Moses and Liminality

Marked by two significant water crossings, the Hebrew Bible establishes the wilderness period in the Pentateuch as a liminal period marking rites of passage for the Israelites. Using a narrative critical approach and an anthropological understanding of liminality, this paper shows that Moses was depicted with an abundance of liminal characteristics and these made him the ultimate transitional tool for God to use in the maturation rites of his people. Further, known Essene beliefs and the Dead Sea Scrolls, the texts of the religious community that inhabited the site of Qumran in the latter half of the second temple period, support this reading of a liminal Moses. By reentering liminal space and placing great importance on ritual purity, the inhabitants of Qumran sought once again to produce a liminal period to prepare for the imminent arrival of a cosmic battle and establishment of a new world age and therefore Moses was the perfect liminal figure with whom they associated

Ontwikkeling en implementatie van geïntegreerde bestrijding in zomerbloemen : toepassing van beschikbare producten en ontwikkeling van nieuwe natuurlijke vijanden

In 2008 en 2009 werden loslatingen verricht van de roofmijten Neoseiulus cucumeris en Amblyseius andersoni, soms aangevuld met Phytoseiulus persimilis, in de zomerbloemen rozenbottel, chrysant, Veronica, Alchemilla en Delphinium. Hierbij bleek dat roofmijten zich niet in alle gewassen in gelijke mate vestigen. In Alchemilla en Delphinium bleek al spontaan Neoseiulus cucumeris voor te kunnen komen. Als in deze gewassen nog geen roofmijten voorkomen, zal introductie van N. cucumeris zeker slagen, mits er geen breedwerkende middelen worden toegepast. Vooral Alchemilla bleek een goede roofmijtenplant te zijn. Behalve Neoseiulus cucumeris werden ook andere soorten gevonden. Roofmijten die in de handel zijn tegen spint, Phytoseiulus persimilis en Neoseiulus californicus, vestigen zich eveneens goed in dit gewas, in tegenstelling tot Amblyseius andersoni. Verder kunnen spontaan andere natuurlijke vijanden van plagen voorkomen: roofwantsen, gaasvliegen en galmuggen. Trips nam in beide jaren af gedurende de teelt of bleef op een laag niveau. Neoseiulus alpinus is een roofmijt, die eerder is verzameld van Alchemilla en in kweek genomen. Een loslating van deze roofmijt in Alchemilla slaagde in 2008 niet, maar in 2009 wel. In Delphinium was in 2008 vanaf het begin van de waarnemingen Neoseiulus cucumeris in het gewas aanwezig. Na introductie van Amblyseius andersoni werd ook deze soort teruggevonden. Spint kwam in 2008 niet tot ontwikkeling. Buiten de proef kwam plaatselijk cyclamenmijt voor. In 2009 werd in Delphinium zwavel verdampt tegen echte meeldauw. Er was geen goede vestiging van roofmijten in het gewas, ook niet van de roofmijt Phytoseiulus persimilis, waardoor chemische bestrijding van spint noodzakelijk was. In Veronica, chrysant en rozenbottel kwamen in vergelijking met Alchemilla en Delphinium minder roofmijten voor. Trips en spint waren in 2008 en 2009 geen probleem in Veronica, chrysant en rozenbottel. Op rozenbottel kwam zonder introductie Neoseiulus cucumeris voor. Andere soorten roofmijten, die soms spontaan optraden waren Neoseiulus reductus in Delphinium, Amblyseius graminis in Alchemilla en chrysant, en roofmijten die tot een andere groep (Bdelloidea) behoren, met name op chrysant en Veronica

Systematic comparative validation of self-report measures of sedentary time against an objective measure of postural sitting (activPAL)

