Potential Anti-Obesogenic Effects of Ginkgo biloba Observed in Epididymal White Adipose Tissue of Obese Rats

Exacerbated expansion of adipose tissue seen in diet-induced obesity leads to endocrine dysfunction and disturbance in adipokine secretion, with such abnormal profile positively associated with type 2 diabetes and other mild chronic inflammatory conditions. Ginkgo biloba extract (GbE), a mixture of polyphenols with antioxidant properties, has been recently investigated in a variety of experimental models of endocrine dysfunction, with several potentially beneficial effects identified, including improvement in insulin sensitivity in obese rats, and reduction of weight gain in ovariectomy-induced obesity and diet-induced obesity. The aim of this study was to investigate in high fat diet-induced obese male rats the effects of GbE supplementation for two weeks on adipocyte volume and adipose tissue lipid accumulation. GbE supplementation was effective in reducing energy intake in obese rats compared to the saline-treated placebo group. Epididymal adipocyte volume was reduced in GbE-supplemented rats, as were epididymal [1-14C]-acetate incorporation into fatty acids, perilipin (Plin 1) and fatty acid synthase (Fasn) mRNA, and FAS protein levels. Adipocyte hypertrophy in obesity is associated with insulin resistance, and in the present study we observed a reduction in the adipocyte volume of GbE-supplemented obese rats to dimensions equivalent to adipocytes from non-obese rats. GbE supplementation significantly reduced acetate accumulation and tended to reduce [3H]-oleate incorporation, into epididymal adipose tissue, suggesting a potentially anti-obesogenic effect in longer term therapies. Further studies that investigate the effects of GbE supplementation in other experimental models are required to fully elucidate its suggested beneficial effects on mild chronic inflammatory conditions

Srovnání závěrkových účetních výkazů centrální banky v České republice a ve Spolkové republice Německo

Import 20/04/2006Prezenční výpůjčkaVŠB - Technická univerzita Ostrava. Ekonomická fakulta. Katedra (156) makroekonomik

Perceptions of Curability in Outpatients with Advanced Cancer

Objectives. (1) To identify patient characteristics associated with the perception cancer is incurable. (2) To examine whether this perception is associated with (i) patients’ goals of care (GOC) and (ii) perceptions that their family and physician are aware of their future care wishes. Methods. Medical oncology outpatients with advanced cancer completed a GOC questionnaire. Results. Previous discussion of cancer curability was associated with the perception cancer was incurable when controlling for patient age, income, and ECOG (OR=4.35, 95%CI=1.18-17.11, p=0.03). Most patients perceiving cancer was incurable reported GOC wishes of living longer (56%) over curing their cancer (7%). A total of 77% believed their family was aware of their future care wishes, but only 13% believed their physician was aware. Conclusion. Discussion of cancer curability with patients may improve their understanding of prognosis and enable GOC decision-making. Physician-patient discussions about advance care planning appear to be lacking and should be encouraged.M.Sc

Media image of Jan Hamáček during two political events

Jan Hamáček experienced two events in one year that led to his end in high politics. Firstly, at the beginning of the coronavirus crisis, during his tenure at the Ministry of the Interior, he positioned himself as a minister who, through his contacts in China, was able to secure sufficient amount of medical supplies. A year later, after the resolution of the involvement of Russian agents in the Vrbětice ammunition depot explosions, Seznam Zprávy published information that the ČSSD chairman wanted to exchange this finding for Russian Sputnik V coronavirus vaccines and a presidential summit in Prague. The thesis analysed how Hamáček's media image was portrayed in these situations and how it varied in four Czech newspapers

Comparison of the effects of two peptide analogues on EEG and acetylcholinesterase activity

Experimentální srovnání účinku nově syntetizovaného fragmentu arginin-vazopresinu na elektroencefalogram a na aktivitu acetylcholinesterázy ve vybraných strukturách limbického systému mozku laboratorního potkana s účinky známého peptidu leucin-enkefalinu se zaměřením na paměťové funkce.Dokončená práce s úspěšnou obhajobo

The impact of transport on time spent walking in the city

Tato práce se zabývá problematikou časové náročnosti chůze ve městě. Práce je rozdělena na tři části. První část se zabývá analýzou faktoru ovlivňujících rychlost chůze ve městě. Druhá část analyzuje časovou náročnost chůze ve vybraném městě a v třetí části jsou obsaženy návrhy na eliminaci míst ovlivňujících časovou náročnost chůze.This work drala with problematic of time spent walking in city. The work is dividend into three parts. The first one deals with the analysis of factors influencing swiftness if walking. The second part analyzes the time spent walking in selected city and the third part provides the suggests of elimination of places that influence the time spent walking.Katedra technologie a řízení dopravyStudent obhájil diplomovou práci a zodpověděl dotazy uvedené v posudcích oponenta a vedoucího práce a členů státní zkušební komise

Business Project

This diploma thesis deals with questions about prospectus assembly for the company GASTROSUN SK, s.r.o with detailed focus on refinement of its prerequisites. The aim of this diploma thesis is to put together the comprehensive and integrated prospectus with the focus on its usability in practice. It’s important so that all assemblage plans in this prospectus reflected the real estate. Partial aim of this diploma thesis is matching other possible kinds of investments with the investment embedded in business by the help of indicator of return on capital employed before taxation