Methidathion-induced hematological, biochemical and hepatohistological alterations in rat: Ameliorative effects of selenium and zinc

The aim of this study was to determine the effect of a sub-acute 4-week exposure to methidathion (MD) on the hematological system and hepatic integrity of rats. We also assessed whether co-administration of micronutrients such as selenium (Se) and zinc (Zn) prevented MD-induced hepatic damage. Rats were randomly divided into four groups of six each: the first group served as a control which received standard diet, the second group received both Se (0.5mg/kg of diet) and Zn (0.227 g/l drinking water), the third group received only MD (5 mg/kg b.w. by gavage using corn oil as a vehicle), and the fourth group received MD and combined selenium and zinc. After four weeks, exposure to MD induced a significant increase in plasmatic activities of AST, ALT, ALP, LDH, and liver malondialdehyde level. In contrast, reduced glutathione level (GSH), and the activities of catalase (CAT), superoxide dismutase (SOD), and the glutathione peroxidase (GPx) content of hepatic tissue decreased significantly. Moreover, treatment with Se and Zn in MD-treated rats maintained all the biochemical parameters cited above. In conclusion, the obtained results indicate the ability of Se and Zn to attenuate the MD-induced liver and erythrocytes oxidative damage.Key words: Biochemical studies, liver, methidathion, oxidative stress, rat, selenium, zinc

Carcinome basocellulaire métatypique : a propos de deux cas

Introduction : : Le carcinome métatypique est une entité rare. Il touche essentiellement la région cervico-faciale chez un sujet de sexe masculin. Les auteurs étudieront, à travers deux observations, les caractéristiques cliniques et évolutives du cancer métatypique ainsi que les difficultés thérapeutiques. Observation 1 : Un homme âgé de 41 ans, a présenté un carcinome métatypique temporo-pariétal droit traité initialement par chirurgie. Cinq ans plus tard, il a été réopéré pour une récidive locale et ganglionnaire et a bénéficié ensuite d’une cobaltothérapie, stabilisant ainsi la maladie pendant 4 ans au bout desquels on a noté la survenue d’une deuxième récidive locale avec des métastases pulmonaires. Le malade est décédé, à 10 ans de recul, dans un tableau de pneumopathie diffuse avec septicémie sévère. Observation 2 : Un homme de 71 ans, a présenté un carcinome métatypique de la région rétro- auriculaire. Il a eu une exérèse tumorale avec des limites chirurgicales envahies. Il a présenté plusieurs récidives locales traitées par des exérèses larges jusqu’à une pétrectomie totale. Les limites chirurgicales étaient toujours tumorales. Une radiothérapie postopératoire a été réalisée pour chaque récidive. A 7 ans de recul, il a présenté une récidive locale envahissant l’angleponto-cérébelleux et le cerveau, jugée en dehors de toutes ressources thérapeutiques. Discussion : Le carcinome métatypique est caractérisé par son agressivité et sa tendance à la récidive. Son traitementest essentiellement chirurgical. Une large marge de sécurité lors de l’exérèse est indispensable. La radiothérapie est un traitement adjuvant, devenu incontournable vu le haut risque de récidive. Le rôle de la chimiothérapie n’est pas encore prouvé.

Verrucous Carcinoma of the Vulva: A Case Report and Review of the Literature.

Verrucous carcinoma of the vulva is a rare lesion (1). Affecting essentially postmenopausal women, this lesion is a distinct and particular entity in vulval carcinoma classification and its scalability is uncertain and unpredictable. Here, we present a case concerning a 48-year-old patient, without follow-up after a condyloma acuminate of the vulva (large left lip). The origin of this case will be discussed in this article. The treatment decided was only surgical. A review of literature shows the rarity of this lesion of the female genital tract

