Study and applications of retrodirective and self-adaptive electromagnetic wave controls to a Mars probe Quarterly report, 1 Oct. - 31 Dec. 1965

Design feasibility and applications of adaptive antenna circuits for deep space communication - antenna concepts, environmental effects, and phase lock loops and adaptive circuitr

Study and applications of retrodirective and self adaptive electromagnetic-wave phase controls to a Mars probe

Computer analyses of retrodirective, and self adaptive antenna phase control techniques for Mars prob

Molecular diagnosis of multiple endocrine neoplasia type 2A

Objective. To identify by means of genetic analyses individuals who are at risk of developing medullary thyroid cancer that is a component of multiple endocrine neoplasia.Subjects. A three-generation kindred with clinically and biochemically diagnosed medUllary thyroid cancer.Method. Identification of a heterozygote mutation by nucleic acid sequencing and restriction analyses.Results. A heterozygote T → C (Cys → Arg) mutation at codon 618 in exon 10 of the RET proto-oncogene was identified in 4 family members who had previously been diagnosed with medullary thyroid cancer. The same mutation was also found in one of the proband's presymptomatic children who subsequently underwent a preemptive thyroidectomy. The genetic diagnosis was confirmed by histology. No mutations were detected in any other family members.Conclusion. Identification of heterozygote germline mutations in multiple endocrine neoplasia is direct, highly accurate and cost-effective. This study demonstrates that, appropriately used, molecular diagnosis can supersede conventional biochemical methods in the management of patients with inherited cancers

Cosmic Evolution of a Sample of Infrared Luminous Galaxies

A sample of faint, southern-hemisphere 60 μm sources (f_(60) > 100mJy) detected as part of the IRAS Additional Observations has been used, in conjunction with CCD imaging, to produce a list of faint infrared galaxies. Redshifts of this sample of galaxies can be compared with model predictions for several evolutionary scenarios; the comparisons show an excess of galaxies at higher redshifts (z > 0.1) compared with the predictions of models which assume no evolution of the infrared-galaxy luminosity function

The Extragalactic IR Background

Current limits on the intensity of the extragalactic infrared background are consistent with the expected contribution from evolving galaxies. Depending on the behaviour of the star formation rate and of the initial mass function, we can expect that dust extinction during early evolutionary phases ranges from moderate to strong. An example of the latter case may be the ultraluminous galaxy IRAS F$10214 + 4724$. The remarkable lack of high redshift galaxies in faint optically selected samples may be indirect evidence that strong extinction is common during early phases. Testable implications of different scenarios are discussed; ISO can play a key role in this context. Estimates of possible contributions of galaxies to the background under different assumptions are presented. The COBE/FIRAS limits on deviations from a blackbody spectrum at sub-mm wavelengths already set important constraints on the evolution of the far-IR emission of galaxies and on the density of obscured (``Type 2'') AGNs. A major progress in the field is expected at the completion of the analysis of COBE/DIRBE data.Comment: 1994, invited review to be published in the Proc. of the Internatinal Conf. "Dust, Molecules and Backgrounds: from Laboratory to Space", Capri (NA), Italy, 12--15 September, 1994, in press. Tex file, 16 pages, 6 figures not included. ASTRPD-94-10-0