303 research outputs found
Evidence of photospheric vortex flows at supergranular junctions observed by FG/SOT (Hinode)
Twisting motions of different nature are observed in several layers of the
solar atmosphere. Chromospheric sunspot whorls and rotation of sunspots or even
higher up in the lower corona sigmoids are examples of the large scale twisted
topology of many solar features. Nevertheless, their occurrence at large scale
in the quiet photosphere has not been investigated. The present study reveals
the existence of vortex flows located at the supergranular junctions of the
quiet Sun. We use a 1-hour and a 5-hour time series of the granulation in Blue
continuum and G-band images from FG/SOT to derive the photospheric flows. A
feature tracking technique called Balltracking is performed to track the
granules and reveal the underlying flow fields. In both time series we identify
long-lasting vortex flow located at supergranular junctions. The first vortex
flow lasts at least 1 hour and is ~20-arcsec-wide (~15.5 Mm). The second vortex
flow lasts more than 2 hours and is ~27-arcsec-wide (~21 Mm).Comment: 4 pages, 10 figure
Dynamics of the solar chromosphere. V. High-frequency modulation in ultraviolet image sequences from TRACE
We search for signatures of high-frequency oscillations in the upper solar
photosphere and low chromosphere in the context of acoustic heating of outer
stellar atmospheres. We use ultraviolet image sequences of a quiet center-disk
area from the Transition Region and Coronal Explorer (TRACE) mission which were
taken with strict cadence regularity. The latter permits more reliable
high-frequency diagnosis than in earlier work. Spatial Fourier power maps,
spatially averaged coherence and phase-difference spectra, and spatio-temporal
k-f decompositions all contain high-frequency features that at first sight seem
of considerable intrinsic interest but actually are more likely to represent
artifacts of different nature. Spatially averaged phase difference measurement
provides the most sensitive diagnostic and indicates the presence of acoustic
modulation up to f=20 mHz (periods down to 50 seconds) in internetwork areas.Comment: 9 pages, 8 figure
Numerical Simulations of Magnetoacoustic-Gravity Waves in the Solar Atmosphere
We investigate the excitation of magnetoacoustic-gravity waves generated from
localized pulses in the gas pressure as well as in vertical component of
velocity. These pulses are initially launched at the top of the solar
photosphere that is permeated by a weak magnetic field. We investigate three
different configurations of the background magnetic field lines: horizontal,
vertical and oblique to the gravitational force. We numerically model
magnetoacoustic-gravity waves by implementing a realistic (VAL-C) model of
solar temperature. We solve two-dimensional ideal magnetohydrodynamic equations
numerically with the use of the FLASH code to simulate the dynamics of the
lower solar atmosphere. The initial pulses result in shocks at higher
altitudes. Our numerical simulations reveal that a small-amplitude initial
pulse can produce magnetoacoustic-gravity waves, which are later reflected from
the transition region due to the large temperature gradient. The atmospheric
cavities in the lower solar atmosphere are found to be the ideal places that
may act as a resonator for various oscillations, including their trapping and
leakage into the higher atmosphere. Our numerical simulations successfully
model the excitation of such wave modes, their reflection and trapping, as well
as the associated plasma dynamics
Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants
Background: Fetal lung development requires proper coordination between lung epithelial and vascular morphogenesis. A major determinant in lung vascular development is vascular endothelial growth factor (VEGF), which is regulated by hypoxia-inducible factors (HIFs). VEGF is expressed in the airway epithelium, while its receptors (VEGFRs) are expressed in the pulmonary mesenchyme. The hypoxic environment in utero is beneficial for fetal organogenesis, especially vascular development. However, little is known about the expression of HIFs and VEGFR-2 in the human fetal lung in vitro. Objectives: The purpose of this study was to investigate the effects of hypoxia on fetal lung morphology and mRNA expression of VEGF, VEGFR-2, HIF-2α, and HIF-3α. Methods: An explant culture technique was used to study the effects of normoxic and hypoxic conditions on human fetal lung. Results: The morphology remained largely unchanged in explants cultured under hypoxic or normoxic conditions. Quantitative RT-PCR showed that the mRNA expression of VEGF-A, but not VEGFR-2 is upregulated in explants cultured at 1.5% compared with 21% oxygen. We observed a nonsignificant increase in HIF-2α and HIF-3α mRNA expression in explants cultured at 1.5% oxygen. These data suggest that the mRNA expression of VEGF, and possibly HIF-2α and HIF-3α, is regulated by hypoxia in the developing human lung. Conclusion: This lung explant culture model appears to be a valuable model to unravel the molecular mechanisms of human lung development
