9 research outputs found
Modelling of Mass Transfer Resistances in Non-uniformly Washcoated Monolith Reactors
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
There are various methodologies to account for mass transfer within non-uniformly distributed washcoats in monolith reactors in 1D models (axially). However, 1+1D models (axially/radially) fail to capture local variations in mass transfer from different coating thicknesses or cracks. In this paper, we present a novel way to account for local material properties in a washcoated monolith reactor. The suggested method uses an existing 1+1D modelling framework and sectionalizes the washcoat into multiple tangential segments which are solved independently. Intelligent gravimetric analysis and scanning electron microscopy are used in combination to calculate local effective diffusivity as an input for each simulation. The new model is compared to the original 1+1D model using NO light-off simulations. The new model predicted increased conversion at elevated temperatures, where mass transfer limitations are present, due to the higher porosity in the corners. The simulation time for each model was similar due to the parallelizable nature of the new model
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
- Author
- A'hern R
- A\u2019hern R
- Abe O
- Abe R
- Abu\u2010zahra Ht
- Af Trampe E
- Aft R
- Ahlgren J
- Ahn Jh
- Aihara T
- Albain K
- Albano J
- Alberro Ja
- Amadori D
- Anderson H
- Anderson S
- Andr\ue9 F
- Arnesson Lg
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Barlow W
- Barrett\u2010lee Pj
- Bartelink H
- Bartlett J
- Bartsch R
- Bass G
- Bastert G
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Bengtsson No
- Benraadt J
- Bergh J
- Bergsten\u2010nordstr\uf6m E
- Berry D
- Bighin C
- Bijker N
- Bishop H
- Blamey Rw
- Bliss J
- Bliss Jm
- Blohmer Ju
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesson T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell Vh
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brockschmidt J
- Brookes C
- Brown A
- Browne L
- Brufsky Am
- Bruzzi P
- Bryant Ajs
- Bryant J
- Bundred Nj
- Burrett Ja
- Buyse M
- Buzdar Au
- Caffier H.
- Calais G
- Camerini T
- Cameron D
- Camisa R
- Camphausen K
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter Jt
- Carrasco E
- Carstensen J
- Castiglione M
- Celebioglu F
- Chen Be
- Chen Zm
- Chetty U
- Chilvers Ced
- Chlebowski Rt
- Christiaens R
- Christiansen P
- Cirrincione C
- Clack G
- Clarke M
- Coates A
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- Dalesio O
- Danforth D
- Davidson N
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- Davis Hl
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- De La Lande B
- De Lafontan B
- De Laurentiis M
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- De Pablo Jl
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- De Schryver A
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- Del Mastro L
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- Delmestri A
- Delozier T
- Dent Dm
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- Deulofeu P
- Deutsch Gp
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- Math\ue9 G
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- Mlineritsch B
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- Monypenny Ij
- Moral A
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- Mouridsen H
- Mouridsen Ht
- Mukai H
- Murray E
- Murray N
- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen\u2010meyer R
- Nitz U
- Nogaret Jm
- Nomura Y
- Nordenskj\uf6ld B
- Norton L
- Notter G
- Oates Gd
- Ogawa M
- Ohashi Y
- Ohno S
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- Owen Jr
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- Paik S
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- Palshof T
- Paltuev R
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- Thomssen C
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- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment
Novel PCR-based diagnostic tools for Charcot-Marie-Tooth type 1A and hereditary neuropathy with liability to pressure palsies
- Author