PERUBAHAN FUNGSI PEMANFAATAN RUANG DI KELURAHAN MOGOLAING KOTA KOTAMOBAGU

Kota dalam perjalanannya selalu tumbuh dan berkembang. Seiring dengan perkembangan kota, berbagai macam aktifitas perkotaan mulai tumbuh dan salah satu yang memicu perkembangan tersebut adalah Penduduk. Peningkatan jumlah penduduk mengakibatkan semakin tingginya permintaan lahan untuk fungsi permukiman. Seperti yang terjadi di Kota Kotamobagu, dimana salah satu wilayah yang mengalami perubahan dalam pemanfaatan ruang adalah Kelurahan Mogolaing. Pembangunan yang terjadi rata-rata berfokus mengikuti jalur jalan dengan kepadatan yang tinggi terutama pada Jln. Adampe Dolot dan Jln Kampus yang masing masing mengalami perubahan dengan fungsi pemanfaatan ruang yang berbeda. Tujuan penelitian ini pada dasarnya adalah untuk mengidentifikasi perubahan-perubahan tersebut serta mengkaji faktor-faktor apa saja yang menyebabkan terjadinya perubahan dengan mengambil 10 tahun perbandingan. Penelitian menggunakan pendekatan deskriptif dimana pengumpulan data menggunakan kuesioner dan analisis dengan SIG. Hasil analisis menunjukan peningkatan persen lahan terbangun yang dimanfaatkan untuk fungsi komersial serta adanya perubahan fungsi bangunan seperti perubahan hunian menjadi hunian sekaligus komersial dimana perubahan tersebut mengikuti koridor atau merembet secara linear dan terfokus pada bagian wilayah penelitian yang berdekatan dengan pusat kota. Selanjutnya ditemukan faktor yang menyebabkan perubahan fungsi pemanfaatan ruang adalah Topografi, Penduduk, Nilai Lahan, Aksesibilitas, dan Daya Dukung Lahan. Kata Kunci : Perubahan Fungsi, Pemanfaatan Ruang, Koridor, Mogolaing Kotamobag

Recommendations for the surgical treatment of endometriosis—part 1: ovarian endometrioma

Study question: What does this document on the surgical treatment of endometriosis jointly prepared by the European Society for Gynaecological Endoscopy (ESGE), ESHRE, and the World Endometriosis Society (WES) provide? / Summary answer: This document provides recommendations covering technical aspects of different methods of surgery for endometriomas in women of reproductive age. / What is already known: Endometriomas (ovarian endometriotic cysts) are a commonly diagnosed form of endometriosis, owing to the relative ease and accuracy of ultrasound diagnosis. They frequently present a clinical dilemma as to whether and how to treat them when found during imaging or incidentally during surgery. Previously published guidelines have provided recommendations based on the best available evidence, but without technical details on the management of endometriosis. / Study design, size and duration: A working group of ESGE, ESHRE and WES collaborated on writing recommendations on the practical aspects of endometrioma surgery. / Participants/materials, setting and methods: This document focused on endometrioma surgery. Further documents in this series will provide recommendations for surgery of deep and peritoneal endometriosis. / Main results and the role of chance: The document presents general recommendations for surgery of endometrioma and specific recommendations for cystectomy, ablation by laser or by plasma energy, electrocoagulation and a combination of these techniques applied together or with an interval between them. / Limitations and reasons for caution: Owing to the limited evidence available, recommendations are mostly based on clinical expertise. / Wider implications of the findings: These recommendations complement previous guidelines on the management of endometriosis. / Study funding/competing interests: The meetings of the working group were funded by ESGE, ESHRE and WES. CB declares to be a member of the independent data monitoring committee for a clinical study by ObsEva and receiving research grants from Bayer, Roche Diagnostics, MDNA Life Sciences and Volition. ES received honoraria for provision of training to healthcare professionals from Ethicon, Olympus and Gedeon Richter. The other authors declare that they have no conflict of interest

Building an XML document warehouse

International audienceData Warehouses and OLAP (On Line Analytical Processing) technologies are dedicated to analyzing structured data issued from organizations' OLTP (On Line Transaction Processing) systems. Furthermore, in order to enhance their decision support systems, these organizations need to explore XML (eXtensible Markup Language) documents as an additional and important source of unstructured data. In this context, this paper addresses the warehousing of document-centric XML documents. More specifically, we propose a two-method approach to build Document Warehouse conceptual schemas. The first method is for the unification of XML document structures; it aims to elaborate a global and generic view for a set of XML documents belonging to the same domain. The second method is for designing multidimensional galaxy schemas for Document Warehouses

The Sentinel Lymph Node in Breast Cancer: Problems Posed by Examination During Surgery. A Review of Current Literature and Management