An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic annotation data along with multi-platform molecular profiles of more than 11,000 human tumors across 33 different cancer types. TCGA clinical data contain key features representing the democratized nature of the data collection process. To ensure proper use of this large clinical dataset associated with genomic features, we developed a standardized dataset named the TCGA Pan-Cancer Clinical Data Resource (TCGA-CDR), which includes four major clinical outcome endpoints. In addition to detailing major challenges and statistical limitations encountered during the effort of integrating the acquired clinical data, we present a summary that includes endpoint usage recommendations for each cancer type. These TCGA-CDR findings appear to be consistent with cancer genomics studies independent of the TCGA effort and provide opportunities for investigating cancer biology using clinical correlates at an unprecedented scale. Analysis of clinicopathologic annotations for over 11,000 cancer patients in the TCGA program leads to the generation of TCGA Clinical Data Resource, which provides recommendations of clinical outcome endpoint usage for 33 cancer types
Congenital diaphragmatic hernia and chromosome 15q26: determination of a candidate region by use of fluorescent in situ hybridization and array-based comparative genomic hybridization
Congenital diaphragmatic hernia (CDH) has an incidence of 1 in 3,000
births and a high mortality rate (33%-58%). Multifactorial inheritance,
teratogenic agents, and genetic abnormalities have all been suggested as
possible etiologic factors. To define candidate regions for CDH, we
analyzed cytogenetic data collected on 200 CDH cases, of which 7% and 5%
showed numerical and structural abnormalities, respectively. This study
focused on the most frequent structural anomaly found: a deletion on
chromosome 15q. We analyzed material from three of our patients and from
four previously published patients with CDH and a 15q deletion. By using
array-based comparative genomic hybridization and fluorescent in situ
hybridization to determine the boundaries of the deletions and by
including data from two individuals with terminal 15q deletions but
without CDH, we were able to exclude a substantial portion of the
telomeric region from the genetic etiology of this disorder. Moreover, one
patient with CDH harbored a small interstitial deletion. Together, these
findings allowed us to define a minimal deletion region of approximately 5
Mb at chromosome 15q26.1-26.2. The region contains four known genes, of
which two--NR2F2 and CHD2--are particularly intriguing gene candidates for
CDH
Multiwavelength studies of MHD waves in the solar chromosphere: An overview of recent results
The chromosphere is a thin layer of the solar atmosphere that bridges the
relatively cool photosphere and the intensely heated transition region and
corona. Compressible and incompressible waves propagating through the
chromosphere can supply significant amounts of energy to the interface region
and corona. In recent years an abundance of high-resolution observations from
state-of-the-art facilities have provided new and exciting ways of
disentangling the characteristics of oscillatory phenomena propagating through
the dynamic chromosphere. Coupled with rapid advancements in
magnetohydrodynamic wave theory, we are now in an ideal position to thoroughly
investigate the role waves play in supplying energy to sustain chromospheric
and coronal heating. Here, we review the recent progress made in
characterising, categorising and interpreting oscillations manifesting in the
solar chromosphere, with an impetus placed on their intrinsic energetics.Comment: 48 pages, 25 figures, accepted into Space Science Review
Paroxetine reduces crying in young women watching emotional movies
Rationale: Crying is a unique human emotional reaction that has not received much attention from researchers. Little is known about its underlying neurobiological mechanisms, although there is some indirect evidence suggesting the involvement of central serotonin. Objectives: We examined the acute effects of the administration of 20 mg paroxetine on the crying of young, healthy females in response to emotional movies. Methods: We applied a double-blind, crossover randomised design with 25 healthy young females as study participants. On separate days, they received either paroxetine or placebo and were exposed to one of two emotional movies: 'Once Were Warriors' and 'Brian's Song'. Crying was assessed by self-report. In addition, the reactions to emotional International Affective Picture System (IAPS) pictures and mood were measured. Results: Paroxetine had a significant inhibitory effect on crying. During both films, the paroxetine group cried significantly less than the placebo group. In contrast, no effects on mood and only minor effects on the reaction to the IAPS pictures were observed. Conclusions: A single dose of paroxetine inhibits emotional crying significantly. It is not sure what the underlying mechanism is. However, since there was no effect on mood and only minor effects on the response to emotional pictures, we postulate that paroxetine mainly acts on the physiological processes involved in the crying response
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