Internal Motility in Stiffening Actin-Myosin Networks

We present a study on filamentous actin solutions containing heavy meromyosin subfragments of myosin II motor molecules. We focus on the viscoelastic phase behavior and internal dynamics of such networks during ATP depletion. Upon simultaneously using micro-rheology and fluorescence microscopy as complementary experimental tools, we find a sol-gel transition accompanied by a sudden onset of directed filament motion. We interpret the sol-gel transition in terms of myosin II enzymology, and suggest a "zipping" mechanism to explain the filament motion in the vicinity of the sol-gel transition.Comment: 4 pages, 3 figure

Optimising Spectroscopic and Photometric Galaxy Surveys: Efficient Target Selection and Survey Strategy

The next generation of spectroscopic surveys will have a wealth of photometric data available for use in target selection. Selecting the best targets is likely to be one of the most important hurdles in making these spectroscopic campaigns as successful as possible. Our ability to measure dark energy depends strongly on the types of targets that we are able to select with a given photometric data set. We show in this paper that we will be able to successfully select the targets needed for the next generation of spectroscopic surveys. We also investigate the details of this selection, including optimisation of instrument design and survey strategy in order to measure dark energy. We use color-color selection as well as neural networks to select the best possible emission line galaxies and luminous red galaxies for a cosmological survey. Using the Fisher matrix formalism we forecast the efficiency of each target selection scenario. We show how the dark energy figures of merit change in each target selection regime as a function of target type, survey time, survey density and other survey parameters. We outline the optimal target selection scenarios and survey strategy choices which will be available to the next generation of spectroscopic surveys.Comment: 16 pages, 22 figures, accepted to MNRAS in dec 201

Flood-risk mapping: contributions towards an enhanced assessment of extreme events and associated risks

Currently, a shift from classical flood protection as engineering task towards integrated flood risk management concepts can be observed. In this context, a more consequent consideration of extreme events which exceed the design event of flood protection structures and failure scenarios such as dike breaches have to be investigated. Therefore, this study aims to enhance existing methods for hazard and risk assessment for extreme events and is divided into three parts. In the first part, a regionalization approach for flood peak discharges was further developed and substantiated, especially regarding recurrence intervals of 200 to 10 000 years and a large number of small ungauged catchments. Model comparisons show that more confidence in such flood estimates for ungauged areas and very long recurrence intervals may be given as implied by statistical analysis alone. The hydraulic simulation in the second part is oriented towards hazard mapping and risk analyses covering the whole spectrum of relevant flood events. As the hydrodynamic simulation is directly coupled with a GIS, the results can be easily processed as local inundation depths for spatial risk analyses. For this, a new GIS-based software tool was developed, being presented in the third part, which enables estimations of the direct flood damage to single buildings or areas based on different established stage-damage functions. Furthermore, a new multifactorial approach for damage estimation is presented, aiming at the improvement of damage estimation on local scale by considering factors like building quality, contamination and precautionary measures. The methods and results from this study form the base for comprehensive risk analyses and flood management strategies

Optical Spectroscopy of Active Galactic Nuclei in SA57

The cosmological evolution of X-ray-selected and optically selected Active Galactic Nuclei (AGNs) show different behaviours interpreted in terms of two different populations. The difference is evident mainly for low luminosity AGNs (LLAGNs), many of which are lost by optical photometric surveys. We are conducting a spectroscopical study of a composite sample of AGN candidates selected in SA57 following different searching techniques, to identify low luminosity AGNs and break down the sample into different classes of objects. AGN candidates were obtained through optical variability and/or X-ray emission. Of special interest are the extended variable objects, which are expected to be galaxies hosting LLAGNs. Among the 26 classified objects a fair number (9) show typical AGN spectra. 10 objects show Narrow Emission Line Galaxy spectra, and in most of them (8/10) optical variability suggests the presence of LLAGNs.Comment: 7 pages, 8 figures, to appear in A&

The spectroscopic binary system Gl 375. I. Orbital parameters and chromospheric activity

We study the spectroscopic binary system Gl 375. We employ medium resolution echelle spectra obtained at the 2.15 m telescope at the Argentinian observatory CASLEO and photometric observations obtained from the ASAS database. We separate the composite spectra into those corresponding to both components. The separated spectra allow us to confirm that the spectral types of both components are similar (dMe3.5) and to obtain precise measurements of the orbital period (P = 1.87844 days), minimum masses (M_1 sin^3 i = 0.35 M_sun and M_2 sin^3 i =0.33 M_sun) and other orbital parameters. The photometric observations exhibit a sinusoidal variation with the same period as the orbital period. We interpret this as signs of active regions carried along with rotation in a tidally synchronized system, and study the evolution of the amplitude of the modulation in longer timescales. Together with the mean magnitude, the modulation exhibits a roughly cyclic variation with a period of around 800 days. This periodicity is also found in the flux of the Ca II K lines of both components, which seem to be in phase. The periodic changes in the three observables are interpreted as a sign of a stellar activity cycle. Both components appear to be in phase, which implies that they are magnetically connected. The measured cycle of approximately 2.2 years (800 days) is consistent with previous determinations of activity cycles in similar stars.Comment: 10 pages, including 11 figures and 3 tables. Accepted for publication in Astronomy & Astrophysic

Medical Students\u27 Experiences and Outcomes Using a Virtual Human Simulation to Improve Communication Skills: Mixed Methods Study

