Complex networks in brain electrical activity

We analyze the complex networks associated with brain electrical activity. Multichannel EEG measurements are first processed to obtain 3D voxel activations using the tomographic algorithm LORETA. Then, the correlation of the current intensity activation between voxel pairs is computed to produce a voxel cross-correlation coefficient matrix. Using several correlation thresholds, the cross-correlation matrix is then transformed into a network connectivity matrix and analyzed. To study a specific example, we selected data from an earlier experiment focusing on the MMN brain wave. The resulting analysis highlights significant differences between the spatial activations associated with Standard and Deviant tones, with interesting physiological implications. When compared to random data networks, physiological networks are more connected, with longer links and shorter path lengths. Furthermore, as compared to the Deviant case, Standard data networks are more connected, with longer links and shorter path lengths--i.e., with a stronger ``small worlds'' character. The comparison between both networks shows that areas known to be activated in the MMN wave are connected. In particular, the analysis supports the idea that supra-temporal and inferior frontal data work together in the processing of the differences between sounds by highlighting an increased connectivity in the response to a novel sound.Comment: 22 pages, 5 figures. Starlab preprint. This version is an attempt to include better figures (no content change

Weakly encoded memories due to acute sleep restriction can be rescued after one night of recovery sleep

Sleep is thought to play a complementary role in human memory processing: sleep loss impairs the formation of new memories during the following awake period and, conversely, normal sleep promotes the strengthening of the already encoded memories. However, whether sleep can strengthen deteriorated memories caused by insufficient sleep remains unknown. Here, we showed that sleep restriction in a group of participants caused a reduction in the stability of EEG activity patterns across multiple encoding of the same event during awake, compared with a group of participants that got a full night's sleep. The decrease of neural stability patterns in the sleep-restricted group was associated with higher slow oscillation-spindle coupling during a subsequent night of normal sleep duration, thereby suggesting the instantiation of restorative neural mechanisms adaptively supporting cognition and memory. Importantly, upon awaking, the two groups of participants showed equivalent retrieval accuracy supported by subtle differences in the reinstatement of encoding-related activity: it was longer lasting in sleep-restricted individuals than in controls. In addition, sustained reinstatement over time was associated with increased coupling between spindles and slow oscillations. Taken together, these results suggest that the strength of prior encoding might be an important moderator of memory consolidation during sleep. Supporting this view, spindles nesting in the slow oscillation increased the probability of correct recognition only for weakly encoded memories. Current results demonstrate the benefit that a full night's sleep can induce to impaired memory traces caused by an inadequate amount of sleep

Amygdala Lesions Reduce Anxiety-like Behavior in a Human Benzodiazepine-Sensitive Approach-Avoidance Conflict Test

BACKGROUND: Rodent approach-avoidance conflict tests are common preclinical models of human anxiety disorder. Their translational validity mainly rests on the observation that anxiolytic drugs reduce rodent anxiety-like behavior. Here, we capitalized on a recently developed approach-avoidance conflict computer game to investigate the impact of benzodiazepines and of amygdala lesions on putative human anxiety-like behavior. In successive epochs of this game, participants collect monetary tokens on a spatial grid while under threat of virtual predation. METHODS: In a preregistered, randomized, double-blind, placebo-controlled trial, we tested the effect of a single dose (1 mg) of lorazepam (n = 59). We then compared 2 patients with bilateral amygdala lesions due to Urbach-Wiethe syndrome with age- and gender-matched control participants (n = 17). Based on a previous report, the primary outcome measure was the effect of intra-epoch time (i.e., an adaptation to increasing potential loss) on presence in the safe quadrant of the spatial grid. We hypothesized reduced loss adaptation in this measure under lorazepam and in patients with amygdala lesions. RESULTS: Lorazepam and amygdala lesions reduced loss adaptation in the primary outcome measure. We found similar results in several secondary outcome measures. The relative reduction of anxiety-like behavior in patients with amygdala lesions was qualitatively and quantitatively indistinguishable from an impact of anterior hippocampus lesions found in a previous report. CONCLUSIONS: Our results establish the translational validity of human approach-avoidance conflict tests in terms of anxiolytic drug action. We identified the amygdala, in addition to the hippocampus, as a critical structure in human anxiety-like behavior

