Relationship between ABO Blood Group Distribution and COVID-19 Infection in Patients Admitted to the ICU: A Multicenter Observational Spanish Study

ABO blood-group system; Coronavirus infections; Multivariate analysis.Sistema de grups sanguinis ABO; Infeccions per coronavirus; Anàlisi multivariantSistema de grupos sanguíneos ABO; Infecciones por coronavirus; Análisis multivariableSince the beginning of the COVID-19 pandemic in December 2019, a relationship between the ABO blood group type and the novel coronavirus SARS-CoV-2, the etiological agent of COVID-19, has been reported, noting that individuals with the O blood group are the least likely to be infected. Spain is one of the most badly affected countries worldwide, with high rates of patients diagnosed, hospitalized, and deceased due to COVID-19 infection. The present study aimed to analyze the possible relationship of ABO in COVID-19 patients hospitalized in different Spanish centers during the first wave of the COVID-19 pandemic, for which the ABO group was available. Physicians from the transfusion services of different Spanish hospitals, who have developed a multicenter retrospective observational study, were invited to participate voluntarily in the research and 12,115 patients with COVID-19 infection were admitted to the nine participating hospitals. The blood group was known in 1399 cases (11.5%), of which 365 (26.1%) were admitted to the ICU. Regarding the distribution of ABO blood groups, a significant increase in the non-O blood groups and reduction for the O blood group was observed in patients hospitalized due to COVID-19, compared to the reference general population. Among the patients admitted to the ICU, after multivariate analysis, adjusted for the rest of the confounding variables, patients with the O blood group presented a significantly lower risk for admission to the ICU. We conclude that an association was observed between patients with the O blood group and their lower susceptibility to SARS-CoV-2 infection, both for those admitted to the hospitalization ward and for those who required admission to the ICU

Benzbromarone, Quercetin, and Folic Acid Inhibit Amylin Aggregation

Human Amylin, or islet amyloid polypeptide (hIAPP), is a small hormone secreted by pancreatic-cells that forms aggregates under insulin deficiency metabolic conditions, and it constitutes a pathological hallmark of type II diabetes mellitus. In type II diabetes patients, amylin is abnormally increased, self-assembled into amyloid aggregates, and ultimately contributes to the apoptotic death of -cells by mechanisms that are not completely understood. We have screened a library of approved drugs in order to identify inhibitors of amylin aggregation that could be used as tools to investigate the role of amylin aggregation in type II diabetes or as therapeutics in order to reduce -cell damage. Interestingly, three of the compounds analyzed-benzbromarone, quercetin, and folic acid-are able to slow down amylin fiber formation according to Thioflavin T binding, turbidimetry, and Transmission Electron Microscopy assays. In addition to the in vitro assays, we have tested the effect of these compounds in an amyloid toxicity cell culture model and we have found that one of them, quercetin, has the ability to partly protect cultured pancreatic insulinoma cells from the cytotoxic effect of amylin. Our data suggests that quercetin can contribute to reduce oxidative damage in pancreatic insulinoma cells by modulating the aggregation propensity of amylin

IAA : Información y actualidad astronómica (32)

Sumario : El laboratorio de polvo cósmico del IAA ...2 La interminable historia del agua en la Luna ...6 Multiversos y cómics ...9 HISTORIAS DE ASTRONOMÍA. Caroline Herschel ...13 DECONSTRUCCIÓN Y otros ENSAYOS. Zoom al centro galáctico ...14 EL “MOBY DICK” DE... Marta González (IAA-CSIC)...16 ACTUALIDAD ...17 ENTRE BASTIDORES ...21 CIENCIA: PILARES E INCERTIDUMBRES Tormentas solares ...22 ACTIVIDADES IAA, AGENDA Y RECOMENDADOS ...23 y 24N

Recerca i tecnologia en enginyeria gràfica i disseny a la Universitat Politècnica de Catalunya

Els temps canvien cada vegada més ràpidament, i a la universitat això encara es nota més. L’històric departament d‘Expressió Gràfica a l’Enginyeria (EGE) de la Universitat Politècnica de Catalunya, garant d’una docència de Grau, Màster i Doctorat de qualitat i adaptada a les necessitats de la societat, emprèn l’any 2020 amb una proposta de canvi de nom per adaptar-se al nous coneixements que estan esdevenint la seva matèria principal, al voltant de l’enginyeria gràfica i el disseny. Les àrees de recerca del centenar de professors que formen el departament són àmplies i variades, i sempre en col·laboració en diversos grups tant de la pròpia UPC com d’altres universitats. Una recerca avançada, de caràcter pluridisciplinari, on s'apliquen creativitat i innovació com a eines de coneixement, implicats en un territori ampli, i situats als diferents campus de la UPC. En els capítols d’aquest llibre podeu veure una petita mostra d’aquesta recerca tecnològica en camps ben variats.Postprint (published version

Long COVID in hospitalized and non-hospitalized patients in a large cohort in Northwest Spain, a prospective cohort study

