Antonína Macka Street in Brno

Cílem bakalářské práce je rekonstrukce ulice Antonína Macka v Brně. Ulice se nachází v městské části Brno-Královo Pole. V současné době vede středem ulice vysoký násyp, který dříve sloužil pro vlečky. V dnešní době, se už nepoužívá, a proto v rámci rekonstrukce bude násyp upraven. Stávající ulice Antonína Macka je jednosměrná. Pro zkvalitnění místní dopravy, jsem ulici navrhl jako obousměrně průjezdnou. Také je zde vystavěn příliš dlouhý přechod pro chodce, který při rekonstrukci bude upraven, pro větší bezpečnost chodců dle příslušných norem. Při návrhu rekonstrukce jsem se zaměřil, na zvýšení počtu parkovacích míst ve výše zmíněné ulici. Důležitou součástí práce, bylo také napojení se na stávající okružní křižovatku, která se napojuje na ulici Sportovní. Uvažované byly 3 varianty řešení z kterých se nakonec vybrala jedna na podrobnější zpracování.The aim of the bachelor thesis is the reconstruction of Antonína Macka Street in Brno. The street is located in Brno-Královo Pole district. Currently, there is a high embankment in the middle of the street, which was used by local railway. Currently railway connection is removed and therefore the embankment will be modified as part of the reconstruction. The existing Antonína Macka Street is designed as one-way street. To improve local traffic, I designed the street as two-way. There is also an excessively long pedestrian crossing, which will be modified during the reconstruction, for greater pedestrian safety according to the relevant standards. When designing the reconstruction, I focused on increasing the number of parking spaces in the above-mentioned street. An important part of the work was also the connection to the existing roundabout, which connects to Sportovní Street. 3 variants of the solution were considered, from which one was finally chosen for more detailed design.

Thermal properties of selected bee products

Knowledge of bee products’ physical properties has a decisive importance for the monitoring of their quality. Thermophysical parameters are very important properties. Thermal conductivity and thermal diffusivity of selected bee products (honey, bee pollen and perga) were measured by two different methods. For identification of thermal conductivity and thermal diffusivity transient methods were used: Hot Wire (HW) and Dynamic Plane Source (DPS) method with an instrument Isomet 2104. The principle of measuring process is based on the analysis of timetemperature relation. In the first series of measurements thermal conductivity and diffusivity at constant laboratory temperature of 20 °C were measured. The second series was focused on identification of the changes in the thermophysical parameters during temperature stabilisation in the temperature range of 5–25 °C. For samples with constant temperature standard deviations and probable errors in % were calculated. For relations of thermal parameters to temperature graphical dependencies were obtained. Two different thermophysical methods were used for improvement of data reliability and data statistics

Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex

Cleavage and polyadenylation factor (CPF/CPSF) is a multi-protein complex essential for formation of eukaryotic mRNA 3' ends. CPF cleaves pre-mRNAs at a specific site and adds a poly(A) tail. The cleavage reaction defines the 3' end of the mature mRNA, and thus the activity of the endonuclease is highly regulated. Here, we show that reconstitution of specific pre-mRNA cleavage with recombinant yeast proteins requires incorporation of the Ysh1 endonuclease into an eight-subunit "CPFcore" complex. Cleavage also requires the accessory cleavage factors IA and IB, which bind substrate pre-mRNAs and CPF, likely facilitating assembly of an active complex. Using X-ray crystallography, electron microscopy, and mass spectrometry, we determine the structure of Ysh1 bound to Mpe1 and the arrangement of subunits within CPFcore. Together, our data suggest that the active mRNA 3' end processing machinery is a dynamic assembly that is licensed to cleave only when all protein factors come together at the polyadenylation site

Systematic review with meta-analysis of the epidemiological evidence relating smoking to COPD, chronic bronchitis and emphysema

<p>Abstract</p> <p>Background</p> <p>Smoking is a known cause of the outcomes COPD, chronic bronchitis (CB) and emphysema, but no previous systematic review exists. We summarize evidence for various smoking indices.</p> <p>Methods</p> <p>Based on MEDLINE searches and other sources we obtained papers published to 2006 describing epidemiological studies relating incidence or prevalence of these outcomes to smoking. Studies in children or adolescents, or in populations at high respiratory disease risk or with co-existing diseases were excluded. Study-specific data were extracted on design, exposures and outcomes considered, and confounder adjustment. For each outcome RRs/ORs and 95% CIs were extracted for ever, current and ex smoking and various dose response indices, and meta-analyses and meta-regressions conducted to determine how relationships were modified by various study and RR characteristics.</p> <p>Results</p> <p>Of 218 studies identified, 133 provide data for COPD, 101 for CB and 28 for emphysema. RR estimates are markedly heterogeneous. Based on random-effects meta-analyses of most-adjusted RR/ORs, estimates are elevated for ever smoking (COPD 2.89, CI 2.63-3.17, n = 129 RRs; CB 2.69, 2.50-2.90, n = 114; emphysema 4.51, 3.38-6.02, n = 28), current smoking (COPD 3.51, 3.08-3.99; CB 3.41, 3.13-3.72; emphysema 4.87, 2.83-8.41) and ex smoking (COPD 2.35, 2.11-2.63; CB 1.63, 1.50-1.78; emphysema 3.52, 2.51-4.94). For COPD, RRs are higher for males, for studies conducted in North America, for cigarette smoking rather than any product smoking, and where the unexposed base is never smoking any product, and are markedly lower when asthma is included in the COPD definition. Variations by sex, continent, smoking product and unexposed group are in the same direction for CB, but less clearly demonstrated. For all outcomes RRs are higher when based on mortality, and for COPD are markedly lower when based on lung function. For all outcomes, risk increases with amount smoked and pack-years. Limited data show risk decreases with increasing starting age for COPD and CB and with increasing quitting duration for COPD. No clear relationship is seen with duration of smoking.</p> <p>Conclusions</p> <p>The results confirm and quantify the causal relationships with smoking.</p

