267 research outputs found

    The elastic view of the structural continuum versus the strength of material analysis

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    Congreso celebrado en la Escuela de Arquitectura de la Universidad de Sevilla desde el 24 hasta el 26 de junio de 2015.The appearance of the graphic computing has allowed to deal with analysis of two and threedimensional structural continuum by means of mechanic models that have the capacity to understand the simplest and more complex behaviors between local geometries that classic methodologies are not able to describe. This fact involves the re-adoption of the Elasticity Theory and the prominence of the stresses against the comfortable view to simplify them along one of the geometry dimensions (e.g. one of the beam edges) to convert them into strains. The Strength of Materials concepts and the vectorial calculus might become outdated nowadays. Moreover, the Finite Element Method used in this study allows facing structural geometries with geometric and functional complexity. This would not be possible with classic methods without introducing important simplifications

    Cuerpo carotídeo y fisiopatología del SAOS: hipertensión

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    El cuerpo carotídeo (CC) es un pequeño órgano quimiorreceptor que se activa en situaciones de hipoxia, hipercapnia y acidosis plasmática, originando reflejos ventilatorios y cardiocirculatorios. La apnea obstructiva del sueño es un trastorno frecuente en el que los pacientes padecen de manera crónica interrupciones del flujo aéreo que conducen a modificaciones de los parámetros que activan el CC. Cuando estas modificaciones se prolongan en el tiempo suceden una serie de trastornos cardiocirculatorios, metabólicos y neurocognitivos. Este trabajo tiene como objetivo estudiar la participación del CC en la génesis de la hipertensión que constituye uno de los trastornos fundamentales en el síndrome de apnea obstructiva del sueño. Se ha revisado bibliografía sobre dicha participación y los mecanismos fisiopatológicos que desencadenan la hipertensión y que incluyen la activación del simpático y otras alteraciones vasculares como la disfunción endotelial.Grado en Medicin

    Bernstein polynomials in element-free Galerkin method

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    In the recent decades, meshless methods (MMs), like the element-free Galerkin method (EFGM), have been widely studied and interesting results have been reached when solving partial differential equations. However, such solutions show a problem around boundary conditions, where the accuracy is not adequately achieved. This is caused by the use of moving least squares or residual kernel particle method methods to obtain the shape functions needed in MM, since such methods are good enough in the inner of the integration domains, but not so accurate in boundaries. This way, Bernstein curves, which are a partition of unity themselves,can solve this problem with the same accuracy in the inner area of the domain and at their boundaries

    Aplasia of the lacrimal and major salivary glands (ALSG). First case report in spanish population and review of the literature

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    Aplasia of the lacrimal and the major salivary glands (ALSG) is a rare disorder with scarce cases described in the recent literature. The pattern of genetic inheritance is autosomal dominant with variable expressivity. A 40 years male patient was referred to the Oral and Maxillofacial Service at the Hospital Universitario de A Coruña diagnosed with complete agenesis of all salivary glands. Our case it is the first of ALSG syndrome in the Spanish literature. Imaging tests are necessary to confirm the lack of formation of salivary glands and alteration of lacrimal system. A mutation of FGF10 has been proposed as the responsible of the syndrome. The management of the lacrimal alteration depends of the clinical findings. Clinical suspicion remains the principal tool to diagnose the syndrome

    Early paradoxical increase of dopamine: A neurochemical study of olfactory bulb in asymptomatic and symptomatic MPTP treated monkeys

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    Parkinson’s disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years. The relationship between hyposmia and PD remains elusive. Olfactory bulb (OB) pathology shows an increased number of olfactory dopaminergic cells, protein aggregates and dysfunction of neurotransmitter systems. In this study we examined tissue levels of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, of noradrenaline (NA) and of the amino acid neurotransmitters aspartate, glutamate, taurine and γ-aminobutyric acid in OBs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated Macaca fascicularis in different stages, includin g monkeys who were always asymptomatic, monkeys who recovered from mild parkinsonian signs, and monkeys with stable moderate or severe parkinsonism. DA was increased compared to controls, while neither NA and 5-HT nor the amino acid neurotransmitters were significantly changed. Furthermore, DA increased before stable motor deficits appear with +51% in asymptomatic and +96% in recovered monkeys. Unchanged DA metabolites suggest a special metabolic profile of the newly formed DA neurons. Significant correlation of homovanillic acid (HVA) with taurine single values within the four MPTP groups and of aspartate with taurine within the asymptomatic and recovered MPTP groups, but not within the controls suggest interactions in the OB between taurine and the DA system and taurine and the excitatory neurotransmitter triggered by MPTP. This first investigation of OB in various stages after MPTP administration suggests that the DA increase seems to be an early phenomenon, not requiring profound nigrostriatal neurodegeneration or PD symptoms.This work was funded by grants from the Ministerio de Economía y Competitividad: SAF2015-67239-P; Instituto de Salud Carlos III (CIBERNED) SAF2016-78207, Ministerio de Ciencia e Innovación, Instituto de Salud Carlos III—Fondos FEDER, a way to build Europe FIS PIE14/00034 to JAO and by the chair UAM-Fundación Tatiana Pérez de Guzmán el Bueno to C

    Electrical resistivity tomography: a tool to aid in the detection of mining voids (Arrayanes mine, Linares-Jaén)

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    Electrical resistivity tomography is well suited to find and map subsurface cavities because of its ability to detect resistive features and discriminating subtle resistivity variations. The Linares area (Jaén, Spain), where an important mining activity on metallic sulphides ores was developed, has been selected for this study. This activity has produced a large volume of mining voids. Electrical resistivity tomography is a geophysical tool well suited to the detection and mapping of known and unknown mining voids. The technique is capable of discriminating between the developing cavities, where the target is primarily conductive weathered material, and the empty voids comprising resistive air-filled cavities. Such cavities may be water-filled, in which case they are likely to yield conductive anomalies as the water would be significantly more conductive than the surrounding material (unweathered granite in this case). The survey results suggest that electrical resistivity tomography is an ideal geophysical tool to aid in the detection and monitoring of mining voids and other subsurface cavitie

    Ionoluminescence induced by swift heavy ions in silica and quartz: A comparative analysis

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    Ionoluminescence (IL) of the two SiO 2 phases, amorphous silica and crystalline quartz, has been comparatively investigated in this work, in order to learn about the structural defects generated by means of ion irradiation and the role of crystalline order on the damage processes. Irradiations have been performed with Cl at 10 MeV and Br at 15 MeV, corresponding to the electronic stopping regime (i.e., where the electronic stopping power S e is dominant) and well above the amorphization threshold. The light-emission kinetics for the two main emission bands, located at 1.9 eV (652 nm) and 2.7 eV (459 nm), has been measured under the same ion irradiation conditions as a function of fluence for both, silica and quartz. The role of electronic stopping power has been also investigated and discussed within current views for electronic damage. Our experiments provide a rich phenomenological background that should help to elucidate the mechanisms responsible for light emission and defect creationThis work has been supported by Spanish Ministry MICINN through the project MAT-2008-06794-C03-03, JCI-2009-05681, and by Madrid Community through the project TECHNOFUSION (S2009/ENE-1679). OPR is grateful to CONACyT, Mexico, for extending a postdoctoral fellowshi
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