- Publication venue
- Publication date
- 01/01/1999
- Field of study
Charcot-Marie-Tooth disease: a clinico-genetic confrontation
- Author
- Publication venue
- Publication date
- 01/01/2008
- Field of study
Charcot-Marie-Tooth disease with giant axons: a clinicopathological and genetic entity
- Author
- Publication venue
- Publication date
- 01/01/2003
- Field of study
The authors report an Italian family with autosomal-dominant Charcot-Marie-Tooth disease (CMT) in which there were giant axons in the sural nerve biopsy. Linkage to the known CMT2 loci (CMT2A, CMT2B, CMT2D, CMT2F) and mutations in the known CMT2 genes (Cx32, MPZ, NEFL), GAN, NEFM, and CMT1A duplication/HNPP deletion were excluded. This family with CMT and giant axons has a pathologic and genetic entity distinct from classic CMT
Spastin gene mutations in Bulgarian patients with hereditary spastic paraplegia
- Author
- Publication venue
- Publication date
- 01/01/2006
- Field of study
Outcomes from elective colorectal cancer surgery during the SARS‐CoV‐2 pandemic
- Author
- 6\u11f\ufcc\ufc H
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- Capelli P
- Capezzuoli L
- Capitan\u2010Morales L
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- Cardoso N
- Cardoso P
- Carrano FM
- Carrasco Prats M
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- Castro Ruiz C
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- Choynowski M
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- Cocozza E
- Coffey JC
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- Colombo F
- Confalonieri M
- Connelly TM
- Conti L
- Conti L
- Contis I
- Corbellini C
- Corless K
- Correa Bonito A
- Correia de S\ue1 T
- Correia AM
- Corrigan M
- Cort\ue9s Guiral D
- Corte Real J
- Cosimelli M
- Costa Santos D
- Costa M
- Costa MJMA
- Costanzi A
- Costeira B
- Costigan F
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- Cox Daniel
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- Publication venue
- 'Wiley'
- Publication date
- 01/01/2020
- Field of study
Aim
This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic.
Method
This was an international cohort study of patients undergoing elective resection of colon or rectal cancer without preoperative suspicion of SARS-CoV-2. Centres entered data from their first recorded case of COVID-19 until 19 April 2020. The primary outcome was 30-day mortality. Secondary outcomes included anastomotic leak, postoperative SARS-CoV-2 and a comparison with prepandemic European Society of Coloproctology cohort data.
Results
From 2073 patients in 40 countries, 1.3% (27/2073) had a defunctioning stoma and 3.0% (63/2073) had an end stoma instead of an anastomosis only. Thirty-day mortality was 1.8% (38/2073), the incidence of postoperative SARS-CoV-2 was 3.8% (78/2073) and the anastomotic leak rate was 4.9% (86/1738). Mortality was lowest in patients without a leak or SARS-CoV-2 (14/1601, 0.9%) and highest in patients with both a leak and SARS-CoV-2 (5/13, 38.5%). Mortality was independently associated with anastomotic leak (adjusted odds ratio 6.01, 95% confidence interval 2.58–14.06), postoperative SARS-CoV-2 (16.90, 7.86–36.38), male sex (2.46, 1.01–5.93), age >70 years (2.87, 1.32–6.20) and advanced cancer stage (3.43, 1.16–10.21). Compared with prepandemic data, there were fewer anastomotic leaks (4.9% versus 7.7%) and an overall shorter length of stay (6 versus 7 days) but higher mortality (1.7% versus 1.1%).
Conclusion
Surgeons need to further mitigate against both SARS-CoV-2 and anastomotic leak when offering surgery during current and future COVID-19 waves based on patient, operative and organizational risks
Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials
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- 'Elsevier BV'
- Publication date
- 01/01/2014
- Field of study
Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials.
- Author
- A'Hern R
- A'Hern R
- Abe O
- Abe O
- Abe R
- Abu-Zahra Ht
- Adolfsson J
- af Trampe E
- Ahlgren J
- Albain K
- Albain K
- Albano J
- Altemus R
- Amadori D
- Anderson A
- Anderson H
- Anderson S
- Aogi K
- Arnesson Lg
- Arriagada R
- Arriagada R
- Arriagada R.
