125 research outputs found
Nanoscale electrical conductivity of the purple membrane monolayer
Nanoscale electron transport through the purple membrane monolayer, a two-dimensional crystal lattice of the transmembrane protein bacteriorhodopsin, is studied by conductive atomic force microscopy. We demonstrate that the purple membrane exhibits nonresonant tunneling transport, with two characteristic tunneling regimes depending on the applied voltage (direct and Fowler-Nordheim). Our results show that the purple membrane can carry significant current density at the nanometer scale, several orders of magnitude larger than previously estimated by macroscale measurements
Nanoscale electrical conductivity of the purple membrane monolayer
Nanoscale electron transport through the purple membrane monolayer, a two-dimensional crystal lattice of the transmembrane protein bacteriorhodopsin, is studied by conductive atomic force microscopy. We demonstrate that the purple membrane exhibits nonresonant tunneling transport, with two characteristic tunneling regimes depending on the applied voltage (direct and Fowler-Nordheim). Our results show that the purple membrane can carry significant current density at the nanometer scale, several orders of magnitude larger than previously estimated by macroscale measurements
Does Hypoxia and Stress Erythropoiesis Compromise Cardiac Function in Healthy Adults? A Randomized Trial
Objectives: To investigate whether recombinant human erythropoietin (rHuEPO) injections during an altitude training camp impact heart function.
Methods: Thirty (12 women) moderately trained subjects stayed at 2320 m altitude for 4 weeks while training. Subjects were randomized to placebo (isotonic saline) or rHuEPO (20 IU/kg body weight) i.v. injections. Transthoracic echocardiography imaging was acquired 3 days after arrival to altitude and prior to the first placebo or rHuEPO injection as well as one day after the last rHuEPO injection three weeks later.
Results: rHuEPO did not alter cardiovascular morphology parameters, systolic or diastolic function. In the placebo group, altitude exposure improved left ventricle (LV) systolic function due to an increased twist angle but rHuEPO had no additional effects. Pulmonary arterial systolic pressure was unaffected in either group. Notably, rHuEPO hampered LV untwist rate without affecting LV early filling.
Conclusion: rHuEPO provided during mild altitude exposure does not cause any major effects on heart function. The observed alteration in LV untwist induced by rHuEPO is unlikely to have a meaningful clinical effect
Convalescent plasma treatment for patients of 80 years and older with COVID-19 pneumonia
Background: Older patients, frequently with multiple comorbidities, have a high mortality from COVID-19 infection. Convalescent plasma (CP) is a therapeutic option for these patients. Our objective is to retrospectively evaluate the efficacy and adverse events of CP treatment in this population group.
Methods: Forty one patients over 80 years old with COVID-19 pneumonia received CP added to standard treatment, 51.2% with high anti-SARS-CoV-2 IgG titers and 48.8% with low titers. Median time between the onset of symptoms and the infusion of plasma was 7 days (IQR 4-10). A similar group of 82 patients who received only standard treatment, during a period in which CP was not available, were selected as a control group.
Results: In-hospital mortality was 26.8% for controls and 14.6% for CP patients (P = 0.131) and ICU admission was 8.5% for controls and 4.9% for CP patients (P = 0.467). Mortality tended to be lower in the high-titer group (9.5%) than in the low-titer group (20%), and in patients transfused within the first 7 days of symptom onset (10%) than in patients transfused later (19.1%), although the differences were not statistically significant (P = 0.307 and P = 0.355 respectively). There was no difference in the length of hospitalization. No significant adverse events were associated with CP treatment.
Conclusions: Convalescent plasma treatment in patients over 80 years old with COVID-19 pneumonia was well tolerated but did not present a statistically significant difference in hospital mortality, ICU admission, or length of hospitalization. The results should be interpreted with caution as only half the patients received high-titer CP and the small number of patients included in the study limits the statistical power to detect significant differences
A new chemo-evolutionary population synthesis model for early-type galaxies. II: Observations and Results
We present here the results of applying a new chemo-evolutionary stellar
population model developed by ourselves in a previous paper (Vazdekis et al.
1996) to new high quality observational data of the nuclear regions of two
representative elliptical galaxies and the bulge of the Sombrero galaxy. Here
we fit in detail about 20 absorption lines and 6 optical and near-infrared
colors following two approaches: fitting a single-age single-metallicity model
and fitting our full chemical evolutionary model. We find that all of the iron
lines are weaker than the best fitting models predict, indicating that the
iron-abundance is anomalous and deficient. We also find that the Ca_I index at
4227 A is much lower than predicted by the models. We can obtain good fits for
all the other lines and observed colors with models of old and metal-rich
stellar populations, and can show that the observed radial gradients are due to
metallicity decreasing outward. We find that good fits are obtained both with
fully evolutionary models and with single-age single-metallicity models. This
is due to the fact that in the evolutionary model more than 80% of stars form
with in 1.5 Gyr after the formation of the galaxies. The fact that slightly
better fits are obtained with evolutionary models indicates these galaxies
contain a small spread in metallicity.Comment: 29 pages, Latex with 22 figures and 2 landscape tables in ps-format.
Paper to be published in the Ap. J. Suppl., June 199
Gas flows, star formation and galaxy evolution
In the first part of this article we show how observations of the chemical
evolution of the Galaxy: G- and K-dwarf numbers as functions of metallicity,
and abundances of the light elements, D, Li, Be and B, in both stars and the
interstellar medium (ISM), lead to the conclusion that metal poor HI gas has
been accreting to the Galactic disc during the whole of its lifetime, and is
accreting today at a measurable rate, ~2 Msun per year across the full disc.