Patents as an indicator of the future development of individual region

In today’s world full of changes, whether the advent of new technologies that are authoritative and will be a trend for many economic sectors or impact Covid epidemic whose effects are still unaware can be sure that the changes in consumer preferences and aggregate demand and increasingly more competition between the largest economies in geographical terms, all this puts more importance on research and development. It is expected a new impetus in the field of patents that will respond to new impulses from the market. Monitor the development of patents over the last year in the broader perspective implies growth or decline in individual industries and economies, are interesting differences in the intensity of new know-how even within different regions of the world

Influence of Temperature and Storing Time on Selected Red Wine Physical Properties

Presented article is focused on red wine rheological and thermal properties. Effects of temperature and short term storage on density, rheological parameters and thermal parameters were investigated. First measurement was done at the beginning of storage and then the same sample was measured again after one week of storing. Density was measured by densimeter Mettler Toledo DM 40 at different temperatures. For dynamic viscosity measurement was used rotational viscometer Anton Paar DV-3P. The kinematic viscosity and fluidity were determined according to the definitions. Thermal parameters were measured by instrument Isomet 2104. Temperature dependencies of wine dynamic and kinematic viscosity had decreasing exponential shape and temperature dependencies of fluidity had an increasing exponential shape. Temperature dependencies of red wine thermal conductivity and diffusivity had increasing linear character. Decreasing polynomial functions were obtained for temperature dependencies of red wine density. The values of dynamic and kinematic viscosity, thermal conductivity and diffusivity, and density of red wine were a little bit higher after short term storing, which can be expressed by changed amount of water caused by evaporation. Due to the same reasons were values of fluidity little bit lower after storage

Value-Added Foods: Characteristic, Benefits, and Physical Properties

The growth of diet-related diseases (obesity, diabetes, osteoporosis, and cardiovascular diseases) is becoming an important societal concern and a challenge for a more sustainable society. This has developed important trends in food consumption, including the increasing demand for innovative food with natural attributes and with health claims (foods with added value, enriched foods, and functional foods). The physical properties of food are essential for scientists and engineers at solving the problems in food preservation, processing, storage, marketing, consumption, and even after consumption. In this chapter, we introduce the utilization of physical properties in enriched foods evaluation. The correlations were found between physical properties and other characteristics of foods

Tectonic and lithological controls on denudation rates in the central Bolivian Andes

The topographic signature of a mountain belt depends on the interplay of tectonic, climatic and erosional processes, whose relative importance changes over times, while quantifying these processes and their rates at specific times remains a challenge. The eastern Andes of central Bolivia offer a natural laboratory in which such interplay has been debated. Here, we investigate the Rio Grande catchment which crosses orthogonally the eastern Andes orogen from the Eastern Cordillera into the Subandean Zone, exhibiting a catchment relief of up to 5000 m. Despite an enhanced tectonic activity in the Subandes, local relief, mean and modal slopes and channel steepness indices are largely similar compared to the Eastern Cordillera and the intervening Interandean Zone. Nevertheless, a dataset of 57 new cosmogenic 10Be and 26Al catchment wide denudation rates from the Rio Grande catchment reveals up to one order of magnitude higher denudation rates in the Subandean Zone (mean 0.8 mm/yr) compared to the upstream physiographic regions. We infer that tectonic activity in the thrusting dominated Subandean belt causes higher denudation rates based on cumulative rock uplift investigations and due to the absence of a pronounced climate gradient. Furthermore, the lower rock strength of the Subandean sedimentary units correlates with mean slopes similar to the ones of the Eastern Cordillera and Interandean Zone, highlighting the fact, that lithology and rock strength can control high denudation rates at low slopes. Low denudation rates measured at the outlet of the Rio Grande catchment (Abapo) are interpreted to be a result of a biased cosmogenic nuclide mixing that is dominated by headwater signals from the Eastern Cordillera and the Interandean zone and limited catchment sediment connectivity in the lower river reaches. Therefore, comparisons of short- (i.e., sediment yield) and millennial denudation rates require caution when postulating tectonic and/or climatic forcing without detailed studies.ISSN:0040-195

Laser tests of silicon detectors

This paper collects experiences from the development of a silicon sensor laser testing setup and from tests of silicon strip modules (ATLAS End-cap SCT), pixel modules (DEPFET) and large-area diodes using semiconductor lasers. Lasers of 1060 and 680 nm wavelengths were used. A sophisticated method of focusing the laser was developed. Timing and interstrip properties of modules were measured. Analysis of optical effects involved and detailed discussion about the usability of laser testing for particle detectors are presented.</p