Propuesta para la Distribución de Sistemas de Generación de Electricidad por Medio de Paneles Solares en los Distintos Pueblos del Departamento de la Guajira.

Este trabajo se realizó con el fin de analizar la viabilidad de implementar la instalación de sistemas de paneles solares en el departamento de La Guajira, como alternativa para el mejoramiento de la calidad de vida de la población y considerándolo además como un sistema de generación limpia. Este sistema en comparación con el tipo de servicio de distribución de energía que presta en la actualidad en la región, se puede considerar más estable y autónomo, debido a que se ha evidenciado que estas poblaciones se ven afectadas constantemente con los cortes que se presentan los cuales pueden llegar a ser prolongados.Corporación Universitaria Minuto de Dio

AVANCES EN EL CONTROL DE PLATAFORMAS BÍPEDAS USANDO EL SISTEMA KINECT

This paper presents the UPABOT- humanoid robot teleoperation and biped platform using the Kinect sensor. The user controls the movements of the robots through the Kinect sensor, acquiring the position of the main joints of your body. A simulation using OpenGL libraries was performed, which illustrate the skeleton view of the person and the 3D robot. By means of the inverse kinematic analysis are generated the reference signals control of the UPABOT humanoid robot and Biped robot.En este artículo se presenta la teleoperación del robot humanoide - UPABOTy una plataforma Bípeda por medio del sensor Kinect. El usuario controla los movimientos de los robots por medio del sensor Kinect, adquiriendo la posición de las principales articulaciones de su cuerpo. Se realizó una simulación por medio de las librerías de OpenGL, las cuales ilustran la vista esqueleto de la persona y los robot 3D. Por medio del análisis cinemático inverso se crean las señales de referencia del control del robot humanoide UPABOT y el robot Bípedo

La viabilidad de los juicios políticos contra funcionarios de elección popular desde la óptica del SIDH: Parámetros convencionales para su armonización

Currently, there is controversy within the specialized doctrine about the legitimacy of political trials in accordance with the postulates arising from the American Convention on Human Rights, due to legal uncertainty about a specific regulation and the absence of jurisprudential development within the Inter-American System that functions as a scale to determine the Conventionality of this means of political control, which exists in most countries belonging to the Inter-American System. In this sense, the main objective of this article is aimed at establishing objective parameters that allow the harmonization of political trials with the ACHR. For this purpose, a contextualization of the genesis of this means of political control was carried out through a qualitative methodology, as well as its transfer in the panorama of Latin American constitutional law and, finally, the requirements that allow impeachment to coexist harmoniously with conventional requirements were addressed in a diaphanous way, having as a catalyst the teleological criteria mutatis mutandis within the framework of international guarantees decanted in the Corpus Iuris of  International Law of Human Rights.Actualmente, existe controversia dentro de la doctrina especializada acerca de la legitimación de los juicios políticos conforme los postulados dimanados de la Convención Americana sobre Derechos Humanos, debido a la incertidumbre jurídica sobre una regulación específica y la ausencia de desarrollo jurisprudencial dentro del Sistema Interamericano que funja como baremo para determinar la Convencionalidad de este medio de control político, el cual existe en la mayoría de países pertenecientes al sistema interamericano. En este sentido, el objetivo principal de este artículo se encamina a establecer parámetros objetivos que permitan la armonización de los juicios políticos con la CADH. Para este fin se realizó por medio de una metodología cualitativa una contextualización acerca de la génesis de este medio de control político, así como su trasegar en el panorama del derecho constitucional latinoamericano y finalmente se abordó de manera diáfana dentro de un marco propositivo las exigencias que permiten que el impeachment coexista de manera armónica con las exigencias convencionales, teniendo como eje catalizador los criterios teleológicos que permiten su aplicación mutatis mutandi dentro del marco de las garantías internacionales decantadas en el Corpus Iuris del Derecho Internacional de los Derechos HumanosActuellement, il existe une controverse au sein de la doctrine spécialisée concernant la légitimité des jugements politiques selon les postulats émis par la Convention américaine relative aux droits de l'homme, en raison de l'incertitude juridique concernant une réglementation spécifique et de l'absence de développement jurisprudentiel au sein du système interaméricain qui fonctionne car nous sommes incapables de déterminer la conventionnalité de ce moyen de contrôle politique, qui existe dans la plupart des pays appartenant au système interaméricain. En ce sens, l’objectif principal de cet article est d’établir des paramètres objectifs permettant l’harmonisation des jugements politiques avec le CADH. À cette fin, une contextualisation sur la genèse de ce moyen de contrôle politique a été réalisée en utilisant une méthodologie qualitative, en suivant le panorama du droit constitutionnel latino-américain et en étant finalement abordée de manière diaphane dans un cadre propositionnel des exigences qui ils permettent à la destitution de coexister harmonieusement avec les revendications conventionnelles, ayant comme catalyseur les critères téléologiques qui permettent son application mutatis mutandis dans le cadre des garanties internationales décantées dans le Corpus Iuris del Derecho Internacional de los Derechos Humanos.Atualmente, existe controvérsia na doutrina especializada sobre a legitimação dos julgamentos políticos de acordo com os postulados decorrentes da Convenção Americana sobre Direitos Humanos, devido à insegurança jurídica quanto a uma regulamentação específica e à ausência de desenvolvimento jurisprudencial no âmbito do Sistema Interamericano que funciona como uma escala para determinar a convencionalidade deste meio de controle político, que existe na maioria dos países pertencentes ao sistema interamericano. Nesse sentido, o objetivo principal deste artigo visa estabelecer parâmetros objetivos que permitam a harmonização dos julgamentos políticos com a CADH. Para tanto, foi realizada uma contextualização da gênese deste meio de controle político através de uma metodologia qualitativa, bem como sua transferência no panorama do direito constitucional latino-americano e por fim as demandas que permitem que o impeachment coexista harmoniosamente com as demandas convencionais , tendo como catalisador os critérios teleológicos que permitem a sua aplicação mutatis mutandi no âmbito das garantias internacionais previstas no Corpus Iuris do Direito Internacional dos Direitos Humanos

