Skew-product maps with base having closed set of periodic points

In [Proc. ECIT-89, World Scientific, (1991), 177–183], A. N. Sharkovski˘ı and S.F. Kolyada stated the problem of characterization skew-product maps having zero topological entropy. It is known that, even under some additional assumptions, this aim has not been reached. In [J. Math. Anal. Appl., 287, (2003), 516–521], J. L. G. Guirao and J. Chudziak partially solved the problem in the class of skew-product maps with base map having closed set of periodic points. The present paper has two aims for this class of maps, on one hand to improve that solution showing the equivalence between the property “to have zero topological entropy” and the fact “not to be Li-Yorke chaotic in the union of the ω-limit sets of recurrent points”. On other hand, we show that the properties “to have closed set of periodic points” and “all nonwandering points are periodic” are not mutually equivalent properties, for doing this we disprove a result from Efremova of 1990

Plataforma de entrenamiento para PIC

Parte importante de la formación de un ingeniero en electrónica es el diseño de sistemas basados en microprocesadores. Es por eso que se diseñó una plataforma para facilitar el aprendizaje de este tema, más específicamente microprocesadores de la tecnología PIC. Este documento describe los criterios de diseño de una tarjeta (PCB) de desarrollo, llamada «PIC Experimenta». El propósito es que los alumnos de cursos relacionados con los sistemas digitales cuenten en una tarjeta con todos los elementos necesarios para realizar diversas prácticas y que de esta manera les resulte más fáciltanto el aprendizaje de la programación de microcontroladores, así como el desarrollo de aplicaciones basadas en éstos.Palabra(s) Clave(s): microcontroladores PIC, sistemas de desarrollo didáctico

Automation of an atomic force microscope via Arduino

The Dimension 3000 AFM used in this work was kindly donated by Prof. Nicholas D. Spencer, and facilitated by Prof. Lucio Isa, and Dr. Shivaprakash N. Ramakrishna, from ETH-Zurich. We thank Prof. David Cuartielles for encouraging us to publish this work in this special issue on Arduino Science Hardware. We also thank Llorenc Mercadal Fernandez for frutiful discussions and ideas, and the BiblioMaker unit in the Faculty of Sciences of the University of Granada for their help in 3D printing the gears used here. MAFR acknowledges support by the project PID2020-116615RA-I00 funded by MCIN/AEI/10.13039/501100011033, and the EMERGIA grant with reference EMC21_00008 funded by Consejeria de Universidad, Investigacion e Innovacion de la Junta de Andalucia, and by FEDER "ERDF A way of making Europe". JGGF and CLMM acknowledge support from grant A1S35536 by Conacyt Mexico.The Atomic Force Microscopy is a very versatile technique that allows to characterize surfaces by acquiring topographies with sub-nanometer resolution. This technique often overcomes the problems and capabilities of electron microscopy when characterizing few nanometers thin coatings over solid substrates. They are expensive, in the half million dollar range for standard units, and therefore it is often difficult to upgrade to new units with improved characteristics. One of these improvements, motorization and automation of the measurements is very interesting to sample different parts of a substrate in an unattended way. Here we report a low cost upgrade under 60 $ to a Dimension 3000 AFM based on a control unit using an Arduino Leonardo. It enables to acquire dozens or hundreds of images automatically by mimicking keyboard shortcuts and interfacing the AFM PCI card.MCIN/AEI PID2020-116615RA-I00Consejeria de Universidad, Investigacion e Innovacion de la Junta de Andalucia EMC21_00008Marie Curie ActionsConsejo Nacional de Ciencia y Tecnologia (CONACyT) A1S3553

