Caloric Restriction Suppresses Microglial Activation and Prevents Neuroapoptosis Following Cortical Injury in Rats

Traumatic brain injury (TBI) is a widespread cause of death and a major source of adult disability. Subsequent pathological events occurring in the brain after TBI, referred to as secondary injury, continue to damage surrounding tissue resulting in substantial neuronal loss. One of the hallmarks of the secondary injury process is microglial activation resulting in increased cytokine production. Notwithstanding that recent studies demonstrated that caloric restriction (CR) lasting several months prior to an acute TBI exhibits neuroprotective properties, understanding how exactly CR influences secondary injury is still unclear. The goal of the present study was to examine whether CR (50% of daily food intake for 3 months) alleviates the effects of secondary injury on neuronal loss following cortical stab injury (CSI). To this end, we examined the effects of CR on the microglial activation, tumor necrosis factor-α (TNF-α) and caspase-3 expression in the ipsilateral (injured) cortex of the adult rats during the recovery period (from 2 to 28 days) after injury. Our results demonstrate that CR prior to CSI suppresses microglial activation, induction of TNF-α and caspase-3, as well as neurodegeneration following injury. These results indicate that CR strongly attenuates the effects of secondary injury, thus suggesting that CR may increase the successful outcome following TBI

National Jewish Welfare Board Bureau of War Records, undated, 1940-1969 1943-1946

The Bureau of War Records include approximately 85,000 individual service files and 320,000 surrogate index cards collected by the BWR and the Greater New York War Records Committee on behalf of Jewish soldiers and sailors who served in World War II. The BWR also conducted surveys of Jewish doctors, dentists, farmers and refugees who served in the United States Armed Forces and compiled population studies for cities containing Jewish populations greater than 25,000, among them Trenton, N.J. and New York City. The individual service files typically provide a soldier's name, age, rank, serial number, service branch, home address, civilian occupation, next of kin, awards and casualties. These files contain supporting documentation culled from newspapers, telephone conversations, and correspondence exchanged among BWR staff and volunteers, service personnel and their families, and representatives of the United States Armed Forces. The alphabetical master cards series serves as an abbreviated, annotated index for the more substantial individual service files of Jewish service personnel who won awards or suffered casualties during the war. The Bureau maintained correspondence files for permanent staff members including Salo Baron, Edward Burnstein, Louis Dublin, Elisha Friedman, Dr. Maurice Hexter, Rabbi Edward Israel, Samuel Kohs, Louis Kraft, Samuel Leff, Harry Lurie, Herbert Marks, Benjamin Rabinowitz, Philip Schiff, Selma Schnaper, Jerome Seidman, David Turtletaub, Frank Weil, Milton Weill, Arthur Weyne, and Joseph Zubin.The records were donated by the National Jewish Welfare Board.The National Jewish Welfare Board and its affiliated member organizations established the Bureau of War Records for the purpose of collecting and compiling information about Jewish Americans who served in the United States Armed Forces during World War II.The National Jewish Welfare Board