- Ashley S
- Asmar L
- Asselain B
- Bahi J
- Barlow W
- Barlow W
- Barrett-Lee Pj
- Bartelink H
- Bartsch R
- Bass G
- Bastert G
- Bastiaannet E
- Bates T
- Baum M
- Baum M
- Belfiglio M
- Bengtsson No
- Benraadt J
- Bergh J
- Bergh J
- Berry D
- Bijker N
- Bishop H
- Blamey Rw
- Blamey Rw
- Bliss J
- Bliss J
- Bliss Jm
- Blohmer Ju
- Boccardo F
- Bogaerts J
- Bonadonna G
- Bondesson T
- Bonneterre J
- Borovik R
- Bourgier C
- Bowden S
- Braun S
- Brenner H
- Broadwater G
- Brockschmidt J
- Broglio K
- Brookes C
- Brown A
- Browne L
- Bruzzi P
- Bryant Aj
- Bryant J
- Bundred Nj
- Burrett Ja
- Buyse M
- Buyse M
- Buzdar Au
- Caffier H
- Calais G
- Camerini T
- Cameron D
- Cameron D
- Camisa R
- Camphausen K
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter Jt
- Carrasco E
- Carrasco E
- Carstensen B
- Carstensen J
- Castiglione M
- Castiglione M
- Celebioglu F
- Chapman Ja
- Chen Zm
- Chetty U
- Chetty U
- Chilvers Ce
- Chlebowski Rt
- Christiaens R
- Christiansen P
- Cirrincione C
- Clarke M
- Clarke M
- Clarke M.
- Coates A
- Coates A
- Cocconi G
- Cocconi G
- Colleoni M
- Collett V
- Collins J
- Collins R
- Collins R
- Colozza A
- Comis Rl
- Coombes Rc
- Cooper Mr
- Corcoran N
- Correa C
- Correa C
- Correa C.
- Costa A
- Costa Sd
- Costantino J
- Costantino J
- Cowan K
- Crossley E
- Crowley J
- Cufer T
- Cunningham Mp
- Cutter D
- Cutter D
- Cutter D.
- Cuzick J
- Cuzick J
- Cuzick J
- D'Amico C
- Dafni D
- Dafni U
- Dahlberg K
- Dalesio O
- Danforth D
- Darby S
- Darby S
- Darby S.
- Davidson N
- Davidson Ne
- Davies C
- Davies C
- Davies C
- Davies C.
- Davies K
- Davies K
- Davis Hl
- de la Huerta R
- de Lafontan B
- De Laurentiis M
- de Oliveira Cf
- De Palo G
- De Placido S
- de Schryver A
- de Vries Eg
- Del Mastro L
- Del Mastro L
- Delmestri A
- Delmestri A
- Delmestri A
- Delozier T
- Dent Dm
- Deshpande N
- Deutsch Gp
- di Blasio B
- Di Leo A
- Di Leo A
- di Martino L
- Di Mauro Mg
- Di Palma M
- Dignam J
- Dixon Jm
- Dolci S
- Douglas P
- Dowsett M
- Dowsett M
- Dubois Jb
- Dubsky P
- Dufmats M
- Dunn J
- Durand M
- EARLY BREAST CANCER TRIALISTS' COLLABORATIVE GROUP (EBCTCG)
- Eidtmann H
- Eiermann W
- Ejlertsen B
- Ellis Io
- Ellis Io
- Ellis P
- Elphinstone P
- Elphinstone P
- Emdin S
- Enomoto K
- Erazo A
- Erikstein B
- Erikstein B
- Evans V
- Evans V
- Ewertz M
- Ewertz M
- Ewertz M.
- Ewing Gh
- Falkson Ci
- Fargeot P
- Fentiman Is
- Fentiman Is
- Fernando I
- Fesl C
- Firth La
- Fisher B
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes Jf
- Forbes Jf
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Forsyth S
- Foster L
- Fountzilas G
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- G\uf6ransson E
- Gallen M
- Galligioni E
- Garmo H
- Gazet Jc
- Gelber R
- Gelber Rd
- Gelman Rs
- Gelmon K
- George Wd
- George Wd
- Geraud P
- Gerber G
- Gerv\ue1sio H
- Gettins L
- Gettins L
- Geyer C
- Geyer C
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Godwin J
- Godwin J.
- Goldhirsch A
- Goldhirsch A
- Goldhirsch A
- Goldstein Lj
- Gordilho J
- Gordon Nh
- Goss Pe
- Graham P
- Gralow J
- Gray R
- Gray R
- Gray R
- Gray R
- Gray R.
