5,217 research outputs found
Structural phase transition in IrTe: A combined study of optical spectroscopy and band structure calculations
IrPtTe is an interesting system showing competing phenomenon
between structural instability and superconductivity. Due to the large atomic
numbers of Ir and Te, the spin-orbital coupling is expected to be strong in the
system which may lead to nonconventional superconductivity. We grew single
crystal samples of this system and investigated their electronic properties. In
particular, we performed optical spectroscopic measurements, in combination
with density function calculations, on the undoped compound IrTe in an
effort to elucidate the origin of the structural phase transition at 280 K. The
measurement revealed a dramatic reconstruction of band structure and a
significant reduction of conducting carriers below the phase transition. We
elaborate that the transition is not driven by the density wave type
instability but caused by the crystal field effect which further
splits/separates the energy levels of Te (p, p) and Te p bands.Comment: 16 pages, 5 figure
A genetic variant in the LDLRpromoter is responsible for part of the LDL-cholesterol variability in primary hypercholesterolemia
Beyond the required LISA free-fall performance: new LISA pathfinder results down to 20ââÎŒHz
In the months since the publication of the first results, the noise performance of LISA Pathfinder has improved because of reduced Brownian noise due to the continued decrease in pressure around the test masses, from a better correction of noninertial effects, and from a better calibration of the electrostatic force actuation. In addition, the availability of numerous long noise measurement runs, during which no perturbation is purposely applied to the test masses, has allowed the measurement of noise with good statistics down to 20ââÎŒHz. The Letter presents the measured differential acceleration noise figure, which is at (1.74±0.05)ââfmâs^{-2}/sqrt[Hz] above 2 mHz and (6±1)Ă10ââfmâs^{-2}/sqrt[Hz] at 20ââÎŒHz, and discusses the physical sources for the measured noise. This performance provides an experimental benchmark demonstrating the ability to realize the low-frequency science potential of the LISA mission, recently selected by the European Space Agency
The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulence
This is the final version (corrected proof). The final published version is available from Public Library of Science via the DOI in this recordData Availability: Short reads were submitted to the NCBIâs Sequence Read Archive under accession number SRP154617 (https://www.ncbi.nlm.nih.gov/sra/?term=SRP154617). The ChIPseq data are available from NCBI SRA (sequence read archive) database under accession number PRJNA574873 (https://www.ncbi.nlm.nih.gov/Traces/study/?acc=PRJNA574873&o=acc_s%3Aa).Aspergillus fumigatus is an opportunistic fungal pathogen that secretes an array of immune-modulatory molecules, including secondary metabolites (SMs), which contribute to enhancing fungal fitness and growth within the mammalian host. Gliotoxin (GT) is a SM that interferes with the function and recruitment of innate immune cells, which are essential for eliminating A. fumigatus during invasive infections. We identified a C6 Zn cluster-type transcription factor (TF), subsequently named RglT, important for A. fumigatus oxidative stress resistance, GT biosynthesis and self-protection. RglT regulates the expression of several gli genes of the GT biosynthetic gene cluster, including the oxidoreductase-encoding gene gliT, by directly binding to their respective promoter regions. Subsequently, RglT was shown to be important for virulence in a chemotherapeutic murine model of invasive pulmonary aspergillosis (IPA). Homologues of RglT and GliT are present in eurotiomycete and sordariomycete fungi, including the non-GT-producing fungus A. nidulans, where a conservation of function was described. Phylogenetically informed model testing led to an evolutionary scenario in which the GliT-based resistance mechanism is ancestral and RglT-mediated regulation of GliT occurred subsequently. In conclusion, this work describes the function of a previously uncharacterised TF in oxidative stress resistance, GT biosynthesis and self-protection in both GT-producing and non-producing Aspergillus species.Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESPConselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior â Brasil (CAPES)Wellcome TrustUniversity of MacauNational Science Foundation (NSF)Vanderbilt UniversityHoward Hughes Medical Institut
CD4 response, lipid changes and liver outcome in 506 patients receiving nevirapine-based regimens for a median of 9 years
Asymptotic W-symmetries in three-dimensional higher-spin gauge theories
We discuss how to systematically compute the asymptotic symmetry algebras of
generic three-dimensional bosonic higher-spin gauge theories in backgrounds
that are asymptotically AdS. We apply these techniques to a one-parameter
family of higher-spin gauge theories that can be considered as large N limits
of SL(N) x SL(N) Chern-Simons theories, and we provide a closed formula for the
structure constants of the resulting infinite-dimensional non-linear
W-algebras. Along the way we provide a closed formula for the structure
constants of all classical W_N algebras. In both examples the higher-spin
generators of the W-algebras are Virasoro primaries. We eventually discuss how
to relate our basis to a non-primary quadratic basis that was previously
discussed in literature.Comment: 61 page
ADHD and brain anatomy:What do academic textbooks used in the Netherlands tell students?
Studies of brain size of children classified with ADHD appear to reveal smaller brains when compared to ânormalâ children. Yet, what does this mean? Even with the use of rigorously screened case and control groups, these studies show only small, average group differences between children with and without an ADHD classification. However, academic textbooks used in the Netherlands often portray individual children with an ADHD classification as having a different, malfunctioning brain that necessitates medical intervention. This conceptualisation of ADHD might serve professional interests, but not necessarily the interests of children
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