demonstrate that, mechanistically, isoflurane disturbs the organization of membrane lipid nanodomains and triggers caveolar transport in brain endothelial cells. BBB tightness re-establishes directly after termination of anesthesia, providing a defined window for drug delivery. In a therapeutic glioblastoma trial in mice, simultaneous exposure to isoflurane and cytotoxic agent improves efficacy of chemotherapy. Conclusions: Combination therapy, involving isoflurane-mediated BBB permeation with drug administration has far-reaching therapeutic implications for CNS malignancies
Search for CP Violation in the Decay Z -> b (b bar) g
About three million hadronic decays of the Z collected by ALEPH in the years
1991-1994 are used to search for anomalous CP violation beyond the Standard
Model in the decay Z -> b \bar{b} g. The study is performed by analyzing
angular correlations between the two quarks and the gluon in three-jet events
and by measuring the differential two-jet rate. No signal of CP violation is
found. For the combinations of anomalous CP violating couplings, and , limits of \hat{h}_b < 0.59h^{\ast}_{b} < 3.02$ are given at 95\% CL.Comment: 8 pages, 1 postscript figure, uses here.sty, epsfig.st
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