Allelic Diversity at Abiotic Stress Responsive Genes in Relationship to Ecological Drought Indices for Cultivated Tepary Bean, Phaseolus acutifolius A. Gray, and Its Wild Relatives

Some of the major impacts of climate change are expected in regions where drought stress is already an issue. Grain legumes are generally drought susceptible. However, tepary bean and its wild relatives within Phaseolus acutifolius or P. parvifolius are from arid areas between Mexico and the United States. Therefore, we hypothesize that these bean accessions have diversity signals indicative of adaptation to drought at key candidate genes such as: Asr2, Dreb2B, and ERECTA. By sequencing alleles of these genes and comparing to estimates of drought tolerance indices from climate data for the collection site of geo-referenced, tepary bean accessions, we determined the genotype x environmental association (GEA) of each gene. Diversity analysis found that cultivated and wild P. acutifolius were intermingled with var. tenuifolius and P. parvifolius, signifying that allele diversity was ample in the wild and cultivated clade over a broad sense (sensu lato) evaluation. Genes Dreb2B and ERECTA harbored signatures of directional selection, represented by six SNPs correlated with the environmental drought indices. This suggests that wild tepary bean is a reservoir of novel alleles at genes for drought tolerance, as expected for a species that originated in arid environments. Our study corroborated that candidate gene approach was effective for marker validation across a broad genetic base of wild tepary accessions

Propuesta geométrica para la intersección vial cl. 1 con cra 28a

Se evaluaron las causas y factores que influyen la problemática presentada en la intersección Calle 1 con Carrera 28ª, ubicada en la comuna 7 de la zona urbana de Villavicencio, mediante un aforo vehicular, estudio y caracterización de la zona, movilidad, entre otros. Se evidencio un factor que afecta la movilidad y genera accidentalidad es el giro en U realizado para retornar a la séptima brigada y entrada al barrio Remansos de Rosa Blanca. Para disminuir la accidentalidad, congestiones vehiculares y quitar el giro en U de la Calle 1, se propone un retorno 440 metros antes de la intersección de estudio, para el ingreso al barrio Remansos de Rosa Blanca dejando esta vía de solo un sentido, habilitando otra vía en sentido opuesto para la salida de este. Así reduciendo el tiempo semafórico de la intersección ya que se cuenta con un movimiento menos, descongestionando este punto ya que se reduce el número de vehículos y con un porcentaje pequeño de probabilidad de accidentalidad.The causes and factors that influence the problems presented at the intersection Calle 1 with Carrera 28ª, located in the commune 7 of the urban area of Villavicencio, were evaluated by means of a vehicular capacity, study and characterization of the area, mobility, among others. It was evidenced that a factor that affects mobility and generates accidents is the U-turn made to return to the seventh brigade and entrance to the Remansos de Rosa Blanca neighborhood. To decrease the accident rate, vehicular traffic jams and remove the U-turn of Calle 1, a return is proposed 440 meters before the intersection of the study, to enter the Remansos de Rosa Blanca neighborhood, leaving this way of only one direction, enabling another way in the opposite direction for the exit of this. Thus reducing the semaphoric time of the intersection since there is a less movement, decongesting this point since the number of vehicles is reduced and with a small percentage of accident probability.Resumen -- Abstract -- 1. Generalidades -- 1.1 Antecedentes -- 1.2 Planteamiento del problema -- 1.3 Pregunta de investigación -- 1.4 Objetivos -- 1.4.1 Objetivo General -- 1.4.1 Objetivos Específicos -- 2. Marco Referencial -- 2.1 Marco Teórico -- 2.1.1 Clasificación De Las Carreteras 2.1.1.2 Primarias -- 2.1.1.3 Secundarias -- 2.1.1.4 Terciarias -- 2.1.2 Según el tipo de terreno -- 2.1.2.1 Terreno plano -- 2.1.2.2 Terreno ondulado -- 2.1.2.3 Terreno montañoso -- 2.1.2.4 Terreno escarpado -- 2.1.3 Intersecciones a nivel -- 2.1.3.1 Sin canalizar -- 2.1.3.2 Criterios de diseño -- 2.1.3.3 Canalizadas -- 2.1.3.4 Criterios básicos de diseño -- 2.1.4 Volúmenes de transito -- 2.1.5 Dimensiones y trayectorias de giro -- 2.1.6 Distancias de visibilidad -- 2.2 Marco Legal -- 3. Metodología -- 3.1 Recolección de información -- 3.2 Identificación de las problemáticas y factores de movilidad -- 3.3 Planteamiento de alternativas -- 3.4 Diseño geométrico -- 4. Descripción zona de estudio -- 4.1 Localización -- 4.2 Caracterización de la vía de estudio -- 4.2.1 Tipo de vía -- 4.2.1.1 Vías perfil V2 -- 4.2.2 Movimientos realizados en la intersección -- 4.3 Actividades socioeconómicas de la zona -- 4.4 Aforo vehicular -- 4.4.1 Conteo vehicular -- 4.4.2 Horario máximo volumen vehicular -- 4.5 Accidentalidad estadística vial de Villavicencio -- 4.6 Incremento vehicular de la ciudad de Villavicencio -- 5. Problemática de movilidad -- 5.1 Causas y factores -- 5.1.1 Giro en U -- 5.1.2 Imprudencia vehicular -- 6. Planteamiento de alternativa -- 7. Diseño geométrico -- Bibliografía -- Conclusiones -- Anexos -- Planos -- Imagen georreferenciada con diseño geométrico -- Plano diseño geométrico -- Detalle diseño geométrico giro entrada barrio Remansos de Rosa Blanca -- Detalle diseño geométrico nueva vía salida barrio Remansos de Rosa Blanca -- Registro Fotográfico -- Accidente vehicular en la intersección -- Congestión vehicular en la intersección -- Congestión vehicular por giro en U -- Intersección Calle 1 con Carrera 28ª. -- Datos aforo vehicular -- Aforo vehicular Calle 1 Carrera 28

Myoinvasive pattern as a prognostic marker in low-grade, early-stage endometrioid endometrial carcinoma

Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinomaThis research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (FEDER)

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia en los departamentos Cesar y Santander.

Este trabajo corresponde al Paso 4- Evaluación Nacional: Abordaje de contextos desde los enfoques narrativos de los participantes del grupo del Diplomado de profundización y acompañamiento psicosocial en escenarios de violencia. Se desarrolla análisis psicosocial por cada uno de los integrantes sobre: La Mesa Cesar, La Trocha de Verdecia “Comunidad de Agustín Codazzi”, La Jagua de Ibirico en el Cesar, el Barrio Villa Haidyth en la ciudad de Valledupar, la inmigración venezolana y el impacto psicosocial que han sufrido estas personas por su desplazamiento (Bucaramanga). Así mismo, se presenta Abstrac y Key words, el análisis de relatos de violencia y esperanza (Ana Ligia) y como sufrió el impacto de la guerra en su pueblo de origen y posterior desplazamiento por la violencia en dos ocasiones junto a sus hijos frente a episodios estresantes que tuvo que presenciar y vivir; enfocándose en la búsqueda del mejoramiento de la calidad de vida de su familia. Por consiguiente, a través de trabajo en equipo se aborda aspectos como la subjetividad identidades, situaciones de naturalización, procesos de resiliencia, resignificación, y conocimiento de sus narrativas mediante preguntas la formulación de preguntas circulares, reflexivas y estratégicas, el análisis y presentación de estrategias de abordaje psicosocial para el caso de Cacarica, impactos de la violencia, acciones de intervención a víctimas del conflicto; de igual forma, el informe analítico y reflexivo de la experiencia de foto voz realizada en el paso 3 del diplomado como narrativa y apoyo de imágenes, evidenciándose durante muchos años este flagelo y el gran impacto que ha tenido en las víctimas del conflicto armado. Finalmente, se presentan las conclusiones y link del blog o página wix. El conflicto armado tiene un efecto negativo en la salud mental de las víctimas. El afrontamiento de situaciones críticas para el proceso de recuperación, es la resiliencia, que se define como la capacidad que tienen las personas para hacer frente al dolor, a experiencias difíciles o traumáticas. Wilches (2010). Palabras clave: Psicosocial, Violencia, Intervención, Víctimas del Conflicto Armado.This job corresponds to step 4: National test: Approach of contexts since the narrative approaches of the participants of detailing diploma course group and Psychosocial accompanying in scenes of vidence. It develops Psychosocial análisis for each one of the members about: La Mesa Cesar, the Verdecia path “Community of Agustin Codazzi”, La Jagua de Ibirico in Cesar, The Villa Haydith neighborhood in Valledupar city, the Venezuelan immigration and the psychosocial impact that have suffered these persons for their displacement (Bucaramanga). Moreover, it presents abstract and key Word the análisis of short story of violence and hope (Ana Ligia) and how did she suffer the impacto f the war in her origin village and following displacement for the violence in two ocassions beside her sons fornt to stress ful episodes she had to witness and t olive focus on the search of improvement of her family life quality. Therefore, through work in team presen this aspects as the subjectivity identies, situations of naturalization, resilence process, resignificance and kowledge of her narratives by questions, the formulation of circular, reflexive and estrategic questions, análisis and presentation of estrategies of pychosocial approach by the case of Cacarica, impacts of violence, actions of intervention to victim of conflicto; in the same way, the analytic and reflexive report of photo voice experience carried out in the step 3 of diploma course as narrative and images support evidencing during many years this scourge and the great impact that have hand the victims of armed conflicto. Finally, we capture conclusión and blog link or wix page. The armed conflict has a negative effect on the mental health of the victims. Coping with critical situations for the recovery process is resilience, which is defined as the capacity that people have to face pain, difficult or traumatic experiences. Wilches (2010). Key words: Psychosocial, Violence, Intervention, Victim of Armed Conflict

Clinicopathological features and prognostic significance of CTNNB1 mutation in low-grade, early-stage endometrial endometrioid carcinoma

Low-grade and early-stage endometrioid endometrial carcinomas (EECs) have an overall good prognosis but biomarkers identifying patients at risk of relapse are still lacking. Recently, CTNNB1 exon 3 mutation has been identified as a potential risk factor of recurrence in these patients. We evaluate the prognostic value of CTNNB1 mutation in a single-centre cohort of 218 low-grade, early-stage EECs, and the correlation with beta-catenin and LEF1 immunohistochemistry as candidate surrogate markers. CTNNB1 exon 3 hotspot mutations were evaluated by Sanger sequencing. Immunohistochemical staining of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6), p53, beta-catenin, and LEF1 was performed in representative tissue microarrays. Tumours were also reviewed for mucinous and squamous differentiation, and MELF pattern. Nineteen (8.7%) tumours harboured a mutation in CTNNB1 exon 3. Nuclear beta-catenin and LEF1 were significantly associated with CTNNB1 mutation, showing nuclear beta-catenin a better specificity and positive predictive value for CTNNB1 mutation. Tumours with CTNNB1 exon 3 mutation were associated with reduced disease-free survival (p = 0.010), but no impact on overall survival was found (p = 0.807). The risk of relapse in tumours with CTNNB1 exon 3 mutation was independent of FIGO stage, tumour grade, mismatch repair protein expression, or the presence of lymphovascular space invasion. CTNNB1 exon 3 mutation has a negative impact on disease-free survival in low-grade, early-stage EECs. Nuclear beta-catenin shows a higher positive predictive value than LEF1 for CTNNB1 exon 3 mutation in these tumoursThis research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (FEDER

Prognostic Factors in Patients with Rocky Mountain Spotted Fever

Background: Rocky Mountain Spotted Fever (RMSF) is a disease with a high mortality rate, caused by Rickettsia rickettsii, a bacteria transmitted to humans by infected ticks. In 2008 there was a Rocky Mountain Spotted Fever (RMSF) outbreak in the city of Mexicali, México, resulting in an increased mortality rate amongst the area population. Methods: Case-series study of patients admitted to the General Hospital of Mexicali between 2014 and 2019 with a confirmed diagnosis of RMSF. Mortality was compared dividing the population on those ?20 and younger than ?21 years of age. Results: A total of 129 patients’ records during a 5-year period whose diagnosis was RMSF confirmed with PCR were included. Mortality was compared among patients admitted who were younger than ?20 years of age with that among patients who were older than ?20 years of age (61 versus 68 respectively), the latter being higher with an OR 4.2 (p<0.0001). Conclusion: RMSF in hospitalized patients has a high mortality rate in spite of early treatment in all age groups, without showing any predominance in gender. However, patients older than 20 years of age had a higher mortality rate than those younger than 20 years, without any predominance in gender

Protein Identification and Haplotype Description of Homozygote Mutation Causing Congenital Plasminogen Deficiency

Severe type I Plasminogen (PLG) deficiency was clinically diagnosed after hyaline-positive periodic acid Schiff material was detected in the histologic study of superior tarsal conjunctiva and vulvar pseudomembrane of the patient. Direct immunofluorescence also confirmed multiple deposits of fibrinogen in the dermis. Plasma plasminogen activity was calculated in a <5% value (reference values, 75% to 150%) and sequencing of the PLG gene evidenced the homozygous mutation in c.2377T/A (p.Tyr793Asn), confirming the molecular diagnosis of congenital deficiency of plasminogen type 1. Genotype-Phenotype correlation among family members evidenced the recessive hereditary pattern of clinical manifestations of chronic inflammatory disease of the mucous membranes due to PLG deficiency, but co-dominance effect to present a decreased plasma plasminogen activity (46%) among heterozygous asymptomatic individuals. SNPs/CNVs whole genome array hybridization analysis in the patient, detected long Loss of Heterozygosity regions (LOH) and demonstrated the consanguinity in the family. Proteomic analysis identified impaired secretion of mutant PLG tissue specific proteins, as definitive molecular etiopathogenesis of the type I PLG deficiency in the patient