Background: Attending to the wide range of communication behaviors that convey empathy is an important but often underemphasized concept to reduce errors in care, improve patient satisfaction, and improve cancer patient outcomes. A virtual human (VH)–based simulation, MPathic-VR, was developed to train health care providers in empathic communication with patients and in interprofessional settings and evaluated through a randomized controlled trial. Objective: This mixed methods study aimed to investigate the differential effects of a VH-based simulation developed to train health care providers in empathic patient-provider and interprofessional communication. Methods: We employed a mixed methods intervention design, involving a comparison of 2 quantitative measures—MPathic-VR–calculated scores and the objective structured clinical exam (OSCE) scores—with qualitative reflections by medical students about their experiences. This paper is a secondary, focused analysis of intervention arm data from the larger trial. Students at 3 medical schools in the United States (n=206) received simulation to improve empathic communication skills. We conducted analysis of variance, thematic text analysis, and merging mixed methods analysis. Results: OSCE scores were significantly improved for learners in the intervention group (mean 0.806, SD 0.201) compared with the control group (mean 0.752, SD 0.198; F1,414=6.09; P=.01). Qualitative analysis revealed 3 major positive themes for the MPathic-VR group learners: gaining useful communication skills, learning awareness of nonverbal skills in addition to verbal skills, and feeling motivated to learn more about communication. Finally, the results of the mixed methods analysis indicated that most of the variation between high, middle, and lower performers was noted about nonverbal behaviors. Medium and high OSCE scorers most often commented on the importance of nonverbal communication. Themes of motivation to learn about communication were only present in middle and high scorers. Conclusions: VHs are a promising strategy for improving empathic communication in health care. Higher performers seemed most engaged to learn, particularly nonverbal skills

Optical (VRI) Photometry in the Field of the Galaxy Cluster AC 118 at z=0.31

We present new photometric V-, R- and I-band data for the rich galaxy cluster AC 118 at z=0.31. The new photometry covers an area of 8.6x8.6 arcmin$^2$, corresponding to 2.9$\times$2.9 Mpc$^2$ (H$_0=50$ km s$^{-1}$ Mpc$^{-1}$, q$_0=0.5$ and $\Lambda = 0$). The data have been collected for a project aimed at studying galaxy evolution through the color-magnitude relation and the fundamental plane. We provide a catalogue including all the sources (N = 1206) detected in the cluster field. The galaxy sample is complete to V=22.8 mag (N_gal=574), R=22.3 mag (N_gal=649) and I=20.8 mag (N_gal=419). We give aperture magnitudes within a fixed aperture of 4.4 arcsec and Kron magnitudes. We also give photometric redshifts for 459 sources for which additional U- and K-band photometry is available. We derive and discuss the V- and R-band luminosity functions. The catalogue, which is distributed in electronic form, is intended as a tool for studies in galaxy evolution.Comment: 15 pages, 6 figures, A&A in pres

Cl 1205+44, a fossil group at z = 0.59

This is a report of Chandra, XMM-Newton, HST and ARC observations of an extended X-ray source at z = 0.59. The apparent member galaxies range from spiral to elliptical and are all relatively red (i'-Ks about 3). We interpret this object to be a fossil group based on the difference between the brightness of the first and second brightest cluster members in the i'-band, and because the rest-frame bolometric X-ray luminosity is about 9.2x10^43 h70^-2 erg s^-1. This makes Cl 1205+44 the highest redshift fossil group yet reported. The system also contains a central double-lobed radio galaxy which appears to be growing via the accretion of smaller galaxies. We discuss the formation and evolution of fossil groups in light of the high redshift of Cl 1205+44.Comment: 21 pages, 13 figures, minor corrections to match published ApJ versio

Dynamic Critical Behavior of an Extended Reptation Dynamics for Self-Avoiding Walks

We consider lattice self-avoiding walks and discuss the dynamic critical behavior of two dynamics that use local and bilocal moves and generalize the usual reptation dynamics. We determine the integrated and exponential autocorrelation times for several observables, perform a dynamic finite-size scaling study of the autocorrelation functions, and compute the associated dynamic critical exponents $z$. For the variables that describe the size of the walks, in the absence of interactions we find $z \approx 2.2$ in two dimensions and $z\approx 2.1$ in three dimensions. At the $\theta$-point in two dimensions we have $z\approx 2.3$.Comment: laTeX2e, 32 pages, 11 eps figure

Initial Construct Validity Evidence of a Virtual Human Application for Competency Assessment in Breaking Bad News to a Cancer Patient

Background: Despite interest in using virtual humans (VHs) for assessing health care communication, evidence of validity is limited. We evaluated the validity of a VH application, MPathic-VR, for assessing performance-based competence in breaking bad news (BBN) to a VH patient. Methods: We used a two-group quasi-experimental design, with residents participating in a 3-hour seminar on BBN. Group A (n=15) completed the VH simulation before and after the seminar, and Group B (n=12) completed the VH simulation only after the BBN seminar to avoid the possibility that testing alone affected performance. Pre-and postseminar differences for Group A were analyzed with a paired t-test, and comparisons between Groups A and B were analyzed with an independent t-test. Results: Compared to the preseminar result, Group A\u27s postseminar scores improved significantly, indicating that the VH program was sensitive to differences in assessing performance-based competence in BBN. Postseminar scores of Group A and Group B were not significantly different, indicating that both groups performed similarly on the VH program. Conclusion: Improved pre-post scores demonstrate acquisition of skills in BBN to a VH patient. Pretest sensitization did not appear to influence posttest assessment. These results provide initial construct validity evidence that the VH program is effective for assessing BBN performance-based communication competence