Lung Circulation Modeling: Status and Prospect

Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are affected by lung injury and disease. The indicator dilution method was used to study the activity of redox processes within the lung. A steady-state model of the data was constructed and used to show that pulmonary endothelial cells may play an important role in reducing redox active compounds and that those reduction rates can be altered with oxidative stress induced by exposure to high oxygen environments. In addition, a morphometric model of the pulmonary vasculature was described and used to detect, describe,and predict changes in vascular morphology that occur in response to chronic exposure to low-oxygen environments, a common model of pulmonary hypertension. Finally, the model was used to construct simulated circulatory networks designed to aid in evaluation of competing hypotheses regarding the relative contribution of various morphological and biomechanical changes observed with hypoxia. These examples illustrate the role of mathematical modeling in the integration of the emerging metabolic, hemodynamic, and morphometric databases

Quarkonia production in a Langevin approach

We aim to describe the process of dissociation and recombination of quarkonia in the quark-gluon plasma. Therefore we developed a model which allows to observe the time evolution of a system with various numbers of charm-anticharm-quark pairs at different temperatures. The motion of the heavy quarks is realized within a Langevin approach. We use a simplified version of a formalism developed by Blaizot et al. in which an Abelian plasma is considered where the heavy quarks interact over a Coulomb like potential. We have demonstrated, that the system reaches the expected thermal distribution in the equilibrium limit.Comment: 7 pages, 5 figures, contribution to proceedings of the 34th Winter Workshop on Nuclear Dynamics (WWND 2018), Guadeloup

Coupling of spin and vibrational degrees of freedom of adsorbates at metal surfaces probed by vibrational sum-frequency generation

Vibrational spectroscopy using sum-frequency generation has been used to investigate the coupling between a ferromagnetic thin film and adsorbed molecules, here CO on Ni/Cu(100). The CO stretching vibration exhibits a strong magnetic contrast with a pronounced temperature dependence, underlining the high sensitivity of this adsorbate-specific spectroscopy method. Our results indicate that the strong temperature dependence is caused by dynamical changes in the surface chemical bond when the CO stretch vibration is coupled to thermally excited external vibrational modes

Ultra-cold atoms in an optical cavity: two-mode laser locking to the cavity avoiding radiation pressure

The combination of ultra-cold atomic clouds with the light fields of optical cavities provides a powerful model system for the development of new types of laser cooling and for studying cooperative phenomena. These experiments critically depend on the precise tuning of an incident pump laser with respect to a cavity resonance. Here, we present a simple and reliable experimental tuning scheme based on a two-mode laser spectrometer. The scheme uses a first laser for probing higher-order transversal modes of the cavity having an intensity minimum near the cavity's optical axis, where the atoms are confined by a magnetic trap. In this way the cavity resonance is observed without exposing the atoms to unwanted radiation pressure. A second laser, which is phase-locked to the first one and tuned close to a fundamental cavity mode drives the coherent atom-field dynamics.Comment: 7 pages, 7 figure

Experimental Demonstration of Squeezed State Quantum Averaging

We propose and experimentally demonstrate a universal quantum averaging process implementing the harmonic mean of quadrature variances. The harmonic mean protocol can be used to efficiently stabilize a set of fragile squeezed light sources with statistically fluctuating noise levels. The averaged variances are prepared probabilistically by means of linear optical interference and measurement induced conditioning. We verify that the implemented harmonic mean outperforms the standard arithmetic mean strategy. The effect of quantum averaging is experimentally tested both for uncorrelated and partially correlated noise sources with sub-Poissonian shot noise or super-Poissonian shot noise characteristics.Comment: 4 pages, 5 figure

PI3K mediated activation of GSK‑3β reduces at‑level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias

Background Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the development of post SCI pain syndromes. We previously demonstrated that excitotoxic induced SCI dysesthesias are associated with enhanced dorsal root ganglia (DRG) neuronal outgrowth. Although glycogen synthase kinase-3β (GSK-3β) is a known intracellular regulator neuronal growth, the potential contribution to primary afferent growth responses following SCI are undefined. We hypothesized that SCI triggers inhibition of GSK-3β signaling resulting in enhanced DRG growth responses, and that PI3K mediated activation of GSK-3β can prevent this growth and the development of at-level pain syndromes. Results Excitotoxic SCI using intraspinal quisqualic acid (QUIS) resulted in inhibition of GSK-3β in the superficial spinal cord dorsal horn and adjacent DRG. Double immunofluorescent staining showed that GSK-3βP was expressed in DRG neurons, especially small nociceptive, CGRP and IB4-positive neurons. Intrathecal administration of a potent PI3-kinase inhibitor (LY294002), a known GSK-3β activator, significantly decreased GSK-3βP expression levels in the dorsal horn. QUIS injection resulted in early (3 days) and sustained (14 days) DRG neurite outgrowth of small and subsequently large fibers that was reduced with short term (3 days) administration of LY294002. Furthermore, LY294002 treatment initiated on the date of injury, prevented the development of overgrooming, a spontaneous at-level pain related dysesthesia. Conclusions QUIS induced SCI resulted in inhibition of GSK-3β in primary afferents and enhanced at-level DRG intrinsic growth (neurite elongation and initiation). Early PI3K mediated activation of GSK-3β attenuated QUIS-induced DRG neurite outgrowth and prevented the development of at-level dysesthesias.ECU Open Access Publishing Support Fun

