The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

Background: Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods: Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored. Results: A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays. Conclusions: IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients

Synthesis, spectral studies and biological evaluation of some new 4-substituled coumarins

1548-15504-Dichloroacetamidomethycoumarins 3, 4-2' -naphtho furanyl coumarins 4, 4-2'-benzofurany l coumarins 5 and 4-8' angelicinylcoumarins 6, have been synthesised by using 4-bromomethylcoumarins 1 as synthons. Molecular weights of the compounds have been confirmed by EI and FAB-MS techniques and studied for their antimicrobial activities

8-Formyl-4-methyl-2-oxo-2H-chromen-7-yl 4-methylbenzenesulfonate

In the title compound, C18H14O6S, the coumarin ring system is nearly planar, with a maximum out-of-plane deviation of 0.032 (2) Å. The dihedral angle between the benzene ring and the coumarin ring system is 32.41 (8)°. The crystal packing is stabilized by intermolecular C—H...O interactions, generating C(8), C(10) and C(11) chains and an R22(10) ring. The formyl group is disordered over two sets of sites, with occupancies of 0.548 (5) and 0.452 (5)

N-(2-Chloroquinolin-3-ylmethylene)aniline

The title compound, C16H11ClN2, displays a trans configuration across the C=N bond and a transoid arrangement across the quinoline ring and the azomethine C atom. This arrangement facilitates C—H...Cl interactions. The packing in the crystal structure is due to intermolecular C—H...π and Cl...π (3.52 and 3.84 Å) interactions. The dihedral angle between the least-squares planes of 2-chloroquinoline and phenylamine is 16.61 (2)°

Synthesis, characterization and photophysical studies of zinc(II) complexes derived from a hydralazine hydrazone

In the present study, we report two novel mononuclear zinc(II) complexes (1 and 2) obtained by reacting (E)-1-(phenyl(pyridin-2-yl)methylene)-2-(phthalazin-1-yl)hydrazine (L) with ZnCl2 and Zn(NO3)(2)center dot 6H(2)O respectively. Photophysical properties of the compounds were studied in both solution and solid phase. The fluorescence absolute quantum yield of the complexes in solution varies in the order 1 (0.01) < 2 (0.030), on the other hand in the solid state it varies in the order 2(0.034) < 1(0.69). Quenching of fluorescence intensity of 2 in the solid-state has been attributed to intense and extensive non-covalent interactions present in the crystal structure. Theoretical calculations, density functional theory (DFT) and time-dependent density functional theory (TD-DFT) were also performed to support the experimental findings. (C) 2017 Elsevier B.V. All rights reserved