Estimates of the local star formation rate (SFR) using methods based on stellar
activity, support this picture. The best fits to all these data are for models
where the accretion rate is constant, or slowly rising with epoch. We explain
here how this conclusion, for a galaxy in a small bound group, is not in
conflict with graphs such as the Madau plot, which show that the universal SFR
has declined steadily from z=1 to the present day. We also show that a model in
which disc galaxies in general evolve by accreting major clouds of low
metallicity gas from their surroundings can explain many observations, notably
that the SFR for whole galaxies tends to show obvious variability, and
fractionally more for early than for late types, and yields lower dark to
baryonic matter ratios for large disc galaxies than for dwarfs. In the second
part of the article we use NGC 1530 as a template object, showing from
Fabry-Perot observations of its Halpha emission how strong shear in this
strongly barred galaxy acts to inhibit star formation, while compression acts
to stimulate it.Comment: 20 pages, 10 figures, to be presented at the "Penetrating Bars
through Masks of Cosmic Dust" conference in South Africa, proceedings
published by Kluwer, Eds. D.L. Block, K.C. Freeman, I. Puerari, & R. Groes
Gas Accretion and Galactic Chemical Evolution: Theory and Observations
This chapter reviews how galactic inflows influence galaxy metallicity. The
goal is to discuss predictions from theoretical models, but particular emphasis
is placed on the insights that result from using models to interpret
observations. Even as the classical G-dwarf problem endures in the latest round
of observational confirmation, a rich and tantalizing new phenomenology of
relationships between , , SFR, and gas fraction is emerging both in
observations and in theoretical models. A consensus interpretation is emerging
in which star-forming galaxies do most of their growing in a quiescent way that
balances gas inflows and gas processing, and metal dilution with enrichment.
Models that explicitly invoke this idea via equilibrium conditions can be used
to infer inflow rates from observations, while models that do not assume
equilibrium growth tend to recover it self-consistently. Mergers are an overall
subdominant mechanism for delivering fresh gas to galaxies, but they trigger
radial flows of previously-accreted gas that flatten radial gas-phase
metallicity gradients and temporarily suppress central metallicities. Radial
gradients are generically expected to be steep at early times and then
flattened by mergers and enriched inflows of recycled gas at late times.
However, further theoretical work is required in order to understand how to
interpret observations. Likewise, more observational work is needed in order to
understand how metallicity gradients evolve to high redshifts.Comment: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics
and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by
Springer. 29 pages, 2 figure
Performance of Prognostic Scoring Systems in MINOCA: A Comparison among GRACE, TIMI, HEART, and ACEF Scores
Background: the prognosis of patients with myocardial infarction with non-obstructive coronary arteries (MINOCA) is not benign; thus, prompting the need to validate prognostic scoring systems for this population. Aim: to evaluate and compare the prognostic performance of GRACE, TIMI, HEART, and ACEF scores in MINOCA patients. Methods: A total of 250 MINOCA patients from January 2017 to September 2021 were included. For each patient, the four scores at admission were retrospectively calculated. The primary outcome was a composite of all-cause death and acute myocardial infarction (AMI) at 1-year follow-up. The ability to predict 1-year all-cause death was also tested. Results: Overall, the tested scores presented a sub-optimal performance in predicting the composite major adverse event in MINOCA patients, showing an AUC ranging between 0.7 and 0.8. Among them, the GRACE score appeared to be the best in predicting all-cause death, reaching high specificity with low sensitivity. The best cut-off identified for the GRACE score was 171, higher compared to the cut-off of 140 generally applied to identify high-risk patients with obstructive AMI. When the scores were tested for prediction of 1-year all-cause death, the GRACE and the ACEF score showed very good accuracy (AUC = 0.932 and 0.828, respectively). Conclusion: the prognostic scoring tools, validated in AMI cohorts, could be useful even in MINOCA patients, although their performance appeared sub-optimal, prompting the need for risk assessment tools specific to MINOCA patients
Gas Accretion and Star Formation Rates
Cosmological numerical simulations of galaxy evolution show that accretion of
metal-poor gas from the cosmic web drives the star formation in galaxy disks.
Unfortunately, the observational support for this theoretical prediction is
still indirect, and modeling and analysis are required to identify hints as
actual signs of star-formation feeding from metal-poor gas accretion. Thus, a
meticulous interpretation of the observations is crucial, and this
observational review begins with a simple theoretical description of the
physical process and the key ingredients it involves, including the properties
of the accreted gas and of the star-formation that it induces. A number of
observations pointing out the connection between metal-poor gas accretion and
star-formation are analyzed, specifically, the short gas consumption time-scale
compared to the age of the stellar populations, the fundamental metallicity
relationship, the relationship between disk morphology and gas metallicity, the
existence of metallicity drops in starbursts of star-forming galaxies, the
so-called G dwarf problem, the existence of a minimum metallicity for the
star-forming gas in the local universe, the origin of the alpha-enhanced gas
forming stars in the local universe, the metallicity of the quiescent BCDs, and
the direct measurements of gas accretion onto galaxies. A final section
discusses intrinsic difficulties to obtain direct observational evidence, and
points out alternative observational pathways to further consolidate the
current ideas.Comment: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics
and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by
Springe
Stellar populations of bulges at low redshift
This chapter summarizes our current understanding of the stellar population
properties of bulges and outlines important future research directions.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen
E., Peletier R., Gadotti D., Springer Publishing. 34 pages, 12 figure
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