The presence of tumor cells can be identified in the lymph node when metastasis has occurred from the primary cancer site into the lymph node (1) If the sentinel lymph node ganglion is negative for the presence of tumor cells at the time of histological examination, the other lymph nodes are also negative in 99% of cases. If no tumor cells are identified in the sentinel lymph node ganglion by histological examination, the other lymph nodes are also negative for the presence of tumor cells in 99% of cases. The sentinel lymph node advantageously replaces axillary dissection as a staging method in breast cancer T1 and T2 (2). Approximately 40% of breast cancers metastasize to axillary lymph nodes and metastatic extension depends on disease stage. Sentinel lymph nodes are affected in the following stages: T1a (4.3%), T1b (19.5%), T1c (23.8%), T2 (48.9%), T3 (66.7%)

Recommendations for the surgical treatment of endometriosis. Part 2: deep endometriosis

Study question: How should surgery for endometriosis be performed? / Summary answer: This document provides recommendations covering technical aspects of different methods of surgery for deep endometriosis in women of reproductive age. / What is known already: Endometriosis is highly prevalent and often associated with severe symptoms. Yet compared to equally prevalent conditions it is poorly understood and a challenge to manage. Previously published guidelines have provided recommendations for (surgical) treatment of deep endometriosis, based on the best available evidence, but without technical information and details on how to best perform such treatment in order to be effective and safe. / Study, design, size, duration: A working group of the European Society for Gynaecological Endoscopy (ESGE), European Society of Human Reproduction and Embryology (ESHRE) and the World Endometriosis Society (WES) collaborated on writing recommendations on the practical aspects of surgery for treatment of deep endometriosis. / Participants, materials, setting, methods: This document focused on surgery for deep endometriosis, and is complementary to a previous document in this series focusing on endometrioma surgery. / Main results and the role of chance: The document presents general recommendations for surgery for deep endometriosis, starting from preoperative assessments and first steps of surgery. Different approaches for surgical treatment are discussed and are respective of location and extent of disease; uterosacral ligaments and rectovaginal septum with or without involvement of the rectum, urinary tract or extrapelvic endometriosis. In addition, recommendations are provided on the treatment of frozen pelvis and on hysterectomy as a treatment for deep endometriosis. / Limitations, reasons for caution: Owing to the limited evidence available, recommendations are mostly based on clinical expertise. Where available, references of relevant studies were added. / Wider implications of the findings: These recommendations complement previous guidelines on management of endometriosis and the recommendations for surgical treatment of ovarian endometrioma. / Study funding - Competing interest(s): The meetings of the working group were funded by ESGE, ESHRE and WES

Literature curation of protein interactions: measuring agreement across major public databases

Literature curation of protein interaction data faces a number of challenges. Although curators increasingly adhere to standard data representations, the data that various databases actually record from the same published information may differ significantly. Some of the reasons underlying these differences are well known, but their global impact on the interactions collectively curated by major public databases has not been evaluated. Here we quantify the agreement between curated interactions from 15 471 publications shared across nine major public databases. Results show that on average, two databases fully agree on 42% of the interactions and 62% of the proteins curated from the same publication. Furthermore, a sizable fraction of the measured differences can be attributed to divergent assignments of organism or splice isoforms, different organism focus and alternative representations of multi-protein complexes. Our findings highlight the impact of divergent curation policies across databases, and should be relevant to both curators and data consumers interested in analyzing protein-interaction data generated by the scientific community

Exercise-induced bronchoconstriction and atopy in Tunisian athletes

<p>Abstract</p> <p>Background</p> <p>This study is a cross sectional analysis, aiming to evaluate if atopy is as a risk factor for exercise induced bronchoconstriction (EIB) among Tunisian athletes.</p> <p>Methods</p> <p>Atopy was defined by a skin prick test result and EIB was defined as a decrease of at least 15% in forced expiratory volume in one second (FEV1) after 8-min running at 80–85% HRmaxTheo. The study population was composed of 326 athletes (age: 20.8 ± 2.7 yrs – mean ± SD; 138 women and 188 men) of whom 107 were elite athletes.</p> <p>Results</p> <p>Atopy was found in 26.9% (88/326) of the athletes. Post exercise spirometry revealed the presence of EIB in 9.8% of the athletes including 13% of the elite athletes. Frequency of atopy in athletes with EIB was significantly higher than in athletes without EIB [62.5% vs 23.1%, respectively].</p> <p>Conclusion</p> <p>This study showed that atopic Tunisian athletes presented a higher risk of developing exercise induced bronchoconstriction than non-atopic athletes.</p