Background: Sedentary behaviour is a public health concern that requires surveillance and epidemiological research. For such large scale studies, self-report tools are a pragmatic measurement solution. A large number of self-report tools are currently in use, but few have been validated against an objective measure of sedentary time and there is no comparative information between tools to guide choice or to enable comparison between studies. The aim of this study was to provide a systematic comparison, generalisable to all tools, of the validity of self-report measures of sedentary time against a gold standard sedentary time objective monitor. Methods: Cross sectional data from three cohorts (N = 700) were used in this validation study. Eighteen self-report measures of sedentary time, based on the TAxonomy of Self-report SB Tools (TASST) framework, were compared against an objective measure of postural sitting (activPAL) to provide information, generalizable to all existing tools, on agreement and precision using Bland-Altman statistics, on criterion validity using Pearson correlation, and on data loss. Results: All self-report measures showed poor accuracy compared with the objective measure of sedentary time, with very wide limits of agreement and poor precision (random error > 2.5 h). Most tools under-reported total sedentary time and demonstrated low correlations with objective data. The type of assessment used by the tool, whether direct, proxy, or a composite measure, influenced the measurement characteristics. Proxy measures (TV time) and single item direct measures using a visual analogue scale to assess the proportion of the day spent sitting, showed the best combination of precision and data loss. The recall period (e.g. previous week) had little influence on measurement characteristics. Conclusion: Self-report measures of sedentary time result in large bias, poor precision and low correlation with an objective measure of sedentary time. Choice of tool depends on the research context, design and question. Choice can be guided by this systematic comparative validation and, in the case of population surveillance, it recommends to use a visual analog scale and a 7 day recall period. Comparison between studies and improving population estimates of average sedentary time, is possible with the comparative correction factors provided

Loss of chromosome 10 is an independent prognostic factor in high-grade gliomas

Loss of heterozygosity (LOH) for chromosome 10 is the most frequent genetic abnormality observed in high-grade gliomas. We have used fluorescent microsatellite markers to examine a series of 83 patients, 34 with anaplastic astrocytoma (grade 3) and 49 with glioblastoma multiforme (grade 4), for LOH of chromosome 10. Genotype analysis revealed LOH for all informative chromosome 10 markers in 12 (35%) of patients with grade 3 and 29 (59%) grade 4 tumours respectively, while partial LOH was found in a further eight (24%) grade 3 and ten (20%) grade 4 tumours. Partial LOH, was confined to the long arm (10q) in six and the short arm (10p) in three cases, while alleles from both arms were lost in four cases. Five tumours (one grade 3 and four grade 4) showed heterogeneity with respect to loss at different loci. There was a correlation between any chromosome 10 loss and poorer performance status at presentation (χ2P = 0.005) and with increasing age at diagnosis (Mann–Whitney U-test P = 0.034) but not with tumour grade (χ2P = 0.051). A Cox multivariate model for survival duration identified age (proportional hazards (PH), P = 0.004), grade (PH, P = 0.012) and any loss of chromosome 10 (PH, P = 0.009) as the only independent prognostic variables. Specifically, LOH for chromosome 10 was able to identify a subgroup of patients with grade 3 tumours who had a significantly shorter survival time. We conclude that LOH for chromosome 10 is an independent, adverse prognostic variable in high-grade glioma. © 1999 Cancer Research Campaig

Epilepsy is related to theta band brain connectivity and network topology in brain tumor patients

