1,533 research outputs found
Plasmodium vinckei vinckei, P. v. lentum and P. yoelii yoelli : chronobiology of the asexual cycle in the blood
Using LDGM Codes and Sparse Syndromes to Achieve Digital Signatures
In this paper, we address the problem of achieving efficient code-based
digital signatures with small public keys. The solution we propose exploits
sparse syndromes and randomly designed low-density generator matrix codes.
Based on our evaluations, the proposed scheme is able to outperform existing
solutions, permitting to achieve considerable security levels with very small
public keys.Comment: 16 pages. The final publication is available at springerlink.co
On the universality of small scale turbulence
The proposed universality of small scale turbulence is investigated for a set
of measurements in a cryogenic free jet with a variation of the Reynolds number
(Re) from 8500 to 10^6. The traditional analysis of the statistics of velocity
increments by means of structure functions or probability density functions is
replaced by a new method which is based on the theory of stochastic Markovian
processes. It gives access to a more complete characterization by means of
joint probabilities of finding velocity increments at several scales. Based on
this more precise method our results call in question the concept of
universality.Comment: 4 pages, 4 figure
The European Photon Imaging Camera on XMM-Newton: The MOS Cameras
The EPIC focal plane imaging spectrometers on XMM-Newton use CCDs to record
the images and spectra of celestial X-ray sources focused by the three X-ray
mirrors. There is one camera at the focus of each mirror; two of the cameras
contain seven MOS CCDs, while the third uses twelve PN CCDs, defining a
circular field of view of 30 arcmin diameter in each case. The CCDs were
specially developed for EPIC, and combine high quality imaging with spectral
resolution close to the Fano limit. A filter wheel carrying three kinds of
X-ray transparent light blocking filter, a fully closed, and a fully open
position, is fitted to each EPIC instrument. The CCDs are cooled passively and
are under full closed loop thermal control. A radio-active source is fitted for
internal calibration. Data are processed on-board to save telemetry by removing
cosmic ray tracks, and generating X-ray event files; a variety of different
instrument modes are available to increase the dynamic range of the instrument
and to enable fast timing. The instruments were calibrated using laboratory
X-ray beams, and synchrotron generated monochromatic X-ray beams before launch;
in-orbit calibration makes use of a variety of celestial X-ray targets. The
current calibration is better than 10% over the entire energy range of 0.2 to
10 keV. All three instruments survived launch and are performing nominally in
orbit. In particular full field-of-view coverage is available, all electronic
modes work, and the energy resolution is close to pre-launch values. Radiation
damage is well within pre-launch predictions and does not yet impact on the
energy resolution. The scientific results from EPIC amply fulfil pre-launch
expectations.Comment: 9 pages, 11 figures, accepted for publication in the A&A Special
Issue on XMM-Newto
Identification of a cytokine network sustaining neutrophil and Th17 activation in untreated early rheumatoid arthritis
© 2010 Cascão et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained
synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and
perpetuation of this disease. The main goal of this work was to determine whether cytokines driving neutrophil
and Th17 activation are dysregulated in very early rheumatoid arthritis patients with less than 6 weeks of disease
duration and before treatment (VERA).
Methods: Cytokines related to neutrophil and Th17 activation were quantified in the serum of VERA and
established RA patients and compared with other very early arthritis (VEA) and healthy controls. Synovial fluid (SF)
from RA and osteoarthritis (OA) patients was also analyzed.
Results: VERA patients had increased serum levels of cytokines promoting Th17 polarization (IL-1b and IL-6), as
well as IL-8 and Th17-derived cytokines (IL-17A and IL-22) known to induce neutrophil-mediated inflammation. In
established RA this pattern is more evident within the SF. Early treatment with methotrexate or corticosteroids led
to clinical improvement but without an impact on the cytokine pattern.