ENOBIO - First tests of a dry electrophysiology electrode using carbon nanotubes

We describe the development and first tests of Enobio, a dry electrode sensor concept for biopotential applications. In the proposed electrodes, the tip of the electrode is covered with a forest of multi-walled CNTs that can be coated with Ag/AgCl to provide ionic-electronic transduction. The CNT brush-like structure is to penetrate the outer layers of the skin improving electrical contact as well as increae the contact surface area. In this paper, we report the results of the first tests of this concept -- immersion on saline solution and pig skin signal detection. These indicate performance on a par with state of the art research-oriented wet electrodes.Comment: Submitted and accepted at the 28th IEEE EMBS International Conference, New York City, August 31st-September 3rd, 2006. Figures updated with proper filtering and averagin

Individual differences in true and false memory retrieval are related to white matter brain microstructure

We sometimes vividly remember things that did not happen, a phenomenon with general relevance not only in the court-room. It is unclear, to what extent individual differences in false memories are driven by anatomical differences in memory relevant brain regions. Here we show in humans that microstructural properties of different white matter tracts as quantified using Diffusion Tensor Imaging (DTI) are strongly correlated with true and false memory recollection. To investigate these hypotheses we tested a large group of participants in a version of the Deese-Roediger-McDermott (DRM) paradigm (recall and recognition) and subsequently obtained DTI images. A voxel-based whole-brain level linear regression analysis was performed to relate fractional anisotropy to indices of true and false memory recall and recognition. True memory was correlated to diffusion anisotropy in the inferior longitudinal fascicle, the major connective pathway of the medial temporal lobe, whereas a greater proneness to retrieve false items was related to the superior longitudinal fascicle connecting fronto-parietal structures. Our results show that individual differences in white-matter micro-structure underlie true and false memory performance

First human trials of a dry electrophysiology sensor using a carbon nanotube array interface

Fatigue, sleepiness and disturbed sleep are important factors in health and safety in modern society and there is considerable interest in developing technologies for routine monitoring of associated physiological indicators. Electrophysiology, the measurement of the electrical activity of biological origin, is a key technique for the measurement of physiological parameters in several applications, but it has been traditionally difficult to develop sensors for measurements outside the laboratory or clinic with the required quality and robustness. In this paper we report the results from first human experiments using a new electrophysiology sensor called ENOBIO, using carbon nanotube arrays for penetration of the outer layers of the skin and improved electrical contact. These tests, which have included traditional protocols for the analysis of the electrical activity of the brain--spontaneous EEG and ERP--indicate performance on a par with state of the art research-oriented wet electrodes, suggesting that the envisioned mechanism--skin penetration--is responsible. No ill side-effects have been observed six months after the tests, and the subject did not report any pain or special sensations on application of the electrode

Detección de patrones aberrantes en pruebas tipo test: Una aplicación en el Grado en Psicología de la Universidad de Barcelona

Las pruebas con ítems de respuesta múltiple son una práctica habitual en el contexto universitario. Los patrones de respuesta incoherentes, denominados Patrones Atípicos de Respuesta (PAR), aparecen cuando las respuestas correctas e incorrectas a los ítems no siguen el patrón esperado, i.e., acertar los ítems más fáciles y fallar los más difíciles. Este estudio pretende identificar los PAR en una prueba tipo test de la asignatura Psicometría del Grado en Psicología de la Universidad de Barcelona y explorar su relación con el rendimiento académico. Un total de 214 alumnos matriculados durante el curso 2018-2019 respondieron a una prueba tipo test de 20 ítems. Se calcularon cuatro índices de detección y se identificaron 13 PAR (6,1%), con más presencia en estudiantes con una calificación superior. La detección de PAR debería contribuir a la mejora de los sistemas de evaluación y del proceso de aprendizaje de los alumnos

The Contribution of Sound Intensity in Vocal Emotion Perception: Behavioral and Electrophysiological Evidence

Although its role is frequently stressed in acoustic profile for vocal emotion, sound intensity is frequently regarded as a control parameter in neurocognitive studies of vocal emotion, leaving its role and neural underpinnings unclear. To investigate these issues, we asked participants to rate the angry level of neutral and angry prosodies before and after sound intensity modification in Experiment 1, and recorded electroencephalogram (EEG) for mismatching emotional prosodies with and without sound intensity modification and for matching emotional prosodies while participants performed emotional feature or sound intensity congruity judgment in Experiment 2. It was found that sound intensity modification had significant effect on the rating of angry level for angry prosodies, but not for neutral ones. Moreover, mismatching emotional prosodies, relative to matching ones, induced enhanced N2/P3 complex and theta band synchronization irrespective of sound intensity modification and task demands. However, mismatching emotional prosodies with reduced sound intensity showed prolonged peak latency and decreased amplitude in N2/P3 complex and smaller theta band synchronization. These findings suggest that though it cannot categorically affect emotionality conveyed in emotional prosodies, sound intensity contributes to emotional significance quantitatively, implying that sound intensity should not simply be taken as a control parameter and its unique role needs to be specified in vocal emotion studies