3D Linked Subduction, Dynamic Rupture, Tsunami, and Inundation Modeling: Dynamic Effects of Supershear and Tsunami Earthquakes, Hypocenter Location, and Shallow Fault Slip

Physics-based dynamic rupture models capture the variability of earthquake slip in space and time and can account for the structural complexity inherent to subduction zones. Here we link tsunami generation, propagation, and coastal inundation with 3D earthquake dynamic rupture (DR) models initialized using a 2D seismo-thermo-mechanical geodynamic (SC) model simulating both subduction dynamics and seismic cycles. We analyze a total of 15 subduction-initialized 3D dynamic rupture-tsunami scenarios in which the tsunami source arises from the time-dependent co-seismic seafloor displacements with flat bathymetry and inundation on a linearly sloping beach. We first vary the location of the hypocenter to generate 12 distinct unilateral and bilateral propagating earthquake scenarios. Large-scale fault topography leads to localized up- or downdip propagating supershear rupture depending on hypocentral depth. Albeit dynamic earthquakes differ (rupture speed, peak slip-rate, fault slip, bimaterial effects), the effects of hypocentral depth (25–40 km) on tsunami dynamics are negligible. Lateral hypocenter variations lead to small effects such as delayed wave arrival of up to 100 s and differences in tsunami amplitude of up to 0.4 m at the coast. We next analyse inundation on a coastline with complex topo-bathymetry which increases tsunami wave amplitudes up to ≈1.5 m compared to a linearly sloping beach. Motivated by structural heterogeneity in subduction zones, we analyse a scenario with increased Poisson's ratio of ν = 0.3 which results in close to double the amount of shallow fault slip, ≈1.5 m higher vertical seafloor displacement, and a difference of up to ≈1.5 m in coastal tsunami amplitudes. Lastly, we model a dynamic rupture “tsunami earthquake” with low rupture velocity and low peak slip rates but twice as high tsunami potential energy. We triple fracture energy which again doubles the amount of shallow fault slip, but also causes a 2 m higher vertical seafloor uplift and the highest coastal tsunami amplitude (≈7.5 m) and inundation area compared to all other scenarios. Our mechanically consistent analysis for a generic megathrust setting can provide building blocks toward using physics-based dynamic rupture modeling in Probabilistic Tsunami Hazard Analysis

Direct Observation of Longitudinally Polarised W Bosons

The three different helicity states of W bosons, produced in the reaction e+e- -> W+W- -> l nu q q~ are studied using leptonic and hadronic W decays at sqrt{s}=183GeV and 189GeV. The W polarisation is also measured as a function of the scattering angle between the W- and the direction of the e- beam. The analysis demonstrates that W bosons are produced with all three helicities, the longitudinal and the two transverse states. Combining the results from the two center-of-mass energies and with leptonic and hadronic W decays, the fraction of longitudinally polarised W bosons is measured to be 0.261 +/- 0.051(stat.) +/- 0.016(syst.) in agreement with the expectation from the Standard Model

Formation of the ηc\eta_c in Two-Photon Collisions at LEP

The two-photon width $\Gamma_{\gamma\gamma}$ of the $\eta_c$ meson has been measured with the L3 detector at LEP. The $\eta_c$ is studied in the decay modes $\pi^+\pi^-\pi^+\pi^-$, $\pi^+\pi^-$K$^+$K$^-$, K$_s^0$K$^\pm\pi^\mp$, K$^+$K$^-\pi^{0}$, $\pi^+\pi^-\eta$, $\pi^+\pi^-\eta'$, and $\rho^+\rho^-$ using an integrated luminosity of 140 pb$^{-1}$ at $\sqrt{s} \simeq 91$ GeV and of 52 pb$^{-1}$ at $\sqrt{s} \simeq 183$ GeV. The result is $\Gamma_{\gamma\gamma}(\eta_c) = 6.9 \pm 1.7 (stat.) \pm 0.8 (sys.) \pm 2.0$(BR) keV. The $Q^2$ dependence of the $\eta_c$ cross section is studied for $Q^2 < 9$ GeV$^{2}$. It is found to be better described by a Vector Meson Dominance model form factor with a J-pole than with a $\rho$-pole. In addition, a signal of $29 \pm 11$ events is observed at the $\chi_c0$ mass. Upper limits for the two-photon widths of the $\chi_c0$, $\chi_c2$, and $\eta_c'$ are also given

Study of Z Boson Pair Production in e+e- Collisions at LEP at \sqrt{s}=189 GeV

The pair production of Z bosons is studied using the data collected by the L3 detector at LEP in 1998 in e+e- collisions at a centre-of-mass energy of 189 GeV. All the visible final states are considered and the cross section of this process is measured to be 0.74 +0.15 -0.14 (stat.) +/- 0.04 (syst.) pb. Final states containing b quarks are enhanced by a dedicated selection and their production cross section is found to be 0.18 +0.09 -0.07 (stat.) +/- 0.02 (syst.) pb. Both results are in agreement with the Standard Model predictions. Limits on anomalous couplings between neutral gauge bosons are derived from these measurements