TRIMÁLAGA

[ES] La siguiente comunicación pretende hacer la presentación del proyecto TRIMÁLAGA en el contexto del presente Congreso Internacional de Arqueología e Informática Gráfica, Patrimonio e Innovación. Creemos que es el foro ideal para dar a conocer nuestro trabajo. Básicamente con el proyecto TRIMÁLAGA se pretende hacer una maqueta virtual, un modelo tridimensional de la Málaga de finales del siglo XVIII (haciendo uso de las nuevas tecnologías informáticas que nos brinda el s. XXI) tomando como referencia el plano de 1791 de D. Joseph Carrión de Mula.[EN] The following communication tries to do the presentation of the project TRIMÁLAGA in the context of the present International Congress of Archaeology and Graphical Computer science, Heritage and Innovation. We believe that it is the ideal forum to announce our work. Basically with the project TRIMÁLAGA one tries to do a virtual model, a three-dimensional model of the Malaga of ends of the 18th century (using the new IT technologies that it offers to us s. The XXIst) taking as a reference the plane of 1791 of D. Joseph Carrión de Mula.Guerrero-Strachan Carrillo, J.; Contreras López, MÁ. (2012). TRIMÁLAGA. Virtual Archaeology Review. 3(5):121-125. https://doi.org/10.4995/var.2012.4540OJS12112535AYALA ÁLVAREZ, Francisco Javier (1992): Análisis sobre la evolución de la arquitectura de Málaga en los siglos XVIII y XIX, Colegio Oficial de aparejadores y arquitectos técnicos de Málaga.BARBÁN DE CASTRO, F. y MEDINA CONDE, C. (2000): Descripción de Málaga. Universidad de Málaga. (342)BEJARANO ROBLES, Francisco (2000): Las calles de Málaga. Ed. Sarria.CABRERA PABLOS, Francisco; OLMEDO CHECA, Manuel (2006): Málaga a finales del siglo XVIII, Real Academia de Bellas Artes de San Telmo.CAMACHO MARTÍNEZ, Rosario (1981): "Málaga Barroca. Arquitectura religiosa de los s. XVII y XVIII", Málaga, Universidad, 1980, pp. 234-237.OLMEDO CHECA, Manuel (1997): "José Carrión de Mula", en Revista Péndulo XVI, Málaga, Colegio Oficial de ingenieros técnicos industriales, s.a., pp. 196-210.PORTILLO FRANQUELO, Pedro (1983): "Presentación de los Planos de la ciudad y puerto de Málaga de Joseph Carrión de Mula y de Onofre Rodríguez", Málaga.REINA MENDOZA, José Manuel (1982): La vivienda en la Málaga de la segunda mitad del siglo XVIII, Biblioteca popular malagueña, D.L.RODRÍGUEZ MARÍN, Francisco José (2000): Málaga Conventual. Estudio histórico, artístico y urbanístico de los conventos malagueños, Ed. Argaval.TEMBOURY ÁLVAREZ, Juan, Colección fotográfica disponible en el Archivo Provincial de Málaga

Nutrition Therapy in Critically Ill Patients with Liver Disease: A Narrative Review

Nutrition therapy in critically ill patients with liver disease represents a challenge for Intensive Care Units (ICUs). Nutritional status is correlated with the degree of hepatic dysfunction and the presence of malnutrition worsens outcomes in these patients. The nutritional risk that critically ill patients represent, together with the pathophysiological alterations of liver disease, especially in terms of nutrition intake and protein depletion, leads to malnutrition and sarcopenia. Nutrition therapy improves the survival of these patients; however, this is challenging since they more frequently experience difficulties with nutrition delivery. In consequence, both evaluation of nutritional status and an individualized approach seem mandatory for achieving nutrition objectives. The present narrative review discusses the importance of nutrition therapy, the recommendations of contemporary clinical practice guidelines, and a practical approach to provide the best possible nutrition therapy in patients with liver disease admitted to ICUs

Cost-effectiveness analysis of using innovative therapies for the management of moderate-to-severe ulcerative colitis in Spain

Background: To evaluate the cost-effectiveness of tofacitinib in comparison to vedolizumab for the treatment of moderate-to-severe ulcerative colitis (UC) after failure or intolerance to conventional therapy (bio-naive) or first-line biologic treatment (bio-experienced), from the Spanish National Health System (NHS) perspective. Methods: A lifetime Markov model with eight-week cycles was developed including five health states: remission, response, active UC, remission after surgery, and death. Response and remission probabilities (for induction and maintenance periods) were obtained from a multinomial network meta-analysis. Drug acquisition – biosimilar prices included – (ex-factory price with mandatory deductions), adminis- tration, surgery, patient management, and adverse event management costs (€, year 2019) were considered. A 3% discount rate (cost/outcomes) was applied. Probabilistic and deterministic sensitivity analyses (PSA) were conducted. Results: Tofacitinib was dominant versus vedolizumab (both in bio-naive and bio-experienced patients) entailing total cost savings of €23,816 (bio-naïve) and €11,438 (bio-experienced). Differences in quality- adjusted life-year (QALY) were smaller than 0.1 for both populations. PSA results showed that tofacitinib has a high probability of being cost-effective (bio-naïve: 82.5%; bio-experienced: 90.6%) versus vedolizumab. Conclusions: From the Spanish NHS perspective, tofacitinib could be a dominant treatment (less costly and more effective) in comparison to vedolizumab, with relevant cost savings and similar QALY gains

