From ANT to Material agency: a design and science research workshop

International audienceThis paper studies a design workshop that investigates complex collaboration between fundamental physics and design. Our research focuses on how students create original artefacts that bridge the gap between disciplines that have very little in common. Our goal is to study the micro-evolutions of their projects. Elaborating first on Actor Network Theory (Latour, 1996; 2005) we study how students' projects evolved over time and through a diversity of inputs and media. Throughout this longitudinal study, we use then a semiotic and pragmatic approach to observe three "aesthetical formations": translation, composition, and stabilization. These formations suggest that the question of material agency developed in the field of archeology and cognitive science (Knappett & Malafouris, 2008) need to be considered in the design field (Renon, 2016) to explain metamorphoses from the brief to the final realizations

The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD.

Excessive checking is a common, debilitating symptom of obsessive-compulsive disorder (OCD). In an established rodent model of OCD checking behaviour, quinpirole (dopamine D2/3-receptor agonist) increased checking in open-field tests, indicating dopaminergic modulation of checking-like behaviours. We designed a novel operant paradigm for rats (observing response task (ORT)) to further examine cognitive processes underpinning checking behaviour and clarify how and why checking develops. We investigated i) how quinpirole increases checking, ii) dependence of these effects on D2/3 receptor function (following treatment with D2/3 receptor antagonist sulpiride) and iii) effects of reward uncertainty. In the ORT, rats pressed an 'observing' lever for information about the location of an 'active' lever that provided food reinforcement. High- and low-checkers (defined from baseline observing) received quinpirole (0.5mg/kg, 10 treatments) or vehicle. Parametric task manipulations assessed observing/checking under increasing task demands relating to reinforcement uncertainty (variable response requirement and active-lever location switching). Treatment with sulpiride further probed the pharmacological basis of long-term behavioural changes. Quinpirole selectively increased checking, both functional observing lever presses (OLPs) and non-functional extra OLPs (EOLPs). The increase in OLPs and EOLPs was long-lasting, without further quinpirole administration. Quinpirole did not affect the immediate ability to use information from checking. Vehicle and quinpirole-treated rats (VEH and QNP respectively) were selectively sensitive to different forms of uncertainty. Sulpiride reduced non-functional EOLPs in QNP rats but had no effect on functional OLPs. These data have implications for treatment of compulsive checking in OCD, particularly for serotonin-reuptake-inhibitor treatment-refractory cases, where supplementation with dopamine receptor antagonists may be beneficial

What do I do now? Intolerance of uncertainty is associated with discrete patterns of anticipatory physiological responding to different contexts

Heightened physiological responses to uncertainty are a common hallmark of anxiety disorders. Many separate studies have examined the relationship between individual differences in intolerance of uncertainty (IU) and physiological responses to uncertainty during different contexts. Despite this there is a scarcity of research examining the extent to which individual differences in IU are related to shared or discrete patterns of anticipatory physiological responding across different contexts. Anticipatory physiological responses to uncertainty were assessed in three different contexts (associative threat learning and extinction, threat uncertainty, decision-making) within the same sample (n = 45). During these tasks, behavioural responses (i.e. reaction times, choices), skin conductance and corrugator supercilli activity were recorded. In addition, self-reported IU and trait anxiety were measured. IU was related to both skin conductance and corrugator supercilii activity for the associative threat learning and extinction context, and decision-making context. However, trait anxiety was related to corrugator supercilii activity during the threat uncertainty context. Ultimately, this research helps us further tease apart the role of IU on different aspects of anticipation (i.e. valence and arousal) across contexts, which will be relevant for future IU-related models of psychopathology

Species and abundance of ectoparasitic flies (Diptera) in pied flycatcher nests in Fennoscandia

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Proposition de concentrations de références en mercure dans l'ichtyofaune de Guyane

La pollution des écosystèmes aquatiques par le mercure est un problème majeur de la Guyane française, soumis à l'orpaillage illégal intensif depuis de nombreuses années. Au niveau européen, une norme de qualité environnementale pour le biote (NQEbiote : 0,02 mg Hg.kg-1 poids frais) a été définie dans le cadre de la directive cadre sur l'eau (DCE). Ce rapport a pour but d'aider à la mise en place de la NQEbiote en Guyane française par : 1/ si possible, l'identification de sites non pollués par le mercure d'origine anthropique ; 2/ la détermination de concentrations de références en mercure pour l'ichtyofaune associées à ces sites ; 3/ l'identification d'espèces de poissons sentinelles potentielles de cette pollution. Une base de données d'environ 9000 poissons (3000 pour les criques et 6000 pour les fleuves) a été constituée à partir des résultats des programmes de recherche et de surveillance depuis 1993. Les concentrations en mercure mesurées dans le muscle de ces poissons se révèlent presque toujours supérieures à la NQEbiote (100% pour les criques et 89 % pour les fleuves). Peu de zones de références potentielles ont été identifiées sur plus de 200 stations échantillonnées. Ainsi pour les criques, 7 stations réparties sur 6 bassins versants différents présentent des concentrations significativement plus faibles que les autres stations. Sur les fleuves, seulement 2 zones (groupe de stations) ont été identifiées comme références potentielles sur le bassin versant de l'Oyapock. L'analyse de ces données a permis de proposer plusieurs espèces sentinelles, c'est à dire intégratives d'une contamination mercurielle. Pour les criques, il s'agit de Copella carsevennensis, Pyrrhulina filamentosa, Jupiaba (abramoides et keithi), Moenkhausia oligolepis, Pimelodella (cristata, geryi et macturki), Gymnotus carapo et Sternopygus macrurus. Pour les fleuves, 3 genres et espèces ont été retenus : Ageneiosus inermis, Acestrorhynchus (falcatus et microlepis) et Hoplias aïmara. Des recommandations opérationnelles sont proposées pour le suivi de la DCE telles que : i/ échantillonner moins de stations (en privilégiant celles suivies par l'OMS), ii/ espacer la fréquence des suivis (tous les 2 ans), iii/ mais, en contrepartie, augmenter l'effort de pêche sur les espèces sentinelles proposées