Conclusions: VERA patients already display increased levels of cytokines related with Th17 polarization and
neutrophil recruitment and activation, a dysregulation also found in SF of established RA. 0 Thus, our data suggest
that a cytokine-milieu favoring Th17 and neutrophil activity is an early event in RA pathogenesis.This work was supported by a grant from Sociedade Portuguesa de Reumatologia/Schering-Plough 2005. RAM and RC were funded by Fundação para a Ciência e a Tecnologia (FCT) SFRH/BD/30247/2006 and
SFRH/BD/40513/2007, respectively. MMS-C was funded by Marie Curie Intra-European Fellowship PERG-2008-239422 and a EULAR Young Investigator Award
Transiting exoplanets from the CoRoT space mission VIII. CoRoT-7b: the first Super-Earth with measured radius
We report the discovery of very shallow (DF/F = 3.4 10-4), periodic dips in
the light curve of an active V = 11.7 G9V star observed by the CoRoT satellite,
which we interpret as due to the presence of a transiting companion. We
describe the 3-colour CoRoT data and complementary ground-based observations
that support the planetary nature of the companion. Methods. We use CoRoT color
information, good angular resolution ground-based photometric observations in-
and out- of transit, adaptive optics imaging, near-infrared spectroscopy and
preliminary results from Radial Velocity measurements, to test the diluted
eclipsing binary scenarios. The parameters of the host star are derived from
optical spectra, which were then combined with the CoRoT light curve to derive
parameters of the companion. We examine carefully all conceivable cases of
false positives, and all tests performed support the planetary hypothesis.
Blends with separation larger than 0.40 arcsec or triple systems are almost
excluded with a 8 10-4 risk left. We conclude that, as far as we have been
exhaustive, we have discovered a planetary companion, named CoRoT-7b, for which
we derive a period of 0.853 59 +/- 3 10-5 day and a radius of Rp = 1.68 +/-
0.09 REarth. Analysis of preliminary radial velocity data yields an upper limit
of 21 MEarth for the companion mass, supporting the finding.
CoRoT-7b is very likely the first Super-Earth with a measured radius.Comment: Accepted in Astronomy and Astrophysics; typos and language
corrections; version sent to the printer w few upgrade
Evidence for Exotic J^{PC}=1^{-+} Meson Production in the Reaction pi- p --> eta pi- p at 18 GeV/c
Details of the analysis of the eta pi- system studied in the reaction pi^{-}
p --> eta pi^{-} p at 18 GeV/c are given. Separate analyses for the 2 gamma and
pi+ pi- pi0 decay modes of the eta are presented. An amplitude analysis of the
data indicates the presence of interference between the a(2)(1320)- and a
J^{PC}=1^{-+} wave between 1.2 and 1.6 GeV/c^2. The phase difference between
these waves shows phase motion not attributable solely to the a(2)(1320)-. The
data can be fitted by interference between the a(2)(1320)- and an exotic 1^{-+}
resonance with M = 1370 +-16 +50 -30} MeV/c^2 and Gamma = 385 +- 40 +65 -105
MeV/c^2. Our results are compared with those of other experiments.Comment: 50 pages of text and 34 figure
A Cryogenic High-Reynolds Turbulence Experiment at CERN
The potential of cryogenic helium flows for studying high-Reynolds number turbulence in the laboratory has been recognised for a long time and implemented in several small-scale hydrodynamic experiments. With its large superconducting particle accelerators and detector magnets, CERN, the European Laboratory for Particle Physics, has become a major world center in helium cryogenics, with several large helium refrigerators having capacities up to 18 kW @ 4.5 K. Combining a small fraction of these resources with the expertise of three laboratories at the forefront of turbulence research, has led to the design, swift implementation, and successful operation of GReC (Grands Reynolds Cryogéniques) a large axisymmetric turbulent-jet experiment. With flow-rates up to 260 g/s of gaseous helium at ~ 5 K and atmospheric pressure, Reynolds numbers up to 107 have been achieved in a 4.6 m high, 1.4 m diameter cryostat. This paper presents the results of the first runs and describes the experimental set-up comprehensively equipped with "hot" wire micro-anemometers, acoustic scattering vorticity measurements and a large-bandwidth data acquisition system
Search for composite and exotic fermions at LEP 2
A search for unstable heavy fermions with the DELPHI detector at LEP is
reported. Sequential and non-canonical leptons, as well as excited leptons and
quarks, are considered. The data analysed correspond to an integrated
luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV
and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172
GeV and 161 GeV. The search for pair-produced new leptons establishes 95%
confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2,
depending on the channel. The search for singly produced excited leptons and
quarks establishes upper limits on the ratio of the coupling of the excited
fermio
Search for charginos in e+e- interactions at sqrt(s) = 189 GeV
An update of the searches for charginos and gravitinos is presented, based on
a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector
in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was
found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a
centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by
combining the chargino searches with neutralino searches at the Z resonance
implies a limit on the mass of the lightest neutralino which, for a heavy
sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure
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