On the dynamics of a quadratic scalar field potential

We review the attractor properties of the simplest chaotic model of inflation, in which a minimally coupled scalar field is endowed with a quadratic scalar potential. The equations of motion in a flat Friedmann-Robertson-Walker universe are written as an autonomous system of equations, and the solutions of physical interest appear as critical points. This new formalism is then applied to the study of inflation dynamics, in which we can go beyond the known slow-roll formalism of inflation.Comment: 14 pages, 6 eps figures, matches version to appear in IJMP

Curvature effects on a simplified reaction-diffusion model of biodegradation

The biodegradation process of some types of polymers occurs due to many different factors including their morphology, structure and chemical composition. Although this is a complicated process, most of its important stages like the diffusion of monomers and the hydrolysis reactions have been modeled phenomenologically through reaction-diffusion equations, where the properties of the polymers were encompassed. Using a simplified reaction-diffusion model for the biodegradation of polymers, in this contribution we study the possible effects of the curvature of the system’s geometry in the degradation process, which is characterized by the interaction of the corresponding reaction rate and the diffusion coefficient. To illustrate the problem of diffusion on a curved surface we consider the surface of a cylinder and of the so-called Gaussian bump. We show how the degradation process is affected by the curvature of the system for the simplified model

High resistance against clindamycin, metronidazole and amoxicillin in Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans isolates of periodontal disease

Objectives: To test the antimicrobial sensitivity of two periodontal pathogens to a panel of five orally administrable antibiotics in periodontal disease. Study design: A total of 69 isolates of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were processed using culture and biochemical tests. Selected colonies of A. actinomycetemcomitans and P. gingivalis were used to evaluate the antibacterial activity of clindamycin, metronidazole, amoxicillin, moxifloxacin and amoxicillin/clavulanic acid. Results: Susceptibility testing revealed a sensitivity of 100% of A. actinomycetemcomitans and P. gingivalis to moxifloxacin and amoxicillin/clavulanic acid but moderate susceptibilities were found for the rest of antibiotics agents evaluated. Conclusions: The widespread use of antibiotics is reflected in the level of resistance of A. actinomycetemcomitans and P. gingivalis in patients with periodontal infections. This suggests that antibiotic susceptibility testing is necessary to determine efficacy of antimicrobial agents. Clinical studies with antibiotics should take these differences into account

Guía de asesoría a personas físicas. Despacho ITESO consultoría

Con base en la investigación realizada sobre la situación actual del país en materia de recaudación fiscal de personas físicas, se abordaron las principales características de estas y sus implicaciones fiscales, acompañado de su debido procedimiento para el cumplimiento correcto. Este proyecto tiene como finalidad ayudar a los contribuyentes obteniendo información de importancia para ellos, se incluyen los antecedentes acerca de los contribuyentes de este país. El proyecto pretender brindar un seguimiento para desarrollo de propuestas de mejora. El objetivo de la guía de asesoría implementada en el Despacho ITESO, es informar, apoyar y resolver cualquier duda al contribuyente de manera gratuita.ITESO, A.C

Producción científica Iberoamericana sobre TIC en el contexto educativo

ICT in the educational context can be seen as information transmitting resources that link the teacher and the student in the improvement of teaching-learning adapted to the needs and characteristics of each subject. From this perspective, we seek to describe the state of Iberoamerican scientific production on the inclusion of ICT in the educational discipline in the period 2010 to 2020, based on a retrospective descriptive analysis of publications collected in journals indexed in Scopus. A total of n=1976 contributions were collected. It was found that production increased by 8.51%. Spain is the Iberoamerican country that contributes with the highest scientific production, authors with Iberoamerican affiliation usually publish through conference articles, highlighting ACM International Conference Proceeding Series. In front of an analysis of maturity of knowledge we are facing a development of scientific production in process of growth.Las TIC en el contexto educativo pueden verse conocidos como recursos transmisores de información que vincula al docente y al estudiante en la mejora de la enseñanza - aprendizaje adaptado a las necesidades y características de cada sujeto. Desde esta perspectiva se busca describir el estado de la producción científica Iberoamericana sobre la inclusión de las TIC en la disciplina educativa en el periodo 2010 al 2020. El estudio se basa en el análisis descriptivo retrospectivo de publicaciones recopiladas en revistas indizadas en Scopus. Se recolectó un total de n=1976 contribuciones. Se encontró que la producción aumentó en un 8,51%. España es el país Iberoamericano que contribuye con mayor producción científica, los autores con afiliación Iberoamericana suelen publicar a través de Artículos de conferencia, destacando ACM International Conference Proceeding Series. Frente a un análisis de madurez de conocimiento estamos ante un desarrollo de producción científica en proceso de crecimiento

