906 research outputs found

    Comparing hurricane and extratropical storm surge for the Mid- Atlantic and Northeast Coast of the United States for 1979–2013

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    This letter examines the magnitude, spatial footprint, and paths of hurricanes and extratropical cyclones (ETCs) that caused strong surge along the east coast of the US between 1979 and 2013. Lagrangian cyclone track information, for hurricanes and ETCs, is used to associate surge events with individual storms. First, hurricane influence is examined using ranked surged events per site. The fraction of hurricanes among storms associated with surge decreases from 20%–60% for the top 10 events to 10%–30% for the top 50 events, and a clear latitudinal gradient of hurricane influence emerges for larger sets of events. Secondly, surges on larger spatial domains are examined by focusing on storms that cause exceedance of the probabilistic 1-year surge return level at multiple stations. Results show that if the strongest events in terms of surge amplitude and spatial extent are considered, then hurricanes are most likely to create the hazards. However, when slightly less strong events that still impact multiple areas during the storm life cycle are considered, the relative importance of hurricanes shrinks as that of ETCs grows. Furthermore we find distinct paths for ETCs causing multisite surge at individual segments of the US east coast

    Crossfit as modern means of physical education

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    Physical education is a pedagogical process aimed at physical development, functional improvement of organism, studies of basic efferent skills of vital importance and knowledge related to them for the future successful professional activities

    The role of students’ individual work in the formation of professional competences of future doctors.

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    Modern requirements for training of high-skilled specialists require the implementation of international medical and educational standards in the educational and integrative process. Formation of cognitive activity, pursuance of professional development, the necessity to correspond to world standards medical students’ of gained knowledge. Medical students’ individual work is very important for medical students’ education because it helps to systematize and use knowledge that was gained in practical classes. The aim of the work – to analyze the forms of students’ individual work, used at in the Department of Internal Medicine 2 and Phthisiology, in order to improve the educational process and to form the future doctor’s medical judgment, their ability to self-improvement and self-education. The recommended hours attempted for students’ individual work is 90 out of the total of 240 hours assigned to the discipline in teaching the module “internal diseases” for the 5th year students at the Depertment of Internal Medicine 2 and Phthisiology. In studying the discipline of "internal diseases" in the 5th year one of the main tasks of medical student’s occupation training is mastering ability of assimilation on his own, of knowledge and refresh it, and then to use knowledge effectively in the future career. The difference of the individual work lies in the fact that students can study individually choosing the necessary kind of extracurricular activity according to their interests. In addition, the lack of strict grading by the teacher has more advantages compared to practical classes. The curriculum, the teacher’s tasks and methodological materials determine the content of the individual work. The article presents the three main directions of students’ individual work in teaching discipline of "internal diseases" for students of the 5th year as: students’ individual work in classroom learning, students’ individual work individual work under the teacher’s supervision. When discussing the results of individual work, students learn to think critically, communicate with each other, and make their own well-thought-out (educated) decision. Well-structured process of the individual work encourages medical students to its qualitative fulfillment and it is a significant motivation for further professional growth. Significant reserves to increase its efficiency inherent in the use of modern computer technology. Medical students’ individual work should be considered as one of the necessary stages of a modern doctor training. The latest information technologies and individual scientific projects adoption into the educational process leads to efficiency improvement and it forms new future doctor’s professional competences

    Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase

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    Acyltransferase domains control the extender unit recognition in Polyketide Synthases (PKS) and thereby the side-chain diversity of the resulting natural products. The enzyme engineering strategy presented here allows the alteration of the acyltransferase substrate profile to enable an engineered biosynthesis of natural product derivatives through the incorporation of a synthetic malonic acid thioester. Experimental sequence−function correlations combined with computational modeling revealed the origins of substrate recognition in these PKS domains and enabled a targeted mutagenesis. We show how a single point mutation was able to direct the incorporation of a malonic acid building block with a non-native functional group into erythromycin. This approach, introduced here as enzyme-directed mutasynthesis, opens a new field of possibilities beyond the state of the art for the combination of organic chemistry and biosynthesis toward natural product analogues

    A review of predictability studies of the Atlantic sector climate on decadal time-scales

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    This review paper discusses the physical basis and the potential for decadal climate predictability over the Atlantic and its adjacent land areas. Many observational and modeling studies describe pronounced decadal and multidecadal variability in the Atlantic Ocean. However, it still needs to be quantified to which extent the variations in the ocean drive variations in the atmosphere and over land. In particular, although a clear impact of the Tropics on the midlatitudes has been demonstrated, it is unclear if and how the extratropical atmosphere responds to midlatitudinal sea surface temperature anomalies. Although the mechanisms behind the decadal to multidecadal variability in the Atlantic sector are still controversial, there is some consensus that some of the longer-term multidecadal variability is driven by variations in the thermohaline circulation. The variations in the North Atlantic thermohaline circulation appear to be predictable one to two decades ahead, as shown by a number of perfect model predictability experiments. The next few decades will be dominated by these multidecadal variations, although the effects of anthropogenic climate change are likely to introduce trends. Some impact of the variations of the thermohaline circulation on the atmosphere has been demonstrated in some studies so that useful decadal predictions with economic benefit may be possible

    Crossfit as modern means of physical education

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    Physical education is a pedagogical process aimed at physical development, functional improvement of organism, studies of basic efferent skills of vital importance and knowledge related to them for the future successful professional activities
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