- Green S
- Gregory C
- Gregory C
- Greil R
- Griffon B
- Gudgeon Ca
- Gundersen S
- H\uf8st H
- H\uf8st H
- Hacking A
- Hacking A
- Hackshaw A
- Hakama M
- Hakes T
- Hall E
- Hannisdal E
- Harbeck N
- Harbeck N
- Harris A
- Harris Jr
- Harvey Vj
- Hauer-Jensen M
- Hayat H
- Haybittle Jl
- Hayes D
- Hayes D
- Hayes D
- Hayes D
- Hayward Jl
- Henderson C
- Hercbergs A
- Hermans D
- Hicks C
- Hilfrich J
- Hill C
- Hill C
- Holdaway Im
- Holli K
- Holmberg L
- Horiguchi J
- Hortobagyi G
- Houghton J
- Howell A
- Hudis Ca
- Huovinen R
- Hupperets Ps
- Iiristo M
- Ikeda T
- Inbar Mj
- Ingle J
- Ingle Jn
- Inokuchi K
- Isola J
- Ivanov V
- J\ue4nicke F
- Jack W
- Jackisch C
- Jackson Im
- Jacobsen Ab
- Jacobsen Ab
- Jakesz R
- Jakesz R
- James S
- James S
- Janauer M
- Janni W
- Jensen Mb
- Joensuu H
- Johansen H
- Johansson U
- Jonat W
- Jones Se
- Jonsson H
- Julien Jp
- Karlsson P
- Kaufmann M
- Kaufmann M
- Kaufmann M
- Kay Rg
- Kerbrat P
- Kerr A
- Kerr A
- Kikuchi K
- Kikuchi K
- Kilburn L
- Killander F
- Kissin M
- Klefstrom P
- Klijn Jg
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscielny S
- Koyama H
- Kreienberg R
- Krushen-Kosloski Jl
- Kunkler I
- Kwong Dl
- L\uea Mg
- L\uf6fgren L
- Lang A
- Laplanche A
- Larsimont D
- Lay M
- Ledermann J
- Lee M
- Lehingue Y
- Lenner E
- Leonard Cf
- Levine M
- Levine Mn
- Lichter A
- Liedtke C
- Liljegren G
- Linderholm Bk
- Lindman H
- Lindsay Ma
- Lindtner A
- Lindtner J
- Lioce M
- Lippman M
- Lissaios B
- Litton A
- Livingston R
- Loibl S
- Lopez M
- Love Rr
- Luporsi E
- Luschin-Ebengreuth G
- Lythgoe Jp
- M\uf8ller S
- Mace Lesec'h J
- Mackey J
- Mackinnon E
- Mackinnon E
- Maibach R
- Makris A
- Mallon E
- Malmstr\uf6m P
- Mamounas Ep
- Mansel Re
- Margreiter R
- Markopoulos C
- Marth C
- Martin Al
- Martin Al
- Martin M
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason Bh
- Masood Mb
- Masuda H
- Math\ue9 G
- Mauriac L
- Mavroudis D
- Mcardle Cs
- Mcgale P
- Mcgale P
- Mcgale P.
- Mchugh T
- Mchugh T
- Meakin Jw
- Medina Jy
- Meier P
- Meisner C
- Meyer R
- Mihura J
- Misset Jl
- Mitchell Ak
- Mlineritsch B
- Monson K
- Monypenny Ij
- Morgan Da
- Morgan Da
- Morimoto K
- Mouridsen Ht
- Mouridsen Ht
- Murray E
- Murray N
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nicolucci A
- Nikolaidis P
- Nissen-Meyer R
- Nissen-Meyer R
- Nitz U
- Nogaret Jm
- Nomura Y
- Nomura Y
- Nordenskj\uf6ld B
- Norton L
- Norton L
- Norton L
- Notter G
- O'Shaughnessy J
- Oates Gd
- Ogawa M
- Ohashi Y
- Ohashi Y
- Ohno S
- Olivotto I
- Osborne Ck
- Owen Jr
- Pai Vr
- Paik S
- Paik S
- Palmer Mk
- Palshof T
- Paltuev R
- Pan Hc
- Pan Hc
- Panieri E
- Pannuti F
- Panzarella T
- Paradiso A
- Paridaens R
- Parker D
- Parulekar W
- Passalacqua R
- Pater Jl
- Paterson Ah
- Patnick J
- Peek U
- Pellegrini F
- Perbeck L
- Perez E
- Perez E
- Peto R
- Peto R
- Peto R.
