COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

A novel concept of the integrated fluorescence detection system and its application in a lab-on-a-chip microdevice

International audienc

A coupled solid phase microextraction with capillary zone electrophoresis for direct analysis of bromhexine and ambroxol in plasma samples

One of the most important tasks of modern biology is molecular investigation of biological objects and biological systems. For this purpose, more and more often chromatographic, electrophoretic and other molecular investigation techniques of separation and analysis are used. One of the main problems in the analysis of biological samples remains preparation of a sample. It usually takes approximately 60 % of the whole analysis process time and it increases the total error of the analysis by 30 %. In order to eliminate the negative impact of the complex sample matrix on accurate and reliable identification and quantification of analytes, it is necessary to create and use simple, fast coupled sample preparation and analysis techniques. [...]Vytauto Didžiojo universiteta

INTEGRATED MICROFLUIDIC-MICROOPTICAL DETECTION SYSTEMS FABRICATED BY DRY ETCHING OF SODA-LIME GLASS

ABSTRACT In this paper, a method of fabrication of a microfluidic system, integrated with fluorescence detection optics, is presented. Soda-lime glass is used as a substrate material, in which the waveguiding optics is fabricated by means of an ion exchange process, whereas the microfluidic channel is manufactured utilising reactive ion etching technique. Basic optical characteristics of the device are also reported

Integrated microfluidic–microoptical systems fabricated by dry etching of soda-lime glass

International audienc

The etching of glass patterned by microcontact printing with application to microfluidics and electrophoresis

International audienc

Grafting of antibodies inside integrated microfluidic–microoptic devices by means of automated microcontact printing

International audienc