Pure phase-locking of beta/gamma oscillation contributes to the N30 frontal component of somatosensory evoked potentials

BACKGROUND: Evoked potentials have been proposed to result from phase-locking of electroencephalographic (EEG) activities within specific frequency bands. However, the respective contribution of phasic activity and phase resetting of ongoing EEG oscillation remains largely debated. We here applied the EEGlab procedure in order to quantify the contribution of electroencephalographic oscillation in the generation of the frontal N30 component of the somatosensory evoked potentials (SEP) triggered by median nerve electrical stimulation at the wrist. Power spectrum and intertrial coherence analysis were performed on EEG recordings in relation to median nerve stimulation. RESULTS: The frontal N30 component was accompanied by a significant phase-locking of beta/gamma oscillation (25-35 Hz) and to a lesser extent of 80 Hz oscillation. After the selection in each subject of the trials for which the power spectrum amplitude remained unchanged, we found pure phase-locking of beta/gamma oscillation (25-35 Hz) peaking about 30 ms after the stimulation. Transition across trials from uniform to normal phase distribution revealed temporal phase reorganization of ongoing 30 Hz EEG oscillations in relation to stimulation. In a proportion of trials, this phase-locking was accompanied by a spectral power increase peaking in the 30 Hz frequency band. This corresponds to the complex situation of 'phase-locking with enhancement' in which the distinction between the contribution of phasic neural event versus EEG phase resetting is hazardous. CONCLUSION: The identification of a pure phase-locking in a large proportion of the SEP trials reinforces the contribution of the oscillatory model for the physiological correlates of the frontal N30. This may imply that ongoing EEG rhythms, such as beta/gamma oscillation, are involved in somatosensory information processing.Comparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tinfo:eu-repo/semantics/publishe

Spectral-temporal EEG dynamics of speech discrimination processing in infants during sleep

BACKGROUND: Oddball paradigms are frequently used to study auditory discrimination by comparing event-related potential (ERP) responses from a standard, high probability sound and to a deviant, low probability sound. Previous research has established that such paradigms, such as the mismatch response or mismatch negativity, are useful for examining auditory processes in young children and infants across various sleep and attention states. The extent to which oddball ERP responses may reflect subtle discrimination effects, such as speech discrimination, is largely unknown, especially in infants that have not yet acquired speech and language. RESULTS: Mismatch responses for three contrasts (non-speech, vowel, and consonant) were computed as a spectral-temporal probability function in 24 infants, and analyzed at the group level by a modified multidimensional scaling. Immediately following an onset gamma response (30-50 Hz), the emergence of a beta oscillation (12-30 Hz) was temporally coupled with a lower frequency theta oscillation (2-8 Hz). The spectral-temporal probability of this coupling effect relative to a subsequent theta modulation corresponds with discrimination difficulty for non-speech, vowel, and consonant contrast features. DISCUSSION: The theta modulation effect suggests that unexpected sounds are encoded as a probabilistic measure of surprise. These results support the notion that auditory discrimination is driven by the development of brain networks for predictive processing, and can be measured in infants during sleep. The results presented here have implications for the interpretation of discrimination as a probabilistic process, and may provide a basis for the development of single-subject and single-trial classification in a clinically useful context. CONCLUSION: An infant's brain is processing information about the environment and performing computations, even during sleep. These computations reflect subtle differences in acoustic feature processing that are necessary for language-learning. Results from this study suggest that brain responses to deviant sounds in an oddball paradigm follow a cascade of oscillatory modulations. This cascade begins with a gamma response that later emerges as a beta synchronization, which is temporally coupled with a theta modulation, and followed by a second, subsequent theta modulation. The difference in frequency and timing of the theta modulations appears to reflect a measure of surprise. These insights into the neurophysiological mechanisms of auditory discrimination provide a basis for exploring the clinically utility of the MM