<p>Abstract</p> <p>Background</p> <p>Both epilepsy patients and brain tumor patients show altered functional connectivity and less optimal brain network topology when compared to healthy controls, particularly in the theta band. Furthermore, the duration and characteristics of epilepsy may also influence functional interactions in brain networks. However, the specific features of connectivity and networks in tumor-related epilepsy have not been investigated yet. We hypothesize that epilepsy characteristics are related to (theta band) connectivity and network architecture in operated glioma patients suffering from epileptic seizures. Included patients participated in a clinical study investigating the effect of levetiracetam monotherapy on seizure frequency in glioma patients, and were assessed at two time points: directly after neurosurgery (t1), and six months later (t2). At these time points, magnetoencephalography (MEG) was recorded and information regarding clinical status and epilepsy history was collected. Functional connectivity was calculated in six frequency bands, as were a number of network measures such as normalized clustering coefficient and path length.</p> <p>Results</p> <p>At the two time points, MEG registrations were performed in respectively 17 and 12 patients. No changes in connectivity or network topology occurred over time. Increased theta band connectivity at t1 and t2 was related to a higher total number of seizures. Furthermore, higher number of seizures was related to a less optimal, more random brain network topology. Other factors were not significantly related to functional connectivity or network topology.</p> <p>Conclusions</p> <p>These results indicate that (pathologically) increased theta band connectivity is related to a higher number of epileptic seizures in brain tumor patients, suggesting that theta band connectivity changes are a hallmark of tumor-related epilepsy. Furthermore, a more random brain network topology is related to greater vulnerability to seizures. Thus, functional connectivity and brain network architecture may prove to be important parameters of tumor-related epilepsy.</p

Validity of Resting Energy Expenditure Predictive Equations before and after an Energy-Restricted Diet Intervention in Obese Women

Background We investigated the validity of REE predictive equations before and after 12-week energy-restricted diet intervention in Spanish obese (30 kg/m2>BMI<40 kg/m2) women. Methods We measured REE (indirect calorimetry), body weight, height, and fat mass (FM) and fat free mass (FFM, dual X-ray absorptiometry) in 86 obese Caucasian premenopausal women aged 36.7±7.2 y, before and after (n = 78 women) the intervention. We investigated the accuracy of ten REE predictive equations using weight, height, age, FFM and FM. Results At baseline, the most accurate equation was the Mifflin et al. (Am J Clin Nutr 1990; 51: 241–247) when using weight (bias:−0.2%, P = 0.982), 74% of accurate predictions. This level of accuracy was not reached after the diet intervention (24% accurate prediction). After the intervention, the lowest bias was found with the Owen et al. (Am J Clin Nutr 1986; 44: 1–19) equation when using weight (bias:−1.7%, P = 0.044), 81% accurate prediction, yet it provided 53% accurate predictions at baseline. Conclusions There is a wide variation in the accuracy of REE predictive equations before and after weight loss in non-morbid obese women. The results acquire especial relevance in the context of the challenging weight regain phenomenon for the overweight/obese population.The present study was supported by the University of the Basque Country (UPV 05/80), Social Foundation of the Caja Vital- Kutxa and by the Department of Health of the Government of the Basque Country (2008/111062), and by the Spanish Ministry of Science and Innovation (RYC-2010-05957)

Proliferation and aneusomy predict survival of young patients with astrocytoma grade II

The clinical course of astrocytoma grade II (AII) is highly variable and not reflected by histological characteristics. As one of the best prognostic factors, higher age identifies rapid progressive A II. For patients over 35 years of age, an aggressive treatment is normally propagated. For patients under 35 years, there is no clear guidance for treatment choices, and therefore also the necessity of histopathological diagnosis is often questioned. We studied the additional prognostic value of the proliferation index and the detection of genetic aberrations for patients with A II. The tumour samples were obtained by stereotactic biopsy or tumour resection and divided into two age groups, that is 18–34 years (n=19) and 35 years (n=28). Factors tested included the proliferation (Ki-67) index, and numerical aberrations for chromosomes 1, 7, and 10, as detected by in situ hybridisation (ISH). The results show that age is a prognostic indicator when studied in the total patient group, with patients above 35 years showing a relatively poor prognosis. Increased proliferation index in the presence of aneusomy appears to identify a subgroup of patients with poor prognosis more accurately than predicted by proliferation index alone. We conclude that histologically classified cases of A II comprise a heterogeneous group of tumours with different biological and genetic constitution, which exhibit a highly variable clinical course. Immunostaining for Ki-67 in combination with the detection of aneusomy by ISH allows the identification of a subgroup of patients with rapidly progressive A II. This is an extra argument not to defer stereotactic biopsy in young patients with radiological suspicion of A II