- Petruzelka
- Philippson C
- Piccart M
- Piccart Mj
- Pierce L
- Pierce L.
- Pierce Lj
- Pierce Lj
- Pinder S
- Pinder Se
- Pirozzoli Mc
- Poole C
- Portnoj Sm
- Possinger K
- Powell J
- Powles Tj
- Pribylova O
- Price Jj
- Price Kn
- Pritchard K
- Pritchard Ki
- Pritchard Ki
- Pritchard Ki
- Pritchard Ki
- Pronzato P
- Pruneri G
- Ragaz J
- Raina V
- Rambert P
- Rauschecker H
- Ravdin P
- Rea D
- Redmond C
- Regan Mm
- Reid M
- Robert N
- Robertson J
- Robertson Jf
- Robinson E
- Roch\ue9 H
- Roch\ue9 H
- Roch\ue9 H
- Rodenhuis S
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle Gt
- Rubagotti A
- Rubens Rd
- Rudenstam Cm
- Rutgers E
- Rutgers E
- Ryd\ue9n L
- S\uf6derberg M
- Saaristo R
- Saarto T
- Sacco M
- Sainz Mg
- Sakai K
- Salmon Rj
- Samonigg H
- Sandelin K
- Sauer R
- Sauerbrei W
- Sawa K
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- Sayer J
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- Schauer A
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Schumacher M
- Segui Ma
- Seifert M
- Semiglazov V
- Senanayake F
- Senn Hj
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- Sertoli Mr
- Sestak I
- Sevelda P
- Shan Y
- Shao Yf
- Shao Yf
- Shapiro Cl
- Shepherd Le
- Simmonds Pd
- Singer Cf
- Skilton D
- Skolyszewski J
- Skoog L
- Sledge G
- Smith Dc
- Smith Ie
- Sohn Hc
- Solin Lj
- Sonoo H
- Sparano Ja
- Spielmann M
- Spittle M
- Spooner D
- St\uf6ger H
- Stallard S
- Steger Gg
- Steinberg S
- Stewart Hj
- Stroner P
- Sugimachi K
- Suman Vj
- Svane G
- Swain S
- Swain S
- Swindell R
- Swindell R
- Takashima S
- Takatsuka Y
- Takei H
- Talbot D
- Taylor C
- Taylor C
- Taylor C.
- Taylor M
- Th\ufcrlimann B
- Thomssen C
- Thuerlimann B
- Tinterri C
- Tobias Js
- Toi M
- Tominaga T
- Tormey Dc
- Trampisch Hj
- Treurniet-Donker Ad
- Tu D
- Uchino J
- Ueo H
- Untch M
- Untch M
- Vakaet L
- Valagussa P
- Valagussa P
- Valagussa P
- Valentini M
- van de Velde Ao
- van de Velde Cj
- van de Velde Cj
- van de Water W
- Van den Bogaert W
- van Dongen Ja
- van Nes Jg
- van Putten Wl
- van Tinteren H
- Varhaug Je
- Venturini M
- Venturini M
- Venzon D
- Vermorken Jb
- Veronesi U
- Viale G
- Viale G
- Vilcoq Jr
- von Minckwitz G
- W\ue4rnberg F
- Wadstr\uf6m C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Y
- Wang Y.
- Weiss Rb
- Werner Id
- Whelan T
- Whelan T
- Whelan T
- Whelan T.
- Wickerham L
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- Williams L
- Winer E
- Winer E
- Wittes R
- Wolmark N
- Wood W
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- Yamashita J
- Yarnold Jr
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- Yosef Hm
- Yoshida M
- Yoshimoto M
- Zhao Db
- Zielinski Cc
- Zujewski Ja
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2011
- Field of study
After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.Journal ArticleMeta-AnalysisResearch Support, Non-U.S. Gov'tReviewinfo:eu-repo/semantics/publishe