Survivors to COVID-19 have described long-term symptoms after acute disease. These signs constitute a heterogeneous group named long COVID or persistent COVID. The aim of this study is to describe persisting symptoms 6 months after COVID-19 diagnosis in a prospective cohort in the Northwest Spain. This is a prospective cohort study performed in the COHVID-GS. This cohort includes patients in clinical follow-up in a health area of 569,534 inhabitants after SARS-CoV-2/COVID-19 diagnosis. Clinical and epidemiological characteristics were collected during the follow up. A total of 248 patients completed 6 months follow-up, 176 (69.4%) required hospitalization and 29 (10.2%) of them needed critical care. At 6 months, 119 (48.0%) patients described one or more persisting symptoms. The most prevalent were: extra-thoracic symptoms (39.1%), chest symptoms (27%), dyspnoea (20.6%), and fatigue (16.1%). These symptoms were more common in hospitalized patients (52.3% vs. 38.2%) and in women (59.0% vs. 40.5%). The multivariate analysis identified COPD, women gender and tobacco consumption as risk factors for long COVID. Persisting symptoms are common after COVID-19 especially in hospitalized patients compared to outpatients (52.3% vs. 38.2%). Based on these findings, special attention and clinical follow-up after acute SARS-CoV-2 infection should be provided for hospitalized patients with previous lung diseases, tobacco consumption, and women

The Strait of Gibraltar: submarine morphology, oceanogra- phic connections and evolution

32 pages, 10 figures[EN] The Strait of Gibraltar is a first-order physiographic feature between southern Iberia and northern Africa. It has been excavated over the Arc of Gibraltar in favor of a conjugated ENE-WSW and WNW-ESE fault system that have acted as weakness structures. The Strait was generated by erosive processes of the water masses coming from the Atlantic Ocean in the lower Pliocene, due to the rude and rapid flooding of the Alboran Sea basin. Once the flood stabilized the exchange and interaction of the Atlantic and Mediterranean water masses began as we know it today; the Atlantic water that circulates on the surface of the Strait towards the Alborán Sea, and the Mediterranean water masses that circulate in depth towards the Atlantic Ocean. The acceleration of the Atlantic and Mediterranean water masses in the Strait corridor has favored the development of erosive processes.These processeshave allowed the outcrops of the rocky substratum, the development of sedimentary instabilities and the generation of paleochannels, carbonate crusts and cold-water coral formations during the Pliocene and Quaternary. Likewise, the acceleration of the Mediterranean water masses on their way in and out of the Strait and their interaction with the sea floor have controlled sedimentation both in the Alborán Sea basin and in the Gulf of Cádiz, forming contouritic depositional systems[ES] El estrecho de Gibraltar es un rasgo fisiográfico de primer orden entre el sur de Iberia y el norte de África. Ha sido excavado sobre el Arco de Gibraltar a favor de un sistema de fallas conjugadas de direcciones ENE-OSO y ONO-ESE que han actuado como estructuras de debilidad. El Estrecho fue generado por procesos erosivos de las masas de agua procedentes del océano Atlántico en el Plioceno inferior, al producirse de forma brusca y rápida la inundación de la cuenca del mar de Alborán. Una vez estabilizada la inundación comenzó el intercambio y la interacción de las masas de agua atlántica y mediterránea tal y como hoy la conocemos: el agua atlántica que circula en la superficie del Estrecho hacia el mar de Alborán, y las masas de agua mediterráneas que transitan en profundidad hacia el océano Atlántico. La aceleración de las masas de agua atlántica y mediterránea en el corredor del Estrecho ha favorecido el desarrollo de procesos erosivos. Estos procesos han permitido los afloramientos del substrato rocoso, el desarrollo de inestabilidades sedimentarias, generación de paleocanales, costras carbonatas y formaciones coralígenas de aguas frías durante el Plioceno y el Cuaternario.Asimismo, la aceleración de las masas de agua mediterráneas en su camino de entrada y salida del Estrecho y su interacción con el suelo marino han controlado la sedimentación tanto en la cuenca del mar de Alborán como en el golfo de Cádiz, formando sistemas deposicionales contorníticosWith the institutional support of the ‘Severo Ochoa Centre of Excellence’ accreditation (CEX2019-000928-S)Peer reviewe

Relatoría III jornadas en tecnologías de la información, telecomunicaciones y el ecosistema digital - Relatoría conferencias magistrales

47 página

COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

El reto en la docencia de la igualdad ante la diversidad

El proyecto presenta iniciativas llevadas a cabo por el equipo investigador encaminadas a incorporar las perspectivas de género y discapacidad en la docencia. Del mismo modo, se señalan algunas actividades incorporadas a la docencia de la asignatura "Políticas Públicas" que se imparte en varias titulaciones, con el objetivo de favorecer la impartición de esta materia en inglés

Plan de parto y nacimiento

Texto en gallego y españo