CLINICAL AND CYTOGENETICAL STUDY OF A PATIENT WITH SYNDROME OF NO NN Е —MILRO V—-M ЕIGE COMBINED WITH SYNDROME OF LAURENCE—MOON—BARDET—BIEDL

No abstrac

CHONDROCALCINOSIS AURICULAE WITH CHONDRODERMATITIS NODULARIS HELICIS

No abstrac

Empirical Investigation on Agile Methods Usage: Issues Identified from Early Adopters in Malaysia

Agile Methods are a set of software practices that can help to produce products faster and at the same time deliver what customers want. Despite the benefits that Agile methods can deliver, however, we found few studies from the Southeast Asia region, particularly Malaysia. As a result, less empirical evidence can be obtained in the country making its implementation harder. To use a new method, experience from other practitioners is critical, which describes what is important, what is possible and what is not possible concerning Agile. We conducted a qualitative study to understand the issues faced by early adopters in Malaysia where Agile methods are still relatively new. The initial study involves 13 participants including project managers, CEOs, founders and software developers from seven organisations. Our study has shown that social and human aspects are important when using Agile methods. While technical aspects have always been considered to exist in software development, we found these factors to be less important when using Agile methods. The results obtained can serve as guidelines to practitioners in the country and the neighbouring regions

The Advantages of Polymer Composites with Detonation Nanodiamond Particles for Medical Applications

ISBN 978-953-307-271-

Identification of immunogenic candidate for new serological tests for Brucella melitensis by a proteomic approach.

Background: The diagnosis of brucellosis by serological tests is based on antigen suspensions derived from smooth lipopolysaccharide extracts, which can give false-positive results linked to cross-reactivity with other Gram-negative microorganisms, especially Yersinia enterocolitica O:9 and Escherichia coli O157:H7. Objective: The objective of the present study was the characterization by proteomic analysis of specific immunogenic proteins not associated with smooth lipopolysaccharide to improve the diagnostic tests used in the ovine brucellosis eradication programs. Methods: The serum from a sheep positive to Brucella melitensis was treated to eliminate all antibodies against such lipopolysaccharides and highlight the reaction towards the immunoreactive proteins in western blotting. Results: The immunoreactive bands were identified by nLC-MS/MS, and through bioinformatics tools, it was possible to select 12 potential candidates as protein antigens specific for Brucella melitensis. Conclusion: The detection of new antigens not subjected to cross-reactivity with other Gram-negative microorganisms can offer additional tools for the serological diagnosis of such diseases

Evaluation of the yield and the yield stability of perspective lines of barley

The study was carried out in the Experimental field of the Department of Genetics and Plant Breeding-Agricultural University, Plovdiv during the period 2009-2011. New breeding lines were investigated using block design with 4 replications and 20 m2 plot size. The aim of the investigation was to estimate barley lines by yield, stability and some important traits, using Obzor as a standard. Applying biometrical and cluster analysis and index of yield stability, it has been established that some breeding lines: numbers 21411003, 21401409 and 21001008, respectively, had better traits in comparison with the standard cultivar "Obzor" as well as stable yields regardless of differences in the climatic conditions over the years. These lines can be certified as new cultivars according to the government's requirements for cultivar testing

UPON THE ETIOLOGICAL TREATMENT OF BACTERIAL NONGONOCOCCAL URETHRITIS

No abstrac

Evaluation of the yield and the yield stability of perspective lines of barley

The study was carried out in the Experimental field of the Department of Genetics and Plant Breeding – Agricultural University, Plovdiv during the period 2009-2011. New breeding lines were investigated using block design with 4 replications and 20 m2 plot size. The aim of the investigation was to estimate barley lines by yield, stability and some important traits, using Obzor as a standard. Applying biometrical and cluster analysis and index of yield stability, it has been established that some  breeding lines: numbers 21411003, 21401409 and 21001008, respectively, had better traits in comparison with the standard cultivar “Obzor” as well as stable yields regardless of differences in the climatic conditions over the years. These lines can be certified as new cultivars according to the government’s requirements for cultivar testing

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus

Generally, the second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium Myxococcus xanthus. In response to starvation, M. xanthus initiates a developmental program that culminates in formation of spore-filled fruiting bodies. We show that c-di-GMP accumulates at elevated levels during development and that this increase is essential for completion of development whereas excess c-di-GMP does not interfere with development. MXAN3735 (renamed DmxB) is identified as a diguanylate cyclase that only functions during development and is responsible for this increased c-di-GMP accumulation. DmxB synthesis is induced in response to starvation, thereby restricting DmxB activity to development. DmxB is essential for development and functions downstream of the Dif chemosensory system to stimulate exopolysaccharide accumulation by inducing transcription of a subset of the genes encoding proteins involved in exopolysaccharide synthesis. The developmental defects in the dmxB mutant are non-cell autonomous and rescued by co-development with a strain proficient in exopolysaccharide synthesis, suggesting reduced exopolysaccharide accumulation as the causative defect in this mutant. The NtrC-like transcriptional regulator EpsI/Nla24, which is required for exopolysaccharide accumulation, is identified as a c-diGMP receptor, and thus a putative target for DmxB generated c-di-GMP. Because DmxB can be—at least partially—functionally replaced by a heterologous diguanylate cyclase, these results altogether suggest a model in which a minimum threshold level of c-di-GMP is essential for the successful completion of multicellular development in M. xanthus