Producción científica Iberoamericana sobre TIC en el contexto educativo

ICT in the educational context can be seen as information transmitting resources that link the teacher and the student in the improvement of teaching-learning adapted to the needs and characteristics of each subject. From this perspective, we seek to describe the state of Iberoamerican scientific production on the inclusion of ICT in the educational discipline in the period 2010 to 2020, based on a retrospective descriptive analysis of publications collected in journals indexed in Scopus. A total of n=1976 contributions were collected. It was found that production increased by 8.51%. Spain is the Iberoamerican country that contributes with the highest scientific production, authors with Iberoamerican affiliation usually publish through conference articles, highlighting ACM International Conference Proceeding Series. In front of an analysis of maturity of knowledge we are facing a development of scientific production in process of growth.Las TIC en el contexto educativo pueden verse conocidos como recursos transmisores de información que vincula al docente y al estudiante en la mejora de la enseñanza - aprendizaje adaptado a las necesidades y características de cada sujeto. Desde esta perspectiva se busca describir el estado de la producción científica Iberoamericana sobre la inclusión de las TIC en la disciplina educativa en el periodo 2010 al 2020. El estudio se basa en el análisis descriptivo retrospectivo de publicaciones recopiladas en revistas indizadas en Scopus. Se recolectó un total de n=1976 contribuciones. Se encontró que la producción aumentó en un 8,51%. España es el país Iberoamericano que contribuye con mayor producción científica, los autores con afiliación Iberoamericana suelen publicar a través de Artículos de conferencia, destacando ACM International Conference Proceeding Series. Frente a un análisis de madurez de conocimiento estamos ante un desarrollo de producción científica en proceso de crecimiento

Producción científica Iberoamericana sobre TIC en el contexto educativo

ICT in the educational context can be seen as information transmitting resources that link the teacher and the student in the improvement of teaching-learning adapted to the needs and characteristics of each subject. From this perspective, we seek to describe the state of Iberoamerican scientific production on the inclusion of ICT in the educational discipline in the period 2010 to 2020, based on a retrospective descriptive analysis of publications collected in journals indexed in Scopus. A total of n=1976 contributions were collected. It was found that production increased by 8.51%. Spain is the Iberoamerican country that contributes with the highest scientific production, authors with Iberoamerican affiliation usually publish through conference articles, highlighting ACM International Conference Proceeding Series. In front of an analysis of maturity of knowledge we are facing a development of scientific production in process of growth.Las TIC en el contexto educativo pueden verse conocidos como recursos transmisores de información que vincula al docente y al estudiante en la mejora de la enseñanza - aprendizaje adaptado a las necesidades y características de cada sujeto. Desde esta perspectiva se busca describir el estado de la producción científica Iberoamericana sobre la inclusión de las TIC en la disciplina educativa en el periodo 2010 al 2020. El estudio se basa en el análisis descriptivo retrospectivo de publicaciones recopiladas en revistas indizadas en Scopus. Se recolectó un total de n=1976 contribuciones. Se encontró que la producción aumentó en un 8,51%. España es el país Iberoamericano que contribuye con mayor producción científica, los autores con afiliación Iberoamericana suelen publicar a través de Artículos de conferencia, destacando ACM International Conference Proceeding Series. Frente a un análisis de madurez de conocimiento estamos ante un desarrollo de producción científica en proceso de crecimiento

