6 research outputs found
Spatial inter-comparison of Top-down emission inventories in European urban areas
This paper presents an inter-comparison of the main Top-down emission inventories currently used for air quality modelling studies at the European level. The comparison is developed for eleven European cities and compares the distribution of emissions of NOx, SO2, VOC and PPM2.5 from the road transport, residential combustion and industry sectors. The analysis shows that substantial differences in terms of total emissions, sectorial emission shares and spatial distribution exist between the datasets. The possible reasons in terms of downscaling approaches and choice of spatial proxies are analysed and recommendations are provided for each inventory in order to work towards the harmonisation of spatial downscaling and proxy calibration, in particular for policy purposes. The proposed methodology may be useful for the development of consistent and harmonised European-wide inventories with the aim of reducing the uncertainties in air quality modelling activities
Curriculum vitae of the LOTOS-EUROS (v2.0) chemistry transport model
The development and application of chemistry transport models has a long
tradition. Within the Netherlands the LOTOS–EUROS model has been developed by
a consortium of institutes, after combining its independently developed
predecessors in 2005. Recently, version 2.0 of the model was released as an
open-source version. This paper presents the curriculum vitae of the model
system, describing the model's history, model philosophy, basic features and a
validation with EMEP stations for the new benchmark year 2012, and presents
cases with the model's most recent and key developments. By setting the model
developments in context and providing an outlook for directions for further
development, the paper goes beyond the common model description. With an
origin in ozone and sulfur modelling for the models LOTOS and EUROS, the
application areas were gradually extended with persistent organic pollutants,
reactive nitrogen, and primary and secondary particulate matter. After the
combination of the models to LOTOS–EUROS in 2005, the model was further
developed to include new source parametrizations (e.g. road resuspension,
desert dust, wildfires), applied for operational smog forecasts in the
Netherlands and Europe, and has been used for emission scenarios, source
apportionment, and long-term hindcast and climate change scenarios.
LOTOS–EUROS has been a front-runner in data assimilation of ground-based and
satellite observations and has participated in many model intercomparison
studies. The model is no longer confined to applications over Europe but is
also applied to other regions of the world, e.g. China. The increasing
interaction with emission experts has also contributed to the improvement of
the model's performance. The philosophy for model development has always been
to use knowledge that is state of the art and proven, to keep a good balance
in the level of detail of process description and accuracy of input and
output, and to keep a good record on the effect of model changes using
benchmarking and validation. The performance of v2.0 with respect to EMEP
observations is good, with spatial correlations around 0.8 or higher for
concentrations and wet deposition. Temporal correlations are around 0.5 or
higher. Recent innovative applications include source apportionment and data
assimilation, particle number modelling, and energy transition scenarios
including corresponding land use changes as well as Saharan dust forecasting.
Future developments would enable more flexibility with respect to model
horizontal and vertical resolution and further detailing of model input data.
This includes the use of different sources of land use characterization
(roughness length and vegetation), detailing of emissions in space and time,
and efficient coupling to meteorology from different meteorological models
Sources of particulate-matter air pollution and its oxidative potential in Europe
International audienceParticulate matter is a component of ambient air pollution that has been linked to millions of annual premature deaths globally1,2,3. Assessments of the chronic and acute effects of particulate matter on human health tend to be based on mass concentration, with particle size and composition also thought to play a part4. Oxidative potential has been suggested to be one of the many possible drivers of the acute health effects of particulate matter, but the link remains uncertain5,6,7,8. Studies investigating the particulate-matter components that manifest an oxidative activity have yielded conflicting results7. In consequence, there is still much to be learned about the sources of particulate matter that may control the oxidative potential concentration7. Here we use field observations and air-quality modelling to quantify the major primary and secondary sources of particulate matter and of oxidative potential in Europe. We find that secondary inorganic components, crustal material and secondary biogenic organic aerosols control the mass concentration of particulate matter. By contrast, oxidative potential concentration is associated mostly with anthropogenic sources, in particular with fine-mode secondary organic aerosols largely from residential biomass burning and coarse-mode metals from vehicular non-exhaust emissions. Our results suggest that mitigation strategies aimed at reducing the mass concentrations of particulate matter alone may not reduce the oxidative potential concentration. If the oxidative potential can be linked to major health impacts, it may be more effective to control specific sources of particulate matter rather than overall particulate mass
Curriculum vitae of the LOTOS–EUROS (v2.0) chemistry transport model
The development and application of chemistry transport models has a long tradition. Within the Netherlands the LOTOS–EUROS model has been developed by a consortium of institutes, after combining its independently developed predecessors in 2005. Recently, version 2.0 of the model was released as an open-source version. This paper presents the curriculum vitae of the model system, describing the model's history, model philosophy, basic features and a validation with EMEP stations for the new benchmark year 2012, and presents cases with the model's most recent and key developments. By setting the model developments in context and providing an outlook for directions for further development, the paper goes beyond the common model description. With an origin in ozone and sulfur modelling for the models LOTOS and EUROS, the application areas were gradually extended with persistent organic pollutants, reactive nitrogen, and primary and secondary particulate matter. After the combination of the models to LOTOS–EUROS in 2005, the model was further developed to include new source parametrizations (e.g. road resuspension, desert dust, wildfires), applied for operational smog forecasts in the Netherlands and Europe, and has been used for emission scenarios, source apportionment, and long-term hindcast and climate change scenarios. LOTOS–EUROS has been a front-runner in data assimilation of ground-based and satellite observations and has participated in many model intercomparison studies. The model is no longer confined to applications over Europe but is also applied to other regions of the world, e.g. China. The increasing interaction with emission experts has also contributed to the improvement of the model's performance. The philosophy for model development has always been to use knowledge that is state of the art and proven, to keep a good balance in the level of detail of process description and accuracy of input and output, and to keep a good record on the effect of model changes using benchmarking and validation. The performance of v2.0 with respect to EMEP observations is good, with spatial correlations around 0.8 or higher for concentrations and wet deposition. Temporal correlations are around 0.5 or higher. Recent innovative applications include source apportionment and data assimilation, particle number modelling, and energy transition scenarios including corresponding land use changes as well as Saharan dust forecasting. Future developments would enable more flexibility with respect to model horizontal and vertical resolution and further detailing of model input data. This includes the use of different sources of land use characterization (roughness length and vegetation), detailing of emissions in space and time, and efficient coupling to meteorology from different meteorological models
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field