Zur Geschichte der russischen Kantforschung. Die philosophische Schule der ersten Hälfte des XIX. Jahrhunderts zu Charkov

The article “From the Russian studying of Kant’s philosophy. Kharkov’s philosophical school of the first part of the XIX century” is devoted to the studying of Kant’s philosophy in the Kharkov’s University at the first decades of XIX century. The importance of Kant’s philosophy in the professional philosophical sphere and influence on the development of motherland philosophical thought has been examine

Analysis of involvement of nanoparticles fullerene C60 in regulation innate and adaptive immune reactions

Background: Nanoparticles fullerene C60 (FC60) have offered new hope for detection, prevention, and treatment in modern medicine due to their key properties, small size, enhanced permeability, surface modification and retention effects. However, the effects of nanoparticle properties on the immune system are still being explored. The main purpose of this investigation was to assess the influence of FCl on functional activity of the phagocytic cells in vitro, production of hemagglutinins, hemolysins and level activity of complement during the primary immune response in vivo. Materials and methods: Peripheral blood (PB) from 10 healthy donors was obtained. FC60 was added at 0,01 and 0,1 pM/1 to PB and incubated for 10 min at 37°C. Level of phagocytosis, Nitroblue Tetrazolium (NBT)-test, level of myeloperoxidase activity, zimozan-induced chemiluminescence was assayed. Peripheral blood mononuclear cells were incubated with PE-conjugated mAb to CD54 and analyzed by flow cytometry. Balb/c mice were immunized by 2% suspensions of ram red blood cells for induction of the primary immune response. Mice were treated i.p. with 50 ng of FC6I| during 1, 3 and 6 days after induction of the primary immune response. Titre of hemagglutinins was determined by reaction of hemagglutination, litre of hemolysins - by reaction of immune lysis, activity of complement - by immune hemolysis. Results: The results demonstrated that FC60 did not affect the phagocytic activity of neutrophils at any doses. FC significantly decreased level of myeloperoxiase activity in neutrophils in doses 0,01 and 0,1 pM/1. FCf significantly increased the indices of the NBT-test in neutrophils in dose 0,01 pM/1. Addition of FC6 to peripheral blood suppressed zimozan-induced chemiluminescence in doses 0,01 and 0,1 pM/1. Moreover, FCf strongly reduced level of expression CD54 on lymphocytes and monocytes in doses 0,01 and 0,1 pM/1, but did not effect on neutrophils. The study revealed that FC( induced the production of hemagglutinins and hemolysins, especially in initial and maximum phase of the generation antibodies during induction of the primary immune response. Additionally, FC60 induced the complement system activation and enlarged its activity after induction of the primary immune response. Conclusion: The studies showed that FCtn can influence on immune reactions via different mechanisms. FC6|| negatively alter phagocytic activity of immune cells in vitro, but it positively influence on production of hemagglutinins and hemolysins, level activity of complement during the primary immune response in Balb/c mice in vivo. Thus, FC60 provides a potential perspective medical application because it can display immunomodulatory properties which are directed on the innate (phagocytosis and complement system) and adaptive mechanisms (production antibodies) of immune system

Physical methods for preparing oil-field waste water for use within system for maintaining reservoir pressure

Available from VNTIC / VNTIC - Scientific & Technical Information Centre of RussiaSIGLERURussian Federatio

A QSAR Toxicity Study of a Series of Alkaloids with the Lycoctonine Skeleton

A QSAR toxicity analysis has been performed for a series of 19 alkaloids with the lycoctonine skeleton. GA-MLRA (Genetic Algorithm combined with Multiple Linear Regression Analysis) technique was applied for the generation of two types of QSARs: first, models containing exclusively 3D-descriptors and second, models consisting of physicochemical descriptors. As expected, 3D-descriptor QSARs have better statistical fits. Physicochemical-descriptor containing models, that are in a good agreement with the mode of toxic action exerted by the alkaloids studied, have also been identified and discussed. In particular, TPSA (Topological Polar Surface Area) and nC=O (number of –C(O)– fragments) parameters give the best statistically significant mono- and bidescriptor models (when combined with lipophilicity, MlogP) confirming the importance of H-bonding capability of the alkaloids for binding at the receptor site