Regulatory Pathway for Licensing Biotherapeutics in Mexico

Biotherapeutic products which are derived from living organisms using recombinant DNA technology significantly contribute to the progress in the treatment of life-threatening and chronic diseases. The worldwide sale of biological drugs in 2016 was near US $263,700 million. In Latin America, where monoclonal antibodies market was worth US$7000 million, being Mexico the second largest market. Approval is one of the key aspects which influences the market of medicinal products, thus it is responsibility of the regulatory authority to establish a regulatory framework that ensure safety and efficacy of the products, and it is responsibility of the applicants to provide a high quality dossier in accordance with the registration requirements of the country. The applicants submitting registration requests in Mexico need to be aware of the requirements. Similar to many other countries, Mexico has adopted the Common Technical Document (CTD) structure for organizing dossier of the medicinal product for submission into main modules (i.e., quality, non-clinical, and clinical). This facilitates the submission process of medicinal products following a logical sequence aligned to the International Council on Harmonisation (ICH) guidelines. Moreover, this structure improves the transparency and clarity of the dossier in process of evaluation of medicinal products. In Mexico, the Ministry of Health has published a regulation, NOM-257-SSA1-2014, which established the general requirements to be followed by applicants to complete the registration of biotherapeutics. This regulation stipulates that the evaluation process is supported by a regulatory framework involving Good Manufacturing Practices, labeling, stability, clinical trials, biocomparability studies, pharmacovigilance, and a technical evaluation performed by a multidisciplinary team of experts in biotherapeutics development. Additionally, the Mexican regulatory agency, COFEPRIS, has published specific guidelines to facilitate the application process. Despite the availability of this information, the scope is limited to regulatory and administrative purposes, rather than technical-scientific supporting knowledge. The aim of this article is to provide concise information to improve and promote communication between industry and regulatory agencies. Herein, we describe the current process of COFEPRIS in regulating biotherapeutics in Mexico. This process explains the basis for the organization and structure of the technical-scientific information of biotherapeutics required for registration application

Salmonella Typhi Porins OmpC and OmpF Are Potent Adjuvants for T-Dependent and T-Independent Antigens

Several microbial components, such as bacterial DNA and flagellin, have been used as experimental vaccine adjuvants because of their inherent capacity to efficiently activate innate immune responses. Likewise, our previous work has shown that the major Salmonella Typhi (S. Typhi) outer membrane proteins OmpC and OmpF (porins) are highly immunogenic protective antigens that efficiently stimulate innate and adaptive immune responses in the absence of exogenous adjuvants. Moreover, S. Typhi porins induce the expression of costimulatory molecules on antigen-presenting cells through toll-like receptor canonical signaling pathways. However, the potential of major S. Typhi porins to be used as vaccine adjuvants remains unknown. Here, we evaluated the adjuvant properties of S. Typhi porins against a range of experimental and clinically relevant antigens. Co-immunization of S. Typhi porins with ovalbumin (OVA), an otherwise poorly immunogenic antigen, enhanced anti-OVA IgG titers, antibody class switching, and affinity maturation. This adjuvant effect was dependent on CD4+ T-cell cooperation and was associated with an increase in IFN-γ, IL-17A, and IL-2 production by OVA-specific CD4+ T cells. Furthermore, co-immunization of S. Typhi porins with an inactivated H1N1 2009 pandemic influenza virus experimental vaccine elicited higher hemagglutinating anti-influenza IgG titers, antibody class switching, and affinity maturation. Unexpectedly, co-administration of S. Typhi porins with purified, unconjugated Vi capsular polysaccharide vaccine (Vi CPS)—a T-independent antigen—induced higher IgG antibody titers and class switching. Together, our results suggest that S. Typhi porins OmpC and OmpF are versatile vaccine adjuvants, which could be used to enhance T-cell immune responses toward a Th1/Th17 profile, while improving antibody responses to otherwise poorly immunogenic T-dependent and T-independent antigens