Guided Weekly Reflection Papers

The experience gained by our team of educational innovation with the implementation of the “Weekly Reflection Papers” has led us to diversify and make more flexible the employed methodology. The modified tool, applied during the academic year 2010-2011, was called “Guided Weekly Reflection Papers”. The aim of this modification has been the development of certain abilities and skills of the students, with particular emphasis on their ability to integrate, review and apply knowledge in a critical and reflective way. The professors guide the student´s work through a series of questions on which the students must apply the most significant concepts studied each week, to prove the acquisition of such aptitudes and skills

Guided Weekly Reflection Papers

The experience gained by our team of educational innovation with the implementation of the “Weekly Reflection Papers” has led us to diversify and make more flexible the employed methodology. The modified tool, applied during the academic year 2010-2011, was called “Guided Weekly Reflection Papers”. The aim of this modification has been the development of certain abilities and skills of the students, with particular emphasis on their ability to integrate, review and apply knowledge in a critical and reflective way. The professors guide the student´s work through a series of questions on which the students must apply the most significant concepts studied each week, to prove the acquisition of such aptitudes and skills

Inclusion of non-inferiority analysis in superiority-based clinical trials with single-arm, two-stage Simon's design

Non-inferiority (NI) analysis is not usually considered in the early phases of clinical development. In some negative phase II trials, a post-hoc NI analysis justified additional phase III trials that were successful. However, the risk of false positive achievements was not controlled in these early phase analyses. We propose to preplan NI analyses in superiority-based Simon's two-stage designs to control type I and II error rates. Simulations have been proposed to assess the control of type I and II errors rates with this method. A total of 12,768 two-stage Simon's design trials were constructed based on different assumptions of rejection response probability, desired response probability, type I and II errors, and NI margins. P-value and type II error were calculated with stochastic ordering using Uniformly Minimum Variance Unbiased Estimator. Type I and II errors were simulated using the Monte Carlo method. The agreement between calculated and simulated values was analyzed with Bland-Altman plots. We observed the same level of agreement between calculated and simulated type I and II errors from both two-stage Simon's superiority designs and designs in which NI analysis was allowed. Different examples has been proposed to explain the utility of this method. Inclusion of NI analysis in superiority-based single-arm clinical trials may be useful for weighing additional factors such as safety, pharmacokinetics, pharmacodynamic, and biomarker data while assessing early efficacy. Implementation of this strategy can be achieved through simple adaptations to existing designs for one-arm phase II clinical trials

Rice and bean AHL-mimic quorum-sensing signals specifically interfere with the capacity to form biofilms by plant-associated bacteria

Many bacteria regulate their gene expression in response to changes in their population density in a process called quorum sensing (QS), which involves communication between cells mediated by small diffusible signal molecules termed autoinducers. n-acyl-homoserine-lactones (AHLs) are the most common autoinducers in proteobacteria. QS-regulated genes are involved in complex interactions between bacteria of the same or different species and even with some eukaryotic organisms. Eukaryotes, including plants, can interfere with bacterial QS systems by synthesizing molecules that interfere with bacterial QS systems. In this work, the presence of AHL-mimic QS molecules in diverse Oryza sativa (rice) and Phaseolus vulgaris (bean) plant-samples were detected employing three biosensor strains. A more intensive analysis using biosensors carrying the lactonase enzyme showed that bean and rice seed-extract contain molecules that lack the typical lactone ring of AHLs. Interestingly, these molecules specifically alter the QS-regulated biofilm formation of two plant-associated bacteria, Sinorhizobium fredii SMH12 and Pantoea ananatis AMG501, suggesting that plants are able to enhance or to inhibit the bacterial QS systems depending on the bacterial strain. Further studies would contribute to a better understanding